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compositionComposition:LAPATINIB-250MG
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Herlapsa Tablet is an anti-cancer medicine used in the treatment of Breast cancer. It contains Lapatinib, which works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells; this causes inhibition of the cancer cell growth and, finally, initiation of apoptosis. It is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Herlapsa Tablet

Herlapsa Tablet is a prescription medicine used to treat specific types of advanced or metastatic breast cancer. It is specifically designed to target cancer cells that produce too much of a protein called HER2. Doctors typically prescribe this medicine in combination with other chemotherapy or hormone therapy drugs to help slow down the spread of the disease.

For this medication to work effectively, you must take it consistently every day at the same time. It is crucial to take Herlapsa Tablet on an empty stomach, either at least 1 hour before or 1 hour after eating a meal. To support your body during treatment, it is helpful to drink plenty of fluids and make dietary adjustments to manage potential digestive changes.

While taking Herlapsa Tablet , you may experience common side effects such as mild diarrhoea, skin rashes, or feeling sick to your stomach. However, you must contact your doctor immediately if you experience severe diarrhoea, extreme tiredness, or signs of liver damage, such as yellowing of your skin or eyes.

Do not take this if you are allergic to any of its ingredients. Before starting treatment, tell your doctor if you have a history of heart problems, liver disease, or electrolyte imbalances. This medicine is not recommended for pregnant women, as it can harm an unborn baby.

Certain medications, alcohol, and smoking can alter how your body processes this medicine, potentially causing severe side effects or making the treatment less effective. If you are breastfeeding or are an older adult, talk to your doctor or pharmacist to discuss specific safety measures before starting Herlapsa Tablet .

Uses of Herlapsa Tablet

Herlapsa Tablet is used to treat specific types of advanced or metastatic breast cancer. The detailed uses of Herlapsa Tablet are as follows:

  • HER2-positive breast cancer: Herlapsa Tablet is prescribed to treat advanced or metastatic breast cancer that overexpresses the HER2 protein, working alongside other therapies to help control cell growth.

Key Benefits

Herlapsa Tablet helps treat certain types of cancer by blocking signals that promote cancer cell growth and spread. With regular use as prescribed, it helps control disease progression, provides the convenience of oral therapy, and enhances the effectiveness of combination treatment.

  • Helps Slow Cancer Progression: By targeting the pathways that drive cancer cell growth and multiplication, this medicine helps slow the progression of the disease and supports better tumour control.
  • Convenient Oral Treatment: As an oral tablet, this medicine can be taken at home as directed by your healthcare provider, reducing the need for frequent hospital visits for intravenous treatment.
  • Enhances Combination Therapy: When used with other prescribed anticancer medicines, this medicine works together to improve treatment effectiveness, strengthen disease control, and support better overall treatment outcomes.
Side effects of Herlapsa Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

  • Herlapsa Tablet can be taken 1 hour before a meal or 2 hours after a meal.
  • It is advised to take Herlapsa Tablet once daily or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, chew or crush Herlapsa Tablet .

How Herlapsa Tablet Works

Herlapsa Tablet contains lapatinib, which belongs to a class of medicines called kinase inhibitors. It works by entering the cancer cells and blocking specific proteins, known as HER1 and HER2 receptors, which act as switches for cell growth. When these proteins are overactive, they signal the cancer cells to grow and divide rapidly. By blocking these signals from the inside, Herlapsa Tablet helps stop the cancer cells from multiplying and slows down the growth of the tumour.
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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

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Pregnancy

Unsafe

Herlapsa Tablet is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Herlapsa Tablet . Use reliable methods of birth control while on treatment with Herlapsa Tablet .

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Herlapsa Tablet as it can cause serious side effects to the newborn baby.

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Driving

Consult your doctor

It is unknown whether Herlapsa Tablet will affect your mental ability to drive or operate machines. Hence, consult your doctor for information regarding this.

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Liver

Caution

Inform your doctor if you have any pre-existing liver disease. Your doctor may adjust the dose of the medicine based on the condition. Herlapsa Tablet is known to cause hepatotoxicity in some patients. If you notice any reactions such as itching, yellowing of the skin or eyes, dark urine, abdominal pain, unusual bleeding, or pale or dark stools, discontinue the treatment and inform your doctor immediately.

