Folitrax-50 Injection 2 ml

Prescription drug

MRP ₹135.5

(Inclusive of all Taxes)

₹20.3 Cashback (15%)

Extra 15% Off with Bank Offers

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Veda Maddala , M Pharmacy

Folitrax-50 Injection 2 ml belongs to the class of antimetabolite medications used in the treatment of polyarticular juvenile rheumatoid arthritis, psoriasis, and cancer. It contains Methotrexate, which works by interfering with the immune system process that causes inflammation and prevents the growth of cancer-causing cells. This medicine may cause side effects like nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, and loss of appetite. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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About Folitrax-50 Injection 2 ml

Folitrax-50 Injection 2 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis.

Folitrax-50 Injection 2 ml is also used to treat cancer, such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), bone cancer, and advanced-stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Folitrax-50 Injection 2 ml contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time.

Folitrax-50 Injection 2 ml prevents and stops the growth of cancer cells, thereby helping treat cancer. Folitrax-50 Injection 2 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Folitrax-50 Injection 2 ml may cause side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, and tingling sensation. Talk to your doctor if you experience any of the side effects persistently.

Do not take Folitrax-50 Injection 2 ml if you are pregnant or breastfeeding. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Folitrax-50 Injection 2 ml

Folitrax-50 Injection 2 ml is used to treat autoimmune diseases and certain types of cancer. The detailed uses of Folitrax-50 Injection 2 ml are as follows:

Treatment of rheumatoid arthritis: Folitrax-50 Injection 2 ml helps reduce joint pain, swelling, and stiffness by suppressing the overactive immune system that causes joint inflammation.
Management of psoriasis: Folitrax-50 Injection 2 ml slows down the rapid growth of skin cells and reduces skin inflammation, helping to control severe psoriasis.
Treatment of cancer: Folitrax-50 Injection 2 ml is used as a chemotherapy agent in certain cancers like leukaemia, lymphoma, and breast cancer by interfering with the growth of cancer cells.

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Directions for Use

Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
Folitrax-50 Injection 2 ml will be administered by the doctor.
Do not self-administer.

Medicinal Benefits

Folitrax-50 Injection 2 ml is used to treat rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain in joints. It slows or prevents joint damage and disease progression.
It helps treat psoriasis by suppressing the overactive immune response that causes skin cell overgrowth. It reduces scaling, redness, and thickness of psoriatic plaques.
Folitrax-50 Injection 2 ml is used in the management of breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas.
It works by interfering with DNA synthesis, thereby stopping or slowing the growth of cancer cells.
It helps manage inflammation in the digestive tract.
Provides disease control by modulating the immune system.
Offers long-term relief from autoimmune and inflammatory conditions.
Improves treatment outcomes in certain cancers by preventing abnormal cell growth.

How Folitrax-50 Injection 2 ml Works

Folitrax-50 Injection 2 ml contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-50 Injection 2 ml prevents and stops the growth of cancer cells, thereby helping treat cancer.

Storage

• Store in a cool and dry place away from sunlight.• Keep Folitrax-50 Injection 2 ml out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Folitrax-50 Injection 2 ml

Loss of appetite

Skin Rash

Itching

Here are the few steps for dealing with itching caused by drug use:

Report the itching to your doctor immediately; they may need to change your medication or dosage.
Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
Try not to scratch, as this can worsen the itching and irritate your skin.
If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.

Redness Of The Skin

Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:

Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Sun Allergy

What if I have taken an overdose of Folitrax-50 Injection 2 ml

Folitrax-50 Injection 2 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include vomiting, diarrhoea and gastrointestinal bleeding, as well as severe bone marrow suppression and disturbance of liver function. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take Folitrax-50 Injection 2 ml if you are allergic to any of its contents; if you are pregnant or breastfeeding.
Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems.
Let your doctor know if you have ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs.
Folitrax-50 Injection 2 ml may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue, runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately.
Inform your doctor if you are undergoing radiation therapy; if you receive Folitrax-50 Injection 2 ml while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.
Keep your doctor informed if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

MethotrexateEtretinate

Critical

MethotrexateBaricitinib

Severe

Drug-Drug Interactions

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MethotrexateEtretinate

Critical

How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Etretinate with Folitrax-50 Injection 2 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Folitrax-50 Injection 2 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.

MethotrexateBaricitinib

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Baricitinib and Folitrax-50 Injection 2 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.

