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  3. Intacept 25 Inj

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Intacept 25 Inj, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Intacept 25 Inj is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Plaque psoriasis. It contains Etanercept, which works by blocking the effects of TNF-alpha, a pro-inflammatory cytokine that becomes elevated in psoriasis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. Common side effects of this medication include tingling or numbness, dizziness, shortness of breath, bleeding, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions.

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Composition :

ETANERCEPT-25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Intacept 25 Inj

Intacept 25 Inj is an immunosuppressant medicine that helps reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of rheumatoid arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, and plaque psoriasis. Intacept 25 Inj is generally used alone or in combination with methotrexate medicine.

Intacept 25 Inj consists of Etanercept, which belongs to the TNF (Tumor necrosis factor) inhibitor class of drugs. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused due to various autoimmune diseases.

Intacept 25 Inj may cause certain side effects such as tingling or numbness, dizziness, shortness of breath, bleeding, pale skin, bruising, vision problem, redness on the skin and arms, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Intacept 25 Inj is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Intacept 25 Inj should be avoided if allergic to it or any other components present.  Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, Hepatitis B Virus infection, heart failure, liver, heart, or kidney diseases, or a weak immune system, as it can worsen your health condition. Intacept 25 Inj may cause dizziness, so drive only if you are alert and focused. Intacept 25 Inj should not be given to children under two years of age as safety has not been established. Avoid consuming alcohol along with Intacept 25 Inj as it could lead to increased dizziness and risk of liver damage. Intacept 25 Inj is not recommended for use in pregnant and nursing mothers as it can cause serious adverse effects on the baby.

Uses of Intacept 25 Inj

Intacept 25 Inj is used to treat various autoimmune joint and skin conditions. The detailed uses of Intacept 25 Inj are as follows:<br/>• Treats rheumatoid arthritis: Intacept 25 Inj is used alone or with other medications to reduce joint pain, swelling, and improve function in people with rheumatoid arthritis.<br/>• Manages polyarticular juvenile idiopathic arthritis (PJIA): Intacept 25 Inj helps control joint pain, swelling, and loss of function in PJIA.<br/>• Used for psoriatic arthritis: Intacept 25 Inj treats joint pain, swelling, and skin scaling in psoriatic arthritis.<br/>• Treats ankylosing spondylitis: Intacept 25 Inj reduces inflammation and pain in the spine and other joints affected by this condition.<br/>• Manages chronic plaque psoriasis: Intacept 25 Inj helps treat red, scaly patches on the skin in cases where psoriasis is too severe for topical treatments alone.<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Intacept 25 Inj will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Intacept 25 Inj consists of Etanercept, which belongs to TNF (Tumor necrosis factor) inhibitor class of drugs. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce pain, redness, and inflammation (swelling) in patients with rheumatoid arthritis, ankylosing spondylitis, and other autoimmune disorders.

How Intacept 25 Inj Works

Intacept 25 Inj consists of Etanercept, which belongs to the TNF (Tumor necrosis factor) inhibitor class of drugs. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused due to various autoimmune diseases.

Storage

• Store in a cool and dry place away from sunlight.• Keep Intacept 25 Inj out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Intacept 25 Inj
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Intacept 25 Inj

Since Intacept 25 Inj is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Intacept 25 Inj should be avoided if allergic to it or any other components present.  Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, Hepatitis B Virus infection, heart failure, liver, heart or kidney diseases, weak immune system, multiple sclerosis (nerve and muscle disease), and diabetes as it can worsen your health condition. Do not take live vaccines while being treated with Intacept 25 Inj to prevent any serious consequences. Intacept 25 Inj may cause dizziness and drowsiness, so drive only if you are alert and focused. Avoid consuming alcohol along with Intacept 25 Inj as it could lead to increased dizziness and risk of stomach bleeding/ulcers. Intacept 25 Inj is not recommended for use in children below two years of age as safety and efficacy is not established. This medicine is not recommended for patients suffering from sepsis as it can worsen the condition.

