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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

G-LOC HP 1 Combikit Tablet is used to treat peptic ulcer disease caused by Helicobacter pylori infection. It kills the bacteria (Helicobacter pylori), causing the infection, and reduces the production of stomach acid. It may cause side effects such as headache, diarrhoea, stomach pain, constipation, flatulence, feeling unwell (nausea), being sick (vomiting), skin rash, difficulty sleeping, changes in taste sensation, indigestion, and excessive sweating.

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Synonym :

AMOXICILLIN TRIHYDRATE+CLARITHROMYCIN+ESOMEPRAZOLE MAGNESIUM TRIHYDRATE

Manufacturer/Marketer :

ASCENTRA HEALTHCARE PVT LTD

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About G-LOC HP 1 Combikit Tablet

G-LOC HP 1 Combikit Tablet is used to treat peptic ulcer disease caused by Helicobacter pylori infection. Helicobacter pylori is a type of bacteria that infects the stomach and leads to excess acid production. This effect leads to the formation of sores or ulcers in the stomach lining.

G-LOC HP 1 Combikit Tablet contains Clarithromycin, Esomeprazole, and Amoxicillin. Clarithromycin kills the bacteria (Helicobacter pylori) causing the infection. Esomeprazole reduces stomach acid secretion. Amoxicillin works by preventing bacterial cell formation, covering necessary for their survival.

G-LOC HP 1 Combikit Tablet may cause side effects such as headache, diarrhoea, stomach pain, constipation, flatulence, nausea, vomiting, skin rash, and indigestion. These side effects typically resolve on their own. However, if any of these side effects persist or worsen, consult your doctor immediately.

Do not take G-LOC HP 1 Combikit Tablet if you are allergic to Esomeprazole, Clarithromycin, Amoxicillin, other antibiotics (especially penicillin), other proton pump inhibitors (pantoprazole, lansoprazole, or omeprazole, etc.), or any other contents of it. Inform your doctor if you are pregnant or breastfeeding. G-LOC HP 1 Combikit Tablet should be used with caution in children and may require dose adjustments.

Uses of G-LOC HP 1 Combikit Tablet

G-LOC HP 1 Combikit Tablet is used in the treatment of hyperacidity, heartburn, stomach ulcer and Zollinger-Ellison syndrome. The detailed uses of G-LOC HP 1 Combikit Tablet are as follows:

  • Management of Gastroesophageal Reflux Disease (GERD): G-LOC HP 1 Combikit Tablet effectively reduces symptoms of GERD, such as heartburn and acid regurgitation, by lowering stomach acid production.
  • Healing of Erosive Esophagitis: G-LOC HP 1 Combikit Tablet is often prescribed to promote the healing of inflamed oesophageal tissue caused by prolonged exposure to stomach acid.
  • Prevention of Peptic Ulcers: G-LOC HP 1 Combikit Tablet helps prevent peptic ulcer formation, particularly in individuals undergoing long-term NSAID treatment.
  • Eradication of Helicobacter pylori: G-LOC HP 1 Combikit Tablet is sometimes included in combination therapy to eliminate Helicobacter pylori infections, which are associated with peptic ulcers.

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Directions for Use

  • Take G-LOC HP 1 Combikit Tablet with or without food as advised by a doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • G-LOC HP 1 Combikit Tablet is a combination medicine that contains Clarithromycin, Esomeprazole, and Amoxicillin.
  • Clarithromycin is an antibiotic that kills bacteria (Helicobacter pylori), causing the infection.
  • Esomeprazole is a proton pump inhibitor (responsible for acid production) and acts by reducing stomach acid production. This effect helps to relieve symptoms of peptic ulcer disease.
  • Amoxicillin is a penicillin antibiotic and bactericidal (kills bacteria), which works by preventing the formation of the bacterial cell wall (protective covering) necessary for their survival.

