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  3. Higest 500mg Injection 1's

Higest 500mg Injection 1's, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Higest 500mg Injection is used in the treatment of dysfunctional uterine bleeding threatened abortion, and amenorrhoea. It is also used in the maintenance of early pregnancy. This medicine contains progesterone, a female hormone which helps increase the progesterone levels in the body. Common side effects include injection site reactions, rash or any other allergy, changes in the breast, darkening of facial skin, scalp hair loss, coarsening of hair in abnormal regions.

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Composition :

PROGESTERONE-0.5MG

Manufacturer/Marketer :

Novamed Pharma

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Higest 500mg Injection

Higest 500mg Injection is used to treat various conditions like early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods)

Higest 500mg Injection contains progesterone, which works by increasing levels of the progesterone hormone in your body.

In some cases, you may experience injection site reactions, changes in the breast, darkening of facial skin, scalp hair loss, nausea, fever, and sleep disturbances. Most of these side effects do not require medical attention and resolve over time. However, if the side effects persist, please consult your doctor.

Higest 500mg Injection will be administered by a healthcare professional; do not self-administer. This medicine is intended for use in female (women) patients only. Hence not recommended for use in men.

Let your doctor know if you are allergic to any component of Higest 500mg Injection. Inform your doctor if you have a blood clot caused by swollen veins (thrombophlebitis), a blocked blood vessel (thromboembolic disorder), a stroke, a suspected vaginal infection, the use of any other vaginal application products, or any ongoing medical conditions such as cancer of the breasts or genital organs. Also inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine.

Uses of Higest 500mg Injection

Higest 500mg Injection is used in the maintenance of early pregnancy and treatment of dysfunctional uterine bleeding, threatened abortion, and amenorrhea. The detailed uses of Higest 500mg Injection are as follows:

  • Menstrual Cycle Regulation: Higest 500mg Injection helps to regulate irregular menstrual cycles, treating conditions like amenorrhea by stabilising hormonal imbalances and promoting a regular menstrual cycle.
  • Treatment of Abnormal Uterine Bleeding: By controlling hormone levels and possibly lowering excessive bleeding during menstruation, Higest 500mg Injection can help manage abnormal uterine bleeding.
  • Luteal Phase Support: Higest 500mg Injection is prescribed to support the luteal phase during assisted reproductive technologies like in vitro fertilisation (IVF), increasing the chances of pregnancy.
     

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • The doctor or healthcare professional will administer Higest 500mg Injection.
  • Higest 500mg Injection is intended for use by women only.
  • Do not self-administer.

Medicinal Benefits

  • Higest 500mg Injection is used to maintain early pregnancy in cases of documented history of repeated miscarriages due to luteal phase defect
  • This medicine is also used as an adjunct to successful infertility treatment with techniques such as in vitro fertilisation (IVF) or gamete intra-fallopian transfer (GIFT) to facilitate uterine implantation of the fertilised ovum.
  • In cases of secondary amenorrhoea (paused or missed periods), it can also be used as a progesterone withdrawal test to assess oestrogen priming.
  • Furthermore, it can treat threatening abortions and dysfunctional uterine haemorrhages.

How Higest 500mg Injection Works

Higest 500mg Injection contains progesterone; it works by increasing levels of the progesterone hormone in your body.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Higest 500mg Injection
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Higest 500mg Injection

Higest 500mg Injection is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Seek immediate medical attention if you experience any of the following symptoms: difficulty speaking, pain, swelling, or warmth in the groin or calf, shortness of breath or rapid breathing, sudden or severe headaches, sudden dizziness or fainting, unusual sweating, or pain in the chest, jaw, or left arm.

Drug Warnings

  • Please tell your doctor if you are allergic to Higest 500mg Injection or any other medicines.
  • Inform your doctor if you are diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, a blocked blood vessel, vaginal infections, and missed abortion.
  • If you are pregnant, planning for pregnancy or breastfeeding, please consult a doctor before taking Higest 500mg Injection.
  • Higest 500mg Injection is not recommended for children below 18 years of age.
  • This medicine is intended for use in female (women) patients only. Hence not recommended for use in men.