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Kidney

Caution

Limited data are available on the effect of Herlapsa Tablet in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Herlapsa Tablet is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Herlapsa Tablet may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Herlapsa Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Herlapsa Tablet to geriatric patients. Your doctor will prescribe Herlapsa Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Herlapsa Tablet

If you take too much of this medicine, seek emergency medical care immediately. An overdose can lead to serious complications and requires prompt medical attention.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear broths throughout the day, especially if you experience loose stools, to replace lost fluids and prevent dehydration.
  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice, as they can cause the medicine to build up to dangerous levels in your body.
  • Protect your skin: Use mild, fragrance-free soaps and moisturisers. Wear sunscreen and protective clothing when outdoors, as your skin may be highly sensitive to light and prone to dryness.
  • Eat bland, small meals: If you experience mild nausea, try eating smaller portions of bland foods like crackers, toast, or bananas rather than large, heavy, or greasy meals.
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Have a query?

How Soon It Starts Working

The time required for Herlapsa Tablet to start to work: Herlapsa Tablet ideally shows its action within 15 to 30 minutes after administration. The time for which the effects of Herlapsa Tablet last: The effect of Herlapsa Tablet lasts for 3 to 4 hours.

What if you forget to take Herlapsa Tablet

If you miss a dose, skip the missed dose completely. Take your next scheduled dose at your regular time the next day. Do not take two doses at the same time to make up for a missed dose.

Storage

•Store Herlapsa Tablet at room temperature, specifically between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Always inspect your tablets before taking them; do not take any tablets that are broken, chipped, or discoloured.
  • Do not take this medicine with food, as eating significantly increases the absorption of the drug and can cause severe side effects.
  • Ensure you attend all scheduled appointments for blood tests and heart scans, as your doctor must regularly check your liver and heart health.
  • Keep an anti-diarrheal medication handy, and start taking it at the first sign of loose stools as previously instructed by your doctor.
  • Inform all your healthcare providers, including dentists and pharmacists, that you are taking Herlapsa Tablet before starting any new treatments or procedures.

Drug-Drug Interactions

verifiedApollotooltip
  • Antifungal medicines (like ketoconazole): May increase the level of Herlapsa Tablet in your blood, raising the risk of severe side effects.
  • Seizure medications (like carbamazepine or phenytoin): Can lower the level of Herlapsa Tablet , making your cancer treatment less effective.
  • Certain heart or blood pressure medicines: May increase the risk of irregular heart rhythms when combined with this medicine.

Drug-Drug Interactions

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How does the drug interact with Herlapsa Tablet:
Coadministration of Morphine with Herlapsa Tablet may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Herlapsa Tablet with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed and motor coordination, headaches, irritation, confusion, oedema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Herlapsa Tablet:
Taking Pazopanib with Herlapsa Tablet may significantly increase the blood levels of pazopanib. This can make you more likely to develop serious side effects such as liver problems, irregular heart rhythm, bleeding and high blood pressure,

How to manage the interaction:
Taking Pazopanib with Herlapsa Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, fast or pounding heartbeats, chest pain or tightness, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, and difficulty speaking. Do not stop using any medications without a doctor's advice.
How does the drug interact with Herlapsa Tablet:
Coadministration of colchicine with Herlapsa Tablet results in increased colchicine levels in the blood, increasing the risk of serious side effects

How to manage the interaction:
Although taking Colchicine and Herlapsa Tablet together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Herlapsa Tablet:
Taking clarithromycin with Herlapsa Tablet may increase the blood levels of Herlapsa Tablet. This might make you more likely to develop side effects such as diarrhea, liver damage, and heart problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Herlapsa Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with Herlapsa Tablet. Do not stop using any medications without a doctor's advice.
How does the drug interact with Herlapsa Tablet:
Taking Herlapsa Tablet with posaconazole can increase the levels of Herlapsa Tablet in the blood, which can lead to an increased risk of side effects such as diarrhea, liver problems, and heart problems.

