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compositionComposition:PROGESTERONE-400MG
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Gestone 400 mg Capsule is a female hormone used in the treatment of female infertility. This medicine helps boost the production of hormones involved in the ovulation process. Common side effects include flushing (reddening of the skin, especially the face), headache, Insomnia, tiredness, dizziness, breast pain or tenderness, heavy periods, etc. It is also used to restore the menstrual cycle in women who have missed their periods. This medicine is only intended for use in women. Hence should not be used in male population, pregnant/breastfeeding women, and children.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PROGESTERONE-400MG

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

Vaginal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Gestone 400 mg Capsule

Gestone 400 mg Capsule is a vaginal medication used to support early pregnancy, especially during fertility treatments, and to help prevent preterm birth in women with high-risk pregnancies. It is also used to treat irregular menstrual cycles or to protect the lining of the womb in women undergoing hormone replacement therapy. By delivering the key hormone directly where it is needed, it helps prepare and maintain a stable environment in the uterus.

To achieve the best results, you must use this medicine consistently at the same time every day as directed by your healthcare provider. Because it is inserted vaginally, its absorption is not affected by food, meaning you can insert it with or without meals. Making certain lifestyle adjustments, such as eating a balanced diet, staying hydrated, and reducing stress, can also help support your overall treatment plan.

While using Gestone 400 mg Capsule , you may experience mild, temporary side effects such as light vaginal discharge, bloating, or breast tenderness. These symptoms are common as your body adjusts to the hormone, but you should consult your doctor immediately if you experience severe symptoms like sudden chest pain, difficulty breathing, or severe headaches.

Before starting this medication, tell your doctor about any health conditions you have, especially if you have ever had liver issues or blood clots. Do not use this medicine if you have unexplained vaginal bleeding, severe liver damage, or a history of active blood clots.

Inform your doctor about all other medicines you are using, as some treatments may interact with Gestone 400 mg Capsule . While this medication is frequently prescribed during early pregnancy to support gestation, you should consult your healthcare provider if you are breastfeeding, and always discuss your treatment plan if you are an older adult, to ensure it is safe for your specific situation.

Gestone 400 mg Capsule is available in different vaginal dosage forms, including gels, tablets/inserts, capsules, and suppositories. Depending on your condition, your doctor may prescribe a brand such as Crinone®, Utrogestan®, or Endogest® or another suitable equivalent.

Uses of Gestone 400 mg Capsule

Your doctor may prescribe Gestone 400 mg Capsule to help manage the following conditions: 

  • Supporting early pregnancy in fertility treatments: Gestone 400 mg Capsule helps prepare and maintain the lining of the womb, making it easier for a fertilised egg to attach and grow during assisted reproduction procedures.
  • Preventing preterm birth: In women with a short cervix or a history of early deliveries, this vaginal treatment helps relax the uterine muscles to reduce the risk of giving birth too early.
  • Treating absent menstrual periods: It helps restore a regular monthly cycle in women who have stopped menstruating due to a lack of natural hormones.
  • Hormone Replacement Therapy: When used alongside estrogen, it protects the lining of the womb from overgrowing, lowering the risk of complications in postmenopausal women.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Targeted Local Support: Gestone 400 mg Capsule provides targeted support directly where your body needs it most.
  • High Uterine Delivery: Because the medicine is inserted vaginally, it delivers high concentrations of Gestone 400 mg Capsule to the uterus (often called the first uterine pass effect).
  • Effective Local Treatment: Although a small amount is also absorbed into the bloodstream, this route helps provide effective local treatment while keeping overall hormone levels relatively lower than with some oral forms, which may help reduce widespread side effects.
  • Supports Early Pregnancy: For women undergoing fertility treatments, this medicine provides the necessary support to secure and nourish an early pregnancy.
  • Helps Prevent Preterm Birth: For those at risk of early labour, it helps prolong the pregnancy, giving the baby vital time to develop.
  • Restores Hormonal Balance: It also helps restore a healthy hormonal balance, bringing comfort and predictability back to irregular menstrual cycles and helping manage postmenopausal health safely.
Side effects of Gestone 400 mg Capsule
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions before using Gestone 400 mg Capsule .
  • Gently insert the applicator into the vagina while lying down or standing with one leg raised. Push the plunger to release the medication.
  • Wash your hands thoroughly with soap and water.
  • Ensure the vaginal area is clean and dry.
  • Remove the applicator carefully and remain lying down for a few minutes to allow the medication to absorb.

