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Fosup 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting. It contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fosup 150 mg Injection

Fosup 150 mg Injection is an injection used to prevent nausea and vomiting caused by chemotherapy treatments. It is prescribed as part of a treatment plan to help manage these common side effects of cancer therapy. This medicine helps ensure you feel more comfortable during and after your treatment cycles. Fosup 150 mg Injection is usually given together with other anti-nausea medicines, such as corticosteroids or serotonin (5-HT3) blockers. These medicines work in different ways to provide better protection against nausea and vomiting caused by chemotherapy.

This medicine is typically given as a single dose on the first day of your chemotherapy cycle. Because it is given as an injection by a healthcare provider, you do not need to worry about taking it with or without food. Making simple dietary choices, like eating light and bland foods before your appointment, can support the medicine's effects.

While taking Fosup 150 mg Injection, some people may experience mild side effects like headaches, tiredness, or mild irritation where the injection was given. These are usually temporary, but you must contact your healthcare provider immediately if you experience severe symptoms, such as difficulty breathing or signs of liver damage.

Do not take this if you are allergic to Fosup 150 mg Injection or any of its ingredients. Before starting treatment, you must tell your healthcare provider if you have a history of liver disease or other serious health problems. Also tell your healthcare provider if you have kidney problems or are receiving dialysis, as this information helps your cancer care team plan and monitor your overall treatment safely. Your doctor will determine if this medicine is safe for your specific situation.

This medicine can interact with other drugs, including blood thinners and hormonal birth control, which may make your birth control less effective. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits of this treatment. When this medicine is used in children or adolescents, the dose and treatment plan are carefully decided by a specialist. Its use may not be suitable for all younger children, depending on their age and body weight.

Uses of Fosup 150 mg Injection

Your doctor may prescribe Fosup 150 mg Injection to help manage the following conditions:

  • Chemotherapy-induced nausea and vomiting: Fosup 150 mg Injection is used to prevent both the immediate and delayed nausea and vomiting that can occur with strong chemotherapy medications.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Relieves Chemotherapy-Related Nausea and Vomiting: Fosup 150 mg Injection provides effective relief from severe nausea and vomiting, allowing patients to complete their scheduled chemotherapy cycles with less physical distress. By blocking the body's sickness signals, it helps you maintain your strength and appetite during treatment.
  • Supports Recovery After Chemotherapy: Because this medicine works to prevent delayed symptoms, it continues to provide protection for several days after your chemotherapy session. This long-lasting effect reduces the need for multiple daily oral anti-nausea medications, making your recovery process easier to manage.
Side effects of Fosup 150 mg Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • The doctor or healthcare professional will administer Fosup 150 mg Injection.
  • Do not self-administer.

How Fosup 150 mg Injection Works

Fosup 150 mg Injection contains fosaprepitant, which is given as an injection into a vein, where your body quickly converts it into its active form. Once active, it works by blocking specific chemical receptors in your brain and digestive system called neurokinin-1 (NK1) receptors. By blocking these receptors, the medicine prevents a natural chemical in your body known as substance P from binding to them. Because substance P is the primary trigger for the vomiting reflex during chemotherapy, blocking this pathway stops the signals that make you feel sick and vomit.
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Alcohol

Consult your doctor

The interaction of alcohol with Fosup 150 mg Injection is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Fosup 150 mg Injection. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Fosaprepitant is excreted in breast milk. Hence, if you are a nursing mother, discuss with your doctor about the best way to feed your baby if you receive Fosup 150 mg Injection.

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Driving

Caution

Fosup 150 mg Injection may cause dizziness or sleepiness in some people. Therefore, if you feel dizzy or sleepy after receiving Fosup 150 mg Injection, avoid driving or operating machinery.

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Liver

Caution

If you have liver disease, inform your doctor before receiving Fosup 150 mg Injection.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before receiving Fosup 150 mg Injection.

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Children

Caution

If you have any concerns regarding the use of Fosup 150 mg Injection in children, please consult a doctor.

