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compositionComposition:ISONIAZID-300MG+PYRIDOXINE-3MG
prescription
Prescription Medicine
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Isocaldin 300 mg Tablet is used to treat tuberculosis (TB). It works by destroying tuberculosis-causing bacteria (Mycobacterium tuberculosis) and treats nerve damage (neuritis) caused by tuberculosis. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, loss of appetite, constipation, stomach upset/pain, dry mouth, ringing in the ears, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ISONIAZID-300MG+PYRIDOXINE-3MG

Manufacturer/Marketer :

Retort Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Isocaldin 300 mg Tablet

Isocaldin 300 mg Tablet is a prescription medicine used to treat active tuberculosis (TB) infections and to prevent latent tuberculosis infection from becoming active disease. It contains isoniazid, an antibiotic that kills tuberculosis bacteria, and pyridoxine (vitamin B6), which helps reduce the risk of nerve damage that can occur during isoniazid treatment. When taken exactly as prescribed, this medicine helps eliminate tuberculosis bacteria from your body while supporting nerve health during treatment.

You must take Isocaldin 300 mg Tablet consistently every day for the full duration prescribed by your doctor, even if you begin to feel better. It is best taken on an empty stomach, either 1 hour before or 2 hours after a meal, with a full glass of water because food can reduce the absorption of isoniazid. Eating a balanced diet, getting enough rest, and attending all follow-up appointments can help support your recovery throughout tuberculosis treatment.

While taking this medicine, you may experience mild side effects such as nausea, stomach upset, or a temporary loss of appetite. However, contact your doctor immediately if you develop symptoms that may suggest liver damage, such as yellowing of your skin or eyes, dark urine, persistent nausea, severe stomach pain, or unusual tiredness. Your doctor will assess your symptoms and advise whether your treatment needs to be changed.

Do not take this medicine if you have previously had a severe allergic reaction to isoniazid or have severe liver disease related to previous isoniazid treatment. Before starting treatment, tell your doctor if you have kidney disease, diabetes, liver problems, nerve disorders, HIV infection, or a history of regular alcohol consumption, as these conditions may require closer monitoring during treatment.

Tell your doctor or pharmacist about all the medicines, vitamins, herbal products, and supplements you are taking before starting treatment. Alcohol significantly increases the risk of liver damage and should be avoided throughout treatment. Some foods that contain large amounts of tyramine or histamine, such as aged cheeses, yeast extracts, cured meats, soy sauce, and certain fish, may occasionally cause flushing, headache, or a faster heartbeat in some people taking isoniazid, although this reaction is generally milder than with medicines known as monoamine oxidase inhibitors (MAOIs). If you are pregnant, breastfeeding, an older adult, or have any long-term medical condition, discuss the benefits and risks of treatment with your doctor.

Uses of Isocaldin 300 mg Tablet

Your doctor may prescribe Isocaldin 300 mg Tablet to help manage the following conditions:

  • Active tuberculosis (TB): Helps kill tuberculosis bacteria when used as part of a combination treatment regimen for active tuberculosis.
  • Latent tuberculosis infection: Helps prevent inactive tuberculosis bacteria from becoming active disease in people at increased risk of developing tuberculosis.

Key Benefits

Isocaldin 300 mg Tablet helps treat and prevent tuberculosis while reducing the risk of certain treatment-related complications.

  • Helps eliminate tuberculosis bacteria: Works as part of combination therapy to treat active tuberculosis and reduce the spread of infection.
  • Helps prevent latent tuberculosis from becoming active: Reduces the risk that inactive tuberculosis bacteria will develop into active disease.
  • Helps protect nerve health: Pyridoxine (vitamin B6) helps reduce the risk of nerve damage, tingling, numbness, and burning sensations that may occur during isoniazid treatment.

