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Frenin Injection 1 ml is used to treat hypotension (low blood pressure) caused by spinal anaesthesia, circulatory failure or certain other medicines. It also treats low blood pressure during surgery or after an injury.  It contains phenylephrine, which constricts and narrows blood vessels by acting on alpha receptors. Thus, it increases blood pressure and decreases heart rate. Common side effects of Frenin Injection 1 ml are headache, vomiting, sweating, nervousness, tremors, shortness of breath, difficulty passing urine or irregular heartbeat.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PHENYLEPHRINE-10MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Frenin Injection 1 ml

Frenin Injection 1 ml is a parenteral medicine used primarily to treat dangerously low blood pressure. It is typically utilized in hospital settings to restore stable blood pressure during surgeries or intensive medical care. Frenin Injection 1 ml helps ensure that your vital organs receive an adequate and steady supply of blood.

Because Frenin Injection 1 ml is given directly into a vein in a clinical environment, it is used only as long as needed to stabilize your vital signs. It is given as a continuous infusion or a single injection, meaning there is no regular daily schedule or home use. Your healthcare team will manage your hydration and nutritional needs during your treatment to support your cardiovascular system.

While receiving this medication, you may experience some mild side effects, such as a mild headache, nausea, or a warm sensation. However, you must inform your healthcare provider immediately if you experience chest pain, an irregular heartbeat, or severe dizziness. Your medical team is trained to recognize and manage these reactions quickly.

Talk to your doctor before starting Frenin Injection 1 ml if you have a history of heart disease, thyroid issues, or poor blood circulation. Do not take this if you have severely high blood pressure, as this medication can raise your pressure even further. Your medical team will evaluate your medical history to ensure this treatment is safe for you.

Frenin Injection 1 ml can interact with certain antidepressants and other blood pressure drugs, which may cause a rapid and dangerous rise in blood pressure. If you are pregnant, breastfeeding, or an older adult, consult your healthcare team to discuss how this treatment might affect you. Your medical provider will adjust your care plan to match your specific health needs.

Uses of Frenin Injection 1 ml

Frenin Injection 1 ml is used in the treatment of Hypotension (low blood pressure). The detailed use of Frenin Injection 1 ml is as follows:

  • Low blood pressure (hypotension): Frenin Injection 1 ml helps raise and stabilize blood pressure when it drops dangerously low during surgical procedures or spinal anesthesia.
  • Shock-related low blood pressure: In critical care settings, Frenin Injection 1 ml works to restore normal blood flow to vital organs when blood pressure drops to life-threatening levels due to shock.

Key Benefits

Frenin Injection 1 ml helps rapidly increase blood pressure in emergency situations by narrowing blood vessels and improving blood flow to vital organs. It is administered under close medical supervision to support cardiovascular stability during critical care or surgical procedures.

Benefits may include:

  • Helps rapidly restore low blood pressure to a safer level.
  • Supports blood flow to vital organs such as the brain, heart, and kidneys.
  • Helps maintain cardiovascular stability during surgery and anesthesia.
  • Provides fast and reliable blood pressure control in emergency and critical care settings.
  • Supports safer medical procedures by helping healthcare teams manage blood pressure effectively.
  • Improves patient outcomes by maintaining adequate circulation when used under medical supervision.
     

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Frenin Injection 1 ml will be administered by a healthcare professional.
  • Do not self-administer.

How Frenin Injection 1 ml Works

Frenin Injection 1 ml helps raise blood pressure by stimulating alpha-1 receptors on the blood vessels. This causes the blood vessels to tighten and narrow, increasing blood pressure and improving blood flow to vital organs. By restoring adequate blood circulation, it helps maintain proper oxygen and nutrient delivery throughout the body, especially in situations where blood pressure has fallen too low.
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Alcohol

Caution

You are advised to be careful when drinking alcohol while you are receiving Frenin Injection 1 ml. However, if you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

Limited data is available on the effect of Frenin Injection 1 ml in pregnancy. Hence, if you are pregnant or planning for pregnancy, inform your doctor before receiving Frenin Injection 1 ml.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of Frenin Injection 1 ml on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Frenin Injection 1 ml.

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Driving

Consult your doctor

Discuss with your doctor if you want to drive or operate machinery after receiving Frenin Injection 1 ml.

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Liver

Consult your doctor

If you have a pre-existing history of liver disease, inform your doctor before receiving Frenin Injection 1 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Frenin Injection 1 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

If you have any concerns regarding the use of Frenin Injection 1 ml in children, please consult your doctor.

