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  3. Etisafe Plus Tablet

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Etisafe Plus Tablet, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Etisafe Plus Tablet is used to treat anxiety disorder. It contains Etizolam and Propanolol, which suppresses the excessive and abnormal activity of nerve cells in the brain and reduces blood pressure, heart rate, and workload on the heart. It may cause side effects such as confusion, slow heart rate, memory impairment, tiredness, cold extremities, uncoordinated body movements, and drowsiness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ETIZOLAM-0.25MG + PROPRANOLOL-20MG

Manufacturer/Marketer :

Organic Living Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Etisafe Plus Tablet

Etisafe Plus Tablet is used to treat anxiety disorder. An anxiety disorder is a mental condition characterized by feelings of excessive fear or worry that affect an individual's daily activities. High levels of anxiety can cause panic attacks, with intense feelings of nervousness, fear, sudden onset of sweating, hyperventilation, fast heartbeat, and skin flushing.

Etisafe Plus Tablet contains Etizolam (benzodiazepine) and Propanolol (a beta-blocker), used to treat anxiety. Etizolam works by increasing the action of a chemical messenger, GABA, which suppresses the excessive and abnormal activity of nerve cells in the brain. Propanolol works by blocking a certain chemical messenger in the heart and blood vessels, reducing blood pressure, heart rate, and workload on the heart.

Take Etisafe Plus Tablet as prescribed by your doctor. You are advised to take Etisafe Plus Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience confusion, slow heart rate, memory impairment, tiredness, cold extremities, uncoordinated body movements, and drowsiness. Most of these side effects of Etisafe Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.  

If you are pregnant, planning to become pregnant, or breastfeeding, please inform your doctor Etisafe Plus Tablet contains Etizolam, a habit-forming drug, so take it in dose and duration prescribed by a doctor. Do not stop taking Etisafe Plus Tablet even if you feel better, as it may lead to withdrawal symptoms. Etisafe Plus Tablet is known to cause drowsiness, so do not drive or operate machinery. Avoid consumption of alcohol as it may reduce the effectiveness of Etisafe Plus Tablet.

Uses of Etisafe Plus Tablet

Etisafe Plus Tablet is used in the treatment of anxiety disorder. The detailed uses of Etisafe Plus Tablet are as follows:

  • Anxiety Relief: Etisafe Plus Tablet can be used to manage symptoms of anxiety disorders, helping to reduce feelings of tension, restlessness, and panic.
  • Sleep Aid: Etisafe Plus Tablet may be prescribed to individuals suffering from insomnia or sleep disturbances, promoting relaxation and facilitating better sleep quality.
  • Panic Disorder Treatment: Etisafe Plus Tablet can be beneficial for those experiencing panic attacks, by providing a calming effect that helps to alleviate acute episodes of anxiety.
  • Muscle Relaxant: Etisafe Plus Tablet may also serve as a muscle relaxant, aiding in the reduction of muscle tension and discomfort associated with various physical conditions.

Directions for Use

• Take Etisafe Plus Tablet with or without food or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Etisafe Plus Tablet is a combination drug containing 'anti-anxiety medication', primarily used to treat anxiety disorder. It contains Etizolam (benzodiazepine) and Propanolol (a beta-blocker), used to treat anxiety. Etizolam works by increasing the action of a chemical messenger, GABA, which suppresses the excessive and abnormal activity of nerve cells in the brain. Propanolol works by blocking a certain chemical messenger in the heart and blood vessels, reducing blood pressure, heart rate, and workload on the heart.

How Etisafe Plus Tablet Works

Etisafe Plus Tablet contains Etizolam (benzodiazepine) and Propanolol (a beta-blocker), used to treat anxiety. Etizolam works by increasing the action of a chemical messenger, GABA, which suppresses the excessive and abnormal activity of nerve cells in the brain. Propanolol works by blocking a certain chemical messenger in the heart and blood vessels, reducing blood pressure, heart rate, and workload on the heart.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Etisafe Plus Tablet
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Reducing the amount of time you spend outside and indoors in the cold.
  • keeping your hands warm by donning mittens, gloves, or other protective clothing.
  • Observing a skincare regimen that safeguards your fingers and hands.
  • To improve circulation, give your hands and feet a little massage.
  • If you experience symptoms like colour change in the affected area, numbness, pain or tingling sensation after taking a medicine, inform your doctor and discuss about change in dose or alternative medicine.
  • Your doctor may prescribe calcium channel blockers like amlodipine or nifedipine to help relax blood vessels and enhance blood flow to the hands and feet.
  • Wear gloves, socks and warm clothes, especially in cold weather.
  • Spend less time in cold environments and avoid touching cold objects.
  • Practice relaxation methods like deep breathing to manage stress.
  • Quit smoking as nicotine constricts blood vessels worsening Raynaud’s symptoms.
  • Keep regular sleeping hours.
  • Don’t consume nicotine, caffeine, or alcohol in the hours leading up to bed.
  • Practice relaxation exercises before bedtime.
  • Regular physical activity can promote deeper and better sleep. However, avoid intense exercise within 2-3 hours of bedtime, as it can disrupt your sleep.
  • If nightmares continue, cognitive behavioral therapy (CBT) may be a helpful treatment option. Your doctor may recommend CBT to address underlying issues and provide coping strategies to manage nightmares.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.

