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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Guide PM1 Tablet SR is used to treat type 2 diabetes. It works by reducing sugar production in the liver, delaying sugar absorption from the intestines, and removing sugar from the blood. In some cases, this medicine may cause side effects such as stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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About Guide PM1 Tablet SR

Guide PM1 Tablet SR belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose.

Guide PM1 Tablet SR contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Guide PM1 Tablet SR helps to control blood sugar levels.

In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache, a metallic taste, or low blood sugar. Most of these side effects of Guide PM1 Tablet SR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Guide PM1 Tablet SR or any other medicines, please tell your doctor. Guide PM1 Tablet SR is not recommended for children. Consult your doctor if you are breastfeeding, pregnant or planning for pregnancy. Avoid alcohol consumption with Guide PM1 Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Guide PM1 Tablet SR

Guide PM1 Tablet SR is used in the treatment of type 2 diabetes mellitus. The detailed uses of Guide PM1 Tablet SR are as follows:

  • Manages Type 2 Diabetes Mellitus: Guide PM1 Tablet SR to treat type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.
  • Reduces Risk of Diabetes-Related Complications: By effectively controlling blood sugar levels, Guide PM1 Tablet SR helps reduce the risk of long-term complications such as neuropathy and cardiovascular disease.

Directions for Use

  • Guide PM1 Tablet SR can be taken with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Guide PM1 Tablet SR as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

  • Guide PM1 Tablet SR is effective in controlling blood sugar levels in people with Type 2 Diabetes.
  • It combines three complementary antidiabetic agents to provide comprehensive glycemic control when diet, exercise, or monotherapy is insufficient.
  • Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
  • Metformin works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
  • Pioglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enabling them to remove glucose from the blood more effectively.
  • This medicine ensures long-lasting glycaemic control, reducing the frequency of dosage. It also prevents unnecessary sugar spikes.
  • Guide PM1 Tablet SR manages blood glucose levels, thereby lowering the risk of complications such as nerve problems, kidney problems, eye problems, and cardiovascular disease.

How Guide PM1 Tablet SR Works

Guide PM1 Tablet SR contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Guide PM1 Tablet SR helps to control blood sugar levels.

Storage

• Store in a cool and dry place away from sunlight.• Keep Guide PM1 Tablet SR out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Guide PM1 Tablet SR

Take Guide PM1 Tablet SR only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include loss of consciousness, lactic acidosis (buildup of lactic acid in the blood), and pancreatitis (inflammation of the pancreas). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • If you are allergic to Guide PM1 Tablet SR or any other medicines, please tell your doctor.
  • Guide PM1 Tablet SR is not recommended for children.
  • Avoid breastfeeding while taking Guide PM1 Tablet SR as it may be excreted in human milk.
  • If you are pregnant or planning for pregnancy, please inform your doctor before taking Guide PM1 Tablet SR as it may harm the unborn baby.
  • Guide PM1 Tablet SR should be used with caution in elderly patients.
  • Avoid alcohol consumption with Guide PM1 Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Drive only if you are alert after taking Guide PM1 Tablet SR.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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MetforminIoversol
Critical
MetforminIodixanol
Critical

Drug-Drug Interactions

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MetforminIoversol
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Ioversol with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iodixanol with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIofendylate
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iofendylate with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iofendylate is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Guide PM1 Tablet SR and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iotroxic acid with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iopentol with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Guide PM1 Tablet SR and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.
MetforminIoglicic acid
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Ioglicic acid with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iopromide with Guide PM1 Tablet SR can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Guide PM1 Tablet SR is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIohexol
Critical
How does the drug interact with Guide PM1 Tablet SR:
Co-administration of Iohexol with Guide PM1 Tablet SR can increase the risk of side effects.

How to manage the interaction:
Taking Guide PM1 Tablet SR with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Guide PM1 Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Guide PM1 Tablet SR is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Guide PM1 Tablet SR as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Guide PM1 Tablet SR if you are breastfeeding.

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Driving

Caution

Guide PM1 Tablet SR may decrease alertness in some people. Therefore, drive only if you are alert after taking Guide PM1 Tablet SR.

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Liver

Caution

Take Guide PM1 Tablet SR with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Guide PM1 Tablet SR with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Guide PM1 Tablet SR is not recommended for children as the safety and effectiveness were not established.

Have a query?

FAQs

Guide PM1 Tablet SR is used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Guide PM1 Tablet SR contains Glimepiride, Metformin, and Pioglitazone. Glimepiride lowers blood sugar by causing the pancreas to produce insulin. Metformin reduces the production of sugar in the liver and delays sugar absorption from the intestines. Pioglitazone increases the body's sensitivity to insulin. Thereby, Guide PM1 Tablet SR helps to control blood sugar levels.

Guide PM1 Tablet SR may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to take Guide PM1 Tablet SR with pregabalin as it may cause weight gain and fluid retention that could lead to heart failure. However, please consult a doctor before using Guide PM1 Tablet SR with other medicines.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are completely destroyed. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Guide PM1 Tablet SR on your own, as discontinuing Guide PM1 Tablet SR suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Guide PM1 Tablet SR, please consult your doctor so that alternative medicine may be prescribed.

Yes, Guide PM1 Tablet SR may cause stomach upset as a side effect. Drink water/fluids in small, frequent amounts and chew the food properly while eating.

You are recommended to avoid consumption of alcohol with Guide PM1 Tablet SR as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Inform the doctor if you are taking any other medicines, have any other medical conditions, and if you are pregnant or breastfeeding.

Yes, Guide PM1 Tablet SR may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin b12 deficiency such as headache, loss of appetite, fatigue, mental impairment, pins and needle sensation, and pale skin.

Store Guide PM1 Tablet SR at room temperature, in a dry place. Keep out of sight and reach of children.

Guide PM1 Tablet SR may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache, metallic taste, or low blood sugar. If the side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - GU78528

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