How Gestone 400 mg Capsule Works

The active hormone in Gestone 400 mg Capsule is identical to the progesterone naturally produced by the ovaries. This hormone is essential for preparing the uterus for pregnancy and maintaining it. The medicine works by binding to specific receptors in the uterus, signalling the uterine lining to thicken and become rich in blood vessels and nutrients, which prepares the womb to receive and support a fertilised egg. When inserted vaginally, the medicine avoids passing through the digestive system first and delivers Gestone 400 mg Capsule directly to the vaginal tissues, allowing high concentrations to reach the uterus while some of the medicine is also absorbed into the bloodstream. This localised action helps relax the muscles of the uterus, preventing premature contractions, and ensures that the uterine lining remains stable and supportive throughout your treatment.
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Alcohol

Caution

It is not known if alcohol affects Gestone 400 mg Capsule . However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Caution

Contact the doctor before using Gestone 400 mg Capsule . Your doctor will decide whether Gestone 400 mg Capsule should be used by the pregnant woman or not depending on her condition.

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Breast Feeding

Unsafe

The use of Gestone 400 mg Capsule during breastfeeding is not recommended.

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Driving

Caution

Gestone 400 mg Capsule does not influence the ability to drive and use machines.

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Liver

Unsafe

Do not use Gestone 400 mg Capsule if you have/had liver disease or abnormal liver tests.

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Kidney

Consult your doctor

Please consult your doctor if you have aany kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Gestone 400 mg Capsule is not recommended for use in children or adolescents.

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Heart

Caution

Gestone 400 mg Capsule should be used with caution in patients with heart conditions, as it may increase the risk of side effects. Please inform your doctor before using Gestone 400 mg Capsule .

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Geriatrics

Consult your doctor

Limited information is available regarding the use of Gestone 400 mg Capsule in elderly patients. If you have any concerns about the usage of Gestone 400 mg Capsule in geriatrics, please consult your doctor.

What if I have taken an overdose of Gestone 400 mg Capsule

Because Gestone 400 mg Capsule is applied locally inside the vagina, a serious overdose is highly unlikely. However, if you or someone else accidentally swallows the medicine, or if you insert far too much, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat fibre-rich foods: Hormonal treatments can sometimes slow down your digestion, which may lead to constipation. Incorporate plenty of whole grains, vegetables, and fruits into your meals to support healthy digestion.
  • Stay well-hydrated: Drink plenty of water throughout the day to support circulation and digestive health, especially during early pregnancy.
  • Wear breathable underwear: It is normal to experience some vaginal discharge or medication leakage. Wear loose, breathable cotton underwear and avoid synthetic fabrics to stay dry and prevent irritation.
  • Avoid douching: Do not use vaginal douches or harsh soaps inside the vaginal area while using this medication, as this can wash away the medicine, cause irritation, or alter your natural vaginal pH.
  • Engage in gentle exercise: If approved by your doctor, light activities like walking can improve circulation and help ease mild bloating or sluggish digestion.
health query

Have a query?

How Soon It Starts Working

The time required for Gestone 400 mg Capsule to start to work: The time required for Gestone 400 mg Capsule to show its action is unknown. 

The time for which the effects of Gestone 400 mg Capsule last: The duration of action for Gestone 400 mg Capsule is unknown.

What if you forget to take Gestone 400 mg Capsule

If you miss a dose, insert it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not insert a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Do not store it in the bathroom where humidity levels change quickly, and do not freeze vaginal gels or inserts.

Drug Warnings

  • Inspect Before Use: Inspect the product before use. Do not use the vaginal gel, tablet, or insert if the wrapper is torn, punctured, or shows any signs of leaking or damage.
  • Use the Provided Applicator: Always use the specific applicator provided in the packaging. Never share applicators with anyone else, and do not reuse disposable, single-use applicators.
  • Avoid Other Vaginal Products: Avoid using other vaginal medications or products (such as anti-yeast creams, vaginal moisturisers, or spermicides) at the same time as Gestone 400 mg Capsule , as they can interfere with how your body absorbs the hormone. If you must use another vaginal product, space them out or talk to your doctor or pharmacist first.
  • Report Unusual Bleeding: If you experience any unexpected vaginal bleeding or spotting while using this medicine, notify your healthcare provider immediately to determine the cause.
  • Wash Hands Before & After Use: Wash your hands thoroughly both before and after inserting the medicine to prevent introducing bacteria into the vaginal area.

