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More about the Product

Composition :

GLYCERYL TRINITRATE-0.4MG

Manufacturer/Marketer :

Medley Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About GTN Spray

GTN Spray is a prescription medication primarily used to prevent and manage chest pain (angina). The long-acting oral form helps prevent angina, while other forms, such as sublingual tablets and sprays, are used to quickly relieve an angina attack once it starts. It belongs to a group of heart medications that help improve blood flow, making it easier for your heart to work without strain.

For long-term protection against chest pain, you must take GTN Spray regularly and consistently at the exact times prescribed by your doctor. It is typically taken on an empty stomach with a full glass of water, though instructions may vary based on your specific prescription. Adopting a heart-healthy diet and making simple lifestyle adjustments can significantly improve how well this medicine works for you.

Over time, your body may become less responsive to GTN Spray if it is taken continuously. Your doctor may recommend a daily nitrate-free interval to help maintain the medicine's effectiveness. Follow your prescribed dosing schedule carefully. 

While taking GTN Spray, you may experience mild side effects like a temporary headache or dizziness as your body gets used to the medication. However, if you experience serious symptoms such as severe lightheadedness, fainting, or an unusually slow heartbeat, you must consult your doctor immediately.

Talk to your doctor before starting this medicine if you have certain health conditions, including low blood pressure, severe anaemia, or a recent head injury. Do not take this medicine if you are using specific medications for erectile dysfunction, as this combination can cause a dangerous and sudden drop in blood pressure.

GTN Spray can interact negatively with alcohol and other blood pressure-lowering medications, which may cause you to feel extremely dizzy or faint. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should consult your doctor or pharmacist to ensure this medicine is safe for your specific situation.

Uses of GTN Spray

GTN Spray helps improve blood flow to the heart and reduce its workload. Your doctor may prescribe it for the following conditions:

  • Angina pectoris (chest pain): GTN Spray is prescribed to prevent or reduce the frequency of sudden chest pain and tightness caused by reduced oxygen and blood flow to the heart muscle.
  • Chronic heart strain management: GTN Spray helps reduce the workload on your heart over time, making it easier to manage long-term cardiovascular conditions.

Key Benefits

Using GTN Spray as prescribed helps improve blood flow to the heart, reduce chest pain, and support your daily activities. Here are the key benefits you can expect:

  • Prevents angina attacks: GTN Spray helps reduce the frequency and severity of chest pain caused by reduced blood flow to the heart.
  • Improves exercise tolerance: By preventing chest discomfort during physical activity, it helps you stay more active and carry out everyday tasks with greater ease.
  • Reduces the need for rescue medication: Regular use may decrease your reliance on fast-acting medicines used to relieve sudden angina attacks.
  • Enhances quality of life: Better control of angina symptoms helps improve physical stamina, confidence, and overall day-to-day comfort.
Side effects of GTN Spray
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • GTN Spray can be taken with or without food as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow GTN Spray as a whole with a glass of water.
  • Do not chew, crush, or break it.

How GTN Spray Works

This medicine contains glyceryl trinitrate, a nitrate medicine that helps prevent and relieve angina by relaxing and widening blood vessels. GTN Spray relaxes the smooth muscles in the walls of blood vessels, causing them to widen. This improves blood flow and reduces the pressure against which the heart has to pump, lowering the heart's workload and oxygen demand. By increasing the supply of oxygen-rich blood to the heart while reducing its oxygen requirements, GTN Spray helps prevent and relieve the chest pain and discomfort associated with angina.
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Alcohol

Unsafe

Concomitant use of nitrates and alcohol may cause hypotension. Hence, avoid consumption of alcohol while on treatment with GTN Spray.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before taking GTN Spray. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are a breastfeeding mother, inform your doctor before taking GTN Spray. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Driving

Unsafe

GTN Spray can affect alertness and coordination. So, driving or operating machinery which requires concentration should be avoided after taking this medicine.

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Liver

Consult your doctor

If you have liver problems, inform your doctor before taking GTN Spray as it may cause circulation abnormalities through the liver.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking GTN Spray.

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Children

Unsafe

GTN Spray is not recommended for children and adolescents under 18 years of age as the safety and efficacy have not been established.

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Heart

Safe if prescribed

GTN Spray is commonly used to treat angina and improve heart blood flow. It must be taken under medical supervision, especially if you have low blood pressure or recent heart complications.

