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compositionComposition:INOTUZUMAB OZOGAMICIN-1MG
prescription
Prescription Medicine
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Inonza 1 mg Injection is used to treat Acute lymphocytic leukemia (ALL). It contains Inotuzumab Ozogamicin, which belongs to the class of monoclonal antibodies. It works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. Inonza 1 mg Injection may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, myalgia, and injection site reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

INOTUZUMAB OZOGAMICIN-1MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Inonza 1 mg Injection

Inonza 1 mg Injection is a prescription injection used to treat adults with B-cell precursor acute lymphoblastic leukaemia (ALL) that has returned (relapsed) or has not responded to previous treatments (refractory). This specialised medication acts as a targeted therapy, specifically finding and attaching to leukaemia cells to deliver a cancer-fighting agent directly to them.

Because Inonza 1 mg Injection is given as an intravenous infusion, it is administered in a hospital or specialised clinic by trained healthcare professionals. The treatment is given in cycles, and staying consistent with your scheduled appointments is essential for the medication to work effectively. There are no direct food restrictions associated with this injection, but maintaining good hydration and eating well-balanced meals can support your overall strength during treatment.

Like many advanced cancer treatments, Inonza 1 mg Injection can cause side effects. Common side effects include low blood cell counts, tiredness, and fever. It can also cause serious liver damage, which requires close and regular monitoring by your doctor through blood tests.

Before starting Inonza 1 mg Injection, talk to your doctor if you have a history of liver disease, hepatitis, or if you have previously had a stem cell transplant. This medication may not be suitable for individuals with certain pre-existing liver conditions, and it must not be used during pregnancy.

This medicine can interact with other drugs, especially those that place stress on your liver or affect your heart rhythm. You should avoid drinking alcohol during treatment to prevent additional strain on your liver. It is also important to consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as this medication can harm an unborn baby.

Uses of Inonza 1 mg Injection

Inonza 1 mg Injection is used to treat adults with B-cell precursor acute lymphoblastic leukaemia (ALL) that has returned (relapsed) or has not responded to previous treatments (refractory). The detailed uses of Inonza 1 mg Injection are as follows:

  • Relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (ALL): Inonza 1 mg Injection is used to treat adults with this specific type of blood and bone marrow cancer when initial treatments have stopped working or failed to clear the cancer cells.

Key Benefits

Inonza 1 mg Injection helps treat certain types of leukaemia by targeting and eliminating cancer cells in the blood and bone marrow. With regular use as prescribed, it helps control the disease, supports remission, and improves treatment outcomes.

  • Targets Leukaemia Cells: By acting directly on cancer cells, this medicine helps reduce the number of leukaemia cells in the blood and bone marrow, supporting effective disease control.
  • Supports Remission: Effective treatment can help achieve and maintain remission by reducing the burden of cancer cells and improving overall response to therapy.
  • Prepares for Stem Cell Transplant: For eligible patients, this medicine helps reduce active leukaemia cells before a bone marrow or stem cell transplant, improving readiness for this potentially curative treatment.
Side effects of Inonza 1 mg Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Inonza 1 mg Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Inonza 1 mg Injection Works

Inonza 1 mg Injection contains inotuzumab ozogamicin, an antibody-drug conjugate, which means it is a combination of a highly specific antibody and a potent cancer-killing agent. It is designed to work like a guided search-and-destroy system inside your body. The antibody portion of the medicine travels through your bloodstream and binds specifically to a protein called CD22, which is found in high amounts on B-cell leukaemia cells. Once the medicine attaches to this protein, the cancer cell absorbs it. Inside the cell, the active cancer-killing substance is released, directly damaging the cancer cell's DNA and causing it to break down and die, while sparing many healthy cells that do not have the CD22 protein.
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Alcohol

Caution

Avoid consuming alcohol while on treatment with Inonza 1 mg Injection as it may cause severe side effects.

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Pregnancy

Unsafe

Inform your doctor if you are pregnant or intend to get pregnant. You should not become pregnant while receiving Inonza 1 mg Injection and for at least eight months following your last dosage. Consult your doctor about birth control techniques that will work for you. If you are a man, you and your female partner should use birth control during therapy and for at least five months following your last dosage. Call your doctor if you or your partner become pregnant while on treatment with this medicine. It may be harmful to the fetus.

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Breast Feeding

Unsafe

If you are breastfeeding, notify your doctor. Your doctor may advise you not to breastfeed during your Inonza 1 mg Injection treatment and for at least two months following the last dose.