Directions for Use

  • Isocaldin 300 mg Tablet should be taken after meals.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Isocaldin 300 mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Isocaldin 300 mg Tablet Works

Isocaldin 300 mg Tablet contains two active ingredients that work together to treat tuberculosis and reduce treatment-related side effects. Isoniazid is an antibiotic that specifically targets tuberculosis bacteria. It works by blocking the production of mycolic acids, which are essential building blocks of the bacterial cell wall. Without these substances, the bacteria cannot maintain a healthy cell wall, preventing them from growing and allowing the infection to be cleared. Pyridoxine (vitamin B6) helps maintain healthy nerve function. Because isoniazid can reduce vitamin B6 levels in the body, taking pyridoxine helps lower the risk of nerve-related side effects such as tingling, numbness, and burning sensations in the hands and feet.
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Alcohol

Unsafe

Refrain from alcohol consumption while taking Isocaldin 300 mg Tablet , as it could lead to increased drowsiness, dizziness, and liver damage.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant. Your doctor will prescribe Isocaldin 300 mg Tablet only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor if you are a breastfeeding mother. Your doctor will prescribe Isocaldin 300 mg Tablet only if the benefits outweigh the risks.

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Driving

Caution

Isocaldin 300 mg Tablet may cause dizziness, blurred vision, drowsiness, numbness, and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Please consult your doctor before taking Isocaldin 300 mg Tablet if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Isocaldin 300 mg Tablet .

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Children

Caution

Isocaldin 300 mg Tablet can be used in children when prescribed by a doctor, who will determine the appropriate dose based on the child’s age and weight.

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Heart

Caution

If you have heart problems, Isocaldin 300 mg Tablet should be used with caution and only under medical supervision.

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Geriatrics

Caution

Geriatric patients can generally receive Isocaldin 300 mg Tablet , but it should be done under medical supervision.

What if I have taken an overdose of Isocaldin 300 mg Tablet

If you think you have taken more than the prescribed dose of Isocaldin 300 mg Tablet , seek emergency medical attention immediately or go to the nearest hospital. Symptoms of an overdose may include severe dizziness, slurred speech, blurred vision, severe nausea or vomiting, confusion, or seizures. Take the medicine pack with you if possible to help healthcare professionals identify the medicine quickly.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Drinking alcohol while taking this medicine greatly increases the risk of liver damage and should be avoided throughout treatment.
  • Limit foods rich in tyramine and histamine: Foods such as aged cheeses, yeast extracts, soy sauce, cured meats, and certain fish may occasionally cause flushing, headache, or a faster heartbeat in some people taking isoniazid. These reactions are generally milder than those seen with medicines called monoamine oxidase inhibitors (MAOIs).
  • Eat a balanced, nutritious diet: Include adequate protein, whole grains, fruits, and vegetables to help support your immune system and overall recovery.
  • Keep all medical appointments: Regular doctor visits and blood tests help monitor your liver function and ensure the treatment is working safely.
  • Take your medicine every day: Missing doses can reduce the effectiveness of treatment and increase the risk of drug-resistant tuberculosis.
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Have a query?

How Soon It Starts Working

The time required for Isocaldin 300 mg Tablet to start to work: Isocaldin 300 mg Tablet starts to show its action within 1-2 hours of administration. The time for which the effects of Isocaldin 300 mg Tablet last: The effect of Isocaldin 300 mg Tablet usually lasts up to 24 hours approximately.

What if you forget to take Isocaldin 300 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your usual dosing schedule. Do not take two doses together to make up for a missed dose. Taking the medicine regularly is important to ensure successful tuberculosis treatment.

Storage

• Store Isocaldin 300 mg Tablet according to the storage instructions provided with your product label, ideally between 20°C to 25°C.

