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compositionComposition:IMATINIB-400MG
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Prescription Medicine
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Imatinate 400 Capsule 30's is used to treat cancer. It contains Imatinib, which works by inhibiting the growth and spread of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IMATINIB-400MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Imatinate 400 Capsule 30's

Imatinate 400 Capsule 30's is an oral prescription medicine used to treat specific types of blood cancers, such as chronic myeloid leukemia, and certain gastrointestinal tumors. It works by targeting and blocking the signals that cause abnormal cells to grow and multiply. By stopping these signals, it helps control the spread of the disease and can help put it into remission.

For the best results, you must take Imatinate 400 Capsule 30's consistently every day at the same time as prescribed by your doctor. It should be taken with a meal and a large glass of water to help prevent severe stomach irritation. Maintaining a balanced diet and staying well-hydrated can also help your body cope better with the treatment.

Some people may experience mild side effects, such as muscle cramps, mild nausea, or fluid retention while taking this medication. However, you must contact your doctor immediately if you experience rapid weight gain, severe shortness of breath, or signs of unusual bleeding. Your medical team will monitor you closely to manage these issues if they arise.

Before starting Imatinate 400 Capsule 30's, talk to your doctor if you have a history of liver disease, kidney problems, or heart failure. Do not take this if you are pregnant, as the medication can cause severe harm to an unborn baby. Women of childbearing age must use highly effective birth control during treatment.

Imatinate 400 Capsule 30's can interact with certain other prescriptions, over-the-counter remedies, and alcohol, which can increase the risk of liver damage. If you are breastfeeding, elderly, or have pre-existing heart conditions, consult your healthcare provider to discuss whether Imatinate 400 Capsule 30's is safe for you.

Uses of Imatinate 400 Capsule 30's

Imatinate 400 Capsule 30's is used in the treatment of cancer. The detailed use of Imatinate 400 Capsule 30's is as follows:

  • Chronic Myeloid Leukemia (CML): Imatinate 400 Capsule 30's helps control the overproduction of abnormal white blood cells in the bone marrow, helping to bring blood cell counts back to safe, normal levels.
  • Acute Lymphoblastic Leukemia (ALL): It targets specific abnormal proteins to stop the rapid growth and spread of cancer cells in certain patients with this type of blood cancer.
  • Gastrointestinal Stromal Tumors (GIST): It prevents the growth and spread of non-cancerous or cancerous tumors within the walls of the stomach or intestines.
  • Dermatofibrosarcoma Protuberans (DFSP): It treats this rare type of skin tissue cancer when the tumor cannot be completely removed by surgery.

Key Benefits

Imatinate 400 Capsule 30's helps treat certain types of cancer by slowing or stopping the growth of abnormal cells. By targeting specific proteins involved in cancer cell growth, it supports disease control and improves long-term treatment outcomes. Benefits may include:

  • Helps slow or stop the growth of certain cancer cells.
  • Supports long-term control of specific blood cancers and gastrointestinal stromal tumours (GIST).
  • May help shrink tumours before surgery or reduce the risk of recurrence after treatment.
  • Helps relieve symptoms caused by tumour growth and improve daily functioning.
  • Supports better treatment outcomes through targeted therapy.
  • Contributes to improved quality of life when used as part of a comprehensive cancer treatment plan.

Directions for Use

  • Imatinate 400 Capsule 30's should be taken with a meal to prevent stomach discomfort and nausea.
  • It is usually taken 1-2 times daily based on the medical condition or as prescribed by your doctor.
  • Swallow Imatinate 400 Capsule 30's as a whole with a glass of water. If you have difficulty swallowing it, you can dissolve it in water or apple juice.
  • Do not crush or chew it. If you accidentally touch a crushed tablet, wash the area thoroughly.

How Imatinate 400 Capsule 30's Works

Imatinate 400 Capsule 30's contains Imatinib, which belongs to a class of medications called tyrosine kinase inhibitors. In certain cancers, an abnormal gene creates a protein that continuously signals cells to divide and grow out of control. Imatinate 400 Capsule 30's works by binding directly to this abnormal protein and switching off its signaling pathway. Without these continuous growth signals, the abnormal cells stop multiplying and eventually die off. This highly targeted mechanism helps control the disease without causing widespread damage to healthy, normal cells throughout your body.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Imatinate 400 Capsule 30's as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Unsafe

Imatinate 400 Capsule 30's is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Imatinate 400 Capsule 30's and your next pregnancy.