MethotrexateOxacillin

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Folitrax-50 Injection 2 ml with oxacillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between oxacillin and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.

MethotrexateKetorolac

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Folitrax-50 Injection 2 ml with ketorolac can increase the blood levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a interaction between Folitrax-50 Injection 2 ml and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.

MethotrexateNaproxen

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Folitrax-50 Injection 2 ml with Naproxen can increase the levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Taking Folitrax-50 Injection 2 ml with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.

MethotrexatePantoprazole

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Folitrax-50 Injection 2 ml with pantoprazole can increase the levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between pantoprazole and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.

MethotrexateEverolimus

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Everolimus with Folitrax-50 Injection 2 ml can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Folitrax-50 Injection 2 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.

MethotrexateProcaine benzylpenicillin

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Folitrax-50 Injection 2 ml with procaine benzyl penicillin can increase the levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.

MethotrexateLansoprazole

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Folitrax-50 Injection 2 ml with Lansoprazole can increase the blood levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between Folitrax-50 Injection 2 ml and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

MethotrexateTacrolimus

Severe

How does the drug interact with Folitrax-50 Injection 2 ml:
Taking tacrolimus with Folitrax-50 Injection 2 ml may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
Performing yoga may also help in improving joint flexibility and pain management.
Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Acupuncture, massage and physical therapy may also be helpful.
Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
Avoid smoking and alcohol consumption.

Psoriasis:

Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
Avoid processed foods, refined sugars, and fatty foods.
Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
Reducing stress and maintaining a good sleep cycle would be helpful.
Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

Consume a healthy diet and exercise regularly to maintain a proper weight.
Avoid smoking and alcohol consumption.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Folitrax-50 Injection 2 ml.

Pregnancy

Unsafe

Folitrax-50 Injection 2 ml may cause serious birth defects. It is not recommended to take Folitrax-50 Injection 2 ml while you are pregnant.

Breast Feeding

Unsafe

Folitrax-50 Injection 2 ml passes into breast milk. Avoid breastfeeding whilst on treatment with Folitrax-50 Injection 2 ml and for at least 1 week after the last dose.

Driving

Caution

Folitrax-50 Injection 2 ml may cause dizziness and tiredness; do not drive or operate heavy machinery until you know how Folitrax-50 Injection 2 ml affects you.

Liver

Caution

Please consult your doctor if you have liver impairment before receiving Folitrax-50 Injection 2 ml.

Kidney

Caution

Please consult your doctor if you have kidney impairment before receiving Folitrax-50 Injection 2 ml.

Children

Caution

The efficacy and safety of Folitrax-50 Injection 2 ml in children have been established in polyarticular-course juvenile rheumatoid arthritis and cancer chemotherapy. Please consult your doctor if you have any concerns regarding the usage of Folitrax-50 Injection 2 ml in children.

Heart

Folitrax-50 Injection 2 ml can be used in heart patients and may even provide cardiovascular benefits. However, it should be administered under medical supervision due to potential side effects and drug interactions.

Geriatrics

Caution

Folitrax-50 Injection 2 ml can be used in geriatric patients, but with caution due to increased sensitivity to side effects like liver toxicity and bone marrow suppression. Regular monitoring and dose adjustments are essential to ensure safe use.

FAQs

What is the use of Folitrax-50 Injection 2 ml?

Folitrax-50 Injection 2 ml acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

How does Folitrax-50 Injection 2 ml help to treat rheumatic arthritis?

Folitrax-50 Injection 2 ml works by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-50 Injection 2 ml interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis.

Does Folitrax-50 Injection 2 ml affect fertility?

Folitrax-50 Injection 2 ml may affect fertility in men and women. Consult your doctor if you have any concerns regarding this.

Does Folitrax-50 Injection 2 ml increase the chance of infections?

Folitrax-50 Injection 2 ml causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infection, such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Does Folitrax-50 Injection 2 ml cause skin sensitivity to sunlight?

Folitrax-50 Injection 2 ml may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary exposure to sunlight or ultraviolet light, such as tanning beds and sunlamps. Wear protective clothing, sunglasses, and sunscreen while going out.

How does Folitrax-50 Injection 2 ml help to treat psoriasis?

Folitrax-50 Injection 2 ml works by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-50 Injection 2 ml interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra

Other Info - FOL0010

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Oct 14, 2025 | 1:08 PM IST

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