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Intacept 25 Inj is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Plaque psoriasis. It contains Etanercept, which works by blocking the effects of TNF-alpha, a pro-inflammatory cytokine that becomes elevated in psoriasis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. Common side effects of this medication include tingling or numbness, dizziness, shortness of breath, bleeding, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETANERCEPT-25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Intacept 25 Inj

Intacept 25 Inj is an injectable prescription medicine used to reduce pain and inflammation caused by certain autoimmune conditions. It is commonly prescribed to treat moderate to severe rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. By controlling chronic swelling, it helps limit progressive joint damage and improves daily physical function.

This medicine is typically injected once or twice a week, and it is crucial to use it consistently to maintain a stable level of the medication in your system. 

Because it is injected under the skin, you can take it with or without food, as meals do not affect how the body absorbs it. Adopting a nutrient-rich, anti-inflammatory diet and engaging in gentle physical activity can further support your joint and skin health during treatment.
 

Some people may experience mild side effects, such as redness, itching, or swelling where the injection was given, as well as minor cold-like symptoms. However, you must contact your doctor immediately if you experience serious side effects, such as a persistent fever, sudden weight loss, severe skin rashes, or unusual bruising or bleeding.

Talk to your doctor before starting this medicine if you have a history of chronic infections, tuberculosis, heart failure, or disorders affecting the nervous system. Do not take this if you currently have a severe, active infection or blood poisoning, as this medicine can weaken your body's ability to fight off illness.

Let your healthcare provider know about all the medicines you use, as certain immune-suppressing therapies can interact with Intacept 25 Inj and increase your risk of severe infections. It is also important to consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as special monitoring may be required.
 

Uses of Intacept 25 Inj

Intacept 25 Inj may be prescribed to treat the following inflammatory and autoimmune conditions:

  • Rheumatoid arthritis: Intacept 25 Inj helps reduce joint pain, swelling, and stiffness in moderate to severe cases, protecting joints from long-term damage.
  • Plaque psoriasis: It calms down the overproduction of skin cells, significantly reducing red, itchy, and scaly patches.
  • Psoriatic arthritis: It eases joint swelling and pain while simultaneously improving psoriasis-related skin symptoms.
  • Ankylosing spondylitis: It relieves stiffness and back pain caused by chronic inflammation in the spine and pelvis.
  • Polyarticular juvenile idiopathic arthritis: It manages joint swelling, pain, and stiffness in children and teenagers with inflammatory arthritis.
     

Key Benefits

Intacept 25 Inj is a biologic medicine used to treat certain inflammatory and autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. It works by blocking tumour necrosis factor (TNF), a protein that plays a key role in inflammation.

  • Reduces Joint Inflammation: Helps decrease pain, swelling, and stiffness in inflammatory joint conditions, making everyday movement more comfortable.
  • Improves Physical Function: By controlling inflammation, it may improve mobility and make activities such as walking, climbing stairs, or using the hands easier.
  • Helps Control Psoriasis: Reduces the severity of red, scaly, and itchy plaques in people with moderate to severe plaque psoriasis.
  • Slows Joint Damage: In conditions such as rheumatoid arthritis and psoriatic arthritis, controlling inflammation may help slow the progression of structural joint damage.
  • Supports Long-Term Disease Control: Regular treatment can reduce disease activity and help improve overall quality of life in people with chronic inflammatory conditions.
     
Side effects of Intacept 25 Inj
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Intacept 25 Inj will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Intacept 25 Inj Works

Intacept 25 Inj contains etanercept. It is a biologic medicine that works by targeting a specific protein in the body called tumour necrosis factor (TNF). In people with autoimmune conditions, the immune system mistakenly produces too much TNF, which triggers healthy tissues to become inflamed, painful, and damaged. By binding directly to excess TNF proteins, Intacept 25 Inj blocks them from attaching to healthy cells. This action helps calm the overactive immune response, reducing the swelling, joint pain, and skin irritation associated with chronic inflammatory disorders.
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Alcohol

Unsafe

Avoid alcohol consumption as alcohol intake, along with Intacept 25 Inj, may cause increased dizziness and risk of stomach bleeding/ulcers.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant, or planning pregnancy inform your doctor before receiving Intacept 25 Inj. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass in to breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Intacept 25 Inj. Your doctor may suggest you to stop feeding while on treatment with this medicine

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Driving

Unsafe

Intacept 25 Inj may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness.