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Heart

Caution

Let your doctor know if you have any history of heart diseases. Your doctor will weigh the benefits and potential risks before prescribing Frenin Injection 1 ml.

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Geriatrics

Caution

Frenin Injection 1 ml should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Frenin Injection 1 ml

Because you will be under continuous medical monitoring, any sign of an overdose will be detected and managed instantly by your healthcare team. Symptoms of receiving too much of Frenin Injection 1 ml may include severe high blood pressure, a very slow heartbeat, or a throbbing headache, which the medical team will treat right away.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink enough fluids before and after your surgical procedure as directed by your healthcare team to help maintain a stable blood volume.
  • Move slowly after surgery: Avoid standing up too quickly from a bed or chair once you are allowed to move, as this can help reduce the risk of dizziness.
  • Follow pre-surgery instructions: Strictly follow all fasting and preparation guidelines provided by your doctor to help ensure safe anesthesia and reduce the risk of complications.
  • Get adequate rest: Rest comfortably after receiving Frenin Injection 1 ml to allow your blood pressure and heart rate to stabilize.
  • Follow your healthcare advice: Since Frenin Injection 1 ml is usually given for a short time in a hospital, carefully follow your healthcare team's instructions to support a safe recovery and maintain stable blood pressure.
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How Soon It Starts Working

The time required for Frenin Injection 1 ml to start to work: Frenin Injection 1 ml can ideally show its effects within 10 to 15 minutes of subcutaneous or IM administration. The time for which the effects of Frenin Injection 1 ml last: Frenin Injection 1 ml effect lasts for 1 hour through subcutaneous and for up to 2 hours through IM administration.

What if you forget to take Frenin Injection 1 ml

Since Frenin Injection 1 ml is given directly by a healthcare provider in a clinical setting, it is highly unlikely that you will miss a dose. If an interruption in your treatment occurs, your healthcare team will adjust your therapy immediately.

Storage

.• In clinical settings, Frenin Injection 1 ml is stored at controlled room temperature, specifically between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the medicine before use: Your healthcare provider should check the vial before administration. The solution should be clear and colorless. Do not use it if it contains visible particles or has changed color.
  • Report injection site problems immediately: Tell your nurse or doctor at once if you notice burning, pain, swelling, or a cold sensation around the IV site, as this may indicate that Frenin Injection 1 ml is leaking into the surrounding tissues.
  • Inform healthcare providers about all medicines: Before receiving Frenin Injection 1 ml, inform your healthcare team about all prescription medicines, over-the-counter products, and herbal supplements you are taking, especially antidepressants, as they may interact with Frenin Injection 1 ml.
  • Attend continuous monitoring during treatment: Your heart rhythm and blood pressure will be monitored throughout the infusion. Inform your healthcare team immediately if you experience a pounding heartbeat, fluttering in your chest, chest pain, dizziness, or any unusual symptoms.
  • Use with caution in certain patients: Frenin Injection 1 ml should not be used in people who are allergic to Frenin Injection 1 ml or any of its ingredients. It is also not recommended for patients with ventricular tachycardia (a dangerously fast heart rhythm), uncontrolled severe high blood pressure unless under close medical supervision, or severe cardiovascular disease when the risks of treatment outweigh the benefits. Your healthcare provider will determine whether Frenin Injection 1 ml is appropriate for your condition.

Drug-Drug Interactions

verifiedApollotooltip

  • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine): Taking these medicines alongside Frenin Injection 1 ml may cause a dangerous increase in blood pressure.
  • Oxytocic medicines (e.g., oxytocin): Using these medicines with Frenin Injection 1 ml may significantly increase the risk of severe high blood pressure.
  • Heart medicines (e.g., propranolol, metoprolol): These medicines may reduce the effectiveness of Frenin Injection 1 ml or increase the risk of a slow heart rate.

Drug-Drug Interactions

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How does the drug interact with Frenin Injection 1 ml:
Co-administration of Frenin Injection 1 ml with Sevoflurane can increase the levels of Frenin Injection 1 ml and lead to side effects.

How to manage the interaction:
Taking Frenin Injection 1 ml with Sevoflurane is not recommended, it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Frenin Injection 1 ml:
Taking Furazolidone with Frenin Injection 1 ml can cause an increase in high blood pressure.

