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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Fotrex Combikit Tablet 24+4's is used to treat rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, and cancer. It contains Methotrexate and Folic acid, which work by reducing inflammation and preventing cancer cell growth. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, and stomach upset. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer :

Alena Lifesciences Llp

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Fotrex Combikit Tablet 24+4's

Fotrex Combikit Tablet 24+4's belongs to the class of 'antimetabolite agents' primarily used to treat rheumatoid arthritis, psoriasis and juvenile idiopathic arthritis. Fotrex Combikit Tablet 24+4's is also used to treat leukaemia (blood cancer), Non-Hodgkin's lymphoma (cancer of the lymphatic system), soft tissue and bone cancer and certain types of cancer/tumours, breast, skin, head and neck, lung or uterus. Fotrex Combikit Tablet 24+4's reduces the immune system's strength to treat conditions of autoimmune diseases. Arthritis is an autoimmune disease which leads to joint pain and damage.

Fotrex Combikit Tablet 24+4's contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused by Methotrexate during chemotherapy.

Your doctor will decide the dosage based on your medical condition. In some cases, you may experience common side effects, such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach upset, stomach pain, leukopenia (decreased number of white blood cells) and soreness of mouth and lips. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are known to be allergic to Fotrex Combikit Tablet 24+4's or its inactive components, please inform your doctor. Do not take Fotrex Combikit Tablet 24+4's if you are pregnant or planning for pregnancy, as Fotrex Combikit Tablet 24+4's causes serious congenital disabilities. Fotrex Combikit Tablet 24+4's should not be taken by breastfeeding mothers as it passes into breast milk. Fotrex Combikit Tablet 24+4's can cause dizziness and drowsiness; hence, drive with caution. Fotrex Combikit Tablet 24+4's should not be given to children below three years of age, as safety and efficacy have not been established. Avoid consuming alcohol along with Fotrex Combikit Tablet 24+4's as it could lead to increased dizziness.

Uses of Fotrex Combikit Tablet 24+4's

Fotrex Combikit Tablet 24+4's is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, Juvenile idiopathic arthritis, Psoriasis, and Cancer. The detailed uses of Fotrex Combikit Tablet 24+4's are as follows:<br/> • Rheumatoid arthritis: Fotrex Combikit Tablet 24+4's reduces joint inflammation and slows disease progression.<br/> • Psoriasis: Fotrex Combikit Tablet 24+4's manages excessive skin cell growth and scaling.<br/> • Certain cancers: Fotrex Combikit Tablet 24+4's helps treat leukaemia, lymphoma, and cancers of the breast, lung, uterus, and skin.<br/> • Juvenile idiopathic arthritis: Fotrex Combikit Tablet 24+4's controls symptoms in children with autoimmune joint inflammation.<br/> • Autoimmune disorders: Fotrex Combikit Tablet 24+4's suppresses abnormal immune responses in various conditions.<br/>

Directions for Use

  • Take Fotrex Combikit Tablet 24+4's with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Fotrex Combikit Tablet 24+4's treats rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, leukaemia and cancer/tumours of the breast, skin, head and neck, lung, or uterus. It contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin B9). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It reduces pain and inflammation and slows down joint damage and disease progression over time. Hence, it is also known as a disease-modifying anti-rheumatic drug (DMARD). It also acts as an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is a water-soluble Vitamin B. It helps in the formation of red blood cells and prevents DNA changes that may lead to cancer. It prevents and treats low blood levels of folate (folate deficiency) caused by Methotrexate during chemotherapy.

How Fotrex Combikit Tablet 24+4's Works

Fotrex Combikit Tablet 24+4's contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused by Methotrexate during chemotherapy.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Fotrex Combikit Tablet 24+4's

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Fotrex Combikit Tablet 24+4's or its inactive components, please inform your doctor. Brief your medical history if you have any liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis), and active infections (including chickenpox). Fotrex Combikit Tablet 24+4's is contraindicated during pregnancy since it has harmful effects on the foetus. Please get a pregnancy test done before starting Fotrex Combikit Tablet 24+4's. You should get a negative pregnancy test for sure before using Fotrex Combikit Tablet 24+4's. Use reliable forms of birth control if you are undergoing treatment with Fotrex Combikit Tablet 24+4's to avoid pregnancy. Fotrex Combikit Tablet 24+4's should not be taken by breastfeeding mothers since it is excreted into the breast milk. Fotrex Combikit Tablet 24+4's can cause dizziness and drowsiness; hence, drive with caution. Avoid consuming alcohol along with Fotrex Combikit Tablet 24+4's as it could lead to increased dizziness. Fotrex Combikit Tablet 24+4's should not be given to children below three years of age, as safety and efficacy have not been established.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Etretinate with Fotrex Combikit Tablet 24+4's may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Fotrex Combikit Tablet 24+4's is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with pantoprazole can increase the levels and side effects of Fotrex Combikit Tablet 24+4's.