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Breast Feeding

Unsafe

Imatinate 400 Capsule 30's is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Imatinate 400 Capsule 30's.

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Driving

Unsafe

Imatinate 400 Capsule 30's may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Imatinate 400 Capsule 30's are not known in children. It should be taken only if prescribed by a doctor.

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Heart

Safe if prescribed

Imatinate 400 Capsule 30's can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Imatinate 400 Capsule 30's is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Imatinate 400 Capsule 30's

If you accidentally take too much Imatinate 400 Capsule 30's, seek emergency medical attention or contact a poison control center immediately. Symptoms of an overdose may include severe stomach upset, extreme muscle pain, or severe skin rashes.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit can interfere with how your body breaks down Imatinate 400 Capsule 30's, leading to dangerously high levels of the medication in your blood.
  • Manage fluid retention: Keep a close eye on your daily weight. To help manage mild swelling, try to reduce your dietary salt intake and elevate your legs when sitting.
  • Protect yourself from infections: Because Imatinate 400 Capsule 30's can lower your white blood cell count, wash your hands frequently, avoid close contact with sick individuals, and seek medical care at the first sign of a fever.
  • Stay hydrated: Drink plenty of fluids throughout the day to support kidney function and help manage mild diarrhoea or nausea.
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How Soon It Starts Working

  • The time required for Imatinate 400 Capsule 30's to start to work: Imatinate 400 Capsule 30's ideally shows its action within 2 to 4 hours after administration.
  • The time for which the effects of Imatinate 400 Capsule 30's last: The effect of Imatinate 400 Capsule 30's lasts for 18 hours.

What if you forget to take Imatinate 400 Capsule 30's

If you miss a dose, take it as soon as you remember, provided you can take it with food. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Imatinate 400 Capsule 30's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor your blood counts: You will need regular blood tests to check your liver function, kidney function, and blood cell levels while taking Imatinate 400 Capsule 30's.
  • Watch for sudden weight gain: Weigh yourself daily; a rapid increase in weight can indicate dangerous fluid retention in your lungs or heart.
  • Protect your skin: Imatinate 400 Capsule 30's can make your skin more sensitive to sunlight, so apply broad-spectrum sunscreen and wear protective clothing when outdoors.
  • Use reliable birth control: Both men and women taking Imatinate 400 Capsule 30's should use highly effective birth control during treatment to prevent pregnancy, as Imatinate 400 Capsule 30's can cause severe birth defects.
  • Do not crush or split tablets routinely: Avoid breathing in any dust from broken tablets, especially if you are pregnant or planning a family.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., carbamazepine, phenytoin): These medicines may reduce the effectiveness of Imatinate 400 Capsule 30's by increasing its breakdown in the body.
  • Certain antifungal medicines (e.g., ketoconazole) and antibiotics (e.g., clarithromycin): These medicines may increase the amount of Imatinate 400 Capsule 30's in the body, raising the risk of serious side effects.
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Imatinate 400 Capsule 30's may increase the risk of serious bleeding and require closer monitoring.
ImatinibNaloxegol
Critical
ImatinibEliglustat
Critical

Drug-Drug Interactions

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ImatinibNaloxegol
Critical
How does the drug interact with Imatinate 400 Capsule:
Taking Imatinate 400 Capsule with Naloxegol may increase the level of naloxegol which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Naloxegol is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the consult.
ImatinibEliglustat
Critical
How does the drug interact with Imatinate 400 Capsule:
When Imatinate 400 Capsule is taken with Eliglustat, Imatinate 400 Capsule increases levels of eliglustat which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Eliglustat is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibCobimetinib
Critical
How does the drug interact with Imatinate 400 Capsule:
When Cobimetinib is taken with Imatinate 400 Capsule, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Cobimetinib is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor.
How does the drug interact with Imatinate 400 Capsule:
When Imatinate 400 Capsule is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Imatinate 400 Capsule with Cisapride is not recommended, it can be taken if a doctor has prescribed this. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Imatinate 400 Capsule:
Coadministration of Ivabradine with Imatinate 400 Capsule can increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Bosutinib together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
ImatinibVenetoclax
Critical
How does the drug interact with Imatinate 400 Capsule:
When Venetoclax is taken with Imatinate 400 Capsule, Imatinate 400 Capsule may increase the level of venetoclax which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Venetoclax is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibConivaptan
Critical
How does the drug interact with Imatinate 400 Capsule:
When Imatinate 400 Capsule is taken with Conivaptan, it can cause increase in the blood levels of conivaptan leading to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Conivaptan is not recommended, it can be taken if recommended by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibLomitapide
Critical
How does the drug interact with Imatinate 400 Capsule:
When Lomitapide is taken with Imatinate 400 Capsule, it can increases levels of lomitapide which may lead to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Lomitapide is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibFlibanserin
Critical
How does the drug interact with Imatinate 400 Capsule:
Taking Imatinate 400 Capsule with Flibanserin may increase the level of flibanserin in body leading to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Flibanserin is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibDihydroergotamine
Critical
How does the drug interact with Imatinate 400 Capsule:
When Dihydroergotamine is taken with Imatinate 400 Capsule, it increases levels of dihydroergotamine leading to side effects.