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Geriatrics

Caution

Geriatric patients can take GTN Spray, but only under medical supervision. Age-related sensitivity to blood pressure changes and dizziness requires careful dose adjustment and monitoring.

What if I have taken an overdose of GTN Spray

In case of an accidental overdose, seek immediate medical attention or call emergency services. Symptoms of an overdose may include a severe throbbing headache, confusion, extreme dizziness, a rapid heartbeat, cold or sweaty skin, and fainting.

Diet & Lifestyle Advise

  • Follow a Heart-Healthy Diet: Eat a balanced diet that is low in salt, saturated fats, and cholesterol, and rich in fruits, vegetables, whole grains, and fibre to support heart health.
  • Avoid Alcohol: Do not drink alcohol while taking GTN Spray, as it may increase the risk of low blood pressure, severe dizziness, or fainting.
  • Stay Physically Active: Engage in regular, moderate exercise as recommended by your doctor to improve cardiovascular fitness.
  • Stand Up Slowly: Rise gradually from a sitting or lying position to reduce the risk of dizziness and falls caused by a sudden drop in blood pressure.
  • Quit Smoking: If you smoke, speak with your doctor about quitting, as smoking narrows blood vessels, reduces oxygen supply to the heart, and can worsen angina.
health query

Have a query?

How Soon It Starts Working

The time required for GTN Spray to start to work: GTN Spray ideally shows its action within 1 to 2 minutes after administration. 

The time for which the effects of GTN Spray last: The effect of GTN Spray lasts for 3 to 5 minutes.

What if you forget to take GTN Spray

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store GTN Spray tablets at room temperature, ideally between 20°C and 25°C.

Drug Warnings

  • Sit or Lie Down Before Taking: If you often feel dizzy or light-headed after taking GTN Spray, sit or lie down before taking your dose to reduce the risk of falls.
  • Do Not Stop Suddenly: Do not stop taking GTN Spray without consulting your doctor, as your chest pain may return or worsen. Your doctor will advise you if the dose needs to be reduced gradually.
  • Keep a Symptom Record: Record your episodes of chest pain, including when they occur and what you were doing at the time, and share this information with your doctor during follow-up visits.
  • Check the Expiry Date: Check the expiry date regularly and do not use the medicine after it has expired, as it may become less effective.
  • Take Care When Driving or Using Machinery: Avoid driving, cycling, or operating machinery until you know how GTN Spray affects you, especially if it causes dizziness or light-headedness.
  • Follow your dosing schedule carefully: Your doctor may recommend a daily nitrate-free interval to help prevent the medicine from becoming less effective. Do not change your dosing schedule without medical advice.

Drug-Drug Interactions

verifiedApollotooltip
  • Phosphodiesterase-5 (PDE-5) inhibitors: Do not take this if you are using medications like sildenafil, tadalafil, or vardenafil, as this combination can cause a severe, life-threatening drop in blood pressure.
  • Blood pressure medications: Taking other medications that lower blood pressure, such as beta-blockers, calcium channel blockers, or water pills (diuretics), alongside GTN Spray can increase your risk of severe dizziness and fainting.
Glyceryl trinitrateVardenafil
Critical
Glyceryl trinitrateMethylergometrine
Critical

Drug-Drug Interactions

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Glyceryl trinitrateVardenafil
Critical
How does the drug interact with GTN Spray:
Taking Vardenafil and GTN Spray together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Vardenafil and GTN Spray is generally avoided as it can lead to an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateMethylergometrine
Critical
How does the drug interact with GTN Spray:
Coadministration of Methylergometrine with GTN Spray can increase the levels and side effects of Methylergometrine.

How to manage the interaction:
Taking Methylergometrine with GTN Spray is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateAvanafil
Critical
How does the drug interact with GTN Spray:
Taking Avanafil and GTN Spray together can increase the risk or severity of low blood pressure.

