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  3. Hipreb-D Tablet 10's

Hipreb-D Tablet 10's, Pack of 10
Hipreb-D Tablet 10's, Pack of 10
Hipreb-D Tablet 10's, Pack of 10
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Hipreb-D Tablet is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. It contains Rabeprazole and Domperidone, which helps reduce stomach acid and increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ). In adults, it may cause common side effects such as headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children, it may cause side effects such as upper respiratory tract infections, headache, fever, diarrhoea, vomiting, rash, and abdominal pain.

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Composition :

DOMPERIDONE-10MG + RABEPRAZOLE-20MG

Manufacturer/Marketer :

Lyssa Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Hipreb-D Tablet

Hipreb-D Tablet belongs to the class of drugs known as Proton pump inhibitors, which reduce the amount of acid your stomach produces. It treats gastroesophageal reflux disease (GERD), stomach ulcers, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour), duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.

Hipreb-D Tablet helps reduce stomach acid by blocking the action of an enzyme (H+/K+ ATPase, also known as the gastric proton pump), thus preventing the release of stomach acid and relieving symptoms of food pipe lining inflammation (esophagitis), gastroesophageal reflux disease (GERD), or heartburn.

Not everyone who is taking Hipreb-D Tablet will get these side effects. Hipreb-D Tablet may have common side effects, such as headache, diarrhoea, nausea, abdominal pain, vomiting, dizziness, and joint pain. These side effects are temporary and may resolve on their own over time. However, if these side effects persist, don't hesitate to contact your doctor.

Take Hipreb-D Tablet as advised. Your physician will decide the dosage based on your medical condition. You should take Hipreb-D Tablet 30 minutes before food. It is recommended not to exceed the recommended dose of Hipreb-D Tablet . Do not chew, crush, or break the medicine.

Inform your physician if you are allergic to Hipreb-D Tablet . Tell your doctor if you have stomach or intestinal cancer, liver problems, are allergic to Hipreb-D Tablet  or will have an endoscopy in the future. Prolonged intake of Hipreb-D Tablet may cause a deficiency of Vitamin B12 and low levels of calcium, magnesium and Vitamin D, leading to osteoporosis. Hipreb-D Tablet is not recommended for children below 5 years of age. Consult the doctor if you are pregnant or breastfeeding.

Uses of Hipreb-D Tablet

Hipreb-D Tablet is used in the treatment of acid reflux symptoms caused by peptic ulcer, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour) and gastroesophageal reflux disease (GERD). The detailed uses of Hipreb-D Tablet are as follows:

  • Support Digestive Health: Hipreb-D Tablet helps alleviate digestive discomfort, promoting a balanced and regular digestive system.
  • Reduce Gastrointestinal Disorders: Hipreb-D Tablet provides relief from various gastrointestinal issues, such as gas, bloating, and irregular bowel movements.
  • Relieve Indigestion: Hipreb-D Tablet offers quick relief from indigestion and related symptoms, soothing the stomach and enhancing overall comfort.

Directions for Use

  • Take Hipreb-D Tablet one hour before a meal or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Hipreb-D Tablet as a whole with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Hipreb-D Tablet is effective in healing erosive esophagitis (inflammation of the food pipe), heartburn, Zollinger-Ellison syndrome, duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
  • Hipreb-D Tablet works by irreversibly blocking the proton pump gate, which secretes stomach acid. It can be prescribed to all age groups, including special populations like the elderly, pregnant, lactating mothers, and patients with kidney and liver disease.
  • Hipreb-D Tablet helps manage acidity-related conditions, promotes digestion, and provides relief from associated discomfort.

How Hipreb-D Tablet Works

Hipreb-D Tablet contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole helps reduce stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Hipreb-D Tablet
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • To help reduce symptoms, eat foods high in vitamin C, such as oranges, bell peppers and strawberries.
  • Lightly blow your nose to remove mucus; steer clear of blowing hard.
  • Infections can be prevented from spreading by washing hands frequently and staying away from other people.
  • If you have allergies, do your best to avoid triggering allergens that could contribute to a runny nose.
  • Don't smoke, as irritating the nasal passages can make a runny nose worse.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

