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  3. Epirest CR 300 mg Tablet 10's

Epirest CR 300 mg Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Epirest CR 300 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SODIUM VALPROATE-300MG

Manufacturer/Marketer :

Sbs Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Epirest CR 300 mg Tablet

Epirest CR 300 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, Epirest CR 300 mg Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
­ 
Epirest CR 300 mg Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Epirest CR 300 mg Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Epirest CR 300 mg Tablet with or without food. You are advised to take Epirest CR 300 mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Epirest CR 300 mg Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Epirest CR 300 mg Tablet . Do not take Epirest CR 300 mg Tablet if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Epirest CR 300 mg Tablet . Consult your doctor before taking Epirest CR 300 mg Tablet if you are breastfeeding. Do not drive or operate machinery as Epirest CR 300 mg Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Epirest CR 300 mg Tablet as it could lead to increased dizziness and sleepiness.

Uses of Epirest CR 300 mg Tablet

Epirest CR 300 mg Tablet is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Epirest CR 300 mg Tablet are as follows:<br/>• Seizure Management: Epirest CR 300 mg Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.<br/>• Bipolar Disorder Treatment: Epirest CR 300 mg Tablet can be utilized in the treatment of bipolar disorder, aiding in mood stabilization and reducing the frequency of mood swings.<br/>• Migraine Prevention: Epirest CR 300 mg Tablet may also be prescribed to prevent migraines, providing relief from recurrent headaches.<br/>

Directions for Use

  • Epirest CR 300 mg Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Epirest CR 300 mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Epirest CR 300 mg Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Epirest CR 300 mg Tablet is also used to treat bipolar disorder and prevent migraine headaches. Epirest CR 300 mg Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Epirest CR 300 mg Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

How Epirest CR 300 mg Tablet Works

Epirest CR 300 mg Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Epirest CR 300 mg Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

Keep Epirest CR 300 mg Tablet out of reach and sight of children.
Side effects of Epirest CR 300 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Include fruits, vegetables, and leafy greens rich in vitamins C and K.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Avoid tobacco products as smoking can worsen gum disease.
  • Stay hydrated by drinking water to flush bacteria and food particles.
  • Consider vitamin supplements if deficient to support gum health.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Swish with coconut oil for its antibacterial properties to reduce plaque.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Consult your dentist if gums bleed consistently.
  • Apply a cold compress to the affected area for 10 to 15 minutes multiple times a day.
  • Elevate your head while resting or sleeping to reduce fluid accumulation.
  • Drink lots of water to eliminate excess fluids.
  • Limit salty foods as they can cause water retention.
  • To stimulate lymphatic drainage, gently massage the swollen area.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • To keep your vocal cords lubricated and hydrated, drink lots of water.
  • Suck on ice chips, popsicles, or lozenges to clear your throat and reduce hoarseness.
  • Your voice cords may be soothed and healed by honey's antibacterial and anti-inflammatory properties.
  • Gargle with salt water.
  • Using a steam humidifier or inhaling steam might help minimize hoarseness and release mucus.

What if I have taken an overdose of Epirest CR 300 mg Tablet

Do not take more than the prescribed dose of Epirest CR 300 mg Tablet as it may cause an overdose. The symptoms of overdose include headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Epirest CR 300 mg Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, an immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Epirest CR 300 mg Tablet . Contact your doctor if your child gets her first period during the treatment with Epirest CR 300 mg Tablet . Do not take Epirest CR 300 mg Tablet if you are pregnant unless prescribed by the doctor, as it is a pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Epirest CR 300 mg Tablet if you are breastfeeding. Epirest CR 300 mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Epirest CR 300 mg Tablet as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateErtapenem
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Epirest CR 300 mg Tablet:
Combining Sodium phenylbutyrate and Epirest CR 300 mg Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Epirest CR 300 mg Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
The combined use of Ertapenem and Epirest CR 300 mg Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Epirest CR 300 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Ketamine and Epirest CR 300 mg Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Epirest CR 300 mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Teriflunomide and Epirest CR 300 mg Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Epirest CR 300 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Using buprenorphine together with Epirest CR 300 mg Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Epirest CR 300 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Vorinostat with Epirest CR 300 mg Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Epirest CR 300 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Epirest CR 300 mg Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Epirest CR 300 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Leflunomide and Epirest CR 300 mg Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Epirest CR 300 mg Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Lithium with Epirest CR 300 mg Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Epirest CR 300 mg Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Epirest CR 300 mg Tablet:
Co-administration of Meropenam and Epirest CR 300 mg Tablet together can reduce the effect of Epirest CR 300 mg Tablet.

How to manage the interaction:
Co-administration of Meropenam and Epirest CR 300 mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Epirest CR 300 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Epirest CR 300 mg Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Epirest CR 300 mg Tablet belongs to pregnancy category D. Avoid taking Epirest CR 300 mg Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Epirest CR 300 mg Tablet may pass into breastmilk. Consult your doctor before taking Epirest CR 300 mg Tablet if you are breastfeeding.

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Driving

Unsafe

Epirest CR 300 mg Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Unsafe

Epirest CR 300 mg Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Safe if prescribed

Epirest CR 300 mg Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

Have a query?

FAQs

Epirest CR 300 mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).

Epirest CR 300 mg Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain&amp;#039;s chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Epirest CR 300 mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Epirest CR 300 mg Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Epirest CR 300 mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Epirest CR 300 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Epirest CR 300 mg Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Epirest CR 300 mg Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Epirest CR 300 mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Epirest CR 300 mg Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Epirest CR 300 mg Tablet . In rare cases, Epirest CR 300 mg Tablet can be a contributing factor in male infertility.

Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.

Epirest CR 300 mg Tablet may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Epirest CR 300 mg Tablet .

Store Epirest CR 300 mg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Epirest CR 300 mg Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

No, avoid consumption of alcohol while taking Epirest CR 300 mg Tablet as it may cause increased dizziness and sleepiness.

Yes, Epirest CR 300 mg Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

No, taking higher than the recommended dose of Epirest CR 300 mg Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Epirest CR 300 mg Tablet as it may cause an overdose.

Country of origin

India

Manufacturer/Marketer address

Nanhera Road, Ambala, Haryana
Other Info - EPI0156

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:42 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.1500.pdf
  2. https://www.nhs.uk/medicines/sodium-valproate/http://mri.cts-mrp.eu/download/DE_H_0642_002_FinalPI_2of4.pdf
  3. https://www.drugs.com/cons/valproate-sodium-intravenous.html
  4. https://www.medsafe.govt.nz/consumers/cmi/e/Epilim.pdf
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