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  3. Epsolin ER 300 Tablet 30's

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Epsolin ER 300 Tablet 30's, Pack of 1 TABLET
Epsolin ER 300 Tablet 30's, Pack of 1 TABLET
Epsolin ER 300 Tablet 30's, Pack of 1 TABLET
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Epsolin ER 300 Tablet is an anticonvulsant medicine used in the treatment of epilepsy/fits and cardiac arrhythmias. This medicine works by preventing the brain's abnormal electrical activity during seizures. Common side effects include dizziness, drowsiness, excitation, headache, tiredness, loss of appetite, nausea, vomiting, constipation, and trouble sleeping.

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Composition :

PHENYTOIN SODIUM-300MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Epsolin ER 300 Tablet

Epsolin ER 300 Tablet belongs to the group of medicines called 'anticonvulsants' used to treat epilepsy/seizures, and prevent seizures during/after brain surgery or after traumatic brain injury. Besides this, Epsolin ER 300 Tablet may also be used to treat trigeminal neuralgia (facial nerve pain). Epilepsy is a central nervous system disorder characterised by a sudden rush of electrical activity in the brain leading to seizures, unusual behaviour, and loss of awareness.

Epsolin ER 300 Tablet contains Phenytoin sodium, which helps prevent neurons from working at a very fast speed, thereby preventing the brain cells from firing together rapidly in an uncontrolled way. As a result, Epsolin ER 300 Tablet controls the overactivity of the brain cells that causes seizures. Epsolin ER 300 Tablet slows down the electrical impulses in the nerves and reduces their ability to transmit pain, thus treating trigeminal neuralgia.

Take Epsolin ER 300 Tablet with or without food. Depending on your medical condition, you are advised to take Epsolin ER 300 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Sometimes, Epsolin ER 300 Tablet may cause common side effects such as weakness, drowsiness, dizziness, restlessness, and constipation. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Epsolin ER 300 Tablet for as long as your doctor has prescribed it. Please do not skip any doses or stop taking Epsolin ER 300 Tablet suddenly without consulting your doctor, as it may lead to increased seizures. Avoid taking Epsolin ER 300 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Avoid alcohol consumption while taking Epsolin ER 300 Tablet as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Epsolin ER 300 Tablet

Epsolin ER 300 Tablet is used in the treatment of epilepsy and seizures. The detailed uses of Epsolin ER 300 Tablet are as follows:<br/>• Treatment of Epilepsy/Seizures: It helps manage epilepsy and seizures by stabilising electrical activity in the brain.<br/>• Prevention of Seizures During/After Brain Surgery or Traumatic Brain Injury: It prevents seizures during or after brain surgery or following a traumatic brain injury.<br/>• Treatment of Trigeminal Neuralgia: It may also treat trigeminal neuralgia, a condition that causes severe facial nerve pain.<br/>

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Directions for Use

  • Epsolin ER 300 Tablet can be taken with or without food, although taking it with food may help avoid stomach upset.
  • Take it as your doctor prescribes, usually at the same time each day.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.

Medicinal Benefits

Epsolin ER 300 Tablet is an anticonvulsant that controls and prevents epilepsy (fits). It is also used to control and prevent fits during or after a severe head injury or brain surgery. Epsolin ER 300 Tablet works by controlling the overactivity of the brain that causes seizures (fits). Thereby, Epsolin ER 300 Tablet helps control epileptic fits involving muscle spasms and jerking. Epsolin ER 300 Tablet may also be used to treat trigeminal neuralgia (facial nerve pain).

How Epsolin ER 300 Tablet Works

Epsolin ER 300 Tablet contains Phenytoin sodium, which helps prevent neurons from working at a very fast speed, thereby preventing the brain cells from firing together rapidly in an uncontrolled way. As a result, Epsolin ER 300 Tablet controls the overactivity of the brain cells that causes seizures. Epsolin ER 300 Tablet slows down the electrical impulses in the nerves and reduces their ability to transmit pain. Thereby, it treats trigeminal neuralgia.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Epsolin ER 300 Tablet
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.

