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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Kronuz 200 mg Infusion Combipack 1's is used to treat fungal infections. It contains Isavuconazole, which works by fungicidal actions by disrupting the biosynthesis of ergosterol, which is essential for their survival and kills the fungus that causes infection. Common side effects of Kronuz 200 mg Infusion Combipack 1's are headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain.
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Whats That

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Composition :

ISAVUCONAZOLE-200MG

Manufacturer/Marketer :

AAA Pharma Trade Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Kronuz 200 mg Infusion Combipack 1's

Kronuz 200 mg Infusion Combipack 1's belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis (in patients for whom Amphotericin B is not suitable). Invasive aspergillosis is an infection caused by Aspergillus fungus. It occurs by breathing and spreads from the lungs to the kidneys, brain, heart or skin. Mucormycosis is a rare but serious fungal infection of the skin or respiratory system that occurs in people with weakened immune systems.

Kronuz 200 mg Infusion Combipack 1's contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.

Kronuz 200 mg Infusion Combipack 1's will be administered by a healthcare professional; do not self-administer. Some people may experience headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of Kronuz 200 mg Infusion Combipack 1's do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to Kronuz 200 mg Infusion Combipack 1's or any other medicines, please tell your doctor. Kronuz 200 mg Infusion Combipack 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Kronuz 200 mg Infusion Combipack 1's. Avoid breastfeeding while taking Kronuz 200 mg Infusion Combipack 1's. Drive only if you are alert after taking Kronuz 200 mg Infusion Combipack 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Kronuz 200 mg Infusion Combipack 1's as it may increase the risk of liver damage.

Uses of Kronuz 200 mg Infusion Combipack 1's

Treatment of Invasive aspergillosis and Mucormycosis

Directions for Use

• Kronuz 200 mg Infusion Combipack 1's is administered only in clinical settings by healthcare professionals.• Dosage and frequency are determined by the doctor based on medical needs.• Do not self-administer this injection, as improper use may lead to side effects.

Medicinal Benefits

Kronuz 200 mg Infusion Combipack 1's contains Isavuconazole, a broad-spectrum antifungal that is effective against a wide variety of microorganisms. It inhibits the synthesis of fungal cell membranes that are essential for their survival. Thereby, Kronuz 200 mg Infusion Combipack 1's kills or stops the growth of the fungus.

How Kronuz 200 mg Infusion Combipack 1's Works

Kronuz 200 mg Infusion Combipack 1's contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.

Storage

• Store in a cool and dry place away from sunlight.• Keep Kronuz 200 mg Infusion Combipack 1's out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC

What if I have taken an overdose of Kronuz 200 mg Infusion Combipack 1's

As Kronuz 200 mg Infusion Combipack 1's is a parenteral formulation, the chance of overdose may be less. However, keep track of your medicine as an overdose of Kronuz 200 mg Infusion Combipack 1's may cause serious side effects. Seek immediate medical attention if you observe any side effects.

Drug Warnings

If you are allergic to Kronuz 200 mg Infusion Combipack 1's or any other medicines, please tell your doctor. Kronuz 200 mg Infusion Combipack 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Kronuz 200 mg Infusion Combipack 1's. Avoid breastfeeding while taking Kronuz 200 mg Infusion Combipack 1's. Drive only if you are alert after taking Kronuz 200 mg Infusion Combipack 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Kronuz 200 mg Infusion Combipack 1's as it may increase the risk of liver damage. If you experience severe blistering of the eyes, mouth, skin or genitals, seek immediate medical help.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir may significantly increase the blood levels of Kronuz 200 mg Infusion Combipack, which may increase the risk of side effects.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsavuconazoleSaquinavir
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Saquinavir, it can increase the risk of liver damage.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Saquinavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
The blood levels and effects of Kronuz 200 mg Infusion Combipack may be significantly enhanced by taking Itraconazole along with it.

