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  3. FOSOLIN 750MG INJECTION 10ML

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FOSOLIN 750MG INJECTION 10ML, Pack of 1
FOSOLIN 750MG INJECTION 10ML, Pack of 1
FOSOLIN 750MG INJECTION 10ML, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

FOSOLIN 750MG INJECTION is used to treat primary generalized tonic-clonic seizures (A tonic-clonic seizure, previously known as a grand mal seizure, causes a loss of consciousness and violent muscle contractions) and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Fosphenytoin injection may also be used to control certain types of seizures in people who cannot take oral phenytoin. It contains 'Fosphenytoin Sodium' that decreases the brain's abnormal electrical activity.

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Synonym :

FOSPHENYTOIN

Composition :

FOSPHENYTOIN SODIUM-750MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About FOSOLIN 750MG INJECTION

FOSOLIN 750MG INJECTION belongs to the class of drugs known as anticonvulsants. It is used to treat generalized tonic-clonic seizures as well as to treat and prevent seizures that may occur during or after brain or nervous system operations. A tonic-clonic seizure, often called a grand mal seizure, is characterized by a loss of consciousness and strong muscle contractions. Seizures are uncontrollable bursts of electrical activity in the brain.

FOSOLIN 750MG INJECTION contains 'Fosphenytoin Sodium' that decreases the brain's abnormal electrical activity.

A healthcare professional will administer FOSOLIN 750MG INJECTION. In some cases, FOSOLIN 750MG INJECTION may cause common side effects such as loss of coordination, confusion, dizziness, weakness, dysarthria (slurred speech), dry mouth, headache, vision problems and constipation. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before using the FOSOLIN 750MG INJECTION, inform your doctor about your medical conditions, sensitivities, and all the ongoing medications. Continue using FOSOLIN 750MG INJECTION for as long as your doctor has prescribed. Treatment with FOSOLIN 750MG INJECTION should be gradually withdrawn, so do not stop taking FOSOLIN 750MG INJECTION without consulting your doctor. Consult your doctor immediately if you observe any behavioural changes or suicidal tendencies. FOSOLIN 750MG INJECTION may impair your ability to judge, think clearly, or respond quickly. Do not drive, operate heavy machinery, or engage in risky activities. Avoid consuming alcohol with FOSOLIN 750MG INJECTION as it could increase drowsiness and dizziness. Breastfeeding is not recommended for women receiving fosphenytoin sodium injections. It is recommended not to use while pregnant, so inform your doctor if you are pregnant or expect pregnancy.

Uses of FOSOLIN 750MG INJECTION

FOSOLIN 750MG INJECTION is used for the treatment and prevention of seizures. The detailed uses of FOSOLIN 750MG INJECTION are as follows:<br/>• Manages generalized tonic-clonic seizures: FOSOLIN 750MG INJECTION is indicated for the treatment of primary generalized tonic-clonic (grand mal) seizures.<br/>• Prevents post-surgical seizures: FOSOLIN 750MG INJECTION is used to treat and prevent seizures occurring during or after brain or nervous system surgery.<br/>• Alternative for oral phenytoin: FOSOLIN 750MG INJECTION is used to control certain types of seizures in individuals who cannot take oral phenytoin.<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• FOSOLIN 750MG INJECTION will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

FOSOLIN 750MG INJECTION belongs to the group of medicines called anticonvulsants. It is used to treat primary generalized tonic-clonic seizures (A tonic-clonic seizure, previously known as a grand mal seizure, causes a loss of consciousness and violent muscle contractions) and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Fosphenytoin injection may also be used to control certain types of seizures in people who cannot take oral phenytoin.

How FOSOLIN 750MG INJECTION Works

FOSOLIN 750MG INJECTION contains 'Fosphenytoin Sodium' that decreases the brain's abnormal electrical activity.

Storage

• Store in a cool and dry place away from sunlight.• Keep FOSOLIN 750MG INJECTION out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Fosolin 750mg Injection 10ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of FOSOLIN 750MG INJECTION

As FOSOLIN 750MG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of FOSOLIN 750MG INJECTION may cause fatigue, fainting, irregular heartbeat, loss of coordination, nausea, slow or slurred speech, uncontrollable eye movements, uncontrollable shaking of a part of the body, and vomiting.

Drug Warnings

Do not take FOSOLIN 750MG INJECTION if you are allergic to any of its contents. Inform your doctor if you have had heart failure, low blood pressure, irregular heart rhythms, or heart block. Do not drive or operate heavy machinery as FOSOLIN 750MG INJECTION may impair your ability to drive or operate machinery. Avoid consumption of alcohol as it may cause increased dizziness/drowsiness and affect the concentration of Fosphenytoin in the blood. While receiving the fosphenytoin injection or afterwards, you may encounter acute or life-threatening low blood pressure or abnormal heart rhythms. If you experience any of the symptoms, contact your doctor right away. It is recommended not to be used in pregnant women and nursing mothers. So inform your doctor if you are pregnant or breastfeeding women before receiving this medicine.

Drug-Drug Interactions

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FosphenytoinLurasidone
Critical
FosphenytoinImatinib
Severe

Drug-Drug Interactions

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FosphenytoinLurasidone
Critical
How does the drug interact with Fosolin 750mg Injection 10ml:
Lurasidone co-administration with Fosolin 750mg Injection 10ml may result in significantly lower blood levels of lurasidone, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
Although there is an interaction between Lurasidone and Fosolin 750mg Injection 10ml, you can take it if your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
FosphenytoinImatinib
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking Imatinib and Fosolin 750mg Injection 10ml together may reduce the blood levels of Imatinib, which could reduce its capacity to treat the cancer, at the same time, Fosolin 750mg Injection 10ml levels may increase leading to side effects.

