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  3. Heplite-400 Tablet 10's

Heplite-400 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Heplite-400 Tablet is used to treat liver disease, depression, and osteoarthritis. It works by protecting the liver from toxins, regulating mood and stimulating the production of cartilage. In some cases, this medicine may cause side effects such as headache, vomiting, diarrhoea, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Synonym :

S ADENOSYL L METHIONINE

Composition :

ADEMETIONINE-400MG

Manufacturer/Marketer :

Spacilac Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Heplite-400 Tablet

Heplite-400 Tablet is used in the treatment of depression, biliary cholangitis (an autoimmune disease of the liver), liver diseases caused by cystic fibrosis, and to reduce pain and swelling in the joints. It is also used to treat liver disease during pregnancy and improve symptoms in people with fibromyalgia.

Heplite-400 Tablet contains Ademetionine, a naturally occurring substance, produced from methionine (amino acid). Heplite-400 Tablet ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It stimulates the production of cartilage, reduces inflammatory mediators, and has analgesic properties.

In some cases, you may experience common side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if these side effects persist.

Take Heplite-400 Tablet as recommended by your doctor. It should be taken with a meal for better absorption. Your doctor will decide the dose and duration of medicine based on the type of condition. Do not chew, crush, or break the medicine.

Avoid taking Heplite-400 Tablet if you are allergic to it. Do not discontinue Heplite-400 Tablet without consulting your doctor. Consult the doctor if you are pregnant or breastfeeding. Heplite-400 Tablet can be given to children with extreme caution if recommended by the doctor. Avoid consuming alcohol with Heplite-400 Tablet as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Heplite-400 Tablet

Heplite-400 Tablet is used for the treatment of depression, primary biliary cholangitis, and osteoarthritis. The detailed uses of Heplite-400 Tablet are as follows:<br/>

  • Depression & Mood Disorders: Heplite-400 Tablet helps regulate neurotransmitters like serotonin and dopamine and treat depression & mood disorders.<br/>
  • Arthritis Management: Heplite-400 Tablet helps to manage arthritis by reducing inflammation and pain, improving joint function and mobility in conditions like rheumatoid arthritis and osteoarthritis.<br/>
  • Treatment for Cholestasis: Heplite-400 Tablet is frequently recommended to treat pregnancy-related cholestasis, a disorder marked by decreased bile flow that usually results in elevated blood bile acids.<br/>
  • Promote Liver Function: Heplite-400 Tablet may be used to enhance bile production and promote liver function, which will help with fat digestion.<br/>
  • Liver Diseases: To improve liver function, Heplite-400 Tablet is occasionally included in treatment plans for a number of liver disorders, including fatty liver disease.<br/>



 

Directions for Use

• Heplite-400 Tablet should be taken before a meal, as food may affect its absorption. • It is recommended to take Heplite-400 Tablet once daily or as advised by your doctor. • Swallow the whole Heplite-400 Tablet with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

  • Heplite-400 Tablet contains Ademetionine, a naturally occurring substance in cells, tissue, and body fluids.
  • In liver disease, Heplite-400 Tablet ensures sufficient glutathione levels in the liver to minimize liver damage.
  • It prevents the increase of lipids associated with cirrhosis outside the liver. 
  • In depression, it affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression.
  • In osteoarthritis, it stimulates the production of cartilage components, reduces inflammatory mediators, and has analgesic properties. Heplite-400 Tablet is also effective in treating nerve problems in people with AIDS, or sexual dysfunction in men with depression.

How Heplite-400 Tablet Works

Heplite-400 Tablet contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. Heplite-400 Tablet ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.

Storage

• Store in a cool and dry place away from sunlight.• Keep Heplite-400 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Heplite-400 Tablet
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Swelling of the throat can worsen if there is no proper rest for your throat.
  • Drink plenty of warm fluids and frequently gargle with salt water.
  • Humidify the surrounding air using a humidifier, as dry air may increase dryness and throat pain.
  • Talk to your doctor if the swelling bothers you while swallowing food.
  • Take enough rest and stay in warm places to reduce pain quickly.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Heplite-400 Tablet

Take Heplite-400 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Heplite-400 Tablet if you are allergic to any of its contents
  • Do not use Heplite-400 Tablet if you have used an MAO inhibitor (antidepressant) in the past 14 days, as a dangerous drug interaction could occur.
  • Let your doctor know if you have any conditions like inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer, heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, or kidney and liver problems.
  • Do not take Heplite-400 Tablet if you are pregnant or breastfeeding unless advised by your doctor.
  • Heplite-400 Tablet can be given to children with caution if recommended by the doctor.
  • Avoid consuming alcohol along with Heplite-400 Tablet as it could lead to increased drowsiness and liver damage.
  • Keep your doctor informed about your health condition and medicines to rule out any unpleasant side effects.
  • Your doctor may advise a regular liver function test to monitor the liver's function and the treatment progress.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

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Diet & Lifestyle Advise

Liver disease:

  • Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
  • Foods rich in vitamins B and C and calcium are good for the gallbladder.
  • Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
  • Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
  • Avoid tobacco and alcohol consumption.

Depression:

  • Maintaining a healthy diet and regular exercise helps improve overall health and boost self-esteem.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Avoid smoking and alcohol consumption.

Osteoarthritis:

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.

Habit Forming

No

Therapeutic Class

NUTRITIONAL SUPPLEMENT

Heplite-400 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Heplite-400 Tablet as it may cause increased dizziness and liver damage.

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Pregnancy

Consult your doctor

Avoid taking Heplite-400 Tablet if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Heplite-400 Tablet , your doctor will decide whether Heplite-400 Tablet can be taken by breastfeeding mothers or not.

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Driving

Safe if prescribed

Heplite-400 Tablet does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Heplite-400 Tablet can be given to children with caution only if recommended by the doctor.

Have a query?

FAQs

Heplite-400 Tablet is used to treat various medical conditions, including depression, osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.

Heplite-400 Tablet contains Ademetionine is used in the treatment of liver disease, depression, and osteoarthritis. It is used in liver conditions associated with reduced bile formation (intrahepatic cholestasis). It restores the balance of serotonin, a natural chemical present in the brain. It also blocks the production of certain inflammatory chemical substances that cause pain and swelling in osteoarthritis.

If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.

Do not discontinue Heplite-400 Tablet without consulting your doctor. To treat your condition effectively, continue taking Heplite-400 Tablet for as long as advised. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Heplite-400 Tablet .

Do not take Heplite-400 Tablet if you have used MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others) in the last 14 days as the co-administration of Heplite-400 Tablet and MAO inhibitor cause serious drug interaction. Let know doctor know about this.

No, the Heplite-400 Tablet does not cure arthritis. Heplite-400 Tablet is only used to relieve symptoms of arthritis, such as joint pain, swelling and stiffness.

Yes, Heplite-400 Tablet is good for the liver. It aids liver function, minimises liver damage and treats liver disease.

Heplite-400 Tablet contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid).

Do not take Heplite-400 Tablet if you are allergic to any of its components, if you have used an MAO inhibitor in the past 14 days, or if you have inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.

Heplite-400 Tablet may cause side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Talk to your doctor if you experience these side effects persistently.

It is not known if Heplite-400 Tablet is safe to use for the long term. Take Heplite-400 Tablet for the duration prescribed by the doctor.

Country of origin

India
Other Info - HEP0471

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 23, 2025 | 1:43 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/s-adenosylmethionine-same.html
  2. https://www.webmd.com/vitamins/ai/ingredientmono-786/same
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