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compositionComposition:S ADENOSYL METHIONINE-200MG
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Prescription Medicine
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HYSAM 200MG TABLET is used to treat S-adenosylmethionine deficiency, depression, primary biliary cholangitis, and osteoarthritis. It minimises liver damage, regulates mood, stimulates the production of cartilage, reduces the inflammatory mediator, and has painkilling properties. In some cases, this medicine may cause side effects such as abdominal discomfort, diarrhoea, nausea, dizziness, and insomnia. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

S ADENOSYL METHIONINE-200MG

Manufacturer/Marketer :

Berfen Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About HYSAM 200MG TABLET

HYSAM 200MG TABLET is a supportive medication primarily suggested to improve joint mobility, support liver health, and help manage certain mood disorders. It works by replenishing a naturally occurring substance in the body that is vital for cell growth and repair. Doctors commonly use it to ease symptoms of wear-and-tear arthritis and specific liver conditions.

To get the best results, you should take HYSAM 200MG TABLET consistently every day exactly as suggested by your doctor. It is highly recommended to take this medicine on an empty stomach, either one hour before or two hours after a meal, as food can significantly reduce how well your body absorbs it. Combining this treatment with a balanced, anti-inflammatory diet and regular, low-impact exercise can help improve your overall physical comfort.

While taking HYSAM 200MG TABLET, you may experience some mild, temporary side effects such as nausea or a mild upset stomach. Most people tolerate this medicine very well, but if you notice any unusual changes in your mood, or signs of a severe allergic reaction, you must consult your doctor immediately.

Talk to your doctor before starting this medicine if you have any pre-existing health conditions, especially mental health disorders. Do not take this if you have been diagnosed with bipolar disorder, as this medication can trigger severe mood swings or episodes of extreme excitement.

This medicine can interact with certain suggested antidepressants, potentially causing a serious condition marked by high serotonin levels, so always share your full medication list with your doctor. You should also avoid heavy alcohol use while taking HYSAM 200MG TABLET, as alcohol can place additional strain on your liver and reduce the benefits of the treatment. If you are pregnant, breastfeeding, or managing health conditions as an older adult, consult your doctor or pharmacist before starting.

Uses of HYSAM 200MG TABLET

The following are the common conditions for which S ADENOSYL METHIONINE is suggested:

  • Osteoarthritis: HYSAM 200MG TABLET helps reduce joint pain, inflammation, and stiffness, making it easier to move comfortably throughout the day.
  • Liver cholestasis: HYSAM 200MG TABLET supports healthy liver function by improving the flow of bile and protecting liver cells from metabolic damage.
  • Depression: HYSAM 200MG TABLET assists in balancing brain chemicals to help relieve symptoms of mild-to-moderate depression.

Key Benefits

The following benefits highlight how S ADENOSYL METHIONINE supports joint health, liver function, and emotional well-being:

  • Improves joint comfort and mobility: It helps reduce joint pain and stiffness, making everyday activities and movement more comfortable.
  • Supports liver health: It promotes healthy bile flow and helps protect liver cells, supporting the liver's natural detoxification processes.
  • Helps maintain emotional well-being: By supporting the balance of important brain chemicals, it may help improve mood in people with mild-to-moderate depression.
  • Promotes overall cellular health: It helps restore essential biochemical processes throughout the body, contributing to better physical function and overall well-being.
Side effects of Hysam 200mg Tablet
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Swelling of the throat can worsen if there is no proper rest for your throat.
  • Drink plenty of warm fluids and frequently gargle with salt water.
  • Humidify the surrounding air using a humidifier, as dry air may increase dryness and throat pain.
  • Talk to your doctor if the swelling bothers you while swallowing food.
  • Take enough rest and stay in warm places to reduce pain quickly.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • HYSAM 200MG TABLET can be taken on an empty stomach, at least 30 to 60 minutes before a meal or two hours after a meal, as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow it as a whole with a glass of water.
  • Do not chew, crush or break it.

How HYSAM 200MG TABLET Works

HYSAM 200MG TABLET delivers a crucial compound that the body uses to perform a process called methylation. This process acts like a chemical switch that is necessary for producing proteins, protecting DNA, and maintaining cell membranes throughout your body, especially in your joints, liver, and brain. In your joints, HYSAM 200MG TABLET aids in the production of proteoglycans, which are the essential building blocks of joint cartilage. By supporting cartilage health, it helps cushion your joints and prevent friction. In the liver, it helps generate a powerful protective substance called glutathione, which neutralises harmful toxins and prevents liver damage. In the brain, it plays a key role in manufacturing neurotransmitters like serotonin and dopamine, which help regulate and lift your mood.
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Alcohol

Caution

Avoid consumption of alcohol while taking HYSAM 200MG TABLET as it may cause increased dizziness and liver damage.

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Pregnancy

Caution

Avoid taking HYSAM 200MG TABLET if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking HYSAM 200MG TABLET, your doctor will decide whether HYSAM 200MG TABLET can be taken by breastfeeding mothers or not.

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Driving

Caution

HYSAM 200MG TABLET does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

HYSAM 200MG TABLET can be given to children with caution only if recommended by the doctor.

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Heart

Consult your doctor

Talk to your doctor if you have a history of heart disease. Your doctor will recommend only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

HYSAM 200MG TABLET should be given to elderly patients only if recommended by a doctor. Seek medical advice if you have any concerns.

