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Histoglob Injection 1 ml is used to treat allergic reactions like allergic rhinitis (inflammation in the nose) and urticaria (the occurrence of swollen, pale red bumps or plaques on the skin). It is also used in treating eczema (a skin condition that causes patches of itchiness, inflammation, swelling, and cracked skin). It contains Human Normal Immunoglobulin, Histamine and Sodium Thiosulphate. It works by blocking the action of certain chemical messengers that are responsible for inflammation, congestion, itching and other allergic reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Bharat Serums and Vaccines Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Histoglob Injection 1 ml

Histoglob Injection 1 ml is a specialised injection therapy approved in India by the CDSCO based primarily on regional post-marketing data to manage long-term allergic conditions like allergic asthma, allergic rhinitis (hay fever), and chronic hives (urticaria). Its clinical evidence base does not meet the rigorous trial thresholds required for approval by major global regulatory bodies such as the US FDA or European Medicines Agency (EMA), nor is it recognised in international guidelines like GINA or ARIA. Unlike standard allergy shots or drops—such as Subcutaneous Immunotherapy (SCIT) or Sublingual Immunotherapy (SLIT), which build targeted tolerance to specific triggers like pollen—this combination acts as a broad, non-specific immune-calming (immunomodulating) treatment used within local medical frameworks.

Because Histoglob Injection 1 ml is administered as an injection, your doctor will determine the frequency and consistency of your dosing schedule, which is typically given in a series of cycles. This medicine does not depend on food intake, so you do not need to worry about taking it with or without meals. Making practical lifestyle adjustments, such as using allergen-proof bedding and keeping indoor air clean, can significantly improve your treatment outcomes.

Like most medical therapies, Histoglob Injection 1 ml may cause some mild side effects, which commonly include pain or redness at the injection site, mild headaches, or a temporary low-grade fever. If you experience severe symptoms, such as difficulty breathing or signs of a severe allergic reaction, you must consult your doctor immediately.

Before beginning your treatment, always inform your healthcare provider about your complete medical history. Do not take this if you have a known history of severe allergic reactions to human blood products or immunoglobulins. Your doctor will carefully evaluate your condition to ensure this treatment is safe for you.

It is also vital to discuss any other medicines, supplements, or vaccines you have recently received, as certain treatments can interfere with how this medicine works. Additionally, if you are pregnant, breastfeeding, or managing health conditions as an elderly individual, consult your doctor to discuss specific safety measures before starting your injections.

Uses of Histoglob Injection 1 ml

Histoglob Injection 1 ml is prescribed primarily within regional clinical contexts (such as India) to manage chronic allergic conditions when conventional antihistamines or inhalers are insufficient. Treatment suitability must be evaluated by an allergy specialist:

  • Allergic Asthma: May help reduce the frequency and severity of breathing difficulties and wheezing episodes triggered by environmental allergens.
  • Allergic Rhinitis: May relieve persistent symptoms like sneezing, runny nose, congestion, and itchy eyes caused by seasonal or year-round allergies.
  • Chronic Urticaria (Hives): Prescribed in select cases to help reduce the recurrence of itchy, red, and swollen welts on the skin.
  • Atopic Dermatitis (Eczema): Considered an off-label use even within the Indian regulatory context, though it may occasionally be prescribed under specialist supervision to help calm skin inflammation, redness, and severe itching despite very limited clinical evidence.

Key Benefits

Histoglob Injection 1 ml may offer several potential benefits in managing chronic allergic conditions, as observed in some patients under specialist care:

  • Long-Term Allergy Relief: The intended benefit of Histoglob Injection 1 ml is to help provide extended relief from persistent, disruptive allergy symptoms. Rather than simply masking your symptoms temporarily, it is proposed to lower your immune system's overreactivity to everyday triggers, helping reduce daily interruptions.
  • Reduced Dependence on Daily medicines: As observed in clinical practice, some patients may experience a reduced need for daily antihistamines, rescue inhalers, or topical steroids. Any reduction in daily medicine dependence should always be managed under direct medical supervision.
  • Improved Quality of Life: Furthermore, by helping to reduce sudden allergy flare-ups, this therapy may support better sleep quality and daily comfort, as observed in post-marketing clinical experience in India.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Histoglob Injection 1 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Histoglob Injection 1 ml Works

