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compositionComposition:APROTININ-50ML
prescription
Prescription Medicine
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Kallistat Injection is used to reduce the risk of bleeding during and after surgery. It contains aprotinin that prevents bleeding by inhibiting the activation of coagulants. In some cases, Kallistat Injection may cause chest pain, stomach upset, fast heartbeat and injection site reactions. It is not recommended for children below 18 years as the safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects/interactions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

APROTININ-50ML

Manufacturer/Marketer :

Biosena Life Sciences

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Kallistat Injection

Kallistat Injection is a specialised injectable medication used during complex heart bypass surgeries to reduce excessive blood loss and limit the need for blood transfusions. By supporting the body's natural clotting processes during major surgical procedures, it helps maintain blood volume and protects vital organs. Because it is administered exclusively in hospital operating rooms, its use is carefully planned and managed by your surgical team.

Since this medication is delivered as a one-time treatment during your surgery, there is no ongoing daily schedule for you to manage. To support your body's recovery after receiving this treatment, your doctor will likely recommend specific lifestyle adjustments during your post-operative period. These recovery measures typically include eating a heart-healthy diet and participating in guided physical rehabilitation.

While Kallistat Injection is highly effective, it can sometimes cause side effects that your medical team will monitor closely. Some patients may experience temporary changes in kidney function or blood pressure, which are usually managed immediately by hospital staff. It is important to notify your healthcare team immediately if you experience any unexpected symptoms, such as breathing difficulties or skin rashes, during your recovery.

Before undergoing surgery, you must discuss your full medical history with your doctor, especially if you have a history of kidney disease or have undergone heart surgery in the past. Do not take this if you have received this specific medication within the last 12 months, as this significantly increases the risk of a severe allergic reaction. Your surgical team will evaluate your eligibility to ensure this treatment is safe for you.

This medication can interact with other treatments, including blood thinners and certain blood pressure medications, which may alter its effectiveness or increase side effect risks. If you are pregnant, breastfeeding, or an older adult, your doctor will carefully weigh the benefits against the potential risks before deciding to use this treatment. Always consult your doctor or pharmacist to discuss how your current medications and health status might affect your treatment plan.

Uses of Kallistat Injection

Kallistat Injection is used during complex heart bypass surgeries to reduce excessive blood loss and limit the need for blood transfusions. The detailed uses of Kallistat Injection are as follows:

  • Reducing blood loss during heart bypass surgery: Kallistat Injection helps control bleeding by preventing the premature breakdown of blood clots during complex cardiopulmonary bypass procedures.
  • Minimising the need for blood transfusions: By preserving your own blood during surgery, Kallistat Injection significantly decreases the likelihood of requiring donor blood transfusions, reducing associated medical risks.

Key Benefits

Kallistat Injection is used during complex heart bypass surgeries to reduce excessive blood loss and limit the need for blood transfusions. The detailed uses of Kallistat Injection are as follows:

  • Reducing blood loss during heart bypass surgery: Kallistat Injection helps control bleeding by preventing the premature breakdown of blood clots during complex cardiopulmonary bypass procedures.
  • Minimising the need for blood transfusions: By preserving your own blood during surgery, Kallistat Injection significantly decreases the likelihood of requiring donor blood transfusions, reducing associated medical risks.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Kallistat Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Kallistat Injection Works

During open-heart surgery, the body's natural systems can become highly stressed, sometimes causing blood clots to break down much faster than normal. This rapid breakdown leads to excessive bleeding. Kallistat Injection contains aprotinin, which works by acting as a targeted shield for your blood clots. It temporarily blocks specific proteins in your bloodstream, primarily plasmin and kallikrein, which are responsible for dissolving clots. By keeping these clot-dissolving proteins in check, Kallistat Injection preserves the structural integrity of your natural blood clots. Additionally, it helps protect your platelets, the tiny cells in your blood responsible for stopping bleeding, ensuring they function effectively throughout your surgical procedure.
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Alcohol

Consult your doctor

It is not known if Kallistat Injection interacts with alcohol. Please consult your doctor.

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Pregnancy

Caution

If you are pregnant, inform your doctor before receiving Kallistat Injection. The doctor will prescribe the medicine only if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Kallistat Injection. The doctor will prescribe the medicine only if the benefits outweigh the risks.

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Driving

Not applicable

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Kallistat Injection.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Kallistat Injection. It should be used only in patients with kidney problems if the doctor/surgeon thinks the benefits outweigh the risks.

