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Hepnotel 5 gm Injection 10 ml is used to treat liver diseases, including hepatitis, fatty liver, jaundice, liver cirrhosis, and hepatic encephalopathy. It contains L-ornithine-L-aspartate, which facilitates the removal of ammonia by increasing glutamine and urea synthesis in the liver and glutamine synthesis in brain and muscle tissues. This medicine may cause side effects such as nausea and vomiting. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Chandra Bhagat Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Hepnotel 5 gm Injection 10 ml

Hepnotel 5 gm Injection 10 ml is a prescription medicine used to treat severe liver disease and hepatic encephalopathy, a condition in which high ammonia levels affect brain function. It helps remove excess ammonia from the blood, improves mental alertness, and supports the liver's natural detoxification process.

This medicine is given as an injection or slow intravenous (IV) infusion in a hospital or clinic. Your doctor will decide the dose, infusion rate, and duration of treatment based on your condition.

For the best results, continue following your doctor's advice regarding protein intake, hydration, and alcohol avoidance. These lifestyle measures help support liver function and reduce ammonia buildup.

Most people tolerate this medicine well. Mild nausea, vomiting, or temporary discomfort at the injection site may occur and usually improve on their own. Seek medical attention immediately if you develop symptoms of a severe allergic reaction, severe pain or swelling around the injection site, or unusual dizziness. Tell your doctor if you have kidney disease, are pregnant, planning pregnancy, breastfeeding, or taking any other medicines before starting treatment.
 

Uses of Hepnotel 5 gm Injection 10 ml

Hepnotel 5 gm Injection 10 ml is used in the treatment of liver diseases. The detailed uses of Hepnotel 5 gm Injection 10 ml are as follows:

  • Hepatic encephalopathy: Hepnotel 5 gm Injection 10 ml helps lower high ammonia levels in people with hepatic encephalopathy caused by liver cirrhosis or other severe liver diseases. This improves mental clarity, alertness, and overall brain function.
  • Severe liver damage: It supports the liver's natural detoxification pathways, helping remove harmful waste products and manage complications associated with acute or chronic liver disease.
     

Key Benefits

Hepnotel 5 gm Injection 10 ml provides critical, fast-acting support for patients dealing with severe liver complications. By addressing the root cause of metabolic toxic buildup, it offers real-world relief from distressing symptoms.

  • It rapidly lowers high ammonia levels that contribute to confusion and altered brain function.
  • It helps improve mental clarity, alertness, and concentration in people with hepatic encephalopathy.
  • It supports the liver's natural detoxification process during severe liver disease.
  • Because it is given directly into a vein, it provides fast treatment when immediate ammonia reduction is needed.
     

Directions for Use

  • The timing and frequency of Hepnotel 5 gm Injection 10 ml will be determined by your doctor, based on your medical condition and response to treatment.
  • Hepnotel 5 gm Injection 10 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Hepnotel 5 gm Injection 10 ml Works

Hepnotel 5 gm Injection 10 ml helps lower the high ammonia levels that build up when a damaged liver cannot remove waste properly. High ammonia levels can affect the brain and cause confusion, drowsiness, poor concentration, and other symptoms of hepatic encephalopathy. After it is given by injection, the medicine helps the liver and muscles remove ammonia from the blood by converting it into harmless substances that the body can eliminate through urine. This reduces ammonia levels, improves brain function, and helps relieve the symptoms of liver-related brain dysfunction.
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Alcohol

Consult your doctor

It is not known if alcohol affects Hepnotel 5 gm Injection 10 ml. Please consult your doctor.

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Pregnancy

Caution

There are no controlled studies on the use of Hepnotel 5 gm Injection 10 ml during pregnancy. Consult your doctor if you are pregnant or have any concerns; your doctor will prescribe this medicine during pregnancy only if the benefits outweigh the risks.