How to manage the interaction:
Although there is a possible interaction between pantoprazole and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Coadministration of Fotrex Combikit Tablet 24+4's with ketorolac can increase the blood levels and side effects of Fotrex Combikit Tablet 24+4's.

How to manage the interaction:
Although there is a interaction between Fotrex Combikit Tablet 24+4's and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Coadministration of trimethoprim with Fotrex Combikit Tablet 24+4's can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between trimethoprim and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with diclofenac can increase the levels and effects of Fotrex Combikit Tablet 24+4's. This can lead to increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Fotrex Combikit Tablet 24+4's and diclofenac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, loss of hunger, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, fits, infection, fever, chills, body aches, sore throat or muscle weakness, consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with dicloxacillin can increase the levels and effects of Fotrex Combikit Tablet 24+4's. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Fotrex Combikit Tablet 24+4's and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with clozapine may increase the risk or severity of clozapine side effects.

How to manage the interaction:
Although there is a possible interaction between clozapine and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Sirolimus with Fotrex Combikit Tablet 24+4's can increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between sirolimus and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Taking tacrolimus with Fotrex Combikit Tablet 24+4's may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Taking Human immunoglobulin with Fotrex Combikit Tablet 24+4's may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Fotrex Combikit Tablet 24+4's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help improve joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Fotrex Combikit Tablet 24+4's Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Fotrex Combikit Tablet 24+4's. It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Fotrex Combikit Tablet 24+4's is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Fotrex Combikit Tablet 24+4's. You should get a negative pregnancy test for sure before using Fotrex Combikit Tablet 24+4's. Also, please use reliable forms of birth control if you are undergoing treatment with Fotrex Combikit Tablet 24+4's to avoid pregnancy.

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Breast Feeding

Unsafe

Fotrex Combikit Tablet 24+4's is excreted into the breast milk and is not recommended during breastfeeding. Please consult your doctor before taking Fotrex Combikit Tablet 24+4's if you are a breastfeeding mother.

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Driving

Caution

Fotrex Combikit Tablet 24+4's may sometimes make you feel dizzy. Do not drive or operate machinery if you are not mentally alert and focused.

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Liver

Caution

Let your doctor know if you have any history of liver disease before taking Fotrex Combikit Tablet 24+4's. Your dosage may be adjusted in case of liver impairment.

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Kidney

Caution

Let your doctor know if you have any history of kidney disease before taking Fotrex Combikit Tablet 24+4's. Your dosage may be adjusted in case of renal impairment.

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Children

Caution

Fotrex Combikit Tablet 24+4's may be given to children for psoriasis treatment. However, it should not be used by children under three years of age, as efficacy and safety have not been established.

Have a query?

FAQs

Fotrex Combikit Tablet 24+4's is used to treat rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, and cancer.

Fotrex Combikit Tablet 24+4's contains Methotrexate and Folic acid. Methotrexate acts as an immunosuppressant and works by suppressing the overactive immune system that causes inflammation in the cells and tissues, thus preventing various autoimmune diseases. Folic acid is used to replace the folic acid deficiency caused by Methotrexate.

Fotrex Combikit Tablet 24+4's works by suppressing the overactive immune system responsible for causing psoriasis. Fotrex Combikit Tablet 24+4's interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Fotrex Combikit Tablet 24+4's. Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Methotrexate in Fotrex Combikit Tablet 24+4's causes leukopenia (decreased number of white blood cells) and may make you more susceptible to infections. Stay away from people with active infections. Consult your doctor if you develop any signs of infection, such as fever, sore throat, breathlessness, jaundice and unexplained bleeding or bruising.

Fotrex Combikit Tablet 24+4's should be used with caution if you have a medical history of liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis) and active infections (including chickenpox).

Country of origin

India

Manufacturer/Marketer address

1102 KAILAS CORPORATE LOUNGE PREM. CHS. LTD.VEER SAVARKAR MARG, VIKROLI PARKSITE, VIKROLI WEST Mumbai, Maharashtra, India - 400079
Other Info - FOT0018

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