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  3. Intalith 450mg Tablet 10's

Intalith 450mg Tablet 10's, Pack of 10 TABLETS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Intalith 450mg Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LITHIUM-450MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Intalith 450mg Tablet

Intalith 450mg Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low-mood depression.

Intalith 450mg Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Intalith 450mg Tablet as prescribed. Your doctor will advise how often you take Intalith 450mg Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Intalith 450mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Intalith 450mg Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Intalith 450mg Tablet . Regular blood tests are recommended while taking Intalith 450mg Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or have had weight loss surgery, please inform your doctor before taking Intalith 450mg Tablet .

Uses of Intalith 450mg Tablet

Intalith 450mg Tablet is used in the treatment of Bipolar disorder, Mania. The detailed uses of Intalith 450mg Tablet are as follows:<br/>• Bipolar Disorder Treatment: Intalith 450mg Tablet is used to treat bipolar disorder by stabilizing mood and reducing episode severity through its action on the brain.<br/>• Mania Management: Intalith 450mg Tablet is effective in managing symptoms of mania, such as elevated mood, increased energy, and impulsive behavior, allowing patients to regain control and function normally.<br/>

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Directions for Use

Take Intalith 450mg Tablet as prescribed by your doctor.

Medicinal Benefits

Intalith 450mg Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Intalith 450mg Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Intalith 450mg Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables one to do daily activities comfortably.

How Intalith 450mg Tablet Works

Intalith 450mg Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Keep Intalith 450mg Tablet out of the sight and reach of children.
Side effects of Intalith 450mg Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Intalith 450mg Tablet

Do not take more than the prescribed dose of Intalith 450mg Tablet as too much Lithium may be dangerous. The symptoms include blurred vision, feeling or being sick, vomiting, fainting, sleepiness, lightheadedness, increased urge to urinate, lack of control over pee or poo, shaking or muscle weakness, muscle twitches, spasms or jerks affecting the face, eyes, neck or tongue, confusion and blackouts. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Regular blood tests are recommended while taking Intalith 450mg Tablet to check lithium levels in blood. If you are pregnant or breastfeeding, please inform your doctor before taking Intalith 450mg Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Intalith 450mg Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Intalith 450mg Tablet:
Cidofovir can cause higher levels of Intalith 450mg Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Intalith 450mg Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Intalith 450mg Tablet:
Taking Cisapride with Intalith 450mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Intalith 450mg Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumDeferasirox
Severe
How does the drug interact with Intalith 450mg Tablet:
Taking deferasirox with Intalith 450mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Intalith 450mg Tablet and Deferasirox, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
LithiumDuloxetine
Severe
How does the drug interact with Intalith 450mg Tablet:
Taking Duloxetine with Intalith 450mg Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Duloxetine and Intalith 450mg Tablet, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumPiroxicam
Severe
How does the drug interact with Intalith 450mg Tablet:
Co-administration of Piroxicam and Intalith 450mg Tablet can increase the levels of Intalith 450mg Tablet, which may lead to side effects.

How to manage the interaction:
Co-administration of Intalith 450mg Tablet with Piroxicam can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination. Do not stop using any medications without talking to a doctor.
LithiumFluvoxamine
Severe
How does the drug interact with Intalith 450mg Tablet:
Taking Intalith 450mg Tablet with Fluvoxamine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Fluvoxamine and Intalith 450mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Lithiumchlorthalidone
Severe
How does the drug interact with Intalith 450mg Tablet:
Co-administration of chlorthalidone together with Intalith 450mg Tablet can increase the effects of Intalith 450mg Tablet.

How to manage the interaction:
Although there is a interaction between chlorthalidone and Intalith 450mg Tablet, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
LithiumPhenylbutazone
Severe
How does the drug interact with Intalith 450mg Tablet:
Taking Intalith 450mg Tablet and Phenylbutazone together may significantly increase the blood levels of Intalith 450mg Tablet.