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Breast Feeding

Caution

The presence of this medicine in human milk is unknown. When deciding whether to stop treatment with either drug, your doctor may consider the advantages of breastfeeding for the infant and Hepnotel 5 gm Injection 10 ml treatment for the breastfeeding mother.

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Driving

Safe if prescribed

Hepnotel 5 gm Injection 10 ml is unlikely to interfere with your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Your doctor will adjust the infusion rate of Hepnotel 5 gm Injection 10 ml if your liver function is seriously compromised.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the use of Hepnotel 5 gm Injection 10 ml in patients with kidney impairment. Hepnotel 5 gm Injection 10 ml should not be used in case of severe renal impairment.

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Children

Consult your doctor

Limited information is available regarding the usage of Hepnotel 5 gm Injection 10 ml in children. Please consult your doctor.

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Heart

Caution

Please consult your doctor if you have any concerns regarding the use of Hepnotel 5 gm Injection 10 ml in patients with heart problems.

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Geriatrics

Caution

Hepnotel 5 gm Injection 10 ml should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Hepnotel 5 gm Injection 10 ml

Since your treatment is monitored and given by trained professionals, an overdose is extremely rare. However, if you suspect you have received too much of this medicine, or if you experience unusual symptoms during or after the infusion, notify your healthcare provider or seek immediate emergency medical care.

Diet & Lifestyle Advise

  • Manage your protein intake: Work closely with a dietitian or doctor to adjust your protein consumption. While your body needs protein, eating too much of it can increase toxic ammonia levels in your blood.
  • Avoid alcohol completely: Alcohol acts as a direct toxin to your liver cells and can severely worsen liver damage. Avoiding it entirely is crucial for your recovery.
  • Eat small, frequent meals: Consuming smaller meals throughout the day instead of three large ones can help prevent a sudden buildup of metabolic waste and lower the workload on your liver.
  • Stay hydrated: Drink plenty of water throughout the day, unless your doctor has advised you to limit fluids due to fluid retention.
     
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How Soon It Starts Working

The time required for Hepnotel 5 gm Injection 10 ml to start to work: The exact onset time of Hepnotel 5 gm Injection 10 ml has not been clinically established.

The time for which the effects of Hepnotel 5 gm Injection 10 ml last: The duration of action for Hepnotel 5 gm Injection 10 ml is unknown.

What if you forget to take Hepnotel 5 gm Injection 10 ml

This injectable medicine is usually reserved for patients with moderate to severe hepatic encephalopathy, particularly those receiving treatment in a hospital. Once the condition improves, your doctor may switch you to the oral form (granules or sachets) if continued treatment is needed.

Storage

• Store the medicine at room temperature, ideally between 20°C and 25°C.

Drug Warnings

  • Check that the solution is clear before it is administered. Do not use it if it looks cloudy, discoloured, or contains particles.
  • Tell your nurse immediately if you feel burning, swelling, pain, or coldness around the injection site.
  • If you receive treatment at home under medical supervision, always use sterile equipment and dispose of needles safely in a puncture-proof sharps container.
  • Inform your healthcare providers before any surgery or dental procedure that you are receiving this medicine.
  • Do not receive this medicine if you have previously had an allergic reaction to Hepnotel 5 gm Injection 10 ml or any of its ingredients.
  • Pregnancy: There is limited information on the use of Hepnotel 5 gm Injection 10 ml during pregnancy. It should only be used if your doctor believes the expected benefits outweigh the potential risks to the baby.
  • Breastfeeding: It is not known whether this medicine passes into breast milk. If you are breastfeeding or planning to breastfeed, discuss the potential benefits and risks with your healthcare provider before starting treatment.
     

verifiedApollotooltip
  • Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you are taking.
  • Medicines that may affect kidney function, such as certain antibiotics (for example, aminoglycosides), non-steroidal anti-inflammatory drugs (NSAIDs), or other nephrotoxic medicines, may require closer monitoring during treatment.
  • Diuretics (water tablets) may affect your body's fluid and electrolyte balance, so your doctor may monitor you more closely if they are used together.
    Hepnotel 5 gm Injection 10 ml is often used together with medicines such as lactulose or rifaximin to manage hepatic encephalopathy. These medicines work in different ways to reduce ammonia levels and are commonly prescribed as part of your overall treatment plan.
  • Do not start, stop, or change any medicine without consulting your healthcare provider.
     