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Liver

Caution

Intacept 25 Inj should be used with caution if you have liver disease. Dose adjustment may be needed in patients with liver impairment. However, Intacept 25 Inj is not recommended in patients with active liver diseases.

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Kidney

Caution

Intacept 25 Inj should be used with caution if you have kidney impairment. Dose adjustment may be needed in patients with liver impairment.

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Children

Caution

Intacept 25 Inj is not recommended in children below two years of age as the safety and efficacy is not established. In children above two years of age, it will be administered by the paediatrician.

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Heart

Caution

Intacept 25 Inj may be used in heart patients, but caution is needed, especially with heart failure. Doctors will assess risks carefully and monitor closely during treatment.

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Geriatrics

Caution

Geriatric patients can receive Intacept 25 Inj, but it may be more susceptible to infections and other side effects. Regular monitoring and medical supervision are important during treatment.

What if I have taken an overdose of Intacept 25 Inj

If you accidentally inject more than your prescribed dose, seek immediate medical attention or contact a poison control centre right away, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Eat an anti-inflammatory diet: Focus on whole foods rich in antioxidants, such as leafy greens, berries, walnuts, and fatty fish, which can help support overall joint and skin health.
  • Protect your joints: Engage in low-impact exercises like swimming, cycling, or yoga to maintain flexibility and strength without overloading your joints.
  • Practice strict hygiene: Wash your hands frequently and avoid close contact with individuals who have active infections, as Intacept 25 Inj can temporarily lower your body's defences.
  • Manage your weight: Maintaining a healthy weight reduces mechanical stress on weight-bearing joints like the knees and hips, which helps ease pain.
  • Avoid raw foods: Steer clear of raw meats, runny eggs, and unpasteurised dairy products to minimise the risk of foodborne infections while your immune system is slightly suppressed.
     
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How Soon It Starts Working

The time required for Intacept 25 Inj to start to work: The onset of time for Intacept 25 Inj is unknown. The time for which the effects of Intacept 25 Inj last: The duration of Intacept 25 Inj’s effect is clinically not established.

What if you forget to take Intacept 25 Inj

If you miss an injection, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed injection and resume your regular schedule. Do not inject a double dose to make up for a missed one. If you are unsure of what to do, talk to your doctor or pharmacist.

Storage

• Store Intacept 25 Inj in the refrigerator between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the liquid first: Inspect the solution inside the syringe or pen before injecting; it should be clear and colourless to pale yellow. Do not use it if it is cloudy, discoloured, or contains floating particles.
  • Do not shake: Shaking the syringe or pen can damage the delicate proteins in the medication, making it less effective.
  • Rotate your sites: Consistently changing your injection spot helps prevent the buildup of hard or fatty lumps under the skin.
  • Get screened first: Ensure your doctor tests you for tuberculosis (TB) and hepatitis B before starting treatment, as Intacept 25 Inj can reactivate dormant infections.
  • Avoid live vaccines: Do not receive live vaccines (such as the nasal spray flu vaccine) while using this medicine, as they could cause a serious infection.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before using Intacept 25 Inj:

  • Other biologic medicines: Taking this medicine alongside other biologics (like anakinra or abatacept) can significantly increase the risk of severe, life-threatening infections.
  • Immune-weakening treatments: Combining this medicine with strong immunosuppressants (like cyclophosphamide) may raise the risk of developing certain blood disorders.
     

Drug-Drug Interactions

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How does the drug interact with Intacept 25 Inj:
Using Intacept 25 Inj together with mitomycin may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Intacept 25 Inj with Mitomycin can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor’s advice.
How does the drug interact with Intacept 25 Inj:
When Atezolizumab is taken with Intacept 25 Inj, the chance or severity of infection might be enhanced.