Histoglob Injection 1 ml contains Human Normal Immunoglobulin, Histamine, and Sodium Thiosulphate, which are proposed to work together to help calm your immune system, though these represent early clinical rationales rather than mechanisms verified by large-scale global trials. Human Normal Immunoglobulin provides donor antibodies (IgG) that assist in general immunomodulation. It helps stabilise overactive immune signalling during allergic flare-ups rather than acting as a direct allergen-specific desensitising agent. Histamine, administered in micro-doses attached to immunoglobulin proteins, was historically hypothesised to stimulate anti-histamine antibody production. However, this theoretical concept is derived primarily from early regional studies and post-marketing observations in India rather than validated mechanisms endorsed by global bodies like GINA or ARIA. Sodium Thiosulphate serves primarily as an auxiliary stabilising agent. While traditionally described as having mild anti-inflammatory properties, its specific isolated therapeutic mechanism in this formulation lacks robust clinical evidence.
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Alcohol

Safe

Histoglob Injection 1 ml may not interact with alcohol. However, limit or avoid the consumption of alcohol to avoid possible side effects.

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Pregnancy

Unsafe

Histoglob Injection 1 ml is not recommended for use in pregnant women. Hence, inform your doctor if you are pregnant or planning to become pregnant before receiving Histoglob Injection 1 ml. Your doctor may suggest an alternative medicine based on your health condition.

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Breast Feeding

Caution

Inform your doctor if you are breastfeeding before receiving Histoglob Injection 1 ml. Your doctor will assess the benefits and the risks before prescribing.

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Driving

Safe

Histoglob Injection 1 ml usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases. Your doctor will weigh the benefits and potential risks before prescribing Histoglob Injection 1 ml.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Histoglob Injection 1 ml.

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Children

Safe if prescribed

Histoglob Injection 1 ml can be safely used in children when prescribed by a paediatrician.

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Heart

Caution

Let your doctor know if you have any history of heart diseases. Your doctor will weigh the benefits and potential risks before prescribing Histoglob Injection 1 ml.

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Geriatrics

Consult your doctor

Limited information available about the use of Histoglob Injection 1 ml in geriatric patients. Please consult your physician.

What if I have taken an overdose of Histoglob Injection 1 ml

Since this medicine is usually injected by a healthcare professional, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe symptoms after an injection, seek immediate medical attention or visit the nearest emergency room.

Diet & Lifestyle Advise

  • Avoid Allergy Triggers: Identify and minimise exposure to your specific allergy triggers, such as dust mites, pet dander, mould, or certain foods.
  • Use a HEPA Purifier: Use a high-efficiency particulate air (HEPA) purifier in your bedroom to reduce airborne allergens while you sleep.
  • Stay Well-Hydrated: Stay well-hydrated by drinking plenty of water, which helps keep your respiratory pathways moist and thins out mucus.
  • Eat a Balanced Diet: Eat a balanced diet rich in antioxidant-filled foods like fresh berries, leafy greens, and nuts to support your immune system's health.
  • Avoid Smoking: Avoid smoking and limit your exposure to secondhand smoke, which can severely irritate your airways and worsen asthma symptoms.
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How Soon It Starts Working

The time required for Histoglob Injection 1 ml to start to work: The time required for Histoglob Injection 1 ml to show its action is unknown. The time for which the effects of Histoglob Injection 1 ml last: The duration of action for Histoglob Injection 1 ml is unknown.

What if you forget to take Histoglob Injection 1 ml

If you miss a scheduled appointment for your injection, contact your healthcare provider or clinic as soon as possible to reschedule. Do not take a double dose to make up for a missed one, as this can increase your risk of side effects.

Storage

•Store Histoglob Injection 1 ml in a refrigerator at a temperature between 2°C and 8°C (35.6°F to 46.4°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the Solution: Always inspect the liquid vial before use; do not inject the medicine if you see any floating particles, cloudiness, or discolouration.
  • Receive Injections in a Healthcare Setting: Ensure your injections are performed in a professional healthcare setting where any rare, immediate allergic reactions can be managed promptly.
  • Rotate Injection Sites: Rotate your injection sites with each scheduled dose to prevent skin hardening, irritation, or localised bruising.
  • Keep a Treatment Log: Keep a detailed log of your injection dates and any symptoms you experience to help your doctor track your treatment progress.
  • Avoid Live Vaccines: Avoid receiving live vaccines (such as the MMR or chickenpox vaccine) close to your treatment schedule, as Histoglob Injection 1 ml may temporarily reduce the vaccine's effectiveness.

