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Klox-D 500 Capsule is used to treat bacterial infections. It contains Dicloxacillin which works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as heartburn, nausea, vomiting, diarrhoea, red or swollen gums, and blisters/ulcers in the mouth. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DICLOXACILLIN-500MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Klox-D 500 Capsule

Klox-D 500 Capsule is an oral antibiotic used to treat a variety of bacterial infections, particularly those affecting the skin, bones, joints, and respiratory tract. Its primary medical purpose is to stop the growth of bacteria that have developed resistance to standard penicillin treatments. By clearing these targeted bacterial infections, this medication helps your body heal and prevents the infection from spreading.

To ensure the medicine works effectively, it must be taken consistently at evenly spaced times throughout the day as prescribed by your doctor. You should always take this medication on an empty stomach, either one hour before or two hours after a meal, because food can significantly decrease how well your body absorbs it. Incorporating daily habits like drinking plenty of water and eating a balanced diet can support your body's recovery process.

While taking Klox-D 500 Capsule , you may experience mild side effects such as nausea, vomiting, or mild diarrhoea. However, you must contact your doctor immediately if you experience severe symptoms like watery or bloody diarrhoea, yellowing of your skin or eyes, or signs of an allergic reaction like a skin rash.

Before starting this medication, tell your doctor if you have a history of allergies, asthma, or kidney disease. Do not take this if you have a known severe allergy to penicillin or cephalosporin antibiotics, as this could lead to a life-threatening reaction.

This medication can interact with other medicines, such as blood thinners, which may increase the risk of bleeding. Current evidence suggests that penicillin-class antibiotics are unlikely to reduce the effectiveness of hormonal contraceptives significantly. If you rely solely on hormonal contraception, discuss with your doctor or pharmacist whether any additional contraceptive precautions are appropriate for your individual situation. It is also important to avoid alcohol while taking this medicine to prevent increased stomach upset and support your immune system. Pregnant, breastfeeding, or elderly individuals should consult their doctor or pharmacist before starting treatment to ensure it is safe for their specific situation.

Uses of Klox-D 500 Capsule

Klox-D 500 Capsule is used to treat a variety of bacterial infections, particularly those affecting the skin, bones, joints, and respiratory tract. The detailed uses of Klox-D 500 Capsule are as follows:

  • Skin and soft tissue infections: Treats painful bacterial skin conditions such as boils, impetigo, cellulitis, and infected wounds by stopping bacterial growth.
  • Bone and joint infections: Helps clear deep-seated bacterial infections in the bones or joints, helping to restore normal movement.
  • Respiratory tract infections: Fights bacterial infections in the lungs and airways, helping you breathe more easily as the infection clears.

Key Benefits

Klox-D 500 Capsule provides effective treatment for bacterial infections by stopping the growth and spread of harmful bacteria. With regular use as prescribed, it helps relieve infection-related symptoms, promotes faster healing, and reduces the risk of complications.

  • Treats Bacterial Infections: By preventing bacteria from multiplying, this medicine helps your body's natural immune system eliminate the infection and heal the affected tissues.
  • Relieves Infection Symptoms: This medicine helps reduce swelling, redness, warmth, tenderness, and other signs of infection, with noticeable improvement often occurring within a few days of starting treatment.
  • Promotes Complete Recovery: Completing the full course of treatment helps clear the infection, reduces the risk of it spreading to deeper tissues or the bloodstream, and lowers the chance of the infection returning.
Side effects of Klox-D 500 Capsule
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Klox-D 500 Capsule should be taken on an empty stomach at least 1 hour before or 2 hours after a meal as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Klox-D 500 Capsule as a whole with a glass of water.
  • Do not chew, crush or break it.

