Gazyva 1000 mg Injection 40 ml

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MRP ₹341107

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Gazyva 1000 mg Injection is used to treat Chronic Lymphocytic Leukaemia and Follicular Lymphoma. Gazyva 1000 mg Injection contains Obinutuzumab. It works by inhibiting the B-cell lymphocytes responsible for the multiplication of cancer cells, thereby preventing the growth and further spread of cancerous or non-cancerous cells. This medicine is known to cause fetal B-cell depletion in neonates. Hence, inform your physician if you are pregnant.

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About Gazyva 1000 mg Injection

Gazyva 1000 mg Injection is an anti-cancer medicine used in the treatment of chronic lymphocytic leukaemia (CLL). Chronic lymphocytic leukaemia is a cancer that occurs in the bone marrow and blood. Gazyva 1000 mg Injection is used in combination with chlorambucil for the treatment of CLL, in combination with bendamustine for the treatment of follicular lymphoma in patients who relapsed after or are refractory to a rituximab-containing regimen and in patients with previously untreated stage II bulky, III or IV follicular lymphoma.

Gazyva 1000 mg Injection contains Obinutuzumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.

Gazyva 1000 mg Injection may cause certain side effects, such as nausea, vomiting, diarrhoea, constipation, fever, decreased platelet count, fatigue, cough, insomnia, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Gazyva 1000 mg Injection. Hence, do not self-administer.

While taking Gazyva 1000 mg Injection if you experience any allergic reaction, inform your doctor. Before taking the Gazyva 1000 mg Injection, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, active infections, skin problems, or any allergic conditions. Gazyva 1000 mg Injection is known to cause fetal B-cell depletion in neonates. Hence, inform your physician if you are pregnant.

Uses of Gazyva 1000 mg Injection

Gazyva 1000 mg Injection is used in the treatment of Chronic Lymphocytic Leukaemia, and Follicular Lymphoma. The detailed uses of Gazyva 1000 mg Injection are as follows:

Chronic lymphocytic leukemia (CLL):Gazyva 1000 mg Injection is used in combination with chlorambucil to treat previously untreated CLL in adults. It helps reduce the number of malignant B cells and delays disease progression.
Follicular lymphoma (FL): Gazyva 1000 mg Injection is used with bendamustine in patients whose FL has relapsed or not responded to a rituximab-containing regimen. It is also used as a first-line treatment for stage II bulky, III, or IV FL in combination with chemotherapy, followed by Gazyva 1000 mg Injection alone as maintenance therapy.
Immunotherapy support: Gazyva 1000 mg Injection is used as a targeted immunotherapy that binds to the CD20 protein on B cells, helping the immune system recognize and destroy cancerous cells while preserving the body’s ability to regenerate healthy blood cells.

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Directions for Use

Follow your doctor's instructions on the dosage and timing of this medication.
A trained healthcare professional will administer Gazyva 1000 mg Injection.
Do not self-administer.

Medicinal Benefits

Gazyva 1000 mg Injection contains Obinutuzumab, which belongs to the class of CD20-directed cytolytic antibodies. It is used in the treatment of chronic lymphocytic leukaemia and follicular lymphoma. This medicine works by binding to the CD20 antibody and causes lysis of B-cell lymphocytes responsible for the multiplication of cancer cells. This causes shrinkage of tumour cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

How Gazyva 1000 mg Injection Works

Gazyva 1000 mg Injection contains Obinutuzumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Gazyva 1000 mg Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Side effects of Gazyva 1000 mg Injection 40 ml

Increased Risk Of Infection Due To Low Neutrophil Count

Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
Avoid contact with people who are sick.
Wash your hands regularly with soap and water.
Avoid unpasteurized dairy products.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Joint Pain

Here are the steps to manage Joint Pain caused by medication usage:

Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Inflammation Of Sinuses

Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):

Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Cough

Here are the steps to manage the medication-triggered Cough:

Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Gazyva 1000 mg Injection

Since Gazyva 1000 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Gazyva 1000 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, active infections, skin problems, or any allergic conditions. Gazyva 1000 mg Injection may cause remission of active infections, severe skin reactions, reactivation of hepatitis B Virus, increased bilirubin levels, progressive multifocal leukoencephalopathy, tumour lysis syndrome (tumor cells release their contents into the bloodstream), and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Gazyva 1000 mg Injection may cause fetal B-cell depletion in infants. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Gazyva 1000 mg Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

ObinutuzumabCladribine

Severe

ObinutuzumabBaricitinib

Severe

Drug-Drug Interactions

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ObinutuzumabCladribine

Severe

How does the drug interact with Gazyva 1000 mg Injection 40 ml:
Combining Cladribine with Gazyva 1000 mg Injection 40 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Gazyva 1000 mg Injection 40 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

ObinutuzumabBaricitinib

Severe

How does the drug interact with Gazyva 1000 mg Injection 40 ml:
Coadministration of Gazyva 1000 mg Injection 40 ml with Baricitinib can increase the risk of developing a serious infection.

How to manage the interaction:
Co-administration of Gazyva 1000 mg Injection 40 ml with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

ObinutuzumabClozapine

Severe

How does the drug interact with Gazyva 1000 mg Injection 40 ml:
Co-administration of Gazyva 1000 mg Injection 40 ml with Clozapine can increase the risk of neutropenia (low white blood cell count).

How to manage the interaction:
Although taking Gazyva 1000 mg Injection 40 ml and Clozapine together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, weight loss, or pain or burning during urination, it is important to contact a doctor right away." Do not stop using any medications without talking to a doctor.

ObinutuzumabInfliximab

Severe

How does the drug interact with Gazyva 1000 mg Injection 40 ml:
Combining Infliximab with Gazyva 1000 mg Injection 40 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Gazyva 1000 mg Injection 40 ml and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

After your treatment begins, dietary adjustments can help you control side effects.
Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
Get optimal sleep; rest well.
Avoid smoking and alcohol consumption.
Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Consult your doctor

It is unknown whether Gazyva 1000 mg Injection interacts with alcohol. Consult your doctor.

Pregnancy

Unsafe

Gazyva 1000 mg Injection is not recommended for use in pregnancy as it may cause fatal B-lymphocyte depletion in your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Gazyva 1000 mg Injection.

Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Gazyva 1000 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

Driving

Caution

Gazyva 1000 mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Gazyva 1000 mg Injection. Gazyva 1000 mg Injection may cause increased bilirubin levels and liver failure. Hence, inform your doctor if you observe any symptoms such as fatigue, yellow discolouration of eyes, and dark coloured urine. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

Kidney

Caution

It is not known whether Gazyva 1000 mg Injection can be taken if you have kidney impairment. However, inform your doctor if you have a pre-existing or a history of kidney disease before receiving Gazyva 1000 mg Injection.

Children

Unsafe

Gazyva 1000 mg Injection is not recommended for use in children as the safety and efficacy are not established.

Heart

Please consult your doctor before receiving Gazyva 1000 mg Injection if you have pre-existing heart problems. Your doctor will prescribe Gazyva 1000 mg Injection if the benefits outweigh the risks.

Geriatrics

Safe if prescribed

Gazyva 1000 mg Injection is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

FAQs

What is the use of Gazyva 1000 mg Injection?

Gazyva 1000 mg Injection is used to treat Chronic Lymphocytic Leukaemia, and Follicular Lymphoma.

How does Gazyva 1000 mg Injection work?

Gazyva 1000 mg Injection contains Obinutuzumab, which works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.

What are the conditions to be noted while receiving Gazyva 1000 mg Injection?

Gazyva 1000 mg Injection may cause reactivation of serious infections, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Country of origin

India

Manufacturer/Marketer address

Bayer Ag, Mã¼Llerstr. 178, 13353 Berlin

Other Info - GAZ0014

Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

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