How G-LOC HP 1 Combikit Tablet Works

G-LOC HP 1 Combikit Tablet is a combination medicine that contains Clarithromycin, Esomeprazole, and Amoxicillin. Clarithromycin is an antibiotic that kills the bacteria (Helicobacter pylori) causing the infection. Esomeprazole is a proton pump inhibitor and acts by reducing the production of stomach acid. Amoxicillin is a penicillin antibiotic and bactericidal (kills the bacteria). It works by preventing the formation of the bacterial cell covering (protective cell wall) necessary for their survival. Together, G-LOC HP 1 Combikit Tablet helps treat and manage peptic ulcer disease effectively.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of G-LOC HP 1 Combikit Tablet

Do not take more than the prescribed dose of G-LOC HP 1 Combikit Tablet as it may cause an overdose. The symptoms of overdose include stomach pain, vomiting, stomach upset, crystals in the urine (may be seen as cloudy urine) or problems urinating. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • G-LOC HP 1 Combikit Tablet should not be used in patients with arrhythmias or taking antiarrhythmic agents, as it may lead to prolonged QT intervals, which can be life-threatening.
  • While using G-LOC HP 1 Combikit Tablet, if you notice severe or prolonged diarrhoea, vomiting food or blood, black stools, unexplained weight loss, or symptoms of liver disease (jaundice (yellowing of the skin), loss of appetite, dark urine, or itching), stop the medication and consult a doctor immediately.
  • Besides, if you notice skin rashes or lesions, especially on sun-exposed skin, stop the treatment and immediately consult a doctor.
  • G-LOC HP 1 Combikit Tablet increases the risk of Clostridium difficile-associated diarrhoea (inflammation of the large intestine due to Clostridium infection).
  • G-LOC HP 1 Combikit Tablet may increase the risk of fractures, cause liver impairment, and impair the absorption of vitamin B12 in the body when used for prolonged periods.

Drug-Drug Interactions

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ClarithromycinDroperidol
Critical

Drug-Drug Interactions

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ClarithromycinDroperidol
Critical
How does the drug interact with G-LOC HP 1 Combikit Tablet:
Co-administration of Droperidol with G-LOC HP 1 Combikit Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking G-LOC HP 1 Combikit Tablet with Droperidol can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
When Methylergometrine is taken with G-LOC HP 1 Combikit Tablet, the amount of Methylergometrine in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking G-LOC HP 1 Combikit Tablet with Methylergometrine is generally avoided as it can lead to an interaction, it can be taken only when advised by a doctor. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with G-LOC HP 1 Combikit Tablet:
When Quinidine is taken with G-LOC HP 1 Combikit Tablet, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of G-LOC HP 1 Combikit Tablet and Quinidine can lead to an interaction, it can be taken if advised by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. However, if you experience any symptoms like headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
Using Lurasidone together with G-LOC HP 1 Combikit Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and G-LOC HP 1 Combikit Tablet may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
Taking G-LOC HP 1 Combikit Tablet with Lovastatin can increase the risk of muscle problems.

How to manage the interaction:
Co-administration of G-LOC HP 1 Combikit Tablet and Lovastatin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinMesoridazine
Critical
How does the drug interact with G-LOC HP 1 Combikit Tablet:
Co-administration of G-LOC HP 1 Combikit Tablet and Mesoridazine may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of G-LOC HP 1 Combikit Tablet and Mesoridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
When Dronedarone is taken with G-LOC HP 1 Combikit Tablet, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking G-LOC HP 1 Combikit Tablet with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
When Cisapride is taken with G-LOC HP 1 Combikit Tablet, the amount of Cisapride in the blood can go up.

How to manage the interaction:
Taking G-LOC HP 1 Combikit Tablet with Cisapride can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with G-LOC HP 1 Combikit Tablet:
Taking Silodosin with G-LOC HP 1 Combikit Tablet may significantly increase the blood levels and effects of Silodosin, this may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position.

How to manage the interaction:
Co-administration of G-LOC HP 1 Combikit Tablet and Silodosin is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not stop using any medications without a doctor's advice.
ClarithromycinAstemizole
Critical
How does the drug interact with G-LOC HP 1 Combikit Tablet:
When Astemizole is taken with G-LOC HP 1 Combikit Tablet, it can cause a decrease in the metabolism of Astemizole.

How to manage the interaction:
Taking G-LOC HP 1 Combikit Tablet with Astemizole is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.
  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows; instead, a single raised block is sufficient. This will not allow the stomach acid to backflow through your food pipe.
  • Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid, leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
  • Include fibre-rich foods, berries, cherries, leafy green veggies (kale, spinach), and black pepper in your meal. These foods are full of antioxidants, calcium, and vitamin B 12 that can help cope with the medicine's long-term effects. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics that help prevent excess stomach acid production. Cranberry juice can be beneficial in peptic ulcers and H Pyroli infection.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a 5-minute break every hour by going for a brisk walk or stretching.

