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FOSOLIN 750MG INJECTION is used to treat primary generalized tonic-clonic seizures (A tonic-clonic seizure, previously known as a grand mal seizure, causes a loss of consciousness and violent muscle contractions) and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Fosphenytoin injection may also be used to control certain types of seizures in people who cannot take oral phenytoin. It contains 'Fosphenytoin Sodium' that decreases the brain's abnormal electrical activity.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About FOSOLIN 750MG INJECTION

FOSOLIN 750MG INJECTION is a prescription injection used to control and prevent severe, rapid seizures, including a dangerous, continuous seizure state called status epilepticus. It is typically given in a hospital or emergency room setting to stabilise your brain's electrical activity during critical moments. This medicine is designed for short-term use when standard oral seizure medicines cannot be given safely.

Because this medicine is injected directly into a vein or muscle by a healthcare professional, you do not need to worry about taking it with or without food. Your care team will ensure it is given on a precise schedule to keep steady levels of the medicine in your body. To support your recovery and long-term seizure control, your doctor may suggest simple daily habits like maintaining a regular sleep routine and managing daily stress.

While receiving this injection, you might experience temporary and mild side effects such as itching, dizziness, or sleepiness. However, if you experience serious issues like a very slow heartbeat, severe skin reactions, or sudden changes in your mood, it is critical to alert your healthcare team immediately. Your safety is always the priority, and close monitoring helps manage these risks.

Before you receive this medicine, talk to your doctor if you have a history of liver damage, kidney issues, or heart disease. You must not receive this medicine if you have a known severe allergy to fosphenytoin, phenytoin, or other hydantoin medicines, or if you have specific conditions such as porphyria (a rare genetic blood disorder), severe heart conditions including sinus bradycardia (an abnormally slow heartbeat), sinoatrial (SA) block, or second- or third-degree AV block. Your doctor will evaluate your health history to ensure this treatment is safe for you.

This injection can interact with other drugs, alcohol, and tobacco, which can unexpectedly raise or lower the medicine's levels in your blood and lead to side effects. If you are pregnant, breastfeeding, or are an elderly individual, please consult your doctor or pharmacist, as you may require special monitoring or a modified treatment plan.

Uses of FOSOLIN 750MG INJECTION

FOSOLIN 750MG INJECTION is used to control and prevent certain types of severe seizures. The detailed uses of FOSOLIN 750MG INJECTION are as follows:

  • Status epilepticus: FOSOLIN 750MG INJECTION helps by quickly stopping continuous, life-threatening seizures to protect your brain and restore stable electrical activity.
  • Seizure prevention during surgery: FOSOLIN 750MG INJECTION helps by protecting the brain from starting new seizures during or directly after brain surgery or head injuries.
  • Temporary seizure control: FOSOLIN 750MG INJECTION helps maintain steady seizure control when you are temporarily unable to take your regular seizure medicines by mouth.

Key Benefits

FOSOLIN 750MG INJECTION provides rapid seizure control during medical emergencies and helps maintain continuous treatment when oral medicines cannot be used. The key benefits of FOSOLIN 750MG INJECTION are as follows:

  • Rapid Seizure Control: FOSOLIN 750MG INJECTION acts quickly when given by injection to stop severe, ongoing seizures, helping protect the brain and reduce the risk of seizure-related complications.
  • Gentler on Veins and Tissues: Unlike older injectable seizure treatments (such as standard IV phenytoin), FOSOLIN 750MG INJECTION has a neutral pH, making it far less prone to causing severe vein irritation, pain, or tissue breakdown at the injection site.
  • Faster and More Flexible Delivery: It can be infused into a vein significantly faster than standard phenytoin and can also be injected into a muscle, allowing healthcare providers to administer critical medicine without delay in emergency situations.
  • Suitable When Oral Medicines Cannot Be Taken: This medicine provides effective seizure control for patients who are unconscious, unable to swallow, or recovering from surgery, ensuring essential treatment continues without interruption.
Side effects of Fosolin 750mg Injection 10ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • FOSOLIN 750MG INJECTION will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How FOSOLIN 750MG INJECTION Works

FOSOLIN 750MG INJECTION contains fosphenytoin sodium, which acts as a temporary vehicle that quickly converts into the active medicine your brain needs to stop a seizure. Once active, it works by calming overactive nerve cells in your brain that are firing out of control. By blocking rapid, repetitive electrical signals, the medicine helps stabilise the brain's natural electrical pathways. This steadying effect brings the brain back to a calm, balanced state, effectively stopping active seizures and keeping new ones from starting.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking FOSOLIN 750MG INJECTION to prevent unpleasant side effects. It might also affect the concentration of Fosphenytoin Sodium in the blood.

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Pregnancy

Caution

FOSOLIN 750MG INJECTION should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Caution

Avoid breastfeeding while on treatment with FOSOLIN 750MG INJECTION. Please discuss with your doctor if you have any concerns.

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Driving

Unsafe

FOSOLIN 750MG INJECTION may temporarily cause vision disturbances; therefore, wait until your vision returns to normal before using machinery or driving.

