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  3. Ev28 Tablet 2mg

Ev28 Tablet 2mg, Pack of 1 Tablet
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Ev28 Tablet 2mg is used for hormonal replacement therapy for treating hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). In addition to this, it also helps in preventing osteoporosis. It is prescribed when the body is not producing a sufficient amount of natural estrogen. It contains estradiol, which regulates the menstrual cycle and ovulation. It works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause. In some cases, it may cause side effects such as headache, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding.

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Composition :

ESTRADIOL-2MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Ev28 Tablet 2mg

Ev28 Tablet 2mg is indicated for hormonal replacement therapy for treating hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). 

Ev28 Tablet 2mg contains estradiol, which works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause. 

You may experience headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding in some cases. Most of these side effects of Ev28 Tablet 2mg do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

You can take Ev28 Tablet 2mg with food or as advised by your doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. It is advised to take Ev28 Tablet 2mg for as long as your doctor has prescribed it for you, depending upon your medical condition.

Inform your doctor if you have any history of vaginal bleeding, breast cancer, or blood clot in the legs or lungs. If you are pregnant or breastfeeding, please do not take Ev28 Tablet 2mg. While taking Ev28 Tablet 2mg, your doctor may advise regular tests to monitor its working. Grapefruit juice and St.John’s wort (a natural remedy for depression) should not be taken along with Ev28 Tablet 2mg.

Uses of Ev28 Tablet 2mg

Ev28 Tablet 2mg is used in the treatment of hormone replacement therapy, osteoporosis and hypoestrogenism. The detailed uses of Ev28 Tablet 2mg are as follows:

  • Hormone Replacement Therapy (HRT): Ev28 Tablet 2mg is widely used in hormone replacement therapy to alleviate menopause symptoms, such as hot flashes and vaginal dryness, by supplying estrogen to the body.
  • Regulation of Menstrual Cycle: Ev28 Tablet 2mg helps regulate menstrual cycles in women with hormonal imbalances, including conditions like polycystic ovary syndrome (PCOS).
  • Support for Fertility Treatments: Ev28 Tablet 2mg is often utilized in fertility protocols, aiding in the preparation of the uterine lining for implantation during assisted reproductive technologies like IVF.
  • Management of Menstrual Disorders: Ev28 Tablet 2mg is prescribed to manage various menstrual disorders, such as heavy menstrual bleeding (menorrhagia) and painful menstruation (dysmenorrhea).
  • Bone Health: By providing estrogen, Ev28 Tablet 2mg supports bone density maintenance and helps reduce the risk of osteoporosis in postmenopausal women, promoting better bone health.

Directions for Use

  • Ev28 Tablet 2mg can be taken with or without food; however, taking it with food or after meals may help prevent stomach upset.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Ev28 Tablet 2mg as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Ev28 Tablet 2mg contains a synthetic female hormone that regulates ovulation and menstruation in women.
  • Ev28 Tablet 2mg is given as a hormone replacement therapy for estrogen.
  • It is also used in the treatment to relieve symptoms of menopause, such as mood swings, reduced sex drive, hot flashes, night sweats and vaginal dryness.
  • In addition to this, it also helps in preventing osteoporosis. 
  • Ev28 Tablet 2mg is prescribed when the body is not producing a sufficient amount of natural estrogen.

How Ev28 Tablet 2mg Works

Ev28 Tablet 2mg contains estradiol, which regulates the menstrual cycle and ovulation. Ev28 Tablet 2mg works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Ev28 Tablet 2mg
  • Mild physical activity can increase blood flow and lessen pain from tense or irritated muscles.
  • Pain might be reduced with a supportive, properly fitting bra, particularly when exercising.
  • Limit or stay away from items that can cause breast pain, like spicy and caffeine-containing foods.
  • vitamin E medication which could ease breast pain and encourage rest.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Wash the vulva with warm water and a mild, unscented soap, avoiding harsh soaps or scrubbing.
  • Do not douche as it can disrupt the natural balance of bacteria in the vagina.
  • After bathing, pat the vulva completely dry with a soft towel.
  • Wear loose-fitting cotton underwear to allow air circulation.
  • Change wet or sweaty clothing regularly.
  • Avoid using scented products like feminine hygiene sprays, lotions, and toilet paper.
  • Wear loose-fitting pants and skirts.
  • Stress can increase itching, so practice relaxation techniques like meditation and yoga.

