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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Gliptalex M 50/500 Tablet 15's is used to treat Type 2 diabetes. It contains Sitagliptin and Metformin, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high. Additionally, it reduces glucose production in the liver, slows glucose absorption from the intestines, and enhances the body's sensitivity to insulin. Thus, it controls blood glucose levels from rising to very high after meals. The most common side effect is hypoglycemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin, among others. To avoid hypoglycemia, it is essential to eat regularly and carry a source of sugar with you. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Manufacturer/Marketer :

Unilex Lifesciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Gliptalex M 50/500 Tablet 15's

Gliptalex M 50/500 Tablet 15's is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes develops when the body does not produce enough insulin or when the body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals.

Gliptalex M 50/500 Tablet 15's contains metformin and vildagliptin, which help control blood sugar levels. It works by causing the pancreas to produce more insulin and less glucagon (the effect of vildagliptin) and also by helping the body utilise insulin more effectively (the effect of metformin).

Not everyone who is taking Gliptalex M 50/500 Tablet 15's will get these side effects. The most common side effect of Gliptalex M 50/500 Tablet 15's is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, hunger pangs, dry mouth and skin, etc. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Gliptalex M 50/500 Tablet 15's should be taken with food to avoid an upset stomach. It is advised to take it at the same time each day for best results. For better advice, your doctor will determine the appropriate dose, which can change quickly depending on your condition. Do not skip your meals, and also carry a form of sugar with you to prevent low blood sugar levels.

Avoid taking Gliptalex M 50/500 Tablet 15's if you are allergic to it. Gliptalex M 50/500 Tablet 15's should not be stopped even if you feel better without consulting your doctor, as sugar levels may change. If you stop taking Gliptalex M 50/500 Tablet 15's abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney damage and nerve damage. Gliptalex M 50/500 Tablet 15's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or are planning to get pregnant or breastfeed. You must continue following the diet and exercise recommended for you while on treatment with Gliptalex M 50/500 Tablet 15's.

Uses of Gliptalex M 50/500 Tablet 15's

Gliptalex M 50/500 Tablet 15's is used in the treatment of Type 2 Diabetes Mellitus. The detailed uses of Gliptalex M 50/500 Tablet 15's are as follows:

  • Management of Diabetes: Gliptalex M 50/500 Tablet 15's is commonly prescribed to help regulate blood sugar levels in patients with type 2 diabetes, particularly those who may require additional medication alongside lifestyle changes.
  • Improvement of Glycemic Control: Gliptalex M 50/500 Tablet 15's aids in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
  • Weight Management: In some cases, Gliptalex M 50/500 Tablet 15's can assist in weight management for diabetic patients, as it may help reduce appetite or modify fat metabolism.
  • Prevention of Diabetes Complications: Regular use of Gliptalex M 50/500 Tablet 15's can contribute to the prevention of long-term complications associated with diabetes, such as neuropathy, nephropathy, and retinopathy.

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Directions for Use

  • Gliptalex M 50/500 Tablet 15's should be taken with meals to avoid stomach upset.
  • It is usually taken twice daily; however, your doctor may adjust the dosage based on your blood sugar levels.
  • Swallow Gliptalex M 50/500 Tablet 15's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Gliptalex M 50/500 Tablet 15's helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes.
  • It helps control the rise of blood sugar levels in your body after a meal. 
  • Gliptalex M 50/500 Tablet 15's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Gliptalex M 50/500 Tablet 15's Works

Gliptalex M 50/500 Tablet 15's is a combination of Sitagliptin and Metformin. Metformin slows the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Gliptalex M 50/500 Tablet 15's controls blood glucose levels from rising to very high after meals.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Gliptalex M 50/500 mg Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Gliptalex M 50/500 Tablet 15's

Do not take more than the prescribed dose of Gliptalex M 50/500 Tablet 15's as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to Gliptalex M 50/500 Tablet 15's.
  • This medicine should not be used in patients with type 1 diabetes or with diabetic ketoacidosis.
  • Some diabetic patients, while taking Gliptalex M 50/500 Tablet 15's, might develop a rare but serious condition called lactic acidosis (too much lactic acid accumulated in the blood) that can damage the working of your liver and kidneys, which are required for the elimination of excess lactic acid from the blood.
  • Before you start taking Gliptalex M 50/500 Tablet 15's, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, or a low vitamin B12 level.
  • Gliptalex M 50/500 Tablet 15's, when used with insulin, may significantly lower the blood sugar level, leading to a hypoglycemic condition, which can be fatal.
  • Inform your doctor if you are pregnant, planning for a pregnancy or breastfeeding before starting the treatment.
  • Prolonged intake of Gliptalex M 50/500 Tablet 15's may lower your thyroid-stimulating hormone (TSH); hence, an annual checkup of TSH is recommended.
  • In rare cases, you may also develop a severe skin reaction known as bullous pemphigoid that requires immediate medical attention.
  • Inform your doctor if you are scheduled to undergo a diagnostic test that involves an injection of dye or an X-ray contrast agent. The use of Gliptalex M 50/500 Tablet 15's should be stopped for a short time before having an X-ray procedure.
  • It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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MetforminIopentol
Critical
MetforminIocetamic acid
Critical