Drug-Drug Interactions

verifiedApollotooltip
  • Other vaginal products: Using other vaginal creams, gels, or suppositories (such as antifungal treatments like clotrimazole or miconazole) at the same time may reduce the effectiveness and absorption of Gestone 400 mg Capsule .
  • Medicines that affect liver enzymes: Some medicines, including rifampicin, certain anti-seizure medicines (such as carbamazepine or phenytoin), and antifungal medicines such as ketoconazole, may change how Gestone 400 mg Capsule is processed in the body. Tell your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking.
ProgesteroneEdoxaban
Severe
ProgesteroneVenetoclax
Severe

Drug-Drug Interactions

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ProgesteroneEdoxaban
Severe
How does the drug interact with Gestone 400 mg Capsule:
When Gestone 400 mg Capsule is taken with Edoxaban, may increase the blood levels of Edoxaban which increases the risk of serious bleeding complications.

How to manage the interaction:
Although taking Gestone 400 mg Capsule and edoxaban together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
ProgesteroneVenetoclax
Severe
How does the drug interact with Gestone 400 mg Capsule:
Co-administration of Gestone 400 mg Capsule with Venetoclax may increase the blood levels of Venetoclax which increases the risk of side effects.

How to manage the interaction:
Although taking Gestone 400 mg Capsule and Venetoclax together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms such as fatigue, nausea, vomiting, diarrhea, and infections, it is advised to consult a doctor. Without consulting a doctor, never stop taking any drugs.
How does the drug interact with Gestone 400 mg Capsule:
Co-administration of Gestone 400 mg Capsule with Morphine may increase the blood levels and side effects of Morphine.

How to manage the interaction:
Co-administration of Morphine with Gestone 400 mg Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Gestone 400 mg Capsule when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Gestone 400 mg Capsule belongs to the class of medicines known as hormones used to treat female infertility and to aid pregnancy. It is also used to restore the menstrual cycle in women who have missed their periods.
Gestone 400 mg Capsule causes secretory changes in the uterine endometrium, relaxes the uterus, prevents follicle maturation, and helps to maintain pregnancy.
Do not use Gestone 400 mg Capsule if you are allergic to any of its components or if you have/had porphyria, breast or genital cancer, abnormal vaginal bleeding due to miscarriage or missed abortion, blood clots or stroke, liver disease or abnormal liver tests.
Abnormal uterine bleeding, irregular or missed periods (amenorrhea), abdominal pain during pregnancy and frequent miscarriages are the signs of low progesterone. Additionally, low progesterone levels lead to high estrogen levels, and women can have decreased sex drive, weight gain or gallbladder problems.
Gestone 400 mg Capsule may cause vaginal spotting, vaginal irritation, or application site reactions. Consult your doctor if the condition persists or worsens.
Yes, in many cases, your doctor will advise you to continue using this medicine even if your period begins. Stopping the medicine suddenly can disrupt your hormonal balance and affect your treatment. Always follow your doctor's instructions, and talk to your doctor if you have questions.
Having intercourse is generally safe, but it is best to wait a few hours after inserting the medicine to ensure it has been fully absorbed. Additionally, some vaginal residues may coat the vaginal walls and transfer to your partner. If you are using this medicine to support a high-risk pregnancy or fertility treatment, talk to your doctor to see if intercourse is recommended.
No, you should avoid using tampons while using this vaginal medication. Tampons can absorb the medicine, preventing your body from receiving the correct dose. Instead, use a sanitary pad or panty liner to manage any discharge or leakage. Talk to your doctor for more information.
Vaginal Gestone 400 mg Capsule is less likely to cause severe drowsiness than oral Gestone 400 mg Capsule pills because it is absorbed locally, with lower levels entering your general bloodstream. However, some mild tiredness or sleepiness can still occur. If you feel unusually drowsy, avoid driving or operating machinery and talk to your doctor.
If the applicator causes irritation, ensure you are inserting it gently and at the correct angle. You can also moisten the tip of the applicator with a little water to make insertion smoother. Do not use petroleum jelly or other oil-based lubricants unless directed. If the irritation persists, talk to your doctor.
Gestone 400 mg Capsule may be prescribed to support early pregnancy in certain situations, such as during fertility treatment or for some women who have had previous miscarriages or are at higher risk. However, it does not guarantee that a miscarriage can be prevented, and it is not appropriate for every pregnancy. If you have bleeding, pain, or any concerns during pregnancy, contact your doctor promptly for advice.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA
Other Info - GES0037
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