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Heart

Caution

Fosup 150 mg Injection should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Fosup 150 mg Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Fosup 150 mg Injection to geriatric patients. Your doctor will prescribe Fosup 150 mg Injection if the benefits outweigh the risks.

What if I have taken an overdose of Fosup 150 mg Injection

Since this medicine is prepared and given by trained medical professionals, an overdose is extremely rare. However, if you suspect you have received too much or if you experience severe, unusual symptoms after your infusion, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat Smaller Meals More Often: Eat small, frequent meals throughout the day instead of three large meals to keep your stomach settled.
  • Choose Gentle, Low-Fat Foods: Choose bland, dry foods like crackers, toast, oatmeal, or plain rice, and avoid greasy, fried, or very spicy foods.
  • Sip Fluids Between Meals: Stay hydrated by sipping clear liquids, water, ginger ale, or herbal teas slowly between your meals rather than during them.
  • Avoid Lying Down After Eating: Avoid lying down flat for at least 30 to 60 minutes after eating; keeping your head elevated supports healthy digestion.
  • Avoid Tight Clothing Around Your Waist: Wear loose, comfortable clothing around your stomach to prevent unnecessary pressure on your abdomen.
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How Soon It Starts Working

The time required for Fosup 150 mg Injection to start to work: Fosup 150 mg Injection ideally shows its action within 30 minutes after administration. The time for which the effects of Fosup 150 mg Injection last: The duration of action for Fosup 150 mg Injection is unknown.

What if you forget to take Fosup 150 mg Injection

Because this medicine is given in a clinic or hospital setting by a healthcare professional, missing a dose is highly unlikely. If you miss your scheduled appointment or if your chemotherapy is delayed, contact your healthcare provider immediately to reschedule your infusion.

Storage

• Unopened vials of Fosup 150 mg Injection powder are stored in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze the vials.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do Not Receive This Medicine if Advised Otherwise: Tell your doctor if you have ever had an allergic reaction to Fosup 150 mg Injection or if you are taking pimozide. If you have severe liver disease, your doctor will carefully decide whether this medicine is suitable for you.
  • Watch for Injection Site Reactions: Watch the injection site closely during your infusion and tell your nurse immediately if you feel any burning, stinging, coldness, or pain.
  • Check IV Solution Before Use: Ensure that the liquid solution in the IV line is clear and free of any visible particles before the infusion begins.
  • Use Backup Birth Control: If you use hormonal birth control (such as pills, patches, or vaginal rings), use a reliable backup barrier method (like condoms) during your treatment and for at least one month after your last dose, as Fosup 150 mg Injection can make hormonal contraceptives less effective.
  • Tell Your Doctor About Blood Thinners: Inform your healthcare provider if you are taking blood thinners, as you may need extra blood tests to monitor your clotting times after receiving this medicine.
  • Avoid Driving if Drowsy or Dizzy: Avoid driving, operating machinery, or performing dangerous tasks if you feel dizzy or extremely tired after your infusion.

Drug-Drug Interactions

verifiedApollotooltip
  • Pimozide: Do not take Fosup 150 mg Injection if you are taking pimozide, as this combination can cause severe and life-threatening heart rhythm issues.
  • Hormonal Contraceptives: May decrease the effectiveness of birth control pills, patches, or implants, which increases the risk of pregnancy.
  • Warfarin: Can decrease the effectiveness of warfarin, increasing the risk of blood clots. Your doctor may need to monitor your blood clotting levels closely.
  • Dexamethasone or Methylprednisolone: May increase the levels of these steroid medicines in your body, so your doctor may choose to lower your steroid dose.
  • Share Your Complete Medication List: Fosup 150 mg Injection can also interact with many other prescription medicines, over-the-counter medicines, vitamins, and herbal supplements because it affects the way certain liver enzymes process medicines. Always give your healthcare provider a complete list of everything you take before starting treatment. 
FosaprepitantEliglustat
Critical
FosaprepitantLomitapide
Critical