Drug Warnings

  • Check the packaging before use: Do not take the tablets if the blister pack is damaged or the tablets appear discoloured.
  • Watch for early signs of liver problems: Unexplained tiredness, poor appetite, nausea, dark urine, or yellowing of the skin or eyes should be reported to your doctor immediately.
  • Do not stop treatment on your own: If you develop symptoms that may suggest liver problems or other serious side effects, contact your doctor immediately. Your doctor will decide whether treatment should be stopped or changed.
  • Do not share your medicine: This medicine has been prescribed specifically for your condition and should not be given to anyone else.
  • Inform healthcare professionals: Tell your doctor, dentist, pharmacist, or laboratory staff that you are taking Isocaldin 300 mg Tablet before any medical tests, surgery, or dental procedures, as it may affect certain laboratory test results.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g. phenytoin, carbamazepine): Isocaldin 300 mg Tablet may increase the levels of these medicines in your blood, increasing the risk of side effects.
  • Blood thinners (e.g. warfarin): This medicine may increase the effect of blood-thinning medicines and raise the risk of bleeding.
  • Antacids containing aluminium: These medicines can reduce the absorption of isoniazid. Take Isocaldin 300 mg Tablet at least 1 to 2 hours before taking an aluminium-containing antacid.
  • Paracetamol: Taking these medicines together may increase the risk of liver problems, especially with prolonged use or high doses.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol because it greatly increases the risk of liver damage.
  • Foods rich in tyramine or histamine: Aged cheeses, soy sauce, yeast extracts, cured meats, and certain fish may occasionally cause flushing, headache, a faster heartbeat, or mild increases in blood pressure in some people taking isoniazid.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Isocaldin 300 mg Tablet is used to treat tuberculosis (TB).
Isocaldin 300 mg Tablet is a combination of two drugs, namely isoniazid and pyridoxine (vitamin B6). Isoniazid works by eliminating the bacteria responsible for tuberculosis (TB). Additionally, vitamin B6 helps treat nerve damage (neuritis) caused by TB medications like isoniazid.
Do not stop taking Isocaldin 300 mg Tablet despite symptomatic relief. To treat your condition effectually, continue taking Isocaldin 300 mg Tablet for as long as it has been prescribed for you.
An overdose of Isocaldin 300 mg Tablet may lead to nausea, vomiting, dizziness, slurred speech, blurred vision, and visual hallucinations (including bright colours and strange designs). In some cases, overdose can lead to coma and seizures.
Isocaldin 300 mg Tablet contains isoniazid, which might interact with foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soy, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Isocaldin 300 mg Tablet .
You are recommended to avoid alcohol while taking Isocaldin 300 mg Tablet to reduce unwanted side effects and excessive drowsiness. Please consult the doctor if you have any concerns.
Store Isocaldin 300 mg Tablet at room temperature. Keep out of reach and sight of children.
Isocaldin 300 mg Tablet is effective when taken as per the dose advised by your doctor for the recommended duration. Even if you start feeling better, do not stop the treatment early. Stopping it early may cause the symptoms to return or worsen.
Isocaldin 300 mg Tablet causes side effects such as nausea, vomiting, diarrhoea, loss of appetite, constipation, stomach upset/pain, dry mouth, ringing in the ears, and dizziness. Most of these side effects do not require any medical attention as they will gradually reduce over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Isocaldin 300 mg Tablet is best taken on an empty stomach, ideally 1 hour before or 2 hours after a meal, because food can reduce the absorption of isoniazid. If stomach upset becomes troublesome, speak with your doctor before changing how you take the medicine.
Isoniazid can lower vitamin B6 levels in the body, which may increase the risk of nerve damage causing tingling, numbness, or burning sensations in the hands and feet. Pyridoxine (vitamin B6) is included to help reduce this risk during tuberculosis treatment. Tell your doctor if you continue to experience these symptoms.
Yellowing of the skin or eyes may be a sign of liver damage. Contact your doctor immediately or seek emergency medical care without delay. Your doctor will assess your condition and advise whether your treatment needs to be stopped or changed.
Yes, but aluminium-containing antacids can reduce the absorption of isoniazid. Take Isocaldin 300 mg Tablet at least 1 to 2 hours before taking an aluminium-containing antacid. If you are unsure how to schedule your medicines, ask your doctor or pharmacist for advice.
If you are pregnant, planning a pregnancy, or breastfeeding, discuss the benefits and risks of treatment with your doctor. Your doctor will decide whether this medicine is appropriate based on your individual circumstances.
Yes. Isoniazid can sometimes affect the nerves and cause tingling, burning, or numbness in the hands and feet. Pyridoxine (vitamin B6) is included in this medicine to help reduce this risk. If you develop these symptoms or notice they are getting worse, contact your doctor for further assessment.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

21, 2, Mc Nichols Rd, Chentarnipet, Chennai, Tamil Nadu 600031
Other Info - ISO0042
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