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verifiedApollotooltip

No clinically significant food interactions are known with Hepnotel 5 gm Injection 10 ml when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Hepnotel 5 gm Injection 10 ml is used to treat liver diseases, including hepatitis, fatty liver, jaundice, liver cirrhosis, and hepatic encephalopathy.
Hepnotel 5 gm Injection 10 ml removes ammonia by increasing glutamine and urea synthesis in the liver and synthesis of glutamine in brain and muscle tissues.
Nausea could be a side effect of Hepnotel 5 gm Injection 10 ml. It is not a common side effect in everyone who takes this medication. However, if the condition persists or worsens, consult a doctor.
Hepnotel 5 gm Injection 10 ml converts toxic, harmful ammonia into non-toxic urea, which is eliminated via the urine. It serves as a stimulus for hepatic glutamine synthesis that could be defective in acute and chronic liver disease.
Hepnotel 5 gm Injection 10 ml may be indicated to treat hepatic encephalopathy. It helps improve psychometric function in patients with hepatic encephalopathy. Hepatic encephalopathy is a liver disease in which the liver does not remove toxins from the body, leading to loss of brain function.
Hepnotel 5 gm Injection 10 ml may cause side effects such as nausea or vomiting in some people. However, if these side effects persist or worsen, please inform your doctor.
No, it is not recommended to take alcohol when taking Hepnotel 5 gm Injection 10 ml. Although, the interaction of alcohol with Hepnotel 5 gm Injection 10 ml is unknown, still alcohol should be avoided in liver failure cases as it may worsen the complication of liver disease.
Hepnotel 5 gm Injection 10 ml will be injected by a doctor or nurse. Do not self-administer.
Because it is injected directly into a vein, it begins working rapidly to help lower toxic ammonia levels in your blood. You may start to notice improvements in mental clarity and energy within a few days of starting treatment. Talk to your doctor if you do not feel better.
Do not take this if you have severe kidney failure. For mild to moderate kidney issues, your doctor will carefully evaluate your health before prescribing it. Talk to your doctor or pharmacist if you have concerns about your kidneys.
Inform the nurse or doctor administering the injection immediately. Pain or burning can indicate that the needle has shifted or that the infusion is running too fast. Talk to your doctor if you experience ongoing pain after the session.
No, this medicine does not cure liver cirrhosis itself. Instead, it manages severe complications of liver disease, such as high ammonia levels and mental confusion. Talk to your doctor to understand your complete treatment plan.
There is limited clinical evidence regarding the safety of this medicine during pregnancy. It should only be used if your doctor determines the benefits outweigh the potential risks. Talk to your doctor if you are pregnant or planning to become pregnant.
This medicine is designed to clear mental confusion and actually improve alertness. However, severe liver disease itself can cause extreme fatigue or drowsiness. Talk to your doctor if you experience persistent or worsening drowsiness.
Yes. Hepnotel 5 gm Injection 10 ml is also available as oral granules or sachets, which are commonly used for patients who are stable enough to take medicines by mouth. The injectable form is generally reserved for hospitalized patients or those who cannot take oral medicines. Your doctor will decide which form is most suitable for you.
This medicine is commonly used for people with moderate to severe hepatic encephalopathy, especially when high ammonia levels cause confusion, drowsiness, or changes in behavior. Once the condition improves, some patients may continue treatment with the oral formulation if recommended by their doctor.

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Country of origin

India

Manufacturer/Marketer address

501, The Bureau, R C Marg, Nr.Chembur Naka, Chembur East, Mumbai - 400071
Other Info - HEP0596
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