How to manage the interaction:
Co-administration of Intalith 450mg Tablet with Phenylbutazone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, or increased urination. Do not stop using any medications without a doctor's advice.
LithiumIvabradine
Severe
How does the drug interact with Intalith 450mg Tablet:
Coadministration of Ivabradine with Intalith 450mg Tablet can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Ivabradine with Intalith 450mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or unusual memory loss. Do not discontinue any medications without consulting a doctor.
LithiumFluoxetine
Severe
How does the drug interact with Intalith 450mg Tablet:
Co-administration of Intalith 450mg Tablet with Fluoxetine can result in effects and also Serotonin syndrome (a condition wherein serotonin levels are increased in the body).

How to manage the interaction:
Although there is a interaction between Fluoxetine and Intalith 450mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid low-sodium diet as it may increase lithium levels in blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Intalith 450mg Tablet .
  • Do regular exercise and maintain a stable weight as Intalith 450mg Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink same amount of water everyday as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Intalith 450mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Intalith 450mg Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Intalith 450mg Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Intalith 450mg Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Intalith 450mg Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Intalith 450mg Tablet .

bannner image

Liver

Safe if prescribed

Intalith 450mg Tablet is safe to use in patients with Liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Intalith 450mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Intalith 450mg Tablet is not recommended for patients with severe kidney problems.

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Children

Caution

Intalith 450mg Tablet is generally not recommended for children below 12 years. However, Intalith 450mg Tablet may be used in children above 7 years for treating bipolar I disorder only if prescribed by a doctor.

FAQs

Intalith 450mg Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It works by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping to stabilize a person’s mood.

No, you are not recommended to take Intalith 450mg Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking or shivering, please consult a doctor immediately. However, before using Intalith 450mg Tablet with any other medicines, you are advised to contact your doctor.

Intalith 450mg Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Intalith 450mg Tablet . Also, thyroid levels are checked generally before starting treatment with Intalith 450mg Tablet so that if the levels are too low, Intalith 450mg Tablet is not advised.

Yes, Intalith 450mg Tablet may cause weight gain but it is not necessary for everyone taking Intalith 450mg Tablet to experience this side effect. However, in order to avoid gaining weight while taking Intalith 450mg Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Yes, Intalith 450mg Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong smelling urine or decrease in urination, it indicates that you are dehydrated and may affect lithium levels in blood. Therefore, you are recommended to drink plenty of fluids while taking Intalith 450mg Tablet to avoid dehydration.

No, you are not recommended to stop taking Intalith 450mg Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Intalith 450mg Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Intalith 450mg Tablet , please consult your doctor so that the dose may be gradually reduced.

Intalith 450mg Tablet may cause side effects such as slurred speech, confusion, mood changes, bloating, or lightheadedness. If these side effects persist or worsen, please consult your doctor.

Intalith 450mg Tablet takes some time to show improvement in your symptoms but it varies from person to person. This is because each patient reacts differently to particular medication. It may take 1 to 3 weeks or longer for you to see the full effects of Intalith 450mg Tablet . Continue taking Intalith 450mg Tablet even if you are not improving and consult your doctor.

Yes, Intalith 450mg Tablet can cause drowsiness or sleepiness. If you feel dizzy or sleepy, avoid driving or using machines or performing any tasks that require your attention.

Yes, Intalith 450mg Tablet may cause kidney problems. Intalith 450mg Tablet is not advised in patients who already have severe kidney impairment. Before starting treatment with Intalith 450mg Tablet , your doctor will recommend blood tests to see if your kidney function is normal. During treatment with Intalith 450mg Tablet , any gradual or sudden changes in kidney function, may indicate that the treatment needs re-evaluation.

Intalith 450mg Tablet should only be started if sufficient facilities are available for evaluating Intalith 450mg Tablet levels as increased blood levels of Intalith 450mg Tablet is related to Intalith 450mg Tablet toxicity. Even at dose which is effective for treatment, Intalith 450mg Tablet toxicity can occur. Therefore, your doctor may closely monitor your Intalith 450mg Tablet levels weekly until stabilization is reached, then weekly for one month and then every month after that.

Take Intalith 450mg Tablet with or without food or as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.

Some medicines decrease Intalith 450mg Tablet levels in blood which means that it will not work well. These include caffeine, theophylline (for asthma), medicines containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea (used to treat skin conditions). Therefore, please inform your doctor about the medicines you are taking before starting Intalith 450mg Tablet to avoid drug interactions.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0118

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:34 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/

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