How Klox-D 500 Capsule Works

Klox-D 500 Capsule contains dicloxacillin, which belongs to a group of medicines known as penicillinase-resistant penicillins. Bacteria often defend themselves against standard penicillins by producing a special enzyme that destroys the medicine. This medication is uniquely designed to resist this enzyme, allowing it to successfully attach to the bacterial cell wall. Klox-D 500 Capsule works by actively interfering with the construction of the bacteria's protective outer wall. Without a stable cell wall, the bacteria cannot survive the pressure within their own cells, causing them to rupture and die. Because human cells do not have cell walls, this process selectively targets and destroys the bacteria without harming your own cells.
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Alcohol

Caution

Avoid alcohol consumption while taking Klox-D 500 Capsule to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

It is not known if Klox-D 500 Capsule affects pregnancy. Please consult your doctor before taking Klox-D 500 Capsule if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Klox-D 500 Capsule is excreted into the breast milk and may harm a nursing baby. Please consult your doctor before taking Klox-D 500 Capsule if you are breastfeeding.

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Driving

Caution

It is unknown whether Klox-D 500 Capsule affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience any dizziness after taking Klox-D 500 Capsule , do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Klox-D 500 Capsule . Your doctor will prescribe Klox-D 500 Capsule only if the benefits outweigh the risk.

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Kidney

Caution

If you have any history of kidney diseases before taking Klox-D 500 Capsule , please inform your doctor. Your doctor will prescribe Klox-D 500 Capsule only if the benefits outweigh the risk.

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Children

Caution

Klox-D 500 Capsule is to be given to children only when prescribed by the doctor.

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Heart

Caution

Klox-D 500 Capsule should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Klox-D 500 Capsule .

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Geriatrics

Caution

Klox-D 500 Capsule should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Klox-D 500 Capsule in geriatrics, please consult your doctor.

What if I have taken an overdose of Klox-D 500 Capsule

In case of an accidental overdose, seek immediate medical attention. Symptoms of an overdose may include severe stomach pain, persistent vomiting, or, in rare cases, seizures.

Diet & Lifestyle Advise

  • Take a high-quality probiotic supplement or eat yoghurt containing live, active cultures a few hours after your antibiotic dose to help maintain a healthy balance of gut bacteria.
  • Drink plenty of fluids, especially water, throughout the day to keep your kidneys functioning well and to help your body flush out toxins.
  • Keep any infected skin wounds clean, dry, and safely covered with sterile dressings to prevent re-infection or spreading the bacteria to others.
  • Take the medicine on an empty stomach: For the best absorption, take Klox-D 500 Capsule at least 1 hour before or 2 hours after meals, unless your doctor advises otherwise. Food in general can reduce how much of the medicine your body absorbs.
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Have a query?

How Soon It Starts Working

The time required for Klox-D 500 Capsule to start to work: Klox-D 500 Capsule ideally shows its action within 30 minutes after administration. The time for which the effects of Klox-D 500 Capsule last: The effect of Klox-D 500 Capsule lasts for 6 hours.

What if you forget to take Klox-D 500 Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular timing. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Klox-D 500 Capsule capsules in their original container, tightly closed to protect them from moisture and contamination •Keep the medicine at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Do not share Klox-D 500 Capsule with anyone else, even if they have symptoms that look identical to yours, as using the wrong antibiotic can be dangerous.
  • If you develop a new skin rash, hives, or difficulty breathing, stop taking the medicine immediately and seek emergency medical care.
  • If you regularly use antacids, ask your doctor or pharmacist whether they should be taken at a different time from Klox-D 500 Capsule . As a general precaution, spacing medicines apart may help minimise the possibility of absorption-related interactions.
  • Current evidence suggests that penicillin-class antibiotics are unlikely to reduce the effectiveness of hormonal contraceptives significantly. If you rely solely on hormonal contraception, speak with your doctor or pharmacist about whether any additional contraceptive precautions are recommended for you.
  • Always inspect the capsules before taking them; do not take any capsule that appears discoloured, cracked, or damaged.

