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compositionComposition:ISOSORBIDE DINITRATE-5MG
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Prescription Medicine
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Isordil 5 Sublingual Tablet is used in the prevention of angina (heart-related chest pain) and heart failure. It contains Isosorbide dinitrate, which works by dilating, relaxing, and widening the constricted blood vessels, thereby increasing the blood and oxygen supply to the heart. It may cause common side effects such as headache, light-headedness, weakness, nausea, vomiting, and dizziness. Let your doctor know if you are allergic to any of its components, if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ISOSORBIDE DINITRATE-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Sublingual

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Isordil 5 Sublingual Tablet

Isordil 5 Sublingual Tablet is a fast-acting sublingual medication primarily prescribed to treat and prevent sudden chest pain, also known as angina. It works by targeting the blood vessels to improve blood flow directly to your heart during periods of physical stress or emotional strain. This medicine is vital for managing acute cardiac chest discomfort and preventing predictable pain triggers.

Unlike daily maintenance medications, the sublingual formulation is typically taken only when you experience an active chest pain attack or just before starting an activity that usually triggers your symptoms. To ensure it works correctly, you must place the tablet under your tongue to dissolve, meaning you should not eat, drink, or swallow while it is absorbing. When Isordil 5 Sublingual Tablet is used regularly, your doctor may schedule doses with a daily nitrate-free interval to reduce the risk of tolerance and loss of effectiveness. Combining this treatment with regular physical activity, a low-sodium diet, and weight management can significantly improve your overall cardiovascular health.

While taking this medication, you may experience mild side effects like temporary headaches, flushing, or lightheadedness as your blood vessels relax. These side effects are usually manageable, but you must contact your doctor immediately if you experience severe dizziness, fainting, or an abnormally fast heartbeat. Your safety is paramount, and monitoring how your body responds is an essential part of your treatment.

Do not take this if you are currently using medications for erectile dysfunction, as this combination can cause a dangerous drop in blood pressure. Isordil 5 Sublingual Tablet should also not be used with riociguat, as the combination can cause a severe and potentially dangerous drop in blood pressure. It is also important to tell your doctor before taking Isordil 5 Sublingual Tablet if you suffer from severe anemia, glaucoma, severe low blood pressure, or low blood volume (hypovolemia), or have recently experienced a head injury. They will help determine if this is the safest option for your condition.

Additionally, Isordil 5 Sublingual Tablet can interact unfavorably with alcohol, which increases the risk of severe dizziness and low blood pressure. If you are pregnant or breastfeeding, tell your doctor before using Isordil 5 Sublingual Tablet . Safety information during pregnancy and breastfeeding is limited, so your doctor will weigh the potential benefits against possible risks before recommending treatment. Older adults may also be more sensitive to the blood-pressure-lowering effects and may require closer monitoring.

Uses of Isordil 5 Sublingual Tablet

Isordil 5 Sublingual Tablet is used to relieve and prevent angina (chest pain) caused by reduced blood flow to the heart. Its uses include:

  • Angina pectoris (chest pain): Isordil 5 Sublingual Tablet helps relieve chest pain caused by reduced blood flow to the heart muscle.
  • Angina prevention: Taking Isordil 5 Sublingual Tablet as prescribed before physical activity or situations that may trigger angina can help prevent chest pain.

Key Benefits

Isordil 5 Sublingual Tablet helps relieve and prevent angina by improving blood flow and reducing the workload on the heart. Its benefits include:

  • Provides rapid relief from an episode of angina when used as directed, helping reduce chest pain and discomfort.
  • Helps prevent predictable episodes of angina when taken as prescribed before activities or situations that may trigger chest pain.
  • Relaxes blood vessels, reducing the amount of work the heart needs to do and lowering its oxygen demand.
  • Helps you perform routine activities more comfortably by reducing the likelihood of exercise- or stress-related chest pain.
Side effects of Isordil 5 Sublingual Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Isordil 5 Sublingual Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Place Isordil 5 Sublingual Tablet below the tongue and allow it to dissolve.
  • Do not swallow Isordil 5 Sublingual Tablet as a whole directly. It is also advised not to chew or crush Isordil 5 Sublingual Tablet .