Drug-Drug Interactions

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HydroxyprogesteroneRifabutin
Severe
HydroxyprogesteroneItraconazole
Severe

Drug-Drug Interactions

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HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Higest 500mg Injection:
Coadministration of Rifabutin and Higest 500mg Injection may reduce the blood levels and effects of Higest 500mg Injection.

How to manage the interaction:
Using Rifabutin and Higest 500mg Injection together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Higest 500mg Injection:
Coadministration of Itraconazole and Higest 500mg Injection can cause an increase in the levels of Higest 500mg Injection.

How to manage the interaction:
Using Itraconazole and Higest 500mg Injection together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneNicotine
Severe
How does the drug interact with Higest 500mg Injection:
Coadministration of Nicotine and Higest 500mg Injection may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Higest 500mg Injection together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneTirzepatide
Moderate
How does the drug interact with Higest 500mg Injection:
Higest 500mg Injection may interfere with blood glucose control and decrease the effectiveness of diabetic treatments.

How to manage the interaction:
Inform doctor about all other medications administering, including vitamins and herbs, is crucial. Consult doctor before stopping any medications.

Drug-Food Interactions

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PROGESTERONE-0.5MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PROGESTERONE-0.5MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Higest 500mg Injection may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Higest 500mg Injection. Avoid or limit taking caffeine and grape juice while taking Higest 500mg Injection as it can lead to interaction.

Diet & Lifestyle Advise

  • Do regular exercise and physical activity to minimize hot flushes and improve sleep. Aerobics, yoga, and activities like tai chi may help relax the body and mind.
  • Try to wear loose clothes before going to bed and sleep in a cool, well-ventilated room. Doing this can prevent symptoms of hot flushes and night sweats. Sleep at least for 8 hours.
  • Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations.
  • Quit smoking as it will help to reduce hot flushes and your risk of developing chronic conditions like heart disease, stroke, and cancer.

Habit Forming

No

Therapeutic Class

HORMONES
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Alcohol

Consult your doctor

It is not known if alcohol affects Higest 500mg Injection. In case of any concerns, discuss them with the doctor. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Consult your doctor

Higest 500mg Injection is used in pregnancy conditions like threatened abortion, luteal phase support, and maintenance of pregnancy. Your doctor will weigh the benefits to outweigh the risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

Let your doctor know if you are a nursing mother before receiving Higest 500mg Injection; your doctor will decide whether Higest 500mg Injection can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Avoid driving or operating machinery if you experience drowsiness after receiving this injection.

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Liver

Consult your doctor

Inform your doctor before receiving the Higest 500mg Injection if you have a history of or ongoing liver disease.

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Kidney

Consult your doctor

Inform your doctor before receiving the Higest 500mg Injection if you have renal insufficiency or kidney problems. This medicine is excreted through urine, and if you have kidney problems, it may worsen your condition. Your doctor will adjust the dose of this medicine if required based on your condition.

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Children

Unsafe

Higest 500mg Injection is not recommended for use in children.

Have a query?

FAQs

Higest 500mg Injection is used to treat various medical conditions, including early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods) to judge oestrogen priming.

Higest 500mg Injection contains progesterone; it works by increasing levels of the hormone progesterone in your body.

The most prevalent negative effect of using Higest 500mg Injection is the darkening of the facial skin. Please report to the doctor immediately if you notice any significant or rapid changes.

Using Higest 500mg Injection is contraindicated in people with cancers such as breast or genital organs. So, inform your doctor if you have cancer in your breasts or genital organs.

Higest 500mg Injection is contraindicated in people allergic to progesterone or people diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, or a blocked blood vessel, vaginal infections, and/or people with missed abortion.

Hair loss is the most prevalent negative effect of utilizing Higest 500mg Injection. If you notice any significant or abnormal hair loss, please immediately report it to the doctor.

Country of origin

India
Other Info - HIG0046

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 11:31 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017362s104lbl.pdf
  2. https://www.drugs.com/cdi/progesterone-injection.html

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