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Liver

Caution

FOSOLIN 750MG INJECTION should be used with caution in patients with liver illness. Inform your doctor before receiving the FOSOLIN 750MG INJECTION if you have/had a liver illness. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

FOSOLIN 750MG INJECTION should be used with caution in patients with kidney illness. Inform your doctor before receiving the FOSOLIN 750MG INJECTION if you have/had a kidney illness. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

FOSOLIN 750MG INJECTION can be given to children if prescribed by the doctor.

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Heart

Caution

Inform your doctor before receiving FOSOLIN 750MG INJECTION if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available about the use of FOSOLIN 750MG INJECTION in geriatric patients. Please consult your physician.

What if I have taken an overdose of FOSOLIN 750MG INJECTION

If you suspect an overdose, seek emergency medical care immediately. Signs of receiving too much of this medicine can include severe drowsiness, rapid or uncontrollable eye movements, slurred speech, loss of balance, or shallow breathing.

Diet & Lifestyle Advise

  • Prioritise sleep: Aim for a consistent, restful sleep schedule every night, as lack of sleep is a common trigger for sudden seizures.
  • Avoid alcohol completely: Alcohol can interfere with FOSOLIN 750MG INJECTION, changing how your body processes the medicine and increasing your risk of seizures.
  • Keep a seizure diary: Note down when your seizures occur, what you were doing, and any side effects you feel to help your doctor optimise your care.
  • Manage stress: Practice simple stress-relief techniques like deep breathing, gentle stretching, or quiet meditation, as high stress can lower your seizure threshold.
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How Soon It Starts Working

The time required for FOSOLIN 750MG INJECTION to start to work: FOSOLIN 750MG INJECTION shows its effect within 30 minutes after intramuscular and rapid action on IV administration. The time for which the effects of FOSOLIN 750MG INJECTION last: The duration of FOSOLIN 750MG INJECTION’s effect is clinically not established.

What if you forget to take FOSOLIN 750MG INJECTION

Since this medicine is usually injected by a healthcare professional in a clinic or hospital, it is unlikely that you will miss a dose. However, if you are using this medicine at home and miss a scheduled injection, contact your doctor or pharmacist immediately for guidance. Do not inject a double dose to make up for a missed one.

Storage

• Store FOSOLIN 750MG INJECTION vials in a refrigerator between 2°C and 8°C (36°F to 46°F).• Do not freeze this medicine, and discard any vial that has been frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the Solution: Always inspect the liquid vial before injecting; the solution should be clear and colourless to pale yellow. Do not use it if it looks cloudy, discoloured, or contains tiny particles.
  • Heart Monitoring: Ensure a healthcare professional monitors your heart rhythm and blood pressure continuously during an intravenous infusion to keep you safe.
  • Injection Site Care: If injecting at home, rotate your injection sites as instructed to prevent skin irritation or muscle damage, and never reuse needles.
  • Driving and Machinery: Do not drive, use tools, or operate machinery until you know how this medicine affects you, as it can cause significant dizziness and drowsiness.
  • Do Not Stop Suddenly: Never stop receiving this medicine suddenly, as stopping it abruptly can trigger severe, continuous seizures that are hard to stop.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart medicines (like amiodarone): May change how your body processes FOSOLIN 750MG INJECTION, increasing the risk of side effects.
  • Hormonal birth control: FOSOLIN 750MG INJECTION can make birth control pills, patches, or implants less effective, raising the risk of unplanned pregnancy.
  • Other seizure medicines: Can unpredictably raise or lower the amount of medicine in your blood, requiring close monitoring by your doctor.
  • Sedatives or sleep aids: Combining these with FOSOLIN 750MG INJECTION can cause severe drowsiness or slow your breathing to a dangerous level.
FosphenytoinLurasidone
Critical
FosphenytoinOlaparib
Severe

Drug-Drug Interactions

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FosphenytoinLurasidone
Critical
How does the drug interact with Fosolin 750mg Injection 10ml:
Lurasidone co-administration with Fosolin 750mg Injection 10ml may result in significantly lower blood levels of lurasidone, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
Although there is an interaction between Lurasidone and Fosolin 750mg Injection 10ml, you can take it if your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
FosphenytoinOlaparib
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Olaparib is taken with Fosolin 750mg Injection 10ml, it can cause Olaparib to be broken down faster in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Olaparib with Fosolin 750mg Injection 10ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
FosphenytoinTemsirolimus
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Temsirolimus is taken with Fosolin 750mg Injection 10ml, it can cause Temsirolimus to be broken down faster in the body. This can lead to low treatment outcomes

How to manage the interaction:
Although taking Fosolin 750mg Injection 10ml and Temsirolimus together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any unusual symptoms or if your condition worsens, make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.
FosphenytoinDasatinib
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Using Dasatinib with Fosolin 750mg Injection 10ml may significantly reduce the blood levels of dasatinib.