How Isordil 5 Sublingual Tablet Works

Isordil 5 Sublingual Tablet belongs to a class of medicines called nitrates, which relax and widen blood vessels. When the sublingual tablet dissolves under your tongue, the medicine enters the systemic circulation (the main bloodstream throughout your body) and starts working faster than a swallowed tablet. It relaxes the muscles in the walls of your blood vessels, similar to widening a garden hose so that blood can flow more easily. This mainly widens the veins and reduces preload (the amount of blood filling the heart before each beat), which lowers the heart's workload and oxygen demand. It can also mildly widen the arteries, reducing the resistance against which the heart pumps (afterload). Together, these effects reduce the heart's oxygen needs and can help relieve angina.
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Alcohol

Caution

Alcohol may worsen the condition by increasing the risk of side effects. So, do not consume alcohol.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if isosorbide dinitrate passes into breastmilk. Please consult your doctor before taking Isordil 5 Sublingual Tablet if you are a breastfeeding mother.

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Driving

Caution

Isordil 5 Sublingual Tablet may cause dizziness and affect your ability to drive. So, avoid driving or operating heavy machinery while using Isordil 5 Sublingual Tablet unless you are alert.

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Liver

Caution

Inform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing.

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Children

Caution

Isordil 5 Sublingual Tablet should not be given to children as safety and effectiveness were not established.

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Heart

Caution

Isordil 5 Sublingual Tablet is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Safe if prescribed

Isordil 5 Sublingual Tablet is safe for elderly patients if used as prescribed and dose adjustment is required.

What if I have taken an overdose of Isordil 5 Sublingual Tablet

An overdose of Isordil 5 Sublingual Tablet can be dangerous and requires immediate emergency medical attention. Symptoms of an overdose may include extreme dizziness, a severe throbbing headache, confusion, fever, sweating, a slow or unusually fast heart rate, fainting, and bluish lips or fingernails. If you suspect an overdose, call emergency services or go to the nearest hospital emergency room immediately.

Diet & Lifestyle Advise

  • Avoid smoking: Tobacco smoke constricts blood vessels and worsens chest pain. Quitting smoking is one of the most effective ways to support your heart health.
  • Limit alcohol intake: Alcohol can dangerously amplify the blood pressure-lowering effects of Isordil 5 Sublingual Tablet , increasing your risk of fainting or severe dizziness.
  • Sit when using the medicine: Always sit or lie down before placing the tablet under your tongue to prevent falls caused by sudden drops in blood pressure.
  • Eat a heart-healthy diet: Incorporate more fiber-rich foods, fresh vegetables, and lean proteins while reducing your intake of sodium and saturated fats to manage your blood pressure.

Health Queries

What should we do if a patient with a history of a blood clot in the heart has severe chest pain that is not relieved after taking Isordil 5?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Because the severe chest pain has not improved after taking Isordil (isosorbide dinitrate), this must be treated as a medical emergency. Please call emergency services (like 911) immediately. Do not attempt to drive to the hospital yourself. While you wait for help to arrive, have him sit quietly and rest. If his doctor has previously advised taking an aspirin during such episodes and he is not allergic, he may chew one.
health query

Have a query?

How Soon It Starts Working

The time required for Isordil 5 Sublingual Tablet to start to work: Isordil 5 Sublingual Tablet ideally shows its action within 1 hour after administration. The time for which the effects of Isordil 5 Sublingual Tablet last: The effect of Isordil 5 Sublingual Tablet lasts for 4 to 6 hours.

