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compositionComposition:ISAVUCONAZOLE-200MG
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Prescription Medicine
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Kronuz 200 mg Injection 1's is used to treat fungal infections. It contains Isavuconazole, which works by fungicidal actions by disrupting the biosynthesis of ergosterol, which is essential for their survival and kills the fungus that causes infection. Common side effects of Kronuz 200 mg Injection 1's are headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISAVUCONAZOLE-200MG

Manufacturer/Marketer :

AAA Pharma Trade Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Kronuz 200 mg Injection 1's

This injection is a prescription medication used to treat serious, deep-tissue fungal infections in adults. It is used to treat life-threatening conditions such as invasive aspergillosis and invasive mucormycosis. This medicine is approved for adults only, and its safety and effectiveness in children have not been established.

Since this medicine is given directly into a vein, a healthcare professional will inject it in a hospital or clinic setting. The treatment is given on a regular schedule determined by your doctor, and keeping every appointment is vital for it to work successfully. Eating a nutrient-rich diet and getting plenty of rest can support your body's immune system during recovery.

Once your condition has improved, your doctor may switch you from the intravenous infusion to the oral capsule form of Kronuz 200 mg Injection 1's to complete your course of treatment. Your doctor will decide when this change is appropriate.

While using this medicine, you may experience common side effects like nausea, vomiting, headache, or diarrhoea. However, you must contact your doctor immediately if you experience severe symptoms such as yellowing of your skin or eyes, dark urine, or severe stomach pain. These can be signs of serious liver damage.

Before starting treatment, tell your medical team if you have liver disease, kidney problems, or a family history of a specific heart rhythm issue known as short QT syndrome. Do not take this if you have hereditary short QT syndrome, as it can affect your heartbeat.

This medication can interact with many other medicines, which may change how they work or increase side effects. Tell your doctor if you drink alcohol or smoke regularly, as these habits can also impact your treatment. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits with your doctor before starting therapy.

Uses of Kronuz 200 mg Injection 1's

Kronuz 200 mg Injection 1's helps treat serious fungal infections by stopping the growth of fungi or destroying their cell membranes. Your doctor may recommend it for the following conditions:

  • Invasive aspergillosis: Kronuz 200 mg Injection 1's helps clear this serious fungal infection of the lungs or other organs by stopping the growth of the fungus in patients with compromised immune systems.
  • Invasive mucormycosis: Kronuz 200 mg Injection 1's helps treat this rare but very severe fungal infection that can spread rapidly, by destroying the cell membranes of the fungus to stop the infection from spreading.

Key Benefits

This medication offers key clinical benefits for managing severe fungal diseases:

  • Targeted fungal clearance: It specifically targets the cell membrane of harmful fungi by disrupting ergosterol production, stopping the fungi from growing and allowing your immune system to fight the infection.
  • Improved recovery outcomes: By rapidly controlling the spread of invasive fungi in the body, it helps patients recover from severe infections that could otherwise be life-threatening.
  • Convenient intravenous delivery: The injection form ensures that the medicine enters your bloodstream immediately, which is crucial for treating fast-moving infections.
Side effects of Kronuz 200 mg Infusion Combipack
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Kronuz 200 mg Injection 1's is administered only in clinical settings by healthcare professionals.
  • Dosage and frequency are determined by the doctor based on medical needs.
  • Do not self-administer this injection, as improper use may lead to side effects.

How Kronuz 200 mg Injection 1's Works

Kronuz 200 mg Injection 1's contains isavuconazole, an antifungal medicine that works by blocking the production of ergosterol, an essential component of the fungal cell membrane. Without enough ergosterol, the fungal cell membrane becomes weak and damaged, making it difficult for the fungus to survive and grow. By disrupting the fungal cell membrane, the medicine stops the fungus from growing and spreading, allowing your body's immune system to clear the infection more effectively. This helps treat serious fungal infections such as invasive aspergillosis and invasive mucormycosis.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Kronuz 200 mg Injection 1's as it may increase the risk of liver damage.

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Pregnancy

Consult your doctor

Kronuz 200 mg Injection 1's is not recommended during pregnancy except in patients with severe or potentially life-threatening fungal infections in whom Kronuz 200 mg Injection 1's may be used if the doctor thinks the benefits outweigh the risks. Therefore, please inform your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Kronuz 200 mg Injection 1's. Please inform your doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking Kronuz 200 mg Injection 1's as it may cause drowsiness, confusion or dizziness.