How to manage the interaction:
Co-administration of Kronuz 200 mg Infusion Combipack and Itraconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Carbamazepine and Kronuz 200 mg Infusion Combipack are taken together, carbamazepine will reduce the effectiveness of the Kronuz 200 mg Infusion Combipack.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Carbamazepine is not recommended, it can be taken if prescribed by the doctor. Do not discontinue any medications without doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Phenobarbital, may decrease the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenobarbital is not recommended it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Co-administration of phenytoin and Kronuz 200 mg Infusion Combipack may significantly reduce the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective in treating your condition.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with primidone may decrease the blood levels of Kronuz 200 mg Infusion Combipack and reduce its effectiveness.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleFosamprenavir
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Fosamprenavir is taken with Kronuz 200 mg Infusion Combipack, it can increase the risk of side effects like liver damage.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Fosamprenavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Posaconazole, it can increase the levels of Kronuz 200 mg Infusion Combipack in the blood.

How to manage the interaction:
Although there is an interaction between Kronuz 200 mg Infusion Combipack and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to avoid areas with a lot of dust like excavation or construction sites. If you can’t avoid it, wear an N95 mask while going to such places.
  • Clean skin injuries with soap and water, especially if they have been exposed to dust or soil to decrease the chances of developing a skin infection.
  • Bandage all wounds until they heal to prevent fungal infections.
  • Wash your hands frequently and keep your hands clean to prevent the spread of germs.
  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt, long pants and a mask while doing outdoor activities such as yard work, gardening or vising wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Kronuz 200 mg Infusion Combipack 1's Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Kronuz 200 mg Infusion Combipack 1's as it may increase the risk of liver damage.

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Pregnancy

Consult your doctor

Kronuz 200 mg Infusion Combipack 1's is not recommended during pregnancy except in patients with severe or potentially life-threatening fungal infections in whom Kronuz 200 mg Infusion Combipack 1's may be used if the doctor thinks the benefits outweigh the risks. Therefore, please inform your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Kronuz 200 mg Infusion Combipack 1's. Please inform your doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking Kronuz 200 mg Infusion Combipack 1's as it may cause drowsiness, confusion or dizziness.

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Liver

Caution

Inform your doctor if you have liver problems before receiving Kronuz 200 mg Infusion Combipack 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Kidney

Caution

The use of Kronuz 200 mg Infusion Combipack 1's in patients with severe Kidney impairment is not established. Inform your doctor if you have kidney problems before receiving Kronuz 200 mg Infusion Combipack 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Children

Unsafe

Kronuz 200 mg Infusion Combipack 1's is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Kronuz 200 mg Infusion Combipack 1's is used to treat Invasive aspergillosis and Mucormycosis.

Kronuz 200 mg Infusion Combipack 1's contains Isavuconazole which works by inhibiting the synthesis of fungal cell membranes which are essential for their survival. Thereby, Kronuz 200 mg Infusion Combipack 1's kills or inhibits the growth of the fungus.

Mucormycosis is not contagious. Mucormycosis is a severe fungal infection of the skin or respiratory system that occurs in people with a weakened immune system.

Kronuz 200 mg Infusion Combipack 1's may cause headaches as a common side effect. However, if the condition persists or worsens, please consult a doctor.

You are not recommended to take Kronuz 200 mg Infusion Combipack 1's with ketoconazole as it may increase the levels of Kronuz 200 mg Infusion Combipack 1's in your blood and increase the risk of side effects such as diarrhoea, vomiting, nausea or liver problems. However, please consult your doctor before taking Kronuz 200 mg Infusion Combipack 1's with other medicines.

Kronuz 200 mg Infusion Combipack 1's should be used with caution in patients with liver problems as Kronuz 200 mg Infusion Combipack 1's may increase liver enzymes. Thus, monitoring of liver enzymes is advised while taking Kronuz 200 mg Infusion Combipack 1's. However, you are recommended to inform your doctor if you have any liver problems.

Country of origin

India

Manufacturer/Marketer address

E-11, Moti Nagar , New Delhi-110015
Other Info - KRO0055

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