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Driving

Caution

Inonza 1 mg Injection is administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Inonza 1 mg Injection is known to cause hepatotoxicity, which may be fatal. If you have any symptoms such as yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-coloured) urine, abdominal pain, bleeding more easily than normal, or tiredness while taking Inonza 1 mg Injection inform your doctor.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Inonza 1 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Inonza 1 mg Injection is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Inonza 1 mg Injection should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Inonza 1 mg Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Inonza 1 mg Injection to geriatric patients. Your doctor will prescribe Inonza 1 mg Injection if the benefits outweigh the risks.

What if I have taken an overdose of Inonza 1 mg Injection

Since this medicine is prepared and given by trained healthcare professionals, an overdose is highly unlikely. However, if an accidental overdose is suspected, medical staff will monitor you closely and provide supportive care immediately.

Diet & Lifestyle Advise

  • Follow clean food preparation practices and avoid raw or undercooked foods to protect yourself from infections when your white blood cell count is low.
  • Drink plenty of water and clear fluids daily to support your kidneys and liver as your body processes the medication.
  • Avoid alcoholic beverages entirely during treatment to protect your liver from extra stress.
  • Stay away from crowded areas and individuals who are actively sick to reduce your risk of catching an infection.
  • Use a soft-bristled toothbrush and take care when handling sharp objects to minimise the risk of bleeding from low platelet counts.
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Have a query?

How Soon It Starts Working

The time required for Inonza 1 mg Injection to start to work: The time required for Inonza 1 mg Injection to show its action is not clinically established. The time for which the effects of Inonza 1 mg Injection last: The duration of action for Inonza 1 mg Injection is not clinically established.

What if you forget to take Inonza 1 mg Injection

Because this medication is scheduled and given by medical professionals in a clinic, it is very important not to miss an appointment. If you miss a scheduled infusion, contact your doctor or clinic immediately to reschedule.

Storage

•Vials of Inonza 1 mg Injection are stored in a secure refrigerator at the hospital or clinic at a temperature between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Confirm with your nurse that your blood tests have been reviewed before each infusion, as your doctor must check your liver health and blood counts regularly.
  • Tell your healthcare provider immediately if you feel any pain, burning, coldness, or swelling around your IV site during the infusion.
  • Use highly effective birth control during treatment and for at least 8 months after your final dose (for women) or 5 months after (for men) to prevent pregnancy.
  • Avoid receiving any 'live' vaccines while receiving this treatment, as your immune system may be weakened.

Drug-Drug Interactions

verifiedApollotooltip
  • Hepatotoxic medicines: Taking other medications that can cause liver damage (such as certain antifungals or high doses of pain relievers) can increase your risk of severe liver issues.
  • QT-prolonging medicines: Certain medications that affect your heart rhythm can interact with Inonza 1 mg Injection and increase the risk of irregular heartbeats.
Inotuzumab ozogamicinMoxifloxacin
Severe

Drug-Drug Interactions

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Inotuzumab ozogamicinMoxifloxacin
Severe
How does the drug interact with Inonza 1 mg Injection:
Using Moxifloxacin together with Inonza 1 mg Injection can increase the risk of an irregular heart Rhythm.

How to manage the interaction:
Although taking Moxifloxacin and Inonza 1 mg Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heartbeat, dizziness, difficulty breathing- make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Inonza 1 mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Inonza 1 mg Injection is used to treat Acute lymphocytic leukemia (ALL).
Inonza 1 mg Injection contains Inotuzumab Ozogamicin, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.
Inonza 1 mg Injection is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman must have a negative pregnancy test before starting treatment with this medicine. Using effective birth control methods to prevent pregnancy while taking this medicine is better.
Yes, Inonza 1 mg Injection can cause serious liver damage, including a condition that blocks the veins in the liver. Your doctor will monitor your liver closely with regular blood tests. Talk to your doctor immediately if you notice yellowing of your skin or eyes.
It is highly recommended to avoid alcohol during treatment, as both alcohol and Inonza 1 mg Injection can place stress on your liver. Talk to your doctor or pharmacist for more personalised advice.
Because this medicine lowers your white blood cell count, a fever can be a sign of a serious infection. Contact your doctor or seek emergency medical care right away if your temperature rises.
Yes, your healthcare team will usually give you medicines like steroids, antihistamines, or fever reducers before your infusion to help prevent allergic or infusion-related reactions. Talk to your doctor about what to expect.
You should avoid "live" vaccines during your treatment, as your immune system will be weakened and may not react safely to the vaccine. Talk to your doctor before scheduling any immunisations.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18Th Floor , Plot No. C-70, €˜G’ Block , Bandra Kurla Complex, Bandra East , Mumbai €“ 400051
Other Info - INO0069
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