What if I have taken an overdose of Etisafe Plus Tablet

Do not take more than the prescribed dose of Etisafe Plus Tablet as it may cause profound sedation, respiratory depression, hypotension, bradycardia, hypothermia, and hypoglycemia. If you suspect that you have taken an overdose, please seek medical advice.

Drug Warnings

Do not take Etisafe Plus Tablet if you are allergic to Etisafe Plus Tablet or any of its ingredients. If you are pregnant or breastfeeding, please inform your doctor before starting Etisafe Plus Tablet as it may cause adverse effects in the baby. Etisafe Plus Tablet should be used with caution in elderly patients as there is an increased risk of adverse reactions such as dizziness, muscle weakness, and drowsiness. Inform your doctor if you have myasthenia gravis (muscle weakness), chronic pulmonary insufficiency, drug addiction, kidney or liver problems before taking Etisafe Plus Tablet. Do not take Etisafe Plus Tablet with opioids as it may cause breathing problems, drowsiness, coma, and even death.

Drug-Drug Interactions

verifiedApollotooltip
PropranololThioridazine
Critical
PropranololVerapamil
Severe

Drug-Drug Interactions

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PropranololThioridazine
Critical
How does the drug interact with Etisafe Plus Tablet:
Coadministration of thioridazine with Etisafe Plus Tablet may increase the blood levels of thioridazine and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Etisafe Plus Tablet and thioridazine, they can be taken together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, and shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololVerapamil
Severe
How does the drug interact with Etisafe Plus Tablet:
Using Etisafe Plus Tablet and verapamil together may lead to increased side effects.

How to manage the interaction:
Although taking Etisafe Plus Tablet together with Verapamil can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. Do not stop taking any medication without consulting a doctor.
PropranololFingolimod
Severe
How does the drug interact with Etisafe Plus Tablet:
Using fingolimod with Etisafe Plus Tablet can cause an excessive lowering of heart rate and can lead to other heart problems.

How to manage the interaction:
Although taking Etisafe Plus Tablet together with Fingolimod can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience lightheadedness, fainting, shortness of breath, chest pain, or heart palpitations. Do not stop using any medicines without consulting a doctor.
PropranololDiltiazem
Severe
How does the drug interact with Etisafe Plus Tablet:
Taking Etisafe Plus Tablet and Diltiazem together increases the risk of side effects.

How to manage the interaction:
Although taking Etisafe Plus Tablet together with Diltiazem can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. Do not stop using any medications without consulting your doctor.
PropranololSalmeterol
Severe
How does the drug interact with Etisafe Plus Tablet:
Using Etisafe Plus Tablet together with salmeterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Etisafe Plus Tablet can sometimes cause breathing problems.

How to manage the interaction:
Although taking Etisafe Plus Tablet together with Salmeterol can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololBitolterol
Severe
How does the drug interact with Etisafe Plus Tablet:
Using Etisafe Plus Tablet together with bitolterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Etisafe Plus Tablet can sometimes cause breathing problems.

How to manage the interaction:
Taking Etisafe Plus Tablet with Bitolterol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololLabetalol
Severe
How does the drug interact with Etisafe Plus Tablet:
Taking Etisafe Plus Tablet with Labetalol can potentially enhance the effects of orthostatic hypotension (low blood pressure that happens when standing after sitting or lying down).

How to manage the interaction:
Although taking Etisafe Plus Tablet together with Labetalol can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience lightheadedness or dizziness upon standing, blurred vision, weakness, fainting, or confusion. Do not discontinue any medicine without consulting a doctor.
PropranololLevosalbutamol
Severe
How does the drug interact with Etisafe Plus Tablet:
Coadministration of Etisafe Plus Tablet and levosalbutamol can increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Etisafe Plus Tablet and levosalbutamol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololAtenolol
Severe
How does the drug interact with Etisafe Plus Tablet:
Taking atenolol and Etisafe Plus Tablet together may lower your blood pressure excessively which may lead to side effects.