Habit Forming

No

Therapeutic Class

ANTACIDS

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Alcohol

Unsafe

Consumption of alcohol may increase the risk of side effects such as nausea, vomiting, and diarrhoea, and worsen the health condition.

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Pregnancy

Consult your doctor

G-LOC HP 1 Combikit Tablet is a pregnancy category C medicine and may cause harmful effects to the fetus if used during pregnancy. However, if clinically needed, your doctor may prescribe G-LOC HP 1 Combikit Tablet if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are breastfeeding, consult your doctor before using G-LOC HP 1 Combikit Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

G-LOC HP 1 Combikit Tablet may cause dizziness or drowsiness in some patients. So, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

In mild to moderate liver impairment, dose adjustments may not be necessary. However, your doctor may have to adjust the dose in patients with severe liver failure.

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Kidney

Caution

In mild to moderate kidney impairment, dose adjustments may not be necessary. However, in patients with severe kidney failure, your doctor may have to adjust the dose.

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Children

Caution

G-LOC HP 1 Combikit Tablet should be used with caution in children under 12 years old. The dose may have to be adjusted by your doctor.

FAQs

G-LOC HP 1 Combikit Tablet is used to treat peptic ulcer disease caused by Helicobacter pylori infection.

G-LOC HP 1 Combikit Tablet is a combination medicine that contains Clarithromycin, Esomeprazole, and Amoxicillin. Clarithromycin is an antibiotic that kills the bacteria (Helicobacter pylori) that cause the infection. Esomeprazole is a proton pump inhibitor (responsible for acid production) and reduces stomach acid production. Amoxicillin is a penicillin antibiotic with bactericidal (bacteria-killing) action. Together, G-LOC HP 1 Combikit Tablet is used to treat the infection and peptic ulcer disease.

G-LOC HP 1 Combikit Tablet contains Esomeprazole, which is an acid suppressant. It can reduce stomach acid production and relieve symptoms such as acid-related heartburn and indigestion.

G-LOC HP 1 Combikit Tablet may cause side effects such as headache, diarrhoea, stomach pain, constipation, flatulence, nausea (feeling sick), vomiting (being sick), skin rash, difficulty sleeping, changes in the sense of taste, indigestion, and excessive sweating. These side effects typically resolve on their own without requiring medical attention. However, consult your doctor immediately if these side effects persist or worsen.

It is advisable to avoid acidic foods, such as citrus fruits and tomatoes, as well as spicy foods, caffeinated drinks, chocolate, and alcohol. These foods may increase stomach acid production and worsen health conditions.

It is not advised to take G-LOC HP 1 Combikit Tablet for prolonged periods unless prescribed by your doctor. Long-term use of G-LOC HP 1 Combikit Tablet may increase the risk of fractures, impair vitamin B12 absorption, and lead to changes in liver function.

Yes, you can take G-LOC HP 1 Combikit Tablet with other medications if prescribed by the doctor. To prevent any interactions, inform the doctor if you are taking any other medicines, including herbal products or supplements, while on treatment with G-LOC HP 1 Combikit Tablet.

No, G-LOC HP 1 Combikit Tablet is not a steroid. It is a combination medication containing a penicillin-type antibiotic (amoxicillin), a macrolide antibiotic (clarithromycin), and a proton pump inhibitor (esomeprazole). It is used to treat peptic ulcer disease caused by Helicobacter pylori infection.

No, G-LOC HP 1 Combikit Tablet should not be chewed or crushed. It should be taken as a whole, accompanied by a glass of water.

The G-LOC HP 1 Combikit Tablet should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

Consult the doctor before starting any new medicine while on treatment with G-LOC HP 1 Combikit Tablet. Talk to the doctor if you experience severe diarrhoea, sore throat, white mouth, or vaginal itching/discharge. Drink plenty of fluids while taking G-LOC HP 1 Combikit Tablet. This medicine may cause dizziness; drive only if you are alert. Consult the doctor if you are pregnant or breastfeeding.

Country of origin

India

Manufacturer/Marketer address

15-16, Vinayak Complex, Near Saraswati Complex, Manjalpur, Vadodara Vadodara Gj 390011 In
Other Info - GLO0794

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