What if I have taken an overdose of Ev28 Tablet 2mg

Do not take more than the prescribed dose of Ev28 Tablet 2mg as it may cause overdose. The symptoms of overdose include vomiting, nausea and vaginal bleeding. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Ev28 Tablet 2mg if you are allergic to any of its ingredients.
  • Inform your doctor if you have breast cancer, vaginal bleeding, blood clot in the leg (deep venous thrombosis), lungs (pulmonary embolism), vein (thrombosis), cancer of the endometrium (womb lining), any blood clotting disorder, recently had a heart attack, liver or kidney disease, porphyria (a group of liver disease), high blood pressure.
  • Avoid smoking as it greatly increases the risk of blood clots, stroke, and heart attack while taking Ev28 Tablet 2mg.
  • Grapefruit juice and St. John’s wort (a natural remedy for depression) should not be taken along with Ev28 Tablet 2mg.
  • Ev28 Tablet 2mg is not recommended for use in pregnant and breastfeeding mothers.
  • It is advised to take the medicine around the same time daily for best results.

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
EstradiolLetrozole
Severe

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
How does the drug interact with Ev28 Tablet 2mg:
When Etodolac is taken with Bivalirudin, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivalirudin with Ev28 Tablet 2mg can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
EstradiolLetrozole
Severe
How does the drug interact with Ev28 Tablet 2mg:
Letrozole may have a negative effect when used with Ev28 Tablet 2mg, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letrozole and Ev28 Tablet 2mg together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EstradiolThalidomide
Severe
How does the drug interact with Ev28 Tablet 2mg:
Taking thalidomide together with Ev28 Tablet 2mg may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Ev28 Tablet 2mg and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
EstradiolClindamycin
Severe
How does the drug interact with Ev28 Tablet 2mg:
When taken in combination, clindamycin can lower the amount or action of Ev28 Tablet 2mg.

How to manage the interaction:
Co-administration of Ev28 Tablet 2mg with Clindamycin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EstradiolCarfilzomib
Severe
How does the drug interact with Ev28 Tablet 2mg:
Carfilzomib can cause serious blood clots and taking it alongside Ev28 Tablet 2mg may enhance the risk.

How to manage the interaction:
Co-administration of Ev28 Tablet 2mg with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolLenalidomide
Severe
How does the drug interact with Ev28 Tablet 2mg:
Coadministration of Ev28 Tablet 2mg and Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Ev28 Tablet 2mg, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolDantrolene
Severe
How does the drug interact with Ev28 Tablet 2mg:
The usage of Ev28 Tablet 2mg with dantrolene might have significant adverse effects on your liver.

How to manage the interaction:
Taking Ev28 Tablet 2mg with Dantrolene together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolPomalidomide
Severe
How does the drug interact with Ev28 Tablet 2mg:
Co-administration of Ev28 Tablet 2mg and Pomalidomide can increase the risk of serious blood clots.

How to manage the interaction:
There may be a possibility of interaction between Ev28 Tablet 2mg and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience symptoms like chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EstradiolTranexamic acid
Severe
How does the drug interact with Ev28 Tablet 2mg:
Co-administration of Ev28 Tablet 2mg with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Ev28 Tablet 2mg with Tranexamic acid can lead to an interaction; however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolAnastrozole
Severe
How does the drug interact with Ev28 Tablet 2mg:
Ev28 Tablet 2mg may interfere with anastrozole's function and make it less effective in treating your condition.

