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Fibrogen-1 Injection is indicated for treating acute bleeding episodes in adults and children with congenital fibrinogen deficiency, including inherited blood disorders such as afibrinogenemia (absence of fibrinogen) and hypofibrinogenemia (low fibrinogen levels). It contains Human Fibrinogen, a protein essential for blood clotting (coagulation). It works by correcting the coagulation defect. Sometimes, this medication may cause side effects such as nausea, vomiting, fever, and thrombocytosis.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Fibrogen-1 Injection

Fibrogen-1 Injection is an injectable medicine used to treat and prevent severe bleeding in people who have an inherited shortage of a key blood-clotting protein. It helps stop bleeding episodes or prevents them during planned surgical procedures. By replacing this missing clotting factor, it allows the blood to clot normally and protects against dangerous blood loss.

This medicine is typically injected into a vein on an as-needed basis to manage active bleeding episodes or before a planned medical procedure. Because it is given directly into the bloodstream under clinical supervision, there are no specific instructions regarding food intake. To support your overall recovery, doctors often recommend resting the affected area and avoiding physical activities that could trigger more bleeding.

While using this medicine, some people may experience mild side effects like a low fever, headache, or redness at the injection site. However, you must seek medical attention immediately if you notice signs of serious complications, such as unexpected swelling, pain in your limbs, sudden shortness of breath, or a severe allergic reaction.

Before receiving Fibrogen-1 Injection, tell your doctor if you have a history of blood clots, heart disease, stroke, kidney disease, or severe allergic reactions to blood products. Do not receive this medicine if you have previously experienced a life-threatening allergic reaction to fibrinogen concentrate or any of its ingredients.

Fibrogen-1 Injection is a plasma-derived medicine, meaning it is made from carefully screened donated human plasma. Manufacturers use multiple purification and viral inactivation steps to greatly reduce the risk of transmitting infections, although the risk cannot be completely eliminated. Inform your healthcare provider about all medicines you take, especially those that affect blood clotting. If you are pregnant, planning pregnancy, breastfeeding, or are an older adult, your doctor will carefully weigh the benefits and risks before treatment.

Fibrogen-1 Injection is available under different brand names depending on the country and hospital. Your healthcare provider will prescribe the product that is most appropriate and available.

Uses of Fibrogen-1 Injection

Fibrogen-1 Injection is used in the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, such as afibrinogenemia and hypofibrinogenemia. The detailed uses of Fibrogen-1 Injection are as follows:

  • Congenital clotting factor deficiency: Fibrogen-1 Injection helps by replacing the missing clotting factor in the blood, allowing normal clot formation to stop or prevent bleeding.
  • Severe bleeding episodes: It is used during acute bleeding crises to quickly restore the body's clotting ability and minimize blood loss.
  • Surgical bleeding prevention: Doctors inject this medicine before surgeries or dental procedures in patients with inherited clotting disorders to prevent excessive bleeding during and after the operation.

Key Benefits

  • Rapid control of bleeding: Replaces the missing fibrinogen protein so your blood can form stable clots quickly and reduce blood loss.
  • Safer surgery: Lowers the risk of excessive bleeding before, during, and after planned surgical or dental procedures in people with congenital fibrinogen deficiency.
  • Protection from long-term complications: Prompt treatment helps reduce repeated bleeding into joints, muscles, and other tissues, helping preserve movement and quality of life.
  • Supports ongoing care: Regular monitoring and treatment help maintain safer fibrinogen levels and reduce the risk of future bleeding episodes.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Fibrogen-1 Injection will be administered by a healthcare professional.
  • Do not self-administer it.

How Fibrogen-1 Injection Works

Fibrogen-1 Injection replaces the clotting protein that your body is missing or does not have enough of, helping your blood form clots and stop bleeding. After the injection, it quickly increases fibrinogen levels in your blood so your body's natural clotting process can work properly. Your doctor may perform regular blood tests to check your fibrinogen level and make sure you have enough medicine to control bleeding while reducing the risk of blood clots.
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Alcohol

Consult your doctor

It is not known if alcohol affects Fibrogen-1 Injection. Please consult your doctor.