How to manage the interaction:
There may be a possibility of interaction between Fosolin 750mg Injection 10ml and Dasatinib, but it can be taken if prescribed by a doctor. However, if you experience side effects like unusual bleeding, swelling, palpitations, shortness of breath, chest pain or tightness, or heart rhythm changes, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
FosphenytoinRisperidone
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking risperidone with Fosolin 750mg Injection 10ml may significantly reduce the blood levels of risperidone.

How to manage the interaction:
Although there is a possible interaction between Fosolin 750mg Injection 10ml and Risperidone, you can take these medicines together if prescribed by a doctor. However, if you experience unusual symptoms contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
FosphenytoinNifedipine
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
When Fosolin 750mg Injection 10ml is taken with Nifedipine, the amount of Fosolin 750mg Injection 10ml in the blood can be reduced.

How to manage the interaction:
Co-administration of Fosolin 750mg Injection 10ml with Nifedipine can result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like sweating, dizziness, confusion, drowsiness, sweating, chest pain or tightness, palpitations, headache, nausea, or vomiting, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FosphenytoinImatinib
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking Imatinib and Fosolin 750mg Injection 10ml together may reduce the blood levels of Imatinib, which could reduce its capacity to treat the cancer, at the same time, Fosolin 750mg Injection 10ml levels may increase leading to side effects.

How to manage the interaction:
There may be a possibility of interaction between Fosolin 750mg Injection 10ml and Imatinib, but it can be taken if prescribed by a doctor. If you're having any of these symptoms- dizziness, tremors, weakness, disorientation, hallucinations, nausea, vomiting, twitching eyelids, blurred vision, difficulty speaking, loss of balance or coordination, contact a doctor right away. Do not stop using any medications without a doctor's advice.
FosphenytoinApixaban
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Coadministration of Fosolin 750mg Injection 10ml can significantly reduce the blood levels of apixaban.

How to manage the interaction:
Although the Co-administration of Fosolin 750mg Injection 10ml and Apixaban can lead to interaction, they can be taken in case a doctor advises it to. Fosolin 750mg Injection 10ml makes Apixaban less effective in treating and preventing blood clots. Never discontinue taking a medication without consulting a doctor.
FosphenytoinNimodipine
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Co-administration of Nimodipine with Fosolin 750mg Injection 10ml may make the medication less effective.

How to manage the interaction:
Although taking Nimodipine and Fosolin 750mg Injection 10ml together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
FosphenytoinEverolimus
Severe
How does the drug interact with Fosolin 750mg Injection 10ml:
Taking Everolimus and Fosolin 750mg Injection 10ml may reduce the blood levels of everolimus, which may make it less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Everolimus and Fosolin 750mg Injection 10ml, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol completely, as it can unpredictably change your blood levels of FOSOLIN 750MG INJECTION and increase your risk of severe seizures.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

FOSOLIN 750MG INJECTION is used to treat Tonic-clonic seizures.
FOSOLIN 750MG INJECTION contains Fosphenytoin Sodium; that decreases the brain's abnormal electrical activity.
One of the most prevalent side effects of FOSOLIN 750MG INJECTION is dysarthria (slurred speech). It normally does not require medical attention and resolves on its own. However, if the illness persists or worsens, please seek medical attention.
FOSOLIN 750MG INJECTION frequently causes vision difficulties and uncontrollable eye movements. It normally does not require medical care and resolves on its own over time. However, if the issue persists or worsens, consult a doctor.
Fosphenytoin is not recommended for patients who have a history of hypersensitivity to fosphenytoin or its constituents, as well as phenytoin or other hydantoins.
You should talk to your doctor if you are pregnant or planning to become pregnant. While this medicine carries risks to an unborn baby, uncontrolled seizures are also highly dangerous to both you and your baby, so your doctor will carefully weigh the risks and benefits. Talk to your doctor to understand your options.
FOSOLIN 750MG INJECTION is designed specifically as an injection to allow the medicine to enter your bloodstream rapidly during emergencies, or when you are unable to swallow tablets safely. Talk to your doctor if you have questions about transitioning to oral medicine later.
Yes, this medicine can make hormonal contraceptives like birth control pills, patches, or rings less effective. It is best to use a reliable, non-hormonal barrier method (such as condoms) while receiving this treatment. Talk to your doctor or pharmacist for advice.
No, you must avoid alcohol. Alcohol can interfere with how your body processes FOSOLIN 750MG INJECTION, which can increase your risk of seizures or make side effects like dizziness and sleepiness much worse. Talk to your doctor if you need support.
Some mild irritation can happen, but if you notice severe pain, swelling, redness, or skin changes where the medicine was injected, notify your healthcare provider or doctor immediately. Talk to your doctor if you experience these symptoms.
Yes, this medicine can occasionally affect your heartbeat, which is why your heart rate is closely monitored during the injection. Talk to your doctor if you have a history of heart conditions before receiving this treatment.
FOSOLIN 750MG INJECTION is a specialised form of the medicine that your body quickly turns into active phenytoin after injection. It is designed to be much gentler on your veins and can be given more rapidly than standard phenytoin injections. Talk to your doctor or pharmacist to learn more.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - FOS0003
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