How to manage the interaction:
Combined use of atenolol and Etisafe Plus Tablet may result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololSalbutamol
Severe
How does the drug interact with Etisafe Plus Tablet:
Using Etisafe Plus Tablet and salbutamol together can reduce the effects or increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of Etisafe Plus Tablet and salbutamol can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise and maintain healthy body weight.
  • Maintain a diet rich in fruits, vegetables, and whole grains.
  • Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during day time.
  • Avoid watching TV, using mobiles or laptops just before bedtime.
  • Avoid consumption of alcohol as it may increase drowsiness

Habit Forming

Yes

Therapeutic Class

ANXIOLYTICS

Etisafe Plus Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid consumption of alcohol with Etisafe Plus Tablet as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Caution

Etisafe Plus Tablet is a Category C pregnancy drug, and safety is unknown. Please consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

It is unknown whether Etisafe Plus Tablet is excreted in human milk. Please consult a doctor before using Etisafe Plus Tablet while breastfeeding.

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Driving

Caution

Etisafe Plus Tablet may cause dizziness, double vision, or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy, or experience any vision problems after taking Etisafe Plus Tablet.

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Liver

Caution

Take Etisafe Plus Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Etisafe Plus Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

The safety of Etisafe Plus Tablet in children is unknown. Please consult a doctor for more information.

Have a query?

FAQs

Etisafe Plus Tablet is used to treat anxiety disorder, a mental condition characterized by feelings of excessive fear or worry that affect an individual's daily activities.

Etisafe Plus Tablet contains Etizolam (benzodiazepine) and Propanolol (a beta-blocker), used to treat anxiety. Etizolam works by increasing the action of a chemical messenger GABA, which suppresses the excessive and abnormal activity of nerve cells in the brain. Propanolol works by blocking a certain chemical messenger in the heart and blood vessels, reducing blood pressure, heart rate, and workload on the heart.

No, you are not recommended to stop taking Etisafe Plus Tablet without consulting your doctor as it may cause withdrawal symptoms such as palpitations (the sensation that the heart skipped a beat or extra beat), anxiety, confusion, difficulty in sleeping, and tremors. Therefore, take Etisafe Plus Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Etisafe Plus Tablet, please consult your doctor so that the dose may be gradually reduced.

No, you are not recommended to take Etisafe Plus Tablet with opioids as co-administration of these medicines may cause breathing problems, drowsiness, or other adverse effects. However, before using Etisafe Plus Tablet with any other medicines, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.

Yes, Etisafe Plus Tablet may cause mental or physical dependence if used for a prolonged time. Therefore, take Etisafe Plus Tablet only in dose and duration as advised by your doctor.

Quitting smoking, avoiding alcohol intake, and caffeine-containing food drinks can help you minimize the common side effect. If side effects like exhausted feeling, sleepiness (sedation), muscle weakness, and body posture imbalance persist, it means you need some blood test to find out the exact cause.

No, do not stop taking Etisafe Plus Tablet without consulting your doctor, even if you feel well. Stopping the medication abruptly can lead to withdrawal symptoms or worsening of your condition. Your doctor will advise you on how to taper off the medication safely.

Etisafe Plus Tablet can cause sleepiness or drowsiness as a side effect in some individuals. To ensure your safety, rest for a while after taking the medication and avoid driving or operating heavy machinery. In most cases, sleepiness subsides as your body adjusts to the medication. However, if it worsens or persists, please consult your doctor for guidance.

Store Etisafe Plus Tablet by keeping it cool, dry, and away from sunlight. Keep it out of children's. To dispose of Etisafe Plus Tablet place it in a plastic bag, and discard it in the household trash. Never flush the medicine down the toilet or sink to protect others and the environment.

Some individuals may experience common side effects of Etisafe Plus Tablet including confusion, slow heart rate, memory impairment, tiredness, cold extremities, uncoordinated body movements, and drowsiness. Most of these side effects of Etisafe Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

5E, 1ST FLOOR, RANI JHANSI ROAD, JHANDEWALAN EXTENSION, NEAR VIDEOCON TOWER, NEW DELHI New Delhi DL 110055 IN
Other Info - ETI0071

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 5, 2025 | 9:10 AM IST

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Reference

  1. https://mims.com/india/drug/info/etizolam?type=full&mtype=generic
  2. https://www.who.int/medicines/access/controlled-substances/5.7_Etizolam_PreRev.pdf
  3. https://www.medicines.org.uk/emc/medicine/24131#gref
  4. https://www.drugs.com/propranolol.html

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