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Pregnancy

Caution

Consult the doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Consult the doctor if you are a nursing mother.

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Driving

Safe

Fibrogen-1 Injection does not influence the ability to drive and use machines. However, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Fibrogen-1 Injection.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before receiving Fibrogen-1 Injection.

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Children

Consult your doctor

Please consult the doctor if you have any concerns regarding the usage of Fibrogen-1 Injection in children.

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Heart

Caution

Inform your doctor before receiving Fibrogen-1 Injection if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Fibrogen-1 Injection should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Fibrogen-1 Injection

Because this medicine is usually given by a healthcare provider, an overdose is highly unlikely. However, if you receive too much, it can increase the risk of blood clots. If you suspect an overdose or experience chest pain or breathing difficulties after an injection, seek emergency medical attention immediately.

Diet & Lifestyle Advise

  • Avoid activities with a high risk of injury: Stay away from contact sports or activities that could lead to falls, bruising, or head injuries, as these can trigger internal bleeding.
  • Maintain excellent dental hygiene: Use a soft-bristled toothbrush and gentle flossing techniques to prevent gum bleeding. Regular dental check-ups are important, but always inform your dentist about your condition beforehand.
  • Avoid medicines that thin the blood: Do not take over-the-counter pain relievers like aspirin or ibuprofen without consulting your doctor, as these can interfere with clotting and worsen bleeding.
  • Wear medical identification: Carry a medical alert card or wear a bracelet indicating that you have a clotting deficiency and use Fibrogen-1 Injection in emergencies.
  • Attend all scheduled follow-up appointments and blood tests so your healthcare provider can monitor your fibrinogen levels and adjust treatment if needed.
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How Soon It Starts Working

The time required for Fibrogen-1 Injection to start to work: The time required for Fibrogen-1 Injection to show its action is not clinically established. The time for which the effects of Fibrogen-1 Injection last: The duration of action for Fibrogen-1 Injection is not clinically established.

What if you forget to take Fibrogen-1 Injection

Since this medication is often given on an as-needed basis for bleeding or scheduled before surgeries, a missed dose is uncommon. If you are on a regular treatment schedule and miss a dose, contact your doctor or pharmacist immediately for instructions. Do not inject a double dose to make up for a missed one.

Storage

• Store Fibrogen-1 Injection according to the temperature instructions on the package. This medicine is typically stored in a refrigerator between 2°C to 8°C (36°F to 46°F), but some formulations may be kept at room temperature (up to 25°C or 77°F) for limited periods.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the vial carefully before use: Do not use the medicine if the liquid is cloudy, contains visible particles, or has changed color.
  • Practice proper needle safety: Never reuse needles, syringes, or infusion sets. Dispose of them immediately in a puncture-proof sharps container.
  • Rotate injection sites: If you require multiple injections, choose different sites on your body to prevent irritation and tissue damage.
  • Monitor for signs of blood clots: Stay highly alert for symptoms like unexplained leg pain, chest tightness, or sudden coughing, and seek immediate help if they occur.
  • Keep a treatment log: Record the date, time, dose, and vial lot number of every injection you receive to share with your healthcare team.
  • Keep a record of your fibrinogen level test results, treatment dates, and infusion details, as these help your healthcare team plan future treatment safely.

verifiedApollotooltip

  • Anticoagulants and antiplatelet drugs (e.g., warfarin, aspirin, clopidogrel): Taking these medications alongside Fibrogen-1 Injection can counteract the clotting effect, reducing the usefulness of your treatment.
  • Other clotting factor concentrates: Combining this with other clotting therapies may increase the risk of developing dangerous blood clots in your veins or arteries.