Drug-Drug Interactions

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EtanerceptChlorambucil
Severe
EtanerceptAdalimumab
Severe

Drug-Drug Interactions

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EtanerceptChlorambucil
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Chlorambucil, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Intacept 25 Inj and Chlorambucil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptAdalimumab
Severe
How does the drug interact with Intacept 25 Inj:
Using adalimumab together with Intacept 25 Inj may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Intacept 25 Inj and Adalimumab, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptAntithymocyte Globulin
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Antithymocyte Globulin, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Antithymocyte Globulin and Intacept 25 Inj, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptPrednisolone
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Prednisolone, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Intacept 25 Inj and Prednisolone, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptProcarbazine
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Procarbazine, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Procarbazine with Intacept 25 Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptValganciclovir
Severe
How does the drug interact with Intacept 25 Inj:
The combined use of Intacept 25 Inj and valganciclovir can increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Valganciclovir and Intacept 25 Inj, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EtanerceptAtezolizumab
Severe
How does the drug interact with Intacept 25 Inj:
When Atezolizumab is taken with Intacept 25 Inj, the chance or severity of infection might be enhanced.

How to manage the interaction:
Although there is a possible interaction between Intacept 25 Inj and Atezolizumab, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptPomalidomide
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Pomalidomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Pomalidomide and Intacept 25 Inj, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtanerceptIdarubicin
Severe
How does the drug interact with Intacept 25 Inj:
Taking Idarubicin and Intacept 25 Inj can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Intacept 25 Inj, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
EtanerceptDocetaxel
Severe
How does the drug interact with Intacept 25 Inj:
When Intacept 25 Inj is used with Docetaxel, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Intacept 25 Inj with Docetaxel can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Intacept 25 Inj Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid alcohol consumption as alcohol intake, along with Intacept 25 Inj, may cause increased dizziness and risk of stomach bleeding/ulcers.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant, or planning pregnancy inform your doctor before receiving Intacept 25 Inj. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass in to breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Intacept 25 Inj. Your doctor may suggest you to stop feeding while on treatment with this medicine

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Driving

Unsafe

Intacept 25 Inj may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness.

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Liver

Caution

Intacept 25 Inj should be used with caution if you have liver disease. Dose adjustment may be needed in patients with liver impairment. However, Intacept 25 Inj is not recommended in patients with active liver diseases.

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Kidney

Caution

Intacept 25 Inj should be used with caution if you have kidney impairment. Dose adjustment may be needed in patients with liver impairment.

bannner image

Children

Caution

Intacept 25 Inj is not recommended in children below two years of age as the safety and efficacy is not established. In children above two years of age, it will be administered by the paediatrician.

FAQs

Intacept 25 Inj is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis and Plaque psoriasis.

Intacept 25 Inj consists of Etanercept, which belong to TNF (Tumor necrosis factor) inhibitor class of drug. It works by inhibiting the TNF-α and TNF-β binding to the cell surface and therby makes the TNF cytokine inactive. This helps reduce inflammation and pain caused due to various autoimmune diseases.

Intacept 25 Inj affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis, hepatitis B, or abnormal liver enzymes. Intacept 25 Inj can also increase the risk of developing cancers; hence, mentioning your doctor if you have a history of any cancer is essential.

Yes, Intacept 25 Inj is a disease-modifying anti-rheumatic drug (DMARD) that works by inhibiting tumour necrosis factor (TNF), a key protein involved in the inflammatory response. By blocking TNF, it helps reduce inflammation, manage symptoms of autoimmune diseases like rheumatoid arthritis, and slow disease progression.

Intacept 25 Inj is neither a steroid nor a monoclonal antibody. It is a biological medicine classified as a TNF inhibitor. It is a fusion protein that binds to tumour necrosis factor (TNF) and prevents it from causing inflammation in autoimmune conditions like rheumatoid arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, and plaque psoriasis.

Yes, Intacept 25 Inj is safe as it is administered by the doctor or nurse in prescribed dose and duration. Ensure you do not skip scheduled appointments to maintain safety and monitor your progress effectively.

Intacept 25 Inj may cause weight gain if you use it for a longer duration. If you notice any weight changes, manage stress, exercise regularly, eat a nutritious-rich diet, take a fibre-rich diet, stay hydrated, and cut down on sugary foods and drinks.

Intacept 25 Inj may cause hair loss in some individuals. If you experience this symptom, manage stress, use gentle hair care practices, and eat nutritious rich food. However, if hair loss persists consult the doctor for further guidance.

Intacept 25 Inj typically starts to show some effects within one to two weeks. However, it may take 3 to 6 months for noticeable improvement.

The side effects of Intacept 25 Inj include tingling or numbness, shortness of breath, bleeding, dizziness, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0365

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:04 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a602013.html#side-effects
  2. https://www.enbrel.com/
  3. https://www.healthline.com/health/drugs/etanercept-injectable-solution#about
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/103795s5503lbl.pdf

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