How to manage the interaction:
Although using Posaconazole and Herlapsa Tablet together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Herlapsa Tablet:
When taken in combination Herlapsa Tablet may significantly raise the loperamide levels in the blood. This can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking loperamide with Herlapsa Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Herlapsa Tablet:
Combining Herlapsa Tablet and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Herlapsa Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Herlapsa Tablet:
Taking Sotalol and Herlapsa Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Herlapsa Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Herlapsa Tablet:
Co-administration of Digoxin and Herlapsa Tablet may increase the blood levels and effects of Digoxin.

How to manage the interaction:
If you are supposed to take Digoxin and Herlapsa Tablet together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive digoxin levels. Do not discontinue the medication without consulting a doctor.
LapatinibEnzalutamide
Severe
How does the drug interact with Herlapsa Tablet:
When Herlapsa Tablet is taken with Enzalutamide, this could reduce the effects of Herlapsa Tablet and its blood levels. Additionally, taking these medications together may enhance enzalutamide's effects and blood levels.

How to manage the interaction:
Co-administration of Enzalutamide with Herlapsa Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like Seizures, exhaustion, fatigue, constipation, discomfort in the muscles or bones, hot flushes, swelling, tingling or prickling, headaches, dizziness, sleeplessness, anxiety, and increased blood pressure, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food (especially high-fat meals): Drastically increases how much of the drug is absorbed, which can cause dangerous side effects.
  • Grapefruit and grapefruit juice: Block the liver enzymes that break down Herlapsa Tablet , leading to toxic levels of the medicine in your body.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Herlapsa Tablet is used to treat breast cancer.
Herlapsa Tablet contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other breast cancer treatment. Herlapsa Tablet may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Herlapsa Tablet .
Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Herlapsa Tablet . Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.
Herlapsa Tablet may cause side effects such as diarrhoea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
Herlapsa Tablet is an anti-cancer medicine used in the treatment of breast cancer.
Yes, Herlapsa Tablet can be given in combination with other anti-cancer drugs if prescribed by the doctor. Talk to the doctor if you have any concerns.
Swallow Herlapsa Tablet whole with a glass of water. Do not crush, chew, or break the tablet. Take it on an empty stomach, either at least 1 hour before or at least 1 hour after food, because taking it with food increases absorption and may increase the risk of side effects.
Diarrhoea is a common side effect of Herlapsa Tablet . Drink plenty of fluids to prevent dehydration and follow your doctor's advice regarding anti-diarrhoeal medicines if needed. Contact your doctor immediately if the diarrhoea is severe, lasts longer than 24 hours, is accompanied by fever, or causes signs of dehydration. Do not stop taking Herlapsa Tablet without consulting your doctor.
Yes. Herlapsa Tablet can cause skin problems such as dry skin, rash, redness, or hand-foot syndrome. To help protect your skin, use a gentle soap-free cleanser, apply fragrance-free moisturisers, use sunscreen, and avoid excessive sun exposure. If you develop severe, painful, blistering, or widespread skin reactions, contact your doctor immediately.
Before starting Herlapsa Tablet , the doctor may advise heart and liver function tests.
This medicine can sometimes lower the pumping strength of your heart or cause irregular heartbeats. Your doctor will perform heart scans before and during your treatment to monitor your heart health. If you experience shortness of breath, swelling in your ankles, or a racing heartbeat, contact your doctor right away. Talk to your doctor or pharmacist for more details.
It is best to avoid alcohol while taking this medicine. Alcohol can increase the strain on your liver and worsen side effects like nausea or dizziness. If you choose to drink, consult your healthcare provider first. Talk to your doctor or pharmacist for safe lifestyle guidelines.
Grapefruit and grapefruit juice interfere with the natural enzymes in your body that break down this medication. This can cause the medicine to build up to unsafe, toxic levels in your blood, significantly increasing the risk of serious side effects. Avoid all grapefruit products during your treatment. Talk to your doctor or pharmacist if you need alternative dietary tips.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7Th To 12Th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - HER0214
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