What if you forget to take Isordil 5 Sublingual Tablet

Because Isordil 5 Sublingual Tablet is typically taken on an as-needed basis to relieve sudden chest pain, missing a dose is not common. However, if your doctor has scheduled you to take this medicine regularly and you miss a dose, take it as soon as you remember. If your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Isordil 5 Sublingual Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Keep it readily available: Always carry Isordil 5 Sublingual Tablet with you so it is available when needed for an angina episode.
  • Check the expiry date: Regularly check the expiration date on the bottle. Do not use tablets that are expired or stored improperly.
  • Seek emergency help for persistent chest pain: If chest pain is not relieved after the first dose, take additional doses as directed by your doctor, generally 5 minutes apart, for up to a total of three doses. Seek emergency medical help if the pain is not relieved after all three doses or worsens at any time.
  • Use the tablet correctly: Do not chew or swallow a sublingual tablet. Place it under the tongue and allow it to dissolve as directed for rapid absorption.
  • Rise slowly: Stand up slowly from a sitting or lying position, as Isordil 5 Sublingual Tablet can lower blood pressure and cause dizziness or lightheadedness.
  • Do not share the medicine: Never give Isordil 5 Sublingual Tablet to another person, even if they have symptoms similar to yours.
  • Monitor changes in angina: Tell your doctor if chest pain becomes more frequent, lasts longer, occurs with less activity, or is no longer relieved as expected. These changes may mean that your angina needs further evaluation or that your treatment plan needs adjustment.
  • Know the difference from your usual angina: Seek emergency medical attention if chest pain is severe, worsening, occurs at rest, feels different from your usual angina, or does not improve according to your prescribed emergency plan.

Drug-Drug Interactions

verifiedApollotooltip
  • Erectile dysfunction drugs (such as sildenafil, tadalafil, or vardenafil): Do not take these with Isordil 5 Sublingual Tablet , as they can cause a life-threatening, sudden drop in blood pressure.
  • Riociguat: Do not take riociguat with Isordil 5 Sublingual Tablet , as the combination can cause a severe and potentially dangerous drop in blood pressure.
  • Blood pressure medications (like beta-blockers or calcium channel blockers): Combining these with Isordil 5 Sublingual Tablet may cause your blood pressure to drop too low, leading to severe dizziness or fainting.
  • Antidepressants (specifically tricyclic antidepressants): May increase the risk of low blood pressure (hypotension) when taken alongside Isordil 5 Sublingual Tablet .
Isosorbide dinitrateTadalafil
Critical
Isosorbide dinitrateAvanafil
Critical

Drug-Drug Interactions

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Isosorbide dinitrateTadalafil
Critical
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Tadalafil with Isordil 5 Sublingual Tablet can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isordil 5 Sublingual Tablet with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateAvanafil
Critical
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Avanafil with Isordil 5 Sublingual Tablet can cause low blood pressure.

How to manage the interaction:
Taking Isordil 5 Sublingual Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateSildenafil
Critical
How does the drug interact with Isordil 5 Sublingual Tablet:
Coadministration of Isordil 5 Sublingual Tablet and Sildenafil can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isordil 5 Sublingual Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Isosorbide dinitrateRiociguat
Critical
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Riociguat with Isordil 5 Sublingual Tablet may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isordil 5 Sublingual Tablet with Riociguat is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateErgotamine
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Isordil 5 Sublingual Tablet together with ergotamine can increase the effects of ergotamine.

How to manage the interaction:
Although taking Isordil 5 Sublingual Tablet and ergotamine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience an irregular heartbeat, nausea, vomiting, weakness, or coldness, numbness, chest pain or pain in the hands, feet, arms, or legs. Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateCabergoline
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Coadministration of Isordil 5 Sublingual Tablet and cabergoline may decrease your blood pressure.