How to manage the interaction:
Although there is a possible interaction between Intacept 25 Inj and Atezolizumab, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptAltretamine
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Altretamine, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Intacept 25 Inj and Altretamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Epirubicin, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Intacept 25 Inj with Epirubicin can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Fludarabine, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Intacept 25 Inj with Fludarabine can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
When Clozapine and Intacept 25 Inj are taken together, may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Intacept 25 Inj, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue the medications without consulting a doctor.
EtanerceptElotuzumab
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Elotuzumab, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Intacept 25 Inj with Elotuzumab can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
Coadministration of Intacept 25 Inj with baricitinib increases the risk of severe infections.

How to manage the interaction:
Although taking Intacept 25 Inj and Baricitinib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Prednisolone, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Intacept 25 Inj and Prednisolone, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Intacept 25 Inj:
The use of Intacept 25 Inj with Methylprednisolone can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Intacept 25 Inj and Methylprednisolone, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Intacept 25 Inj when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Intacept 25 Inj is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis and Plaque psoriasis.
Intacept 25 Inj consists of Etanercept, which belong to TNF (Tumor necrosis factor) inhibitor class of drug. It works by inhibiting the TNF-α and TNF-β binding to the cell surface and therby makes the TNF cytokine inactive. This helps reduce inflammation and pain caused due to various autoimmune diseases.
Intacept 25 Inj affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis, hepatitis B, or abnormal liver enzymes. Intacept 25 Inj can also increase the risk of developing cancers; hence, mentioning your doctor if you have a history of any cancer is essential.
Yes, Intacept 25 Inj is a disease-modifying anti-rheumatic drug (DMARD) that works by inhibiting tumour necrosis factor (TNF), a key protein involved in the inflammatory response. By blocking TNF, it helps reduce inflammation, manage symptoms of autoimmune diseases like rheumatoid arthritis, and slow disease progression.
Intacept 25 Inj is neither a steroid nor a monoclonal antibody. It is a biological medicine classified as a TNF inhibitor. It is a fusion protein that binds to tumour necrosis factor (TNF) and prevents it from causing inflammation in autoimmune conditions like rheumatoid arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, and plaque psoriasis.
Yes, Intacept 25 Inj is safe as it is administered by the doctor or nurse in prescribed dose and duration. Ensure you do not skip scheduled appointments to maintain safety and monitor your progress effectively.
Intacept 25 Inj may cause weight gain if you use it for a longer duration. If you notice any weight changes, manage stress, exercise regularly, eat a nutritious-rich diet, take a fibre-rich diet, stay hydrated, and cut down on sugary foods and drinks.
Intacept 25 Inj may cause hair loss in some individuals. If you experience this symptom, manage stress, use gentle hair care practices, and eat nutritious rich food. However, if hair loss persists consult the doctor for further guidance.
Intacept 25 Inj typically starts to show some effects within one to two weeks. However, it may take 3 to 6 months for noticeable improvement.
The side effects of Intacept 25 Inj include tingling or numbness, shortness of breath, bleeding, dizziness, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.
Yes, but you must keep the medicine cool. Use a travel cooler bag with ice packs to maintain a temperature between 2°C and 8°C, ensuring the syringes or pens do not touch the ice directly to prevent freezing. Talk to your pharmacist for specific travel storage advice.
Contact your doctor immediately if you develop a fever, chills, or a persistent cough. Because this medicine reduces your immune response, even minor infections can quickly become serious and require prompt medical treatment.
You can safely receive non-live vaccines, such as the standard flu shot or updated COVID-19 vaccines. However, you must avoid live vaccines while on this medication, as your immune system may not be able to handle the weakened virus. Talk to your doctor before scheduling any vaccinations.
There is no direct chemical interaction between alcohol and Intacept 25 Inj. However, it is wise to limit alcohol consumption, as excessive drinking can strain your liver and potentially worsen inflammatory symptoms. Talk to your doctor about what is safe for you.
This medicine should only be used during pregnancy if your doctor determines it is clearly needed. Because it can cross the placenta, especially during the third trimester, you must talk to your doctor to weigh the benefits against potential risks to your baby.
Rotating your injection sites helps prevent skin irritation, tenderness, and the development of hard, fatty lumps under the skin, which can interfere with how the medicine is absorbed. Always inject at least one inch away from your previous site.
Do not inject the medicine if the liquid appears cloudy, thick, discoloured, or contains visible floating particles. The solution should always be clear and colourless to pale yellow. Contact your pharmacist or healthcare provider for a replacement.

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Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0365
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