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Eugraf Gel is used in the treatment of diabetic foot ulcers, bedsores, chronic leg ulcers and vascular ulcers. This medicine works by releasing a growth factor that can promote tissue repair, skin regeneration (formation of healthy skin), and accelerate wound healing. Common side effects include headache, nausea, rash, stomach pain, and pruritis.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Eugraf Gel

Eugraf Gel is a specialized topical medication used to treat chronic, slow-healing wounds, most notably diabetic foot ulcers. Its primary medical purpose is to accelerate the body's natural healing process, helping to close deep skin sores and reduce the risk of serious wound complications. By stimulating tissue repair, it helps restore the skin barrier in areas affected by long-term ulceration.

To achieve the best results, you must apply this gel consistently and exactly as directed by your doctor. It is typically applied once daily to the cleaned wound bed, though your doctor will determine the exact frequency based on your wound's progress. Along with using this medication, maintaining strict blood sugar control and keeping pressure off the affected foot are crucial lifestyle adjustments that support successful healing.

Most patients tolerate this gel well, but some may experience mild, localized skin irritation, redness, or a slight burning sensation at the application site. While these common side effects are usually harmless, you should contact your doctor immediately if you notice signs of a worsening infection, such as increased pain, foul-smelling discharge, swelling, or fever.

Before you begin using this medication, talk to your doctor about your complete medical history. Do not use this gel if you have a history of skin cancer or any active tumor growth at or near the application site, as this product promotes cell multiplication. If you have active cancer elsewhere in the body or a history of cancer, discuss the potential benefits and risks with your oncologist or healthcare provider before starting treatment. Do not stop or avoid treatment without medical advice. Your oncologist can help determine whether this gel is appropriate for your individual situation. Tell your doctor if you have a weakened immune system, poor blood circulation due to peripheral arterial disease (a condition where reduced blood flow reaches the legs and feet), severe kidney disease, or any other condition that may affect wound healing. It should also be avoided if you have a known allergy to any of its ingredients.

Because Eugraf Gel is applied topically, it is unlikely to interact with oral medications or alcohol. However, you should avoid applying other creams, ointments, or strong antiseptic solutions to the same wound without consulting your healthcare provider first. If you are pregnant, breastfeeding, or managing multiple chronic conditions, talk to your doctor to ensure this treatment is safe for your specific situation.

Uses of Eugraf Gel

This medicine is used to promote wound healing and support the repair of damaged skin and tissues. The detailed uses of this medicine are as follows:

  • Diabetic foot ulcers: Eugraf Gel helps speed up the healing of deep, slow-healing nerve-related sores (caused by reduced feeling in the feet) in people with diabetes, lowering the risk of deep-tissue infections.
  • Chronic skin wounds: It assists in repairing stubborn pressure sores, bedsores, and other long-standing wounds that have not responded well to standard wound care.
  • Partial-thickness burns (second-degree burns that affect the top two layers of the skin): This gel promotes faster skin regeneration and recovery.
  • Skin grafts: It helps transplanted skin heal more quickly at both the donor site (where the skin was taken from) and the recipient site (where the skin was placed).

 

Key Benefits

Eugraf Gel helps promote wound healing and supports the repair of damaged skin. Its benefits include:

  • Helps wounds close more quickly when used with proper wound care.
  • Supports healthy tissue repair and skin regeneration.
  • May reduce the risk of wound-related complications.
  • Helps improve mobility and day-to-day comfort as wounds heal.
  • May help reduce scarring by promoting healthy skin regeneration.
  • Supports recovery alongside blood sugar control and pressure relief.
     

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication, to improve effectiveness.
  • Apply a small amount of Eugraf Gel to the affected area with a cotton swab.
  • Wash your hands before and after applying it.
  • It is only for external use.

How Eugraf Gel Works

Eugraf Gel works by mimicking a natural protein that our bodies produce to heal injured skin. When you apply the gel to a wound, it attaches to special docking points on skin cells (called receptors), much like a key fitting into a lock. This activates natural healing signals that encourage skin cells to multiply and move into the wound, helping to fill it with healthy new tissue. The healing signals also encourage the cells to produce collagen (a protein that gives skin its strength and structure), helping rebuild the wound from within and form a new protective layer of skin. This process rapidly fills in the wound from the bottom up and encourages the growth of a new, protective outer layer of skin, effectively closing the wound much faster than the body could on its own.
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Alcohol

Caution

There is not enough literature on the effects of alcohol on Eugraf Gel. Exercise caution before taking alcohol with Eugraf Gel. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Eugraf Gel is not recommended for use by pregnant women. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Eugraf Gel is not recommended during nursing. Please consult your doctor if you have any concerns.

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Driving

Safe if prescribed

Eugraf Gel is unlikely to affect your ability to drive.

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Liver

Caution

Please consult your doctor in case of any concerns.

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Kidney

Caution

Please consult your doctor in case of any concerns.

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Children

Caution

Limited information is available. Please consult a doctor.

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Heart

Caution

Please consult your doctor if you have any concerns regarding using Eugraf Gel in patients with heart problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Eugraf Gel should be used in elderly patients only if prescribed by a doctor. If you have any concerns about using Eugraf Gel in older adults, please consult your doctor.