How to manage the interaction:
Co-administration of Isordil 5 Sublingual Tablet with Cabergoline can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
Isosorbide dinitrateChloroprocaine
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Isordil 5 Sublingual Tablet with chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordil 5 Sublingual Tablet and chloroprocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitations, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateSodium nitrite
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Isordil 5 Sublingual Tablet with sodium nitrite may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordil 5 Sublingual Tablet and sodium nitrite together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateLidocaine
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Taking Isordil 5 Sublingual Tablet with lidocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordil 5 Sublingual Tablet and lidocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateBupivacaine
Severe
How does the drug interact with Isordil 5 Sublingual Tablet:
Combining Bupivacaine with Isordil 5 Sublingual Tablet can increase the risk of methemoglobinemia(a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Co-administration of Bupivacaine with Isordil 5 Sublingual Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, confusion, consult a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while using Isordil 5 Sublingual Tablet can cause a dangerous drop in blood pressure, leading to extreme lightheadedness, headaches, or fainting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

Isordil 5 Sublingual Tablet is used to prevent angina (heart-related chest pain) and heart failure.
Isordil 5 Sublingual Tablet works by relaxing the muscles of the blood vessels. It helps to dilate the narrowed blood vessels, resulting in increased blood and oxygen supply to the heart. This prevents heart-related chest pain known as angina.
Isordil 5 Sublingual Tablet may decrease blood pressure (hypotension). Therefore, let the doctor know if you have high/low blood pressure or if you are taking blood pressure medications.
Use of Isordil 5 Sublingual Tablet together with sildenafil is not recommended as it may cause a sudden decrease in blood pressure. Therefore, consult a doctor before taking sildenafil during treatment with Isordil 5 Sublingual Tablet .
Isordil 5 Sublingual Tablet is given for heart-related chest pain (angina), a life-long or chronic disease, especially in high blood pressure patients and coronary heart disease (CAD). So, do not stop taking Isordil 5 Sublingual Tablet even if you feel better. Consult your doctor if you have any concerns.
The common side effects of Isordil 5 Sublingual Tablet are headache, light-headedness, weakness, nausea, vomiting, and dizziness. These side effects usually resolve without requiring medical attention. However, consult your doctor if any of these effects persist or worsen.
Because Isordil 5 Sublingual Tablet is placed under the tongue, it dissolves and is absorbed directly into your bloodstream, typically starting to work within a few minutes, although the exact onset may vary. If your chest pain is not relieved after the first dose, follow your doctor's emergency plan. If instructed to take additional doses, they are generally taken 5 minutes apart, up to a total of three doses. Do not delay emergency medical care if the pain is severe, worsening, or does not improve as directed. Talk to your doctor to understand your specific emergency plan.
No, you should never swallow Isordil 5 Sublingual Tablet whole. Swallowing the tablet forces it through your digestive system and liver, which destroys most of the active medicine and prevents it from working quickly to stop chest pain. Talk to your doctor or pharmacist if you have difficulty using sublingual tablets.
Store Isordil 5 Sublingual Tablet according to the instructions on your specific product label. Keep the tablets in their original packaging and protect them from excessive heat and moisture. Storage requirements can vary between formulations and manufacturers, so do not assume that an amber glass bottle is required. Ask your pharmacist if you are unsure how to store your medicine.
No, you must never combine Isordil 5 Sublingual Tablet with medications for erectile dysfunction, such as sildenafil or tadalafil. Taking these together can cause a sudden, severe, and potentially life-threatening drop in blood pressure. Talk to your doctor about safe alternative treatment options.
No, you should avoid drinking alcohol while taking Isordil 5 Sublingual Tablet . Alcohol relaxes your blood vessels further and can cause a dangerous drop in blood pressure, leading to severe dizziness or fainting. Talk to your doctor if you have questions about alcohol use.
Take the dose exactly as prescribed by your doctor. If your doctor has instructed you to use additional doses when chest pain continues, follow that specific emergency plan, including the recommended interval between doses. Seek emergency medical help if the pain is not relieved as directed, becomes worse, or feels different from your usual angina. Do not take additional doses beyond your prescribed instructions.
It is not recommended to drive immediately after taking Isordil 5 Sublingual Tablet , as it can cause sudden dizziness, lightheadedness, or fainting due to low blood pressure. Wait until you know how the medication affects you before driving or operating machinery. Talk to your doctor if you experience persistent dizziness.

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Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - ISO0013
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