How to manage the interaction:
Co-administration of Anastrozole with Ev28 Tablet 2mg can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
The rate of absorption of oral estrogens may be increased by coadministration with grapefruit juice. Avoid or restrict the consumption of grapefruit juice while taking Ev28 Tablet 2mg.

Diet & Lifestyle Advise

  • Regular exercise and physical activity can minimize hot flashes and improve sleep. Weight-bearing exercises can also help strengthen bones. Aerobics, yoga, and activities like tai chi may help relax the body and mind.
  • Wear loose clothes before going to bed and sleep in a cool, well-ventilated room. This can prevent symptoms of hot flashes and night sweats. Get a minimum of 8 hours of sleep. 
  • Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
  • Quitting smoking will help reduce hot flashes and your risk of developing chronic conditions like heart disease, stroke, and cancer.

Habit Forming

No

Therapeutic Class

HORMONES

Ev28 Tablet 2mg Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Ev28 Tablet 2mg to avoid unpleasant side effects.

bannner image

Pregnancy

Unsafe

Ev28 Tablet 2mg is not recommended during pregnancy, as it may harm the foetus and cause serious complications for the baby and mother.

bannner image

Breast Feeding

Unsafe

Ev28 Tablet 2mg is not recommended for breastfeeding mothers as it is known to cause harm to the baby.

bannner image

Driving

Safe if prescribed

It is not known to cause any side effects which may affect driving.

bannner image

Liver

Caution

Ev28 Tablet 2mg should be taken with caution, especially if you have a history of liver disease.

bannner image

Kidney

Caution

Ev28 Tablet 2mg should be taken with caution, especially if you have a history of kidney disease.

bannner image

Children

Unsafe

Ev28 Tablet 2mg is not recommended for children below 12 years of age.

Have a query?

FAQs

Ev28 Tablet 2mg is used to treat hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). This medicine is prescribed when the body is not producing a sufficient amount of natural estrogen.

Ev28 Tablet 2mg works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.

Do not use Ev28 Tablet 2mg if you are allergic to peanuts, have unusual vaginal bleeding, have/had any cancer (breast or uterus cancer), or undergoing any other estrogen treatment. Tell your doctor if you had a heart attack, stroke, blood clot, or liver problems, if you are pregnant, breastfeeding, or planning to get pregnant.

No, Ev28 Tablet 2mg should not be taken if you are undergoing surgery. You should inform your doctor, and he might ask you to stop hormone replacement therapy about 4 to 6 weeks before surgery to reduce the risk of blood clots.

Ev28 Tablet 2mg may cause weight gain or loss, a common side effect. Regular exercise and a healthy diet can help prevent weight gain.

Do not discontinue Ev28 Tablet 2mg without consulting your doctor as stopping the medicine can cause your symptoms to come back. Consult the doctor, he/she might reduce the dose gradually.

If you miss a dose of Ev28 Tablet 2mg take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

You may experience side effects like headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding. Consult the doctor if the side effects persist or worsen.

Foods like flaxseeds, soy, peaches, garlic, sesame seeds, kale, broccoli, Brussels sprouts, peanuts, almonds, cashews, and pistachios can be included in your diet for oestrogen deficiency.

Do not take Ev28 Tablet 2mg if you are allergic to any of its components or if you had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina or have undiagnosed vaginal bleeding, liver disease, or a bleeding disorder.

Ev28 Tablet 2mg should be swallowed as a whole with water; do not crush or chew it. It can be taken with or without food; taking with food or after meals may help prevent stomach upset.

Country of origin

India
Other Info - EV89992

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 8, 2025 | 1:49 PM IST

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Reference

  1. https://www.fda.gov/media/130242/download
  2. https://www.drugs.com/uk/pdf/leaflet/1080657.pdf
  3. https://www.drugs.com/uk/pdf/leaflet/1080657.pdf
  4. https://www.drugs.com/estradiol.html
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