How to manage the interaction:
There may be a possibility of interaction between Fosolin 750mg Injection 10ml and Imatinib, but it can be taken if prescribed by a doctor. If you're having any of these symptoms- dizziness, tremors, weakness, disorientation, hallucinations, nausea, vomiting, twitching eyelids, blurred vision, difficulty speaking, loss of balance or coordination, contact a doctor right away. Do not stop using any medications without a doctor's advice.
FosphenytoinIrinotecan
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Fosolin 750mg Injection 10ml is taken with Irinotecan, it can make the body process Irinotecan faster. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Fosolin 750mg Injection 10ml and Irinotecan together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without first consulting your doctor.
FosphenytoinPraziquantel
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Praziquantel is taken with Fosolin 750mg Injection 10ml, it can cause the body to break down Praziquantel faster. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Fosolin 750mg Injection 10ml and Praziquantel, but it can be taken if prescribed by a doctor. If you experience symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
FosphenytoinTenofovir disoproxil
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Tenofovir disoproxil is taken with Fosolin 750mg Injection 10ml, the amount of Tenofovir disoproxil in the blood may decrease.

How to manage the interaction:
Taking Fosolin 750mg Injection 10ml with Tenofovir disoproxil together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
FosphenytoinDelavirdine
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Coadministration of Fosolin 750mg Injection 10ml with Delavirdine can reduce the levels of Delavirdine in the body. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Fosolin 750mg Injection 10ml and Delavirdine, but it can be taken if prescribed by a doctor. If you notice any symptoms like Fever and muscle pains, Headache, Sore throat, Night sweats, Mouth sores, Swollen lymph glands, or Diarrhea, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
FosphenytoinClindamycin
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Clindamycin is taken with Fosolin 750mg Injection 10ml, it can cause the body to process Clindamycin faster.

How to manage the interaction:
Although there is a possible interaction between Clindamycin and Fosolin 750mg Injection 10ml, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like sudden drowsiness, fatigue, confusion, itching, burning, or tingling sensation, abnormal body movements, or loss of coordination, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
FosphenytoinDesogestrel
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Coadministration of Fosolin 750mg Injection 10ml with Desogestrel can reduce the levels and effects of Desogestrel in the body. This can lead to low treatment outcomes and increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Co-administration of Desogestrel with Fosolin 750mg Injection 10ml can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms: abnormal menstruation, dryness of the vagina, or increased hot flushes or if you're looking for other birth control options, consult a doctor. Do not discontinue any medications without consulting a doctor.
FosphenytoinCariprazine
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking Cariprazine with Fosolin 750mg Injection 10ml may reduce the blood levels of cariprazine, which may make the medication less effective.

How to manage the interaction:
Taking Cariprazine with Fosolin 750mg Injection 10ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any unusual symptoms or if your condition worsens, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
FosphenytoinVoriconazole
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking Fosolin 750mg Injection 10ml and Voriconazole can alter the levels and effects of both Fosolin 750mg Injection 10ml and Voriconazole.

How to manage the interaction:
Although taking Fosolin 750mg Injection 10ml together with Voriconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, and/or visual disturbances. Do not stop taking any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for people with epilepsy. This diet helps utilise fat instead of glucose to generate energy.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Exercise, meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Install an alarm or emergency device to get assistance during a seizure attack.
  • Have a seizure response plan, which helps those around you know what to do.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking FOSOLIN 750MG INJECTION to prevent unpleasant side effects. It might also affect the concentration of Fosphenytoin Sodium in the blood.

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Pregnancy

Caution

FOSOLIN 750MG INJECTION should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Caution

Avoid breastfeeding while on treatment with FOSOLIN 750MG INJECTION. Please discuss with your doctor if you have any concerns.

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Driving

Unsafe

FOSOLIN 750MG INJECTION may temporarily cause vision disturbances; therefore, wait until your vision returns to normal before using machinery or driving.

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Liver

Caution

FOSOLIN 750MG INJECTION should be used with caution in patients with liver illness. Inform your doctor before receiving the FOSOLIN 750MG INJECTION if you have/had a liver illness. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

FOSOLIN 750MG INJECTION should be used with caution in patients with kidney illness. Inform your doctor before receiving the FOSOLIN 750MG INJECTION if you have/had a kidney illness. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

FOSOLIN 750MG INJECTION can be given to children if prescribed by the doctor.

FAQs

FOSOLIN 750MG INJECTION is used to treat Tonic-clonic seizures.

FOSOLIN 750MG INJECTION contains Fosphenytoin Sodium; that decreases the brain's abnormal electrical activity.

One of the most prevalent side effects of FOSOLIN 750MG INJECTION is dysarthria (slurred speech). It normally does not require medical attention and resolves on its own. However, if the illness persists or worsens, please seek medical attention.

FOSOLIN 750MG INJECTION frequently causes vision difficulties and uncontrollable eye movements. It normally does not require medical care and resolves on its own over time. However, if the issue persists or worsens, consult a doctor.

Fosphenytoin is not recommended for patients who have a history of hypersensitivity to fosphenytoin or its constituents, as well as phenytoin or other hydantoins.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - FOS0003

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:20 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/076886s000lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a619063.html
  3. https://www.drugs.com/drug-interactions/fosphenytoin-index.html

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