Drug-Drug Interactions

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  • Live viral vaccines: May interfere with the immune response to vaccines like measles, mumps, rubella, or varicella. It is generally advised to separate these treatments by several months.
  • Systemic corticosteroids or immunosuppressants: May decrease the effectiveness of Histoglob Injection 1 ml by suppressing the natural immune response your body needs to build tolerance.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Histoglob Injection 1 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNIZING AGENTS]

FAQs

Histoglob Injection 1 ml is used to treat Allergic rhinitis, Urticaria, Eczema and Premenstrual syndrome (PMS).
Histoglob Injection 1 ml contains a combination of three medicines, Human Normal Immunoglobulin, Histamine and Sodium Thiosulphate, which are used in the treatment of allergic reactions like allergic rhinitis and urticaria. This medicine works by blocking the action of certain chemical messengers that are responsible for inflammation, congestion, itching and other allergic reactions. It is also used in the treatment of eczema, premenstrual syndrome, bronchitis, and migraine.
Histoglob Injection 1 ml may alter some blood test results for a certain time, so inform your doctor that you have received Histoglob Injection 1 ml before undergoing blood tests. Taking any vaccines (especially live vaccines) at least three months after the administration of Histoglob Injection 1 ml is not recommended as this medicine may make the vaccines less effective.
Histoglob Injection 1 ml will be administered by the doctor or nurse through a subcutaneous route (injection given in the fatty tissue, just under the skin). Do not self-administer.
Inform the doctor about your complete medical history, including any medications, herbal supplements, and vitamins you are taking or if you have recently received any vaccinations. Let the doctor know if you are breastfeeding, as they will assess the risks and benefits before administering Histoglob Injection 1 ml. This medication is not recommended for use during pregnancy, so inform your doctor if you are pregnant or planning to become pregnant. Your doctor may suggest an alternative treatment based on your health condition.
Allergic rhinitis is an allergic reaction that affects the nasal passages, leading to symptoms such as sneezing, a runny nose, and congestion. Chronic urticaria, or hives, involves the recurring appearance of raised, itchy welts on the skin due to an allergic response or other triggers. The main difference is that allergic rhinitis affects the nose, whereas chronic urticaria affects the skin.
Histoglob Injection 1 ml should not be administered if you are allergic to any of its ingredients. Do not receive any vaccines, especially live vaccines, for at least three months after taking Histoglob Injection 1 ml, as this medication may reduce the effectiveness of the vaccine.
It is unlikely that Histoglob Injection 1 ml interacts with alcohol. However, it is recommended to limit or avoid alcohol consumption to reduce the risk of potential side effects.
The side effects of Histoglob Injection 1 ml include headache, swelling or hardening at the injection site, and flu-like symptoms (such as runny nose and sore throat). These side effects are typically mild and temporary. However, if any of these side effects persist or worsen, consult the doctor.
There is limited clinical information regarding the safety of Histoglob Injection 1 ml during pregnancy. It should only be used if your doctor determines that the benefits clearly outweigh the risks. Talk to your doctor if you are pregnant or planning to become pregnant.
Immunoglobulins can temporarily interfere with your body's ability to develop an effective immune response to live viral vaccines (such as MMR or chickenpox). Because standard multi-month deferral rules apply primarily to high-dose intravenous immunoglobulin (IVIG) therapy, the precise timing and deferral window for this low-dose combination formulation must be determined directly by your treating physician based on your personal injection schedule.
Histoglob Injection 1 ml is designed to significantly reduce your body's sensitivity to allergens and provide long-term symptom control, but it is not classified as a permanent cure. Talk to your doctor to understand your long-term treatment plan.
Mild redness, swelling, or soreness is common and usually goes away on its own within a few days. Applying a cool compress gently to the area can help. If the swelling worsens, becomes hot, or is highly painful, talk to your doctor immediately.
Yes, Histoglob Injection 1 ml does not typically cause drowsiness or affect your ability to drive. However, if you feel dizzy or unwell immediately after your injection, wait until you feel fully alert before driving. Talk to your doctor if you have concerns.
The total number of injections and cycles varies depending on your specific allergic condition and how well you respond to the treatment. Your healthcare provider will establish a personalised schedule for you. Talk to your doctor about your dosing plan.
This medicine can be prescribed to children for specific allergic conditions, but it must be carefully evaluated and monitored by a paediatrician. Talk to your doctor to find out if this treatment is appropriate for your child.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

17th Floor, Hoechst House, Nariman Point, Mumbai – 400 021, Maharashtra, India.
Other Info - HIS0010
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