What if I have taken an overdose of Eugraf Gel

While serious internal harm is unlikely from topical use, always use only the amount prescribed by your doctor. Applying excessive amounts may increase local skin irritation without improving healing. If a large amount of gel is accidentally applied or swallowed, or if you experience a severe reaction, contact your healthcare provider or seek immediate medical attention.

Diet & Lifestyle Advise

  • Control Your Blood Sugar: Keep your blood glucose levels within your target range, as high blood sugar impairs blood circulation and slows down your body's natural healing capacity.
  • Eat Enough Protein: Ensure your diet includes lean proteins, zinc, and Vitamin C, which provide the essential nutrients your body needs to rebuild skin tissue.
  • Keep Pressure Off the Wound: Keep weight and pressure off the wound, especially if it is on your foot. This is called offloading. Use specialized therapeutic footwear, casts, or braces as prescribed by your doctor.
  • Avoid Smoking: Stop smoking, as nicotine constricts your blood vessels, reducing the oxygen and nutrients that reach your healing wound.
  • Stay Hydrated: Drink plenty of water daily to keep your skin hydrated and support overall cellular repair.
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How Soon It Starts Working

The time required for Eugraf Gel to start to work: The time required for Eugraf Gel to show its action is unknown. The time for which the effects of Eugraf Gel last: The duration of action for Eugraf Gel is clinically unknown.

What if you forget to take Eugraf Gel

If you forget to apply Eugraf Gel, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed application and continue with your regular routine. Do not apply a double layer of gel to make up for a missed application.

Storage

•Store this gel in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). • Do not freeze this medication, as freezing will damage the active ingredients. Keep the tube tightly closed when not in use to prevent contamination.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the gel before use: Check the gel before each application. Do not use it if you notice any unusual changes in color, consistency, or appearance.
  • Avoid contaminating the tube: Do not let the tip of the tube touch your wound, fingers, or any other surface to help keep the gel sterile.
  • Do not use other topical products without medical advice: Avoid applying other creams, ointments, or traditional remedies to the treated area unless directed by your doctor.
  • Use only on diagnosed wounds: Do not apply Eugraf Gel to undiagnosed skin lesions, especially if skin cancer is suspected.
  • Attend follow-up appointments: Keep all scheduled follow-up visits so your doctor can monitor your wound healing and adjust treatment if needed.
     

verifiedApollotooltip
  • Other Topical Medications: Using other prescription creams, steroid ointments, or over-the-counter antiseptic lotions on the same wound may interfere with Eugraf Gel. Some harsh topical cleansers containing heavy metals or strong chemicals can break down the active ingredient in this gel, making it less effective.
  • Medicines That May Slow Wound Healing: Long-term systemic corticosteroids (steroid medicines taken by mouth or by injection), immunosuppressants (medicines that lower the body's immune response), or chemotherapy medicines may slow the body's natural wound-healing process. Tell your doctor about all medicines you are taking so your treatment plan can be adjusted if needed.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Eugraf Gel when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS TOPICAL]

FAQs

Eugraf Gel belongs to the group of growth factors used in the treatment of diabetic foot ulcers, bedsores, chronic leg ulcers, and vascular ulcers.Â
Eugraf Gel works by enhancing wound healing, new cell production and collagen synthesis, thereby reducing the time taken for skin to restore and heal.
The absorption of Eugraf Gel is quite rapid. The longer you have it on, the quicker it will absorb into your body. Speak to your doctor in case of any concerns.
Skin-type does not have an effect on Eugraf Gel and is indicated for all skin types. Please consult a skin doctor for further concerns.
Eugraf Gel is for external use only. Do not use it on skin rashes or lesions without discussing it with your doctor. Do not use any heating pads on the feet. Make sure the wound is cleaned properly before applying Eugraf Gel.
Eugraf Gel might not be recommended in case of an immunocompromised state such as HIV as it contains an active biological material. However, your doctor will prescribe an alternate treatment plan in case you suffer from HIV. Clear any concerns with your doctor.
Yes, Eugraf Gel is specifically designed to be applied directly onto clean, open chronic wounds and diabetic foot ulcers to help them heal. Talk to your doctor to see if it is right for your specific wound.
Yes, Eugraf Gel gel must be stored in a refrigerator between 2°C and 8°C to maintain its effectiveness. Do not freeze it. Talk to your doctor or pharmacist if you have questions about proper storage.
No, Eugraf Gel is a prescription-strength medication meant for serious, chronic wounds like diabetic ulcers. It is not approved or recommended for mild cosmetic issues or common acne scars. Talk to your doctor about appropriate scar treatments.
Oozing, bad odor, increased pain, and swelling are signs of a possible wound infection. Stop using the gel and contact your doctor immediately for an evaluation. Talk to your doctor before resuming use.
No, you should not apply any cosmetics, lotions, or other creams over the treated wound area, as they can interfere with the healing process and irritate the tissue. Talk to your doctor for guidance on skin care around the wound.
The safety of Eugraf Gel during pregnancy or breastfeeding has not been fully established. If you are pregnant or planning to breastfeed, talk to your doctor before starting this treatment to weigh the benefits and risks.
Flush your eyes immediately with large amounts of clean, cool water for several minutes. If you experience persistent irritation, pain, or changes in your vision, contact a doctor right away. Talk to your doctor if symptoms continue.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - EUG0013
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