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Liver

Caution

Inform your doctor if you have liver problems before receiving Kronuz 200 mg Injection 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Kidney

Caution

The use of Kronuz 200 mg Injection 1's in patients with severe Kidney impairment is not established. Inform your doctor if you have kidney problems before receiving Kronuz 200 mg Injection 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Children

Unsafe

Kronuz 200 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Inform your doctor if you have heart problems before receiving Kronuz 200 mg Injection 1's, as it may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Geriatrics

Consult your doctor

Limited information available about the use of Kronuz 200 mg Injection 1's in geriatric patients. Please consult your physician.

What if I have taken an overdose of Kronuz 200 mg Injection 1's

Since a trained professional injects this medication, an overdose is rare. If you suspect you have received too much of this medicine, or if you experience unusual chest pain, dizziness, or confusion during or after your infusion, tell your medical team immediately.

Diet & Lifestyle Advise

  • Eat clean, fully cooked foods: Because severe fungal infections often affect people with weaker immune systems, avoid raw or undercooked meats, unpasteurized dairy, and unwashed fruits to reduce the risk of foodborne infections.
  • Stay well-hydrated: Drink plenty of water to help your kidneys flush out waste products and keep your body hydrated during recovery.
  • Prioritize rest: Your body needs energy to fight off deep infections. Ensure you get 7 to 9 hours of sleep nightly and avoid strenuous activities unless cleared by your physician.
  • Practice strict hygiene: Wash your hands frequently with soap and water to protect yourself from other opportunistic infections while your immune system is compromised.
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How Soon It Starts Working

The time required for Kronuz 200 mg Injection 1's to start to work: Kronuz 200 mg Injection 1's shows its action within 1 to 2 hours of IV administration. The time for which the effects of Kronuz 200 mg Injection 1's last: Kronuz 200 mg Injection 1's effect last for a few hours.

What if you forget to take Kronuz 200 mg Injection 1's

Because this medication is usually administered by a healthcare provider in a clinic or hospital, missing a dose is unlikely. However, if you miss an appointment for your infusion, contact your healthcare provider right away to reschedule.

Storage

• Store the unopened vials of Kronuz 200 mg Injection 1's in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze the vials.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect the fluid: Always look at the mixed liquid before it is injected. It should be clear and pale yellow to almost colourless. Do not use it if you see floating particles, cloudiness, or discolouration.
  • Watch for infusion reactions: Let your nurse or doctor know immediately if you experience chills, dizziness, sweating, or a warm feeling during the injection. The infusion may need to be slowed down or stopped.
  • Report new medicines: Keep a complete, updated list of all medications you take and share it with your healthcare team, as Kronuz 200 mg Injection 1's can cause serious interactions with many common drugs.
  • Monitor your liver health: Your doctor will likely order regular blood tests to check how well your liver is working while you are receiving this treatment.
  • Avoid pregnancy: Use effective birth control during treatment and for a short period after your last dose, as this medicine may harm an unborn baby.
  • Monitor your health: Your doctor will perform regular blood tests to check your liver function, kidney function, and electrolyte levels (especially potassium) during treatment to ensure the medicine remains safe and effective.

Drug-Drug Interactions

verifiedApollotooltip

  • Strong CYP3A4 inhibitors (like ketoconazole or ritonavir): May significantly increase the levels of Kronuz 200 mg Injection 1's in your blood, raising the risk of severe side effects.
  • Strong CYP3A4 inducers (like rifampin, carbamazepine, or phenytoin): May severely lower the amount of Kronuz 200 mg Injection 1's in your body, making the treatment much less effective at fighting the infection.
  • Medicines affected by liver enzymes (like midazolam, atorvastatin, or cyclosporine): Kronuz 200 mg Injection 1's can increase the levels of these drugs in your blood, which may require your doctor to adjust their doses.
IsavuconazoleKetoconazole
Critical
IsavuconazoleCisapride
Critical

Drug-Drug Interactions

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IsavuconazoleKetoconazole
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Co-administration of Ketoconazole and Kronuz 200 mg Infusion Combipack can significantly increase the blood levels of Kronuz 200 mg Infusion Combipack, which may increase the risk of side effects.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ketoconazole is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
IsavuconazoleCisapride
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
IsavuconazoleCarbamazepine
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Carbamazepine and Kronuz 200 mg Infusion Combipack are taken together, carbamazepine will reduce the effectiveness of the Kronuz 200 mg Infusion Combipack.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Carbamazepine is not recommended, it can be taken if prescribed by the doctor. Do not discontinue any medications without doctor's advice.
IsavuconazolePosaconazole
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Posaconazole, it can increase the levels of Kronuz 200 mg Infusion Combipack in the blood.