How to manage the interaction:
Taking Imatinate 400 Capsule with Dihydroergotamine is not recommended, it can be taken if advised by your doctor. However, if you experience any unusual symptoms, consult the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit products while taking Imatinate 400 Capsule 30's, as they can increase the amount of the medicine in your bloodstream and raise the risk of side effects.
IMATINIB-400MGHerbal products/medicines

Drug-Food Interactions

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IMATINIB-400MGHerbal products/medicines
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
St. John's Wort may reduce the effectiveness of Imatinate 400 Capsule. Avoid St. John's Wort during treatment with Imatinate 400 Capsule.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Imatinate 400 Capsule 30's is used to treat chronic myeloid leukaemia (cancer that begins in the bone marrow), acute lymphocytic leukaemia (cancer of the blood and bone marrow) and gastrointestinal stromal tumour (tumour that occurs in the gastrointestinal tract).
Imatinate 400 Capsule 30's contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.
Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Imatinate 400 Capsule 30's.
Yes, you might become more sensitive to sunlight while taking Imatinate 400 Capsule 30's, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.
In elderly patients taking Imatinate 400 Capsule 30's, the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
If you are having surgery, including dental surgery, please inform your doctor if you are taking Imatinate 400 Capsule 30's as your doctor might stop Imatinate 400 Capsule 30's before undergoing surgery.
Imatinate 400 Capsule 30's can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.
Imatinate 400 Capsule 30's contains Imatinib, an anti-cancer medication.
Imatinate 400 Capsule 30's can be taken along with food as it helps prevent nausea.
Imatinate 400 Capsule 30's may cause weakness, dizziness and drowsiness. Do not drive or operate machinery until you know how the medicine affects you.
Imatinate 400 Capsule 30's may cause foetal harm, therefore let the doctor know if you are pregnant, planning for pregnancy or think you may be pregnant. Regular monitoring of weight and blood count is advised. Inform the doctor if you have liver, heart, kidney or thyroid problems.
Imatinate 400 Capsule 30's can cause sensitivity to sunlight leading to itching and rashes when exposed to the sun. Wear protective clothing, hat and use sunscreen whilst going out.
Imatinate 400 Capsule 30's might cause liver damage and taking paracetamol with Imatinate 400 Capsule 30's might increase that risk. Therefore, consult the doctor before taking paracetamol or any other medicine with Imatinate 400 Capsule 30's to prevent any interactions.
Taking Imatinate 400 Capsule 30's regularly as advised by the doctor helps improve the outcome of patients with chronic myeloid leukaemia (CML). Please consult the doctor if you have any concerns.
Side effects of Imatinate 400 Capsule 30's are nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Talk to your doctor if you experience these side effects persistently.
Muscle cramps are a common side effect. Ensure you are drinking enough fluids and ask your doctor if mineral supplements like calcium or magnesium are safe for you. Talk to your doctor before starting any new supplements.
You should avoid live vaccines during treatment because Imatinate 400 Capsule 30's can weaken your immune system. Always talk to your doctor or pharmacist before getting any vaccine.
In some cases, Imatinate 400 Capsule 30's can cause fluid retention that puts extra strain on your heart, or it may directly affect heart function. If you notice swelling, shortness of breath, or rapid weight gain, talk to your doctor immediately.
Avoid using paracetamol (acetaminophen) in high doses as it can stress your liver, and avoid NSAIDs like ibuprofen if you are at risk of bleeding. Talk to your doctor or pharmacist for a safe pain relief recommendation.
If you vomit after taking your dose, do not take an extra tablet to replace it. Wait and take your next scheduled dose the following day. Talk to your doctor if vomiting becomes a regular issue.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

87, Dattaram Lad Path, Ghodapdeo, Byculla East, Parel, Mumbai, Maharashtra 400 033.
Other Info - IMA0064
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