Drug-Drug Interactions

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MetforminIopentol
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Iopentol with Gliptalex M 50/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Gliptalex M 50/500 mg Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Iopromide with Gliptalex M 50/500 mg Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Gliptalex M 50/500 mg Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminMetrizamide
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Gliptalex M 50/500 mg Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIobenzamic acid
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Gliptalex M 50/500 mg Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Ioglycamic acid with Gliptalex M 50/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopydol
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Iopydol with Gliptalex M 50/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminIoxitalamic acid
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Gliptalex M 50/500 mg Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Iopanoic acid with Gliptalex M 50/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIomeprol
Critical
How does the drug interact with Gliptalex M 50/500 mg Tablet:
Co-administration of Iomeprol with Gliptalex M 50/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Gliptalex M 50/500 mg Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include starchy veggies, proteins, and whole grains in your diet.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly.
  • If you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
  • Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Gliptalex M 50/500 Tablet 15's.

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Pregnancy

Consult your doctor

Gliptalex M 50/500 Tablet 15's is only recommended during pregnancy when the benefit outweighs the risk. Please consult your doctor before starting Gliptalex M 50/500 Tablet 15's if you are pregnant or planning to conceive.

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Breast Feeding

Consult your doctor

Consult your doctor; Gliptalex M 50/500 Tablet 15's should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Consult your doctor

If you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Consult your doctor

It is advisable to consult a doctor before using it.

FAQs

Gliptalex M 50/500 Tablet 15's is used to treat Type 2 Diabetes Mellitus.

Sitagliptin and Metformin are combined to form $ name. Metformin slows down the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Gliptalex M 50/500 Tablet 15's controls blood glucose levels from rising to very high after meals.

Increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sore healing, and frequent infections are the signs of type 2 diabetes. Please consult your doctor if you notice such symptoms.

No. Gliptalex M 50/500 Tablet 15's is only prescribed for the treatment of type 2 diabetes, also called non-insulin-dependent diabetes.

Gliptalex M 50/500 Tablet 15's needs to be taken with food to avoid stomach upset. Take it as prescribed by your doctor.

Do not crush or chew Gliptalex M 50/500 Tablet 15's as it may release all of the medicine at once and cause side effects. It should be taken as a whole, with food, or as advised by your doctor.

Generally, Gliptalex M 50/500 Tablet 15's does not cause hypoglycemia. It can cause low blood sugar if taken along with other antidiabetic medications, especially when engaging in strenuous exercise or consuming low-calorie foods. Symptoms of low blood sugar include sudden sweating, blurred vision, shaking, hunger, increased heart rate, dizziness, or tingling sensations in the hands or feet. If you experience low blood sugar while taking Gliptalex M 50/500 Tablet 15's, consult your doctor.

To quickly increase your blood sugar, eat sugar, candy, honey, or drink fruit juice or non-diet soda if you have sudden sweating, blurry vision, shaking, dizziness, increased heartbeat, or hunger.

Long-term use of Gliptalex M 50/500 Tablet 15's can lead to Vitamin B12 deficiency. It interferes with the absorption of Vitamin B12 in the stomach. If left untreated, it may lead to anaemia and nerve problems, which can cause the patient to experience tingling sensations and numbness in the hands and feet, urinary problems, weakness, changes in mental status, and difficulty maintaining balance (ataxia). Some researchers recommend the intake of vitamin B12 from external sources at least once a year to avoid such problems.

Gliptalex M 50/500 Tablet 15's may cause side effects such as headache, nausea, vomiting, diarrhoea, low blood sugar, or upper respiratory tract infection. If these side effects persist or worsen, please consult your doctor.

Gliptalex M 50/500 Tablet 15's should be avoided in patients with known allergy to any of the components or excipients in it and in patients with severe liver impairment, kidney impairment, congestive heart failure, diabetic ketoacidosis or lactic acidosis.

No, it is not safe to take alcohol while using Gliptalex M 50/500 Tablet 15's as it may increase the chance of a life-threatening condition known as lactic acidosis.

Store Gliptalex M 50/500 Tablet 15's at room temperature. Protect from light and moisture. Keep it out of reach of children.

Yes, the use of Gliptalex M 50/500 Tablet 15's can lead to lactic acidosis. It is a life threatening condition caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect of metformin and thus, it is avoided in patients with underlying kidney disease, elderly patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, tiredness, dizziness, difficulty in breathing, feeling of cold in arms and legs, stomach pain, nausea, vomiting, or slow heart rate. If you have these symptoms, stop taking Gliptalex M 50/500 Tablet 15's and consult your doctor immediately.

Gliptalex M 50/500 Tablet 15's can lower the chance of severe complications such as nerve problems, kidney damage, blindness, limb amputations, and heart diseases by controlling high blood sugar.

You are recommended to consult your doctor before taking other medications with Gliptalex M 50/500 Tablet 15's to avoid drug interactions.

Avoid alcohol consumption while taking Gliptalex M 50/500 Tablet 15's and ensure regular monitoring of kidney function. Always take Gliptalex M 50/500 Tablet 15's as prescribed by your doctor.

Country of origin

India

Manufacturer/Marketer address

No. 38/455 (New No. 63/2503), Ground Floor, Near Manoramma Junction, Near Metro Pillar No.755, Panampilly Nagar, Kochi-682016
Other Info - GLI2999

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