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compositionComposition:LINEZOLID-200MG
prescriptionPrescription Medicine

Gufilinoz Injection 300 ml is an antibiotic medication used to treat bacterial infections of the skin and soft tissues, lungs (pneumonia) and bloodstream infections. It is also used to treat infections that are resistant to other antibiotics, such as vancomycin-resistant enterococcal infections.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LINEZOLID-200MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Gufilinoz Injection 300 ml

Gufilinoz Injection 300 ml is used to treat bacterial infections of the lungs (pneumonia), skin and soft tissues. It is also used to treat infections that are resistant to other antibiotics, such as vancomycin-resistant enterococcal infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body.

Gufilinoz Injection 300 ml contains Linezolid, which inhibits bacterial protein synthesis, thereby killing the bacteria.

You may experience common side effects, such as headache, a metallic taste, diarrhoea, nausea, vomiting, dizziness, constipation, pain at the injection site, and indigestion. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Do not take Gufilinoz Injection 300 ml on your own, as it may lead to antibiotic resistance, in which antibiotics fail to act against specific bacterial infections. Consult your doctor if you are pregnant or planning to become pregnant before taking Gufilinoz Injection 300 ml.

Uses of Gufilinoz Injection 300 ml

Gufilinoz Injection 300 ml is used in the treatment of bacterial infections. The detailed uses of Gufilinoz Injection 300 ml are as follows:

  • Pneumonia (Lung Infection): Gufilinoz Injection 300 ml is effective in treating both community-acquired and hospital-acquired pneumonia caused by susceptible bacteria.
  • Skin and Skin Structure Infections: Gufilinoz Injection 300 ml is used to treat mild to severe bacterial infections of the skin and its underlying tissues. It is also indicated for the treatment of diabetic foot infections without associated bone infections (osteomyelitis).
  • Antibiotic-Resistant Infections: Gufilinoz Injection 300 ml is indicated for infections caused by the bacteria Enterococcus faecium that are resistant to vancomycin, including intra-abdominal infections, skin and soft tissue infections, urinary tract infections, and concurrent bacteremia (presence of bacteria in the bloodstream).

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Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Gufilinoz Injection 300 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

Key Benefits

For Pneumonia:

  • Cures pneumonia brought on by resistant gram-positive bacteria.
  • Beneficial for ventilator-associated pneumonia and pneumonia acquired in hospitals
  • Relieves the symptoms of infection, breathing and fever when other antibiotics are ineffective.
  • Ideal for people who don't react to or can't handle other antibiotics

For soft skin structures:

  • Beneficial for complex soft tissue and skin infections, such as cellulitis, abscesses, and wound infections
  • Ensures efficient infection control by having good penetration into soft tissues and skin.
  • Aids in lowering infection-related discomfort, redness, swelling, and pus production

For Vancomycin-resistant enterococcal infections

  • Beneficial for severe infections include bloodstream infections, intra-abdominal infections, and complex VRE-caused urinary tract infections
  • When other antibiotics are ineffective or poorly tolerated, it helps patients achieve better clinical results.

How Gufilinoz Injection 300 ml Works

Gufilinoz Injection 300 ml contains Linezolid (an antibiotic), which works by stopping the bacteria from making proteins necessary for their growth and multiplication, ultimately killing the bacteria. Thus, it helps treat the bacterial infection.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Gufilinoz Injection 300 ml

Gufilinoz Injection 300 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Overdose of Gufilinoz Injection 300 ml may cause wheezing, chest tightness, seizures, swelling of the face, lips, tongue, or throat, and severe diarrhoea. Your doctor will initiate necessary measures when an overdose is suspected.

Drug Warnings

  • Do not take Gufilinoz Injection 300 ml if you are allergic to any of its contents or if you are taking or have taken monoamine oxidase (MAO-antidepressants) inhibitors in the last 14 days.
  • Talk to your doctor if you have high blood pressure, an overactive thyroid, phaeochromocytoma (tumour of adrenal glands), carcinoid syndrome (tumours of the hormone system), manic depression, schizophrenia, confusion, or other mental problems.
  • Consult your doctor if you are pregnant before taking Gufilinoz Injection 300 ml.
  • Gufilinoz Injection 300 ml passes into breastmilk, so do not take Gufilinoz Injection 300 ml if you are breastfeeding.
  • Gufilinoz Injection 300 ml may cause dizziness and vision problems; therefore, exercise caution when driving and operating machinery.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Gufilinoz Injection 300 ml:
Using phenylephrine together with Gufilinoz Injection 300 ml can increase your blood pressure.

How to manage the interaction:
Taking Pheniramine with Gufilinoz Injection 300 ml is not recommended but can be taken if prescribed by a doctor. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Coadministration of Entacapone with Gufilinoz Injection 300 ml might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Entacapone with Gufilinoz Injection 300 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Using Gufilinoz Injection 300 ml together with Paroxetine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Taking Paroxetine with Gufilinoz Injection 300 ml is not recommended but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Co-administration of Gufilinoz Injection 300 ml with Vortioxetine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Vortioxetine can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Combining Gufilinoz Injection 300 ml with Buspirone can increase the risk of high blood pressure.