What if I have taken an overdose of HYSAM 200MG TABLET

If you suspect an accidental overdose, or if someone has taken a large amount of HYSAM 200MG TABLET, seek immediate medical attention or contact your local poison control centre right away, even if there are no immediate symptoms.

Diet & Lifestyle Advise

  • Ensure adequate B-vitamin intake: Ensure your diet includes plenty of foods rich in Vitamin B12 and folate, such as leafy greens, eggs, and fortified grains, as your body requires these vitamins to properly process and utilize HYSAM 200MG TABLET.
  • Protect your liver: Avoid consuming alcohol, as it can cause liver damage and reduce the effectiveness of this medicine in supporting liver health.
  • Engage in low-impact exercise: If taking this for joint discomfort, incorporate gentle exercises like swimming, walking, or cycling to help keep your joints lubricated and strong.
  • Stay hydrated: Drink plenty of water throughout the day to support overall cellular function and help your kidneys process waste efficiently.
health query

Have a query?

How Soon It Starts Working

The time required for HYSAM 200MG TABLET to start to work: HYSAM 200MG TABLET ideally shows its action within 3 to 4 hours after administration. The time for which the effects of HYSAM 200MG TABLET last: The duration of action for HYSAM 200MG TABLET is clinically unknown.

What if you forget to take HYSAM 200MG TABLET

If you miss a dose of HYSAM 200MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a forgotten one.

Storage

• Store HYSAM 200MG TABLET tablets in a cool, dry place, keeping the temperature below 25°C.

Drug Warnings

  • Inspect the packaging: Always check the blister foil before use; if the seal is broken, torn, or if the tablets look discoloured or soft, do not take them.
  • Avoid late-day doses: Try to take your final dose of the day by early afternoon, as taking this medicine close to bedtime can cause trouble sleeping.
  • Watch for mood changes: Alert family members or close friends to monitor you for sudden shifts in energy or mood, especially if you have a history of depression.
  • Inform your surgical team: If you are scheduled for any medical or dental surgeries, tell your doctor or surgeon that you are taking HYSAM 200MG TABLET, as you may need to stop taking it temporarily.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with HYSAM 200MG TABLET and affect its safety or effectiveness. Inform your doctor about all the medicines and supplements you are taking before starting treatment.

  • Antidepressants (such as SSRIs, SNRIs, or MAOIs): Combining HYSAM 200MG TABLET with these medications can cause a dangerous buildup of serotonin in your body, leading to confusion, rapid heart rate, and sweating.
  • Levodopa (Parkinson's medication): Taking HYSAM 200MG TABLET may reduce the effectiveness of levodopa, which can cause Parkinson's symptoms to worsen.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

The following food-related precautions can help ensure HYSAM 200MG TABLET is absorbed properly and works effectively.

  • Food and meals: Consuming food close to your dose can significantly lower how much of the active medicine is absorbed by your digestive tract.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[NUTRITIONAL SUPPLEMENT]

FAQs

No. Do not stop taking HYSAM 200MG TABLET without consulting your doctor, even if you feel better. Stopping treatment abruptly may cause your symptoms, such as depression or joint pain, to return. Your doctor will advise whether treatment should continue or if the dose should be reduced gradually before stopping.
It is best to take HYSAM 200MG TABLET with a full glass of water on an empty stomach. Caffeine does not directly interact with the medicine, but coffee can sometimes speed up digestion and affect how well the tablet is absorbed. Talk to your doctor or pharmacist for personalised advice.
The safety of this medicine during pregnancy has not been fully established. Do not start taking it if you are pregnant or planning to become pregnant without consulting your obstetrician. Talk to your doctor to weigh the potential risks and benefits.
Food in your stomach significantly blocks the absorption of this medicine, meaning your body will receive a much lower dose than intended. Taking it at least 1 hour before a meal ensures maximum benefit. Talk to your doctor if you experience stomach upset when taking it this way.
Yes, because this medicine affects brain chemicals involved in energy and mood, some patients may experience mild anxiety, nervousness, or trouble sleeping, especially when first starting. If these feelings become bothersome, talk to your doctor.
Your body requires adequate levels of Vitamin B12 and folate to utilise HYSAM 200MG TABLET effectively. If you are deficient in these vitamins, the medicine may not work as well, so your doctor may recommend a combined supplement. Talk to your doctor about checking your vitamin levels.
While there is no direct chemical reaction, alcohol can worsen liver strain and affect your mood, directly opposing the beneficial properties of this medication. It is highly recommended to limit or avoid alcohol during treatment. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. S Adenosylmethionine Same Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Same Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Abbott. Heptral 200/400. MIMS.com. [Accessed on 25th November 2022] 200-400?type=fullCheck here
  4. Central Drug Standard Control Organisation (CDSCO). Ademetionine enteric coated Tablets.200mg/400mg. [Revised in September 2010] [Accessed on 25th November 2022]Check here
  5. AbbVie S.r.L. Abbott Laboratories. Ademetionine butanedisulfonate (Transmetil). [Accessed on 25th November 2022] 500mg.pdfCheck here
  6. La Renon Healthcare Private Limited. Methosam. Ademetionine Enteric Coated Tablets 200mg. [Accessed on 25th November 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - HYS0013

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