How to manage the interaction:
Taking Furazolidone with Frenin Injection 1 ml is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sweating, lightheadedness, fainting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, consult the doctor immediately. It is advised to use Frenin Injection 1 ml only after 14 days of stopping Furazolidone.
How does the drug interact with Frenin Injection 1 ml:
Co-administration of Selegiline with Frenin Injection 1 ml together can raise blood pressure.

How to manage the interaction:
Taking Selegiline with Frenin Injection 1 ml is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience any symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting Do not discontinue any medications without consulting a doctor.
How does the drug interact with Frenin Injection 1 ml:
Taking Frenin Injection 1 ml with Propofol may lead to increased levels of Frenin Injection 1 ml leading to side effects like high blood pressure.

How to manage the interaction:
Taking Frenin Injection 1 ml with Propofol is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Frenin Injection 1 ml:
Taking Tranylcypromine with Frenin Injection 1 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Frenin Injection 1 ml is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting Do not discontinue any medications without consulting a doctor.
PhenylephrineErgotamine
Severe
How does the drug interact with Frenin Injection 1 ml:
Co-administration of Ergotamine and Frenin Injection 1 ml, can raise the risk of side effects including high blood pressure.

How to manage the interaction:
Although taking Frenin Injection 1 ml and Ergotamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of your fingers or toes, pale or cold skin, tightness in your chest, a severe headache, breathing difficulty, irregular heartbeat, vision disturbances, confusion, unclear speech, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Frenin Injection 1 ml:
Co-administration of Nortriptyline with Frenin Injection 1 ml may lead to side effects like increased blood pressure.

How to manage the interaction:
Although taking Nortriptyline and Frenin Injection 1 ml together can result in an interaction, it can be taken if a doctor has prescribed it. Regular monitoring of blood pressure is advised. Do not discontinue any medications without a doctor's advice.
PhenylephrineMethoxyflurane
Severe
How does the drug interact with Frenin Injection 1 ml:
Co-administration of Frenin Injection 1 ml with Methoxyflurane can increase the side effects of Methoxyflurane.

How to manage the interaction:
There may be a possibility of interaction between Frenin Injection 1 ml and Methoxyflurane, but it can be taken if prescribed by a doctor. Do not discontinue any medications without doctor's advice.
How does the drug interact with Frenin Injection 1 ml:
Co-administration of Frenin Injection 1 ml with Halothane may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Frenin Injection 1 ml with Halothane together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms like lightheadedness, fainting, irregular heart beat, dizziness, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Frenin Injection 1 ml:
Taking Doxepin and Frenin Injection 1 ml together may lead to side effects like increased blood pressure.

How to manage the interaction:
Although taking Doxepin and Frenin Injection 1 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms, contact your doctor immediately. Regular monitoring of blood pressure is advised. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Frenin Injection 1 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIHYPOTENSIVES]

FAQs

Frenin Injection 1 ml is used to treat Hypotension (low blood pressure).
Frenin Injection 1 ml contains Phenylephrine that works by constricting and narrowing blood vessels by acting on alpha receptors. Thus, it increases blood pressure and decreases heart rate.
Phenylephrine in Frenin Injection 1 ml may worsen heart failure due to constriction of blood vessels. Therefore, inform your doctor if you have heart failure or any other heart problem before receiving Frenin Injection 1 ml.
Frenin Injection 1 ml may cause a headache as a temporary side effect. However, if the condition persists or worsens, please inform your doctor.
When injected directly into a vein, Frenin Injection 1 ml begins working almost immediately, typically within one to two minutes, to raise your blood pressure.
It is given directly into a vein as a single injection or as a continuous liquid drip (infusion) by a nurse or doctor.
Frenin Injection 1 ml is commonly used to treat low blood pressure during spinal anesthesia for childbirth, but its use must be carefully evaluated by your medical team. Consult your doctor about the benefits and risks of this medication during pregnancy.
Alert your nurse or doctor immediately if you feel any pain, burning, or coldness around your IV line. Inform your doctor if you experience any discomfort during your infusion.
While it increases blood pressure, Frenin Injection 1 ml often causes a reflex slowing of the heart rate rather than making it beat faster. Inform your doctor if you notice any unusual sensations in your chest.
Since Frenin Injection 1 ml is typically given during surgery or critical medical care, you should completely avoid alcohol until you have fully recovered and your doctor says it is safe.
Because Frenin Injection 1 ml is injected directly into your veins in a controlled hospital setting, there are no specific food interactions, though you should follow your hospital-prescribed diet. Talk to your doctor or clinical dietitian for specific dietary guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - FRE0005
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