What if I have taken an overdose of Hipreb-D Tablet

Do not take more than the prescribed dose of Hipreb-D Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking Hipreb-D Tablet if you are allergic to Hipreb-D Tablet or have any history of gastric cancer, liver disease, low magnesium levels, or low vitamin B1.
  • Prolonged intake of Hipreb-D Tablet may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), vitamin B12, and magnesium deficiency.
  • Hipreb-D Tablet may interact with blood thinners, antifungals, anti-HIV drugs, iron supplements, and anti-cancer medications. Please inform your doctor if you are taking any of these medications.
  • Intake of Hipreb-D Tablet may mask the symptoms of gastric cancer, so if you have any severe stomach pain or blood in stool, immediately consult the doctor.
  • It is advised to stop consuming alcohol and smoking, as it can cause serious side effects. This medicine is not recommended for use in children below 16 years of age.
  • Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
  • Although Hipreb-D Tablet is safe for use during pregnancy or breastfeeding, inform your doctor if you are pregnant or breastfeeding before starting treatment with Hipreb-D Tablet . Let your doctor know if you are taking any other medicines, including supplements and herbal products, to prevent any interactions.
  • Store Hipreb-D Tablet at room temperature. Keep the medicine out of reach of children. Do not take more than the recommended dose of medicine, as it can cause undesirable effects.
  • It is always important to check the expiry date of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
RabeprazoleRilpivirine
Critical

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
How does the drug interact with Hipreb-D Tablet:
When used in combination with erlotinib, Hipreb-D Tablet may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Hipreb-D Tablet with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Hipreb-D Tablet:
Co-administration of Hipreb-D Tablet can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Hipreb-D Tablet with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
DomperidoneRitonavir
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Ritonavir can increase the blood levels of Hipreb-D Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hipreb-D Tablet and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneKetoconazole
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneCisapride
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Cisapride can increase the blood levels of Hipreb-D Tablet.

How to manage the interaction:
There may be a possibility of interaction between Hipreb-D Tablet and Cisapride, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneCitalopram
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Citalopram can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Citalopram together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneHalofantrine
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Halofantrine can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Halofantrine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMethadone
Severe
How does the drug interact with Hipreb-D Tablet:
Coadministration of Hipreb-D Tablet with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneBepridil
Severe
How does the drug interact with Hipreb-D Tablet:
Co-administration of Domeperidone and Bepridil can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Hipreb-D Tablet and Bepridil together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.
  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
  • Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine.
  • Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Hipreb-D Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Drinking alcohol with Hipreb-D Tablet may cause dehydration and elevate the level of stomach acid, thereby decreasing its efficiency. So try to avoid, limit alcohol or contact a doctor before intake of Hipreb-D Tablet .

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Pregnancy

Consult your doctor

It is not known whether the Hipreb-D Tablet affects the baby or not. So, contact a doctor before intake of Hipreb-D Tablet . Your doctor will weigh the benefits and potential risks before prescribing them.

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Breast Feeding

Consult your doctor

Domperidone present in Hipreb-D Tablet passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Hipreb-D Tablet . Your doctor will weigh the benefits and potential risks before prescribing them.

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Driving

Caution

In some cases, Hipreb-D Tablet may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.

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Liver

Consult your doctor

If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

bannner image

Children

Unsafe

Hipreb-D Tablet is not recommended for use in children due to a lack of data on safety and efficacy. Please consult your doctor.

Have a query?

FAQs

Hipreb-D Tablet is used to treat Gastro-Esophagal Reflux Disease (GERD), acid reflux, heartburn, peptic ulcer, stomach ulcers, and dyspepsia (stomach discomfort due to indigestion). It works by blocking the actions of the gastric proton pump, increasing the motility of the upper gastrointestinal tract and blocking the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

No. Hipreb-D Tablet prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.

Yes, Hipreb-D Tablet can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.

Diarrhoea might be a side-effect of Hipreb-D Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Hipreb-D Tablet is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole or any other inactive ingredients of Hipreb-D Tablet . Hipreb-D Tablet should be used with caution in patients with underlying liver or kidney disease.

Store Hipreb-D Tablet at room temperature in a cool and dry place protected from light. Keep it out of reach of children.

Yes, Hipreb-D Tablet is safe for most of the patients. However, in some patients it may cause common side effects such as stomach pain, diarrhea, flatulence (gas), dryness in mouth, headache, dizziness, and other uncommon and rare side effects. If these side effects persist or worsen, please consult your doctor.

It is preferable to take Hipreb-D Tablet on an empty stomach or before the first meal of the day.

Yes, Hipreb-D Tablet may increase the risk of developing irregular heartbeat (serious arrhythmias). Although, it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.

Country of origin

India

Manufacturer/Marketer address

46-A Extn, Krishan Kunj, Laxmi Nagar, New Delhi, Delhi 110092, India
Other Info - HIP0095

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 10:46 AM IST

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Reference

  1. https://www.ciplamed.com/content/rabicip-d-capsules

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