How to manage the interaction:
Combining Avanafil and GTN Spray is generally avoided as it can lead to an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity), consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateBupivacaine
Severe
How does the drug interact with GTN Spray:
Coadministration of bupivacaine and GTN Spray can increase the risk and severity of developing methemoglobinemia, (Red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and GTN Spray together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Glyceryl trinitrateProcaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Procaine and GTN Spray has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking procaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateTetracaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Tetracaine and GTN Spray has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Tetracaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Glyceryl trinitrateChloroprocaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Chloroprocaine and GTN Spray can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Chloroprocaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateMepivacaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Mepivacaine and GTN Spray has the potential to induce methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Mepivacaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateLevobupivacaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Levobupivacaine and GTN Spray can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levobupivacaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.
Glyceryl trinitrateEtidocaine
Severe
How does the drug interact with GTN Spray:
Coadministration of Etidocaine and GTN Spray can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Etidocaine and GTN Spray together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol, as it significantly enhances the blood pressure-lowering effect of GTN Spray, which can lead to extreme lightheadedness or fainting.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIANGINALS]

FAQs

GTN Spray is primarily indicated in preventing attacks of angina (chest pain) and treatment of angina due to coronary artery disease.
GTN Spray contains Glyceryl Trinitrate, is a vasodilator in nature. It works by relaxing the blood vessels and decreasing the demand for oxygen the heart requires. As a result, it reduces heart workload and prevents attacks of angina.
A person taking phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, should not take GTN Spray as it may cause serious side effects in the body.
GTN Spray should not be taken before doing any physical workout to prevent angina pain. take this medicine in the dosage regimen as prescribed by your doctor.
It is suggested to take GTN Spray in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
No, you cannot stop taking GTN Spray even if you feel better as discontinuing suddenly may lead to angina attack (sudden chest pain) and other conditions resulting in difficulty in breathing and heartattack. Complete the full course of treatment prescribed by your doctor.
GTN Spray relaxes the blood vessels and decreases the blood pressure. This reduces the heart workload.
Yes, the effect of GTN Spray can wear off over time due to tolerance with excessive use. To reduce this, doctors mostly recommend smallest dose necessary for relieving acute angina attack effectively.
No, GTN Spray doesn’t stop heart-attacks. Instead it helps prevent angina (chest pain) in people with coronary artery disease. It works by relaxing blood vessels, reducing the hearts workload, and improving oxygen flow to the heart muscles, which reduces chest pain. However, consult the doctor before using GTN Spray.
GTN Spray causes side effects as dry mouth, insomnia, headache, weakness, blurred vision. Please, consult a doctor, if side effects persists for longer durations.
No, you must avoid alcohol while taking GTN Spray. Alcohol can cause your blood pressure to drop dangerously low, making you feel extremely dizzy, lightheaded, or faint. Talk to your doctor if you have questions about alcohol use.
Headaches are a very common side effect of GTN Spray because the medicine widens the blood vessels in your head as well as your heart. These headaches usually become less severe as your body gets used to the medication. Talk to your doctor or pharmacist for safe pain relief options.
If you are taking extended-release or long-acting oral tablets, you must swallow them whole. Crushing, chewing, or breaking the tablet can cause too much medication to be released into your body at once, which increases the risk of side effects. Talk to your doctor if you have trouble swallowing pills.
No, GTN Spray does not cure heart disease; it is a long-term treatment used to manage and prevent chest pain symptoms. It must be taken regularly as prescribed alongside recommended lifestyle changes. Talk to your doctor about your complete cardiovascular treatment plan.
If you feel dizzy, sit or lie down immediately to prevent yourself from falling or fainting. Avoid standing up too quickly from a sitting or lying position, and rest until the feeling passes. Talk to your doctor if your dizziness is severe or does not improve.
The safety of GTN Spray during pregnancy has not been fully established. It should only be used if the benefits clearly outweigh the potential risks to the developing baby. Talk to your doctor if you are pregnant, planning a pregnancy, or breastfeeding before starting this medicine

Disclaimer

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Reference

  1. National Health Service (NHS). Glyceryl Trinitrate Gtn - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Glyceryl Trinitrate 5 mg/ml Sterile Concentrate — Summary of Product Characteristics (SmPC) – (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 26 Sep 2025]Check here
  3. Kim KH, Kerndt CC, Adnan G, et al. Nitroglycerin. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed on 11 Mar 2025]Check here
  4. Elkayam U, Aronow WS. Glyceryl trinitrate (nitroglycerin) ointment and isosorbide dinitrate: a review of their pharmacological properties and therapeutic use. Drugs. 1982 Mar;23(3):165-94 [Accessed on 11 Mar 2025]Check here
  5. Torrent Pharmaceuticals Ltd. VASOVIN XL: Summary of Product Characteristics [Internet]. Feb 2022 [Accessed on 2025 Sep 26]Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 22 April 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Medley House, D2, M.I.D.C. Area, Andheri (East), Mumbai-400 093, INDIA
Other Info - GTN0005
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