How to manage the interaction:
Taking Buspirone with Gufilinoz Injection 300 ml is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice
How does the drug interact with Gufilinoz Injection 300 ml:
When Gufilinoz Injection 300 ml is taken with Sertraline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
taking Gufilinoz Injection 300 ml and Sertraline is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhoea-contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Gufilinoz Injection 300 ml:
Taking Gufilinoz Injection 300 ml with Methylphenidate together may increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Methylphenidate is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden and severe headaches, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, contact a doctor immediately. You may use methylphenidate only after you have been off Gufilinoz Injection 300 ml for at least 14 days. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Taking Safinamide with Gufilinoz Injection 300 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Gufilinoz Injection 300 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and loose stools, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Using Gufilinoz Injection 300 ml with Trazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Trazodone with Gufilinoz Injection 300 ml is not recommended but can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gufilinoz Injection 300 ml:
Taking Gufilinoz Injection 300 ml with Epinephrine can increase the risk of high blood pressure.

How to manage the interaction:
Taking Gufilinoz Injection 300 ml with Epinephrine is not recommended as it can result in an interaction. It should be taken only if a doctor has advised it. However, if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eating changes:

  • Avoid foods like salami, smoked meats, red wine, beer, pickles, soy sauce, aged cheeses, and fermented foods.
  • Consume foods that are newly cooked rather than ones that are aged or preserved.
  • Eat a diet rich in fruits, vegetables, whole grains, and lean meats to stay balanced.

Physical activity:

  • As tolerated, engage in mild-to-moderate exercise, such as walking or gentle stretching.
  • Ensure adequate sleep to support the healing process after an infection.

Environment changes:

  • To reduce the risk of developing or worsening infections, stay in a clean, well-ventilated environment.
  • Avoid dusty or congested areas, particularly during treatment for severe diseases.
  • Keep your house and workplace clean and practice good hand hygiene.

Stress management:

  • To manage stress and blood pressure, engage in mindfulness, meditation, or deep breathing exercises.
  • To lessen mental stress, get emotional support from friends or family.

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]
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Alcohol

Unsafe

Avoid consuming alcohol while taking Gufilinoz Injection 300 ml as it may cause increased dizziness.

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Pregnancy

Consult your doctor

The safety of Gufilinoz Injection 300 ml in pregnant women is not known. If you are pregnant, consult your doctor.

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Breast Feeding

Caution

If you are a breastfeeding mother, inform your doctor before receiving this medicine. Gufilinoz Injection 300 ml passes into breastmilk and can cause diarrhoea and vomiting in infants; therefore, discontinue breastfeeding prior to and throughout the treatment.

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Driving

Caution

Gufilinoz Injection 300 ml may cause dizziness and vision problems. So, drive only if you are alert.

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Liver

Caution

Long-term treatment with Gufilinoz Injection 300 ml may worsen your liver condition if you have liver problems. Dose adjustment may be needed. Please inform your doctor before taking Gufilinoz Injection 300 ml if you have liver impairment/liver disease or a history of liver conditions.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before receiving this injection.

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Children

Consult your doctor

Your doctor will weigh the benefits and potential risks before prescribing Gufilinoz Injection 300 ml for your children based on age and the condition of the child.

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Heart

Caution

Gufilinoz Injection 300 ml can be used in heart patients but requires caution due to potential blood pressure changes. Always inform your doctor about your heart condition and medications to avoid serious interactions.

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Geriatrics

Caution

Geriatric patients can receive Gufilinoz Injection 300 ml, but it may be more prone to side effects like low blood cell counts or neuropathy. Regular monitoring and dose adjustments help ensure safe and effective treatment.

FAQs

Gufilinoz Injection 300 ml belongs to the class of medicines called oxazolidinones, used to treat bacterial infections of the lungs (pneumonia) and skin. It is also used to treat infections which are resistant to other antibiotics.

Gufilinoz Injection 300 ml works by stopping the growth of infection-causing bacteria. Thus, it treats the infection.

Diarrhoea might be a side-effect of Gufilinoz Injection 300 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have prolonged diarrhoea with abdominal pain while on treatment with Gufilinoz Injection 300 ml, inform your doctor. Do not take anti-diarrheal medicine on your own.

Gufilinoz Injection 300 ml may cause oral or vaginal thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth/throat or vagina. Consult your doctor if the condition persists or worsens.

Gufilinoz Injection 300 ml may affect certain laboratory test results such as blood tests, blood sugar tests, and liver and kidney function tests. Inform the lab technician that you are on treatment with Gufilinoz Injection 300 ml.

Gufilinoz Injection 300 ml may cause anaemia due to a decrease in the number of red blood cells. This could also cause unexplained bleeding or bruising. Consult your doctor if you experience unexplained bleeding or bruising.

Gufilinoz Injection 300 ml may cause side effects, such as headache, a metallic taste, diarrhoea, nausea, vomiting, dizziness, constipation, pain at the injection site, and indigestion. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

37,1St Floor, Kamala Bhavan Ii, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (India).
Other Info - GUF0043

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