Drug-Drug Interactions

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  • Blood thinners (such as warfarin): Klox-D 500 Capsule may increase the blood-thinning effect, which can raise your risk of bleeding or bruising.
  • Methotrexate: This antibiotic can slow down how quickly your body clears methotrexate, potentially leading to toxic levels of the medication in your blood.
  • Hormonal contraceptives: Current evidence suggests that penicillin antibiotics are unlikely to significantly reduce the effectiveness of hormonal contraceptives. If you rely solely on hormonal contraception, consult your doctor or pharmacist for personalised advice.
  • Other antibiotics (like tetracyclines): Taking certain other antibiotics at the same time can interfere with how effectively Klox-D 500 Capsule kills bacteria.

Drug-Drug Interactions

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How does the drug interact with Klox-D 500 Capsule:
Co-administration of methotrexate with Klox-D 500 Capsule can increase the levels and effects of methotrexate. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Klox-D 500 Capsule, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

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  • Food: Taking Klox-D 500 Capsule with food can reduce its absorption and make it less effective. For best results, take it on an empty stomach, 1 hour before or 2 hours after meals, unless your doctor advises otherwise.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Klox-D 500 Capsule contains Dicloxacillin. It inhibits bacterial cell wall synthesis and causes cell lysis or death. Thus, Klox-D 500 Capsule helps in treating various bacterial infections.
Klox-D 500 Capsule should be used with proper caution and doctor consultation if you have any medical history of asthma, kidney disease, stomach problems (nausea, vomiting, digestive issues), bleeding disorders, and heart or liver diseases.
Klox-D 500 Capsule can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Klox-D 500 Capsule if you are undergoing any vaccinations.
It is recommended to complete the course of Klox-D 500 Capsule even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Klox-D 500 Capsule for as long as your doctor has prescribed to treat your condition effectually.
Klox-D 500 Capsule is an antibiotic used to treat bacterial infections, such as bronchitis (inflammation of the tubes that carry air to your lungs), pneumonia (infection in one or both lungs), and staphylococcal infections.
The common side effects of Klox-D 500 Capsule include heartburn, nausea, vomiting, diarrhoea, red or swollen gums, and blisters/ulcers in the mouth. If any of these effects persist or worsen, please inform your doctor.
No, you should not take Klox-D 500 Capsule with food. For the medicine to work properly, take it on an empty stomach, either 1 hour before or 2 hours after a meal. Food greatly reduces how much of the medicine your body can absorb. Talk to your doctor or pharmacist if you are having trouble timing your doses.
Mild diarrhoea is a common side effect of antibiotics. However, if you develop severe, watery, or bloody diarrhoea, stop taking the medicine and call your doctor right away. Do not take any over-the-counter anti-diarrhoea medicines without asking your doctor first. Talk to your doctor for further guidance.
This medicine is generally considered safe during pregnancy, but it should only be used when clearly needed. Small amounts of the medicine can pass into breast milk, which might affect a nursing infant. Talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.
While alcohol does not directly stop the medicine from working, it is highly recommended to avoid alcohol while treating an infection. Alcohol can dehydrate your body, weaken your immune system, and worsen side effects like nausea or stomach upset. Talk to your doctor if you have questions about alcohol use.
No, Klox-D 500 Capsule is an antibiotic and only works against infections caused by bacteria. It has no effect against viral infections, such as the common cold, flu, or certain bronchial infections. Using antibiotics when they are not needed can make future bacterial infections harder to treat. Talk to your doctor for an accurate diagnosis.
If you develop a skin rash, hives, itching, or any swelling, stop taking the medicine immediately. These are common warning signs of a penicillin allergy, which can quickly become dangerous. Seek medical care right away and talk to your doctor before taking any similar medications.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Dicloxacillin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here
  4. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Klox D 500 Capsule
  5. Petri WA Jr Penicillins, Cephalosporins, and Other β -Lactam Antibiotics. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1486-87

Country of origin

INDIA

Manufacturer/Marketer address

7-2-A2, Hetero Corporate, Industrial Estates, Sanath Nagar, Hyderabad – 500 018. Telangana, INDIA
Other Info - KLO0007
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