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verifiedApollotooltip
  • There are no known direct interactions between Fibrogen-1 Injection and specific foods or beverages. However, avoid excessive alcohol consumption, as it can affect overall liver function and blood health.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Fibrogen-1 Injection is used to treat acute bleeding episodes in patients with congenital fibrinogen deficiency, such as afibrinogenemia and hypofibrinogenemia.
Fibrogen-1 Injection works by correcting the coagulation defect. Thereby, it helps arrest bleeding.
Fibrogen-1 Injection is not indicated in the treatment of dysfibrinogenemia, a coagulation disorder characterised by having an abnormal form of fibrinogen.
Fibrogen-1 Injection contains fibrinogen, a protein that helps platelets stick together and form a clot. While fibrinogen does not directly activate platelets, it supports platelet aggregation by binding to a receptor (called GPIIb-IIIa) on activated platelets. This binding helps platelets stick together and form a more substantial clot.
No, Fibrogen-1 Injection is not an insoluble plasma protein. It contains fibrinogen, a soluble protein the liver makes and is found in the blood plasma. Fibrinogen remains soluble in the blood until it is turned into insoluble fibrin to help form a clot.
No, fibrinogen is not typically found in serum. It is usually present in plasma. During the clotting process, fibrinogen is used and converted into fibrin, which forms a clot. After the clot is removed, the remaining liquid is called serum, which does not contain fibrinogen. On the other hand, plasma still contains fibrinogen because it has not undergone clotting.
No, Fibrogen-1 Injection is not a formed element in blood. It is a medication containing fibrinogen, a protein produced in the liver and found in the blood during bleeding in blood vessels, where it helps with clotting. The formed elements in blood are red blood cells, white blood cells, and platelets.
Fibrogen-1 Injection may cause common side effects such as nausea, vomiting, fever, and thrombocytosis in some people. These side effects do not require medical attention and often resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Fibrogen-1 Injection is injected directly into a vein (intravenously), usually by a healthcare provider in a clinic or hospital. In some cases, you may be trained to perform the injections at home. Talk to your doctor to learn more about your administration options.
There is limited clinical data on the safety of using this medicine during pregnancy or while breastfeeding. Your doctor will weigh the benefits of stopping severe bleeding against any potential risks to the baby. Talk to your doctor if you are pregnant or planning to breastfeed.
Because it is injected directly into the bloodstream, Fibrogen-1 Injection begins working almost immediately to help your blood form clots and control bleeding. However, the exact time to see full relief depends on the severity of the bleed. Talk to your doctor for more details.
Mild redness, warmth, or irritation at the injection site is a common and usually harmless side effect. If the pain worsens, or if you notice swelling or leaking around the site, contact your healthcare provider. Talk to your doctor if these symptoms do not go away.
Yes, because this medicine helps your blood clot, there is a risk that it could cause unwanted blood clots in the veins or arteries, especially if used in high amounts. Your medical team will monitor you closely during treatment. Talk to your doctor about your risk factors.
While there is no direct chemical interaction between alcohol and Fibrogen-1 Injection, drinking alcohol can affect your coordination and increase your risk of falls or injuries that cause bleeding. Talk to your doctor about whether it is safe for you to drink alcohol.
You should avoid taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen while using Fibrogen-1 Injection unless specifically directed by your physician. These medicines can thin your blood and worsen bleeding. Talk to your doctor about safe pain relief options.
Yes, but elderly patients may have a higher risk of pre-existing heart or blood vessel conditions that could increase the risk of blood clots. Your doctor will carefully evaluate your health history before prescribing this medicine. Talk to your doctor for personalized advice.
Yes. Fibrogen-1 Injection is made from donated human plasma. Plasma donations are carefully screened, and the manufacturing process includes several purification and viral inactivation steps to greatly reduce the risk of transmitting infections. Although the risk cannot be completely eliminated, modern plasma-derived medicines have an excellent safety record when manufactured according to approved standards.
Your doctor may order blood tests to measure your fibrinogen level before and after treatment. These tests help determine whether your blood contains enough fibrinogen to control bleeding or prepare safely for surgery and guide any additional doses you may need.
In some hospitals or emergency situations, doctors may use cryoprecipitate or fresh frozen plasma (FFP) to replace fibrinogen when fibrinogen concentrate is unavailable. These treatments also provide clotting proteins but may require larger infusion volumes. Your doctor will choose the most appropriate treatment based on your medical condition and local availability.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - FIB0124
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