How to manage the interaction:
Although there is an interaction between Kronuz 200 mg Infusion Combipack and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleCeritinib
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking ceritinib with Kronuz 200 mg Infusion Combipack may significantly increase the blood levels of Kronuz 200 mg Infusion Combipack.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleItraconazole
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
The blood levels and effects of Kronuz 200 mg Infusion Combipack may be significantly enhanced by taking Itraconazole along with it.

How to manage the interaction:
Co-administration of Kronuz 200 mg Infusion Combipack and Itraconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleRitonavir
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir may significantly increase the blood levels of Kronuz 200 mg Infusion Combipack, which may increase the risk of side effects.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsavuconazolePrimidone
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with primidone may decrease the blood levels of Kronuz 200 mg Infusion Combipack and reduce its effectiveness.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazolePhenytoin
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Co-administration of phenytoin and Kronuz 200 mg Infusion Combipack may significantly reduce the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective in treating your condition.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
IsavuconazolePhenobarbital
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Phenobarbital, may decrease the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenobarbital is not recommended it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Grapefruit and grapefruit juice may affect how Kronuz 200 mg Injection 1's is broken down in the body, potentially changing its effectiveness or increasing the risk of side effects. Avoid consuming grapefruit products unless your doctor advises otherwise.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Yes. Kronuz 200 mg Injection 1's can cause increases in liver enzymes and, in some cases, serious liver injury. Patients with existing liver disease should use this medicine with caution and may require regular liver function tests during treatment. Inform your doctor if you have liver disease or develop symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea.
Before starting Kronuz 200 mg Injection 1's, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, have liver disease, heart rhythm problems (including short QT syndrome), or are taking any prescription medicines, over-the-counter medicines, supplements, or herbal products. Kronuz 200 mg Injection 1's is generally not recommended during pregnancy because it may harm the unborn baby. Your doctor will determine whether this treatment is appropriate for you.
This medication is given as an intravenous (IV) infusion directly into a vein by a healthcare professional, usually in a hospital or clinic setting. Talk to your doctor if you have questions about your infusion schedule.
Each intravenous infusion of this medicine typically takes between 1 to 2 hours to complete. Talk to your doctor if you experience any discomfort during the process.
It is best to avoid alcohol during your treatment, as alcohol can place extra stress on your liver, which is already processing this medication. Talk to your doctor about your lifestyle habits.
You should report any new skin rash, blistering, or peeling to your medical team immediately, as severe skin reactions can occur with this medicine. Talk to your doctor right away if you notice these signs.
No, this medication is a specialized antifungal used only to treat serious, invasive fungal infections and will not work against viral infections like the cold or flu. Talk to your doctor if you suspect you have an infection.
You should tell your healthcare provider about all of your medical conditions, especially if you have heart rhythm issues (like short QT syndrome), liver disease, or if you are taking any other medications, supplements, or herbal products. Talk to your doctor to ensure this treatment is safe for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.5069 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 207500Orig1S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Isavuconazonium sulfate [EMC Label]. 2021. [Accessed on 03 Jul. 2021]Check here
  4. Clinical research advances of isavuconazole in the treatment of invasive fungal diseases. National Center for Biotechnology Information. National Library of Medicine. PMC. PubMed Central. December 2022. [Accessed on 22nd August 2024]Check here
  5. NHS Manchester University. Isavuconazole. National Aspergillosis Centre. [Accessed on 22nd August 2024]Check here
  6. Isavuconazole. Cresemba 100mg Hard Capsules. EMC. UK. [Revised in October 2023]. [Accessed on 22nd August 2024]Check here
  7. Cresemba Epar Product Information En. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

E-11, Moti Nagar , New Delhi-110015
Other Info - KRO0055
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