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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Imatinate 400 Capsule 30's is used to treat cancer. It contains Imatinib which works by inhibiting the growth and spread of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

IMATINIB-400MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Imatinate 400 Capsule 30's

Imatinate 400 Capsule 30's belongs to a class of drugs known as 'anti-cancer medication', primarily used to treat various types of cancer. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. Cancer is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer, etc.

Imatinate 400 Capsule 30's contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

You are advised to take Imatinate 400 Capsule 30's for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently. 

Do not take Imatinate 400 Capsule 30's if you are allergic to any of its ingredients. While taking Imatinate 400 Capsule 30's, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Imatinate 400 Capsule 30's. Imatinate 400 Capsule 30's can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Imatinate 400 Capsule 30's as it can make hepatitis B active again. 

Uses of Imatinate 400 Capsule 30's

Imatinate 400 Capsule 30's is used in the treatment of cancer. The detailed use of Imatinate 400 Capsule 30's is as follows:

  • Treatment of cancer: Imatinate 400 Capsule 30's is used to treat various cancers such as Chronic Myeloid Leukemia (CML), Acute Lymphoblastic Leukemia (ALL), Gastrointestinal Stromal Tumors (GIST), Dermatofibrosarcoma Protuberans (DFSP), Myelodysplastic/Myeloproliferative Diseases, and Hypereosinophilic Syndrome.

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Directions for Use

  • Imatinate 400 Capsule 30's should be taken with a meal to prevent stomach discomfort and nausea.
  • It is usually taken 1-2 times daily based on the medical condition or as prescribed by your doctor.
  • Swallow Imatinate 400 Capsule 30's as a whole with a glass of water. If you have difficulty swallowing it, you can dissolve it in water or apple juice.
  • Do not crush or chew it. If you accidentally touch a crushed tablet, wash the area thoroughly.

Medicinal Benefits

Imatinate 400 Capsule 30's belongs to a class of drugs known as 'anti-cancer medication' containing Imatinib, primarily used to treat various cancer types. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

How Imatinate 400 Capsule 30's Works

Imatinate 400 Capsule 30's contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Storage

• Store in a cool and dry place away from sunlight.• Keep Imatinate 400 Capsule 30's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Imatinate 400 Capsule 30's

Take Imatinate 400 Capsule 30's only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, diarrhoea, rash, swelling, extreme tiredness, muscle spasms/cramps, abdominal pain, headache, or loss of appetite. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Imatinate 400 Capsule 30's if you are allergic to any of its ingredients. Imatinate 400 Capsule 30's may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. While taking Imatinate 400 Capsule 30's, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF. Imatinate 400 Capsule 30's can cause leg swelling and water retention (oedema), so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Imatinate 400 Capsule 30's as it can make hepatitis B active again. Imatinate 400 Capsule 30's may make you more susceptible to infections; consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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ImatinibNaloxegol
Critical
ImatinibEliglustat
Critical

Drug-Drug Interactions

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ImatinibNaloxegol
Critical
How does the drug interact with Imatinate 400 Capsule:
Taking Imatinate 400 Capsule with Naloxegol may increase the level of naloxegol which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Naloxegol is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the consult.
ImatinibEliglustat
Critical
How does the drug interact with Imatinate 400 Capsule:
When Imatinate 400 Capsule is taken with Eliglustat, Imatinate 400 Capsule increases levels of eliglustat which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Eliglustat is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
How does the drug interact with Imatinate 400 Capsule:
When Regorafenib is taken with Imatinate 400 Capsule, it may increase the level of Imatinate 400 Capsule which may lead to side effects.

How to manage the interaction:
Taking Regorafenib with Imatinate 400 Capsule is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
How does the drug interact with Imatinate 400 Capsule:
Using Lurasidone together with Imatinate 400 Capsule may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
Taking Lurasidone with Imatinate 400 Capsule is not recommended as it leads to an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ImatinibFlibanserin
Critical
How does the drug interact with Imatinate 400 Capsule:
Taking Imatinate 400 Capsule with Flibanserin may increase the level of flibanserin in body leading to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Flibanserin is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
How does the drug interact with Imatinate 400 Capsule:
When Imatinate 400 Capsule is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Imatinate 400 Capsule with Cisapride is not recommended, it can be taken if a doctor has prescribed this. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue the medication without consulting a doctor.
ImatinibLomitapide
Critical
How does the drug interact with Imatinate 400 Capsule:
When Lomitapide is taken with Imatinate 400 Capsule, it can increases levels of lomitapide which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Lomitapide is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibVenetoclax
Critical
How does the drug interact with Imatinate 400 Capsule:
When Venetoclax is taken with Imatinate 400 Capsule, Imatinate 400 Capsule may increase the level of venetoclax which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Venetoclax is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
How does the drug interact with Imatinate 400 Capsule:
Coadministration of Ivabradine with Imatinate 400 Capsule can increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Bosutinib together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
ImatinibDihydroergotamine
Critical
How does the drug interact with Imatinate 400 Capsule:
When Dihydroergotamine is taken with Imatinate 400 Capsule, it increases levels of dihydroergotamine leading to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Dihydroergotamine is not recommended, it can be taken if advised by your doctor. However, if you experience any unusual symptoms, consult the doctor.

Drug-Food Interactions

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IMATINIB-400MGHerbal products/medicines

Drug-Food Interactions

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IMATINIB-400MGHerbal products/medicines
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
St. John's Wort may reduce the effectiveness of Imatinate 400 Capsule. Avoid St. John's Wort during treatment with Imatinate 400 Capsule.

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Avoid alcohol consumption while taking Imatinate 400 Capsule 30's as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Unsafe

Imatinate 400 Capsule 30's is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Imatinate 400 Capsule 30's and your next pregnancy.

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Breast Feeding

Unsafe

Imatinate 400 Capsule 30's is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Imatinate 400 Capsule 30's.

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Driving

Unsafe

Imatinate 400 Capsule 30's may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Imatinate 400 Capsule 30's are not known in children. It should be taken only if prescribed by a doctor.

FAQs

Imatinate 400 Capsule 30's is used to treat chronic myeloid leukaemia (cancer that begins in the bone marrow), acute lymphocytic leukaemia (cancer of the blood and bone marrow) and gastrointestinal stromal tumour (tumour that occurs in the gastrointestinal tract).

Imatinate 400 Capsule 30's contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Imatinate 400 Capsule 30's.

Yes, you might become more sensitive to sunlight while taking Imatinate 400 Capsule 30's, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.

In elderly patients taking Imatinate 400 Capsule 30's, the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

Country of origin

India

Manufacturer/Marketer address

87, Dattaram Lad Path, Ghodapdeo, Byculla East, Parel, Mumbai, Maharashtra 400 033.
Other Info - IMA0064

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