Drug-Drug Interactions

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FosaprepitantEliglustat
Critical
How does the drug interact with Fosup 150 mg Injection:
When Fosup 150 mg Injection is taken with Eliglustat, can increase Eliglustat levels in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Fosup 150 mg Injection and Eliglustat, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantLomitapide
Critical
How does the drug interact with Fosup 150 mg Injection:
When Fosup 150 mg Injection is taken with Lomitapide, it can increase the levels of Lomitapide. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection with Lomitapide together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - diarrhea, nausea, vomiting, pain, discomfort, indigestion, constipation, liver damage, fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, dark colored urine, bleeding or vomiting - make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
FosaprepitantTerfenadine
Critical
How does the drug interact with Fosup 150 mg Injection:
When Fosup 150 mg Injection is taken with Terfenadine, it can lower the rate at which Fosup 150 mg Injection is broken down and increases its levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection and Terfenadine together is generally avoided as it can show an interaction, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like Chest discomfort, Shortness of breath, Weakness, or palpitations, it's important to call your doctor right away - they can be serious heart problems. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fosup 150 mg Injection:
When Pimozide is taken with Fosup 150 mg Injection, it can increase the Pimozide levels in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection with Pimozide is not recommended, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, prolonged diarrhea, or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Cisapride can increase the levels of Cisapride in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection with Cisapride together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantFlibanserin
Critical
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Flibanserin can increase the levels of Flibanserin in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection with Flibanserin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FosaprepitantAstemizole
Critical
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Astemizole can increase the levels of Astemizole in the body. This increases the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Fosup 150 mg Injection with Astemizole together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantGuanfacine
Severe
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Guanfacine can increase the levels of Guanfacine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Fosup 150 mg Injection and Guanfacine, but it can be taken if prescribed by a doctor. If you start feeling drowsiness, dizziness, lightheadedness, fainting, headache, or palpitations, it's a good idea to call a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Deflazacort can increase the levels of Deflazacort in the body.

How to manage the interaction:
Taking Fosup 150 mg Injection with Deflazacort together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like high blood pressure, high blood glucose, muscle weakness, mood swings, acne, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FosaprepitantCobimetinib
Severe
How does the drug interact with Fosup 150 mg Injection:
Coadministration of Fosup 150 mg Injection with Cobimetinib can increase the levels of Cobimetinib in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosup 150 mg Injection with Cobimetinib together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, diarrhea, mouth sores, bleeding, heart problems, rash, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Fosup 150 mg Injection when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Fosup 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting.
Fosup 150 mg Injection works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.
Fosup 150 mg Injection may cause constipation as a common side effect. However, if the condition persists or worsens, please consult your doctor.
You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain intrauterine devices (IUDs) as they may not work properly when taken together with Fosup 150 mg Injection. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Fosup 150 mg Injection and for up to 1 month after using Fosup 150 mg Injection.
Fosup 150 mg Injection is given as an intravenous infusion (an injection into a vein) by a healthcare provider in a clinic or hospital. Talk to your doctor if you have questions about your injection schedule.
It is not fully known if Fosup 150 mg Injection is safe to use during pregnancy. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the benefits and risks of this treatment.
No, Fosup 150 mg Injection is specifically used to prevent nausea and vomiting caused by chemotherapy treatments. It is not meant for motion sickness or other general causes of stomach upset. Talk to your doctor for more details.
Mild pain or redness can occur at the injection site. However, if the pain is severe, or if you notice swelling, warmth, or skin peeling, contact your doctor immediately.
Alcohol can worsen chemotherapy side effects like nausea, dizziness, and dehydration. It is best to avoid alcohol during your treatment. Talk to your doctor or pharmacist for personalised advice.
No, Fosup 150 mg Injection is used to prevent nausea and vomiting before it starts, rather than treating active symptoms. Talk to your doctor about other medicines if you are currently feeling sick.

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Country of origin

India

Manufacturer/Marketer address

D' Block, 3Rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - FOS0057
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