What if I have taken an overdose of Epsolin ER 300 Tablet

Do not take more than the prescribed dose of Epsolin ER 300 Tablet as it may cause overdose which can be fatal. The symptoms of overdose include lightheadedness, nausea, vomiting, fainitng, slurred speech, twitching eye movements, tremor, muscle weakness or stiffness, loss of balance, and slow or shallow breathing. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Please stop taking Epsolin ER 300 Tablet and consult your doctor if you develop any skin rashes (Stevens-Johnson syndrome), swollen glands (anticonvulsant hypersensitivity syndrome- AHS), or have suicidal thoughts. Do not take Epsolin ER 300 Tablet if you are allergic to any of its contents. Talk to your doctor about heart, kidney, or liver problems and diabetes before starting Epsolin ER 300 Tablet . Avoid taking Epsolin ER 300 Tablet if you are pregnant or breastfeeding unless prescribed by your doctor. Avoid alcohol consumption while taking Epsolin ER 300 Tablet as it might cause unpleasant side effects. Intake of Epsolin ER 300 Tablet may cause dizziness. So be cautious while driving or operating any heavy machinery. Notify your doctor if you are taking anti-HIV medicines (like delavirdine) before intake of Epsolin ER 300 Tablet , as both might react with each other, leading to serious conditions.

Drug-Drug Interactions

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PhenytoinCeritinib
Critical
PhenytoinPraziquantel
Critical

Drug-Drug Interactions

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PhenytoinCeritinib
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Taking ceritinib with Epsolin ER 300 Tablet may significantly reduce the blood levels and effectiveness of Ceritinib.

How to manage the interaction:
Taking Epsolin ER 300 Tablet with Ceritinib is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PhenytoinPraziquantel
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using praziquantel together with Epsolin ER 300 Tablet may significantly reduce the blood levels of praziquantel leading decreased effectiveness.

How to manage the interaction:
Taking Epsolin ER 300 Tablet with Praziquantelcan is not recommended as it cause an interaction, it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
PhenytoinVenetoclax
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using venetoclax together with Epsolin ER 300 Tablet may significantly reduce the blood levels of venetoclax leading to decreased effectiveness of venetoclax in treating in your condition.

How to manage the interaction:
Taking Epsolin ER 300 Tablet with Venetoclax is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
PhenytoinRilpivirine
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using rilpivirine together with Epsolin ER 300 Tablet may significantly reduce the blood levels of rilpivirine.

How to manage the interaction:
Taking Rilpivirine with Epsolin ER 300 Tablet is not recommended, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
PhenytoinRanolazine
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using ranolazine together with Epsolin ER 300 Tablet may significantly reduce the blood levels of ranolazine leading to dreceased effectiveness of ranolazine in treating your condition.

How to manage the interaction:
Taking Epsolin ER 300 Tablet with Ranolazine is not recommended. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PhenytoinCimetidine
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using Epsolin ER 300 Tablet together with cimetidine may increase the effects of Epsolin ER 300 Tablet.

How to manage the interaction:
Taking Epsolin ER 300 Tablet with Cimetidine is not recommended, it can be taken if prescribed by the doctor. Contact a doctor, if you experience twitching eye movements, slurred speech, loss of balance, tremors, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. Do not stop using any medications without talking to a doctor.
PhenytoinLurasidone
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Using lurasidone together with Epsolin ER 300 Tablet may significantly decrease the blood levels of lurasidone.

How to manage the interaction:
Using lurasidone with Epsolin ER 300 Tablet is not recommended, it can be taken if a doctor has prescribed it. Consult a doctor, if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
PhenytoinIsavuconazole
Critical
How does the drug interact with Epsolin ER 300 Tablet:
Co-administration of Epsolin ER 300 Tablet and Isavuconazole may significantly reduce the blood levels of Isavuconazole, which may make Isavuconazole less effective in treating your condition.

How to manage the interaction:
Taking Isavuconazole with Epsolin ER 300 Tablet is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
PhenytoinNimodipine
Severe
How does the drug interact with Epsolin ER 300 Tablet:
Co-administration of Epsolin ER 300 Tablet and Nimodipine may decrease the blood levels of Nimodipine, which may make Nimodipine less effective.

How to manage the interaction:
Although taking Nimodipine and Epsolin ER 300 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
PhenytoinBosutinib
Severe
How does the drug interact with Epsolin ER 300 Tablet:
Coadministration of Epsolin ER 300 Tablet and Bosutinib may decrease the blood levels of bosutinib, which may make bosutinib less effective.

How to manage the interaction:
Although there is an interaction between Epsolin ER 300 Tablet and bosutinib, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Following a ketogenic diet (low in carbohydrates and high in fat) is recommended.
  • Meditation, walking, participating in a task, and smelling a strong odour are a few self-control methods for preventing seizures.
  • Acupuncture therapy may also be helpful.
  • Rest properly, and avoid stress by doing meditation or yoga.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Include Vitamin D-rich foods like fatty fish, mackerel, tuna, dairy products, orange juice, soy milk, cereals, beef liver, cheese, and egg yolks in your diet.
  • Also, taking folic acid and vitamin K-rich foods and supplements during pregnancy is advised.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Epsolin ER 300 Tablet to prevent unpleasant side effects.

