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  3. Flu-Stim 50 mg Injection 2 ml

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Flu-Stim 50 mg Injection 2 ml, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Flu-Stim 50 mg Injection 2 ml is used to treat Chronic lymphocytic leukaemia. Flu-Stim 50 mg Injection 2 ml contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, it slows or stops the growth of cancer cells in the body. Common side effects of this medicine may include fever, chills, hair loss, depression, fatigue, vomiting, nausea, headache, cough, constipation, oedema, weakness, and pain at the injection site.

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Synonym :

FLUDARABINE PHOSPHATE

Composition :

FLUDARABINE-25MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Flu-Stim 50 mg Injection 2 ml

Flu-Stim 50 mg Injection 2 ml belongs to a group of anticancer medicines called purine analogue used in the treatment of chronic lymphocytic leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

Flu-Stim 50 mg Injection 2 ml contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Flu-Stim 50 mg Injection 2 ml slows or stops the growth of cancer cells in the body.

Flu-Stim 50 mg Injection 2 ml may cause certain side effects such as fever, chills, hair loss, depression, fatigue, vomiting, nausea, headache, cough, constipation, oedema, weakness, and pain at the site of injection. Most of these side effects of Flu-Stim 50 mg Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please seek medical help. A trained healthcare professional will administer Flu-Stim 50 mg Injection 2 ml. Hence, do not self-administer.

If you are allergic to Flu-Stim 50 mg Injection 2 ml, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Flu-Stim 50 mg Injection 2 ml. Flu-Stim 50 mg Injection 2 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, severe bone marrow suppression, thrombocytopenia, or neutropenia before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of Flu-Stim 50 mg Injection 2 ml

Flu-Stim 50 mg Injection 2 ml is used in the treatment of Chronic lymphocytic leukemia. The detailed use of Flu-Stim 50 mg Injection 2 ml is as follows:<br/>• Chronic Lymphocytic Leukemia (CLL): Flu-Stim 50 mg Injection 2 ml is used in the treatment of chronic lymphocytic leukemia (CLL).<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Flu-Stim 50 mg Injection 2 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Flu-Stim 50 mg Injection 2 ml contains Fludarabine, which belongs to the class of purine analogues. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Flu-Stim 50 mg Injection 2 ml stops the multiplication of abnormal cells and causes the death of cancer cells.

How Flu-Stim 50 mg Injection 2 ml Works

Flu-Stim 50 mg Injection 2 ml contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Flu-Stim 50 mg Injection 2 ml slows or stops the growth of cancer cells in the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Flu-Stim 50 mg Injection 2 ml out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Flu-Stim 50 mg Injection 2 ml
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Flu-Stim 50 mg Injection 2 ml

Since Flu-Stim 50 mg Injection 2 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Flu-Stim 50 mg Injection 2 ml may cause unusual bruising or bleeding, fever, chills, cough, sore throat, or other signs of infection, delayed blindness, and coma.

Drug Warnings

If you are allergic to Flu-Stim 50 mg Injection 2 ml, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Flu-Stim 50 mg Injection 2 ml. Flu-Stim 50 mg Injection 2 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor that you are taking Flu-Stim 50 mg Injection 2 ml as it may cause infection.

Drug-Drug Interactions

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FludarabineBaricitinib
Severe
FludarabineCladribine
Severe

Drug-Drug Interactions

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FludarabineBaricitinib
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
Coadministration of baricitinib and Flu-Stim 50 mg Injection 2 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Flu-Stim 50 mg Injection 2 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
FludarabineCladribine
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
Taking Cladribine with Flu-Stim 50 mg Injection 2 ml can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Flu-Stim 50 mg Injection 2 ml with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FludarabineEtanercept
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
When Etanercept is used with Flu-Stim 50 mg Injection 2 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Flu-Stim 50 mg Injection 2 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
FludarabineInfliximab
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
Combining Infliximab with Flu-Stim 50 mg Injection 2 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Flu-Stim 50 mg Injection 2 ml and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineClozapine
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
Co-administration of Flu-Stim 50 mg Injection 2 ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Flu-Stim 50 mg Injection 2 ml and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineThalidomide
Severe
How does the drug interact with Flu-Stim 50 mg Injection 2 ml:
Taking thalidomide together with Flu-Stim 50 mg Injection 2 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Flu-Stim 50 mg Injection 2 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Flu-Stim 50 mg Injection 2 ml Substitute

Substitutes safety advice
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Alcohol

Caution

It is not known if alcohol interacts with Flu-Stim 50 mg Injection 2 ml. Please consult the doctor.

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Pregnancy

Unsafe

Flu-Stim 50 mg Injection 2 ml is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Flu-Stim 50 mg Injection 2 ml. You should not become pregnant while on treatment with Flu-Stim 50 mg Injection 2 ml.

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Breast Feeding

Unsafe

Flu-Stim 50 mg Injection 2 ml is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Flu-Stim 50 mg Injection 2 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Flu-Stim 50 mg Injection 2 ml will be administered in a hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Flu-Stim 50 mg Injection 2 ml.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Flu-Stim 50 mg Injection 2 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

It is unknown whether Flu-Stim 50 mg Injection 2 ml can be given to children or not. Therefore, consult your paediatrician if needed.

FAQs

Flu-Stim 50 mg Injection 2 ml is used to treat Chronic lymphocytic leukemia.

Flu-Stim 50 mg Injection 2 ml contains Fludarabine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

If you are about to receive any vaccinations, it is advised to inform your doctor that you are on treatment with Flu-Stim 50 mg Injection 2 ml as it may cause infections.

Flu-Stim 50 mg Injection 2 ml may interfere with the normal menstrual cycle in women and may stop sperm production in men. Therefore, please consult a doctor if you plan to have a baby.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad - 380015 Gujarat, India.
Other Info - FLU1053

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://go.drugbank.com/drugs/DB01073
  2. https://medlineplus.gov/druginfo/meds/a692003.html
  3. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/fludarabine
  4. https://reference.medscape.com/drug/fludara-oforta-fludarabine-342217
  5. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cf5255cc-91fd-4132-973b-764dba142eae

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