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Children

Unsafe

Kallistat Injection is not recommended for children below 18 years as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Kallistat Injection if you have pre-existing heart problems. Your doctor will prescribe Kallistat Injection if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Kallistat Injection to geriatric patients. Your doctor will prescribe Kallistat Injection if the benefits outweigh the risks.

What if I have taken an overdose of Kallistat Injection

Because Kallistat Injection is carefully measured and administered by specialised medical professionals in a monitored surgical environment, an overdose is extremely unlikely. In the rare event that too much medication is given, your hospital care team is equipped to manage it immediately. If you have concerns, talk to your doctor or pharmacist.

Diet & Lifestyle Advise

  • Adhere strictly to a heart-healthy, low-sodium diet to manage your blood pressure and reduce strain on your cardiovascular system during recovery.
  • Drink adequate fluids as recommended by your physician to keep your kidneys well-hydrated and help them recover from surgery.
  • Participate in a structured cardiac rehabilitation program or engage in gentle, doctor-approved daily walking to gradually rebuild your physical strength.
  • Avoid smoking and limit alcohol consumption completely, as both can impair wound healing, elevate blood pressure, and strain your heart.
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How Soon It Starts Working

The time required for Kallistat Injection to start to work: The time required for Kallistat Injection to show its action is not clinically established. The time for which the effects of Kallistat Injection last: The duration of action for Kallistat Injection is not clinically established.

What if you forget to take Kallistat Injection

Since this medication is given as a single-session infusion by healthcare professionals during surgery, there is no risk of missing a dose. Your medical team manages the entire administration process.

Storage

•In a hospital setting, Kallistat Injection should be stored at controlled room temperature, ideally between 15°C and 25°C (59°F to 77°F).

Drug Warnings

  • Always inform your surgeon if you have received Kallistat Injection in a previous surgery, especially if it was within the last 12 months, to prevent severe allergic reactions.
  • Ensure that your healthcare team administers a test dose before the full infusion begins to check for any immediate sensitivities.
  • Your medical team will closely monitor your kidney function and urine output using blood tests during and after the procedure.
  • Before administration, the injection solution must be visually inspected by a healthcare provider for any particles or unusual discolouration.
  • Report any sudden itching, hives, or breathing issues immediately to your care team during the recovery phase.

verifiedApollotooltip
  • Blood thinners (such as heparin): Combining these can alter your blood's clotting behaviour, requiring careful monitoring of clotting times by your medical team.
  • Thrombolytics (clot-dissolving drugs): Kallistat Injection can block the effects of these medicines, making them less effective.
  • ACE inhibitors (blood pressure drugs): This combination may reduce the blood-pressure-lowering effects of these medications.

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verifiedApollotooltip

  • No clinically significant food interactions are known with Kallistat Injection when used as directed. 

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Habit Forming

No

Therapeutic Class

[ANTIFIBRINOLYTIC AGENTS]

FAQs

Kallistat Injection is used to reduce the risk of bleeding during and after surgery.
Kallistat Injection works by inhibiting the activation of coagulants. Thereby, Kallistat Injection prevents bleeding.
Kallistat Injection is prescribed when the doctor has decided that you will benefit from the treatment because you are at an increased risk of major blood loss as you will undergo a heart bypass operation using the heart-lung machine (circulation outside the body). Your doctor will prescribe Kallistat Injection only after careful consideration of the benefits and risks.
Yes. Kallistat Injection may increase the risk of kidney problems, including kidney injury that may rarely require dialysis after surgery. The risk is higher in people with existing kidney disease or those taking medicines that can affect the kidneys (such as gentamicin). Your healthcare team will monitor your kidney function before and after surgery. Inform your doctor if you have any history of kidney disease.
Kallistat Injection is injected directly into a vein as an intravenous infusion by a healthcare professional in a hospital operating room. Talk to your doctor.
A test dose is given to check for any sudden or severe allergic reactions before the full dose is administered, ensuring your safety during surgery. Talk to your doctor.
You must tell your doctor if you have had heart surgery before, have kidney disease, or have ever received this medication in the past. Talk to your doctor.
This medication is typically only used during pregnancy if the potential benefits outweigh the risks, as its effects on unborn babies are not fully known. Talk to your doctor.
Yes, but because older adults are more prone to kidney issues, the medical team will monitor their kidney health and dosage very closely. Talk to your doctor.
If you received this specific medicine during a surgery within the past 12 months, you should not receive it again due to a high risk of a severe allergic reaction. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - KA97159
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