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Pregnancy

Caution

Do not take Epsolin ER 300 Tablet if you are pregnant unless prescribed by the doctor. Your doctor will prescribe Epsolin ER 300 Tablet only if the benefits outweigh the risks. If you become pregnant while taking Epsolin ER 300 Tablet , then do not stop taking Epsolin ER 300 Tablet without consulting your doctor.

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Breast Feeding

Caution

Please consult your doctor if you have any concerns about this; your doctor will decide whether Epsolin ER 300 Tablet can be given to breastfeeding mothers.

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Driving

Caution

Epsolin ER 300 Tablet may cause dizziness and drowsiness, drive and operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Epsolin ER 300 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Epsolin ER 300 Tablet should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Epsolin ER 300 Tablet can be given to children only when prescribed by the doctor.

FAQs

Epsolin ER 300 Tablet belongs to the group of medicines called anticonvulsants used to treat epilepsy/seizures, and prevent seizures during/after brain surgery or after traumatic brain injury. It is also be used to treat trigeminal neuralgia (facial nerve pain).

Epsolin ER 300 Tablet works by controlling the brain's overactivity that causes seizures (fits). Thus, Epsolin ER 300 Tablet helps control epileptic fits involving muscle spasms and jerking.

Epsolin ER 300 Tablet can make hormonal birth control pills less effective. Talk to your doctor about using non-hormonal contraceptives like condoms and a diaphragm with spermicide to prevent pregnancy.

Please do not stop taking Epsolin ER 300 Tablet without consulting your doctor, as it may cause increased seizures. Continue taking Epsolin ER 300 Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Epsolin ER 300 Tablet .

Epsolin ER 300 Tablet may cause swelling in the gums. Brush and floss your teeth daily; visit your dentist if you experience this problem regularly.

Epsolin ER 300 Tablet may affect the breakdown of the blood sugar/glucose and may prevent insulin release, thereby leading to high blood sugar. So, contact a doctor before using Epsolin ER 300 Tablet if you have diabetes.

A typical seizure can last from a few seconds to a few minutes. If it lasts more than 5 minutes, consult the doctor immediately.

Epsolin ER 300 Tablet should be taken as advised by the doctor at the same time daily. Swallow Epsolin ER 300 Tablet as a whole with a glass of water. Do not chew, break or crush it.

Avoid consuming alcohol while taking Epsolin ER 300 Tablet as it may cause unpleasant side effects. Consult the doctor if you have any concerns.

Epsolin ER 300 Tablet stays in the system for a few days. However, this might vary from person to person.

The symptoms that occur if you take more than the recommended dose are loss of balance, nausea, vomiting, tremors, twitching eye movements, slurred speech, muscle stiffness or weakness, light-headedness, fainting, and slow or shallow breathing. Consult the doctor if you notice any of these symptoms.

Yes, the overdose of Epsolin ER 300 Tablet may be fatal. Therefore, take Epsolin ER 300 Tablet in the dose prescribed by the doctor.

People who are allergic to any of the components in Epsolin ER 300 Tablet or hydantoins should avoid taking this medicine.

Epsolin ER 300 Tablet may have interactions with ibuprofen. Dose adjustment may be needed to take both medicines together. Consult the doctor before taking Epsolin ER 300 Tablet with ibuprofen.

Epsolin ER 300 Tablet may cause jerky eye movements, loss of energy, thinking or behavioural problems, slow or clumsy movements, and mood changes in children. Talk to the doctor if you notice any of these signs in your child during treatment with Epsolin ER 300 Tablet .

Epsolin ER 300 Tablet is not known to cause weight gain. However, if you notice any weight changes, manage it by exercising regularly, cutting down on high-calorie diets, eating a nutrition-rich diet, reducing processed and sugary foods, and staying hydrated.

Yes, Epsolin ER 300 Tablet may cause sleepiness as a common side effect. If you experience sleepiness, avoid driving and operating machinery.

Yes, Epsolin ER 300 Tablet may affect birth control by reducing the effectiveness of hormonal contraceptives like birth control pills, rings, patches, and injections. Consult the doctor regarding other methods of contraception to be used while on treatment with Epsolin ER 300 Tablet .

The side effects of Epsolin ER 300 Tablet include drowsiness, dizziness, weakness, restlessness, and constipation. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - EPS0010

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 9:24 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.4326.pdf
  2. https://www.medicines.org.uk/emc/files/pil.5046.pdf
  3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8848de76-8d74-4620-bcc7-a86a596e5dd9
  4. https://www.drugs.com/phenytoin.html

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