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compositionComposition:ERIBULIN MESYLATE-0.44MG
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Prescription Medicine
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₹19936 with coupons & bank offers*

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Epbriv 0.44 Injection 2 ml is used to treat Breast Cancer and Liposarcoma (cancer that develops in your fatty tissue). It contains Eribulin, which works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. While on therapy with this medicine, both women and men should use birth control to avoid pregnancy. Discontinue nursing while on treatment, considering the importance of the drug to the mother.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ERIBULIN MESYLATE-0.44MG

Manufacturer/Marketer :

Hetero Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Epbriv 0.44 Injection 2 ml

Epbriv 0.44 Injection 2 ml belongs to a group of medicines known as 'anti-cancer' used to treat various cancers, including breast and liposarcoma. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. Breast cancer is cancer that forms in the cells of the breasts. A liposarcoma is a rare cancer that develops in your fatty tissue.

Epbriv 0.44 Injection 2 ml contains Eribulin, which works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer.

Epbriv 0.44 Injection 2 ml should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions that occur while on therapy are neutropenia (lower-than-normal levels of neutrophils), anaemia (lack of blood), asthenia (weakness), fatigue(tiredness), alopecia (hair loss), peripheral neuropathy (Weakness, numbness, and pain from nerve damage), nausea, and constipation. Most of these side effects of Epbriv 0.44 Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Epbriv 0.44 Injection 2 ml for as long as your doctor has prescribed. Do not stop using the Epbriv 0.44 Injection 2 ml midway. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Epbriv 0.44 Injection 2 ml should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Epbriv 0.44 Injection 2 ml in patients with hepatic, renal, heart dysfunction and or Neutropenia (Lower-than-normal levels of neutrophils), so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Epbriv 0.44 Injection 2 ml

Epbriv 0.44 Injection 2 ml is used in the treatment of Breast Cancer and Liposarcoma (cancer that develops in your fatty tissue). The detailed uses of Epbriv 0.44 Injection 2 ml are as follows:

  • Metastatic Breast Cancer: Epbriv 0.44 Injection 2 ml is used in the treatment of Metastatic Breast Cancer.
  • Unresectable or Metastatic Liposarcoma: Epbriv 0.44 Injection 2 ml is used especially when prior treatment with an anthracycline-containing regimen has been given.

Key Benefits

Epbriv 0.44 Injection 2 ml helps treat certain advanced cancers by slowing the growth and spread of cancer cells. With regular use as prescribed, it helps control disease progression, relieve cancer-related symptoms, and support improved treatment outcomes.

  • Helps Control Cancer Progression: By targeting rapidly dividing cancer cells, this medicine helps slow the growth and spread of advanced cancers, supporting effective disease management.
  • Relieves Tumour-Related Symptoms: As tumour growth is controlled, this medicine may help reduce pain, pressure, and other symptoms caused by the cancer, improving daily comfort.
  • Supports Better Quality of Life: By helping stabilise the disease, this medicine may improve physical functioning, maintain daily activities, and support overall well-being throughout treatment.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Epbriv 0.44 Injection 2 ml will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
  • Do not self-administer.

How Epbriv 0.44 Injection 2 ml Works

Epbriv 0.44 Injection 2 ml contains eribulin mesylate, which works by disrupting the internal scaffolding of cancer cells. Cells need a tiny structural network called microtubules to divide and multiply. This medicine binds to these structures and blocks them from working properly. When the cancer cells cannot divide, they stop growing and eventually break down. Because cancer cells divide much faster than most normal cells, they are highly sensitive to this blocking action, which helps limit the spread of the disease throughout the body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Epbriv 0.44 Injection 2 ml.

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Pregnancy

Unsafe

Epbriv 0.44 Injection 2 ml should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

Epbriv 0.44 Injection 2 ml may cause side effects such as tiredness and dizziness. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

A lower starting dose is recommended for patients with mild (Child-Pugh A) and moderate (ChildPugh B) liver impairment. There is no information available on patients with severe liver impairment.

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Kidney

Caution

A lower starting dose is recommended for patients with moderate (CrCl 30-50 mL/min) kidney impairment. There is no information available on patients with severe kidney impairment.

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Children

Unsafe

Do not use this medicine for children between 0 to 18 years old.

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Heart

Caution

Epbriv 0.44 Injection 2 ml may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Epbriv 0.44 Injection 2 ml.

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Geriatrics

Safe if prescribed

Epbriv 0.44 Injection 2 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Epbriv 0.44 Injection 2 ml

Since this medicine is prepared and given by trained medical professionals, an overdose is highly unlikely. If you suspect you have received too much or experience unusual, severe symptoms after an injection, notify your doctor or seek immediate medical attention.

Diet & Lifestyle Advise

  • Stay Hydrated: Drink plenty of water and clear fluids throughout the day to help your kidneys flush out the medicine and prevent dehydration.
  • Prevent Infections: Wash your hands frequently and avoid close contact with people who are sick, as this medicine can temporarily lower your white blood cell count.
  • Manage Fatigue: Balance light physical activity, like short walks, with plenty of rest to help manage treatment-related tiredness.
  • Eat Small, Frequent Meals: If you experience nausea or loss of appetite, eating small portions throughout the day can be easier on your stomach than three large meals.
  • Protect Your Skin and Nails: Use gentle, fragrance-free moisturisers and avoid harsh chemicals to protect your skin and nails, which may become dry or brittle during treatment.
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How Soon It Starts Working

The time required for Epbriv 0.44 Injection 2 ml to start to work: The time required for Epbriv 0.44 Injection 2 ml to show its action is not clinically established. The time for which the effects of Epbriv 0.44 Injection 2 ml last: The duration of action for Epbriv 0.44 Injection 2 ml is not clinically established.

What if you forget to take Epbriv 0.44 Injection 2 ml

Because this medication is given at a clinic by a healthcare provider, missing a dose is uncommon. However, if you miss an appointment or need to delay your treatment, call your doctor or clinic immediately to reschedule. Talk to your doctor or pharmacist if you need to adjust your schedule.

Storage

• Under normal circumstances, Epbriv 0.44 Injection 2 ml is stored at the clinic or hospital pharmacy.

Drug Warnings

  • Check the Liquid: Ensure the healthcare provider inspects the vial before use; the liquid should be clear and colourless, without any visible particles.
  • Report Nerve Tingling Early: Let your healthcare team know immediately if you start feeling numbness or tingling in your fingers or toes, as this may require a change in your treatment schedule.
  • Watch the Injection Site: Tell your nurse right away if you feel burning, pain, or swelling at the injection site during the injection.
  • Monitor Your Temperature: Keep a reliable thermometer at home and check your temperature if you feel warm or unwell; a fever can be a medical emergency during this treatment.
  • Avoid Pregnancy: Use effective birth control during treatment and for at least several months after your last dose to prevent pregnancy.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain prescription medicines that affect liver enzymes may alter how Epbriv 0.44 Injection 2 ml is cleared from your body, which could increase side effects. Always share a complete list of your current medications with your doctor.
EribulinMoxifloxacin
Severe
EribulinBaricitinib
Severe

Drug-Drug Interactions

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EribulinMoxifloxacin
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Using Moxifloxacin together with Epbriv 0.44 Injection 2 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Epbriv 0.44 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience irregular heartbeat, dizziness, or difficulty breathing, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
EribulinBaricitinib
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Coadministration of Epbriv 0.44 Injection 2 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Taking Baricitinib with Epbriv 0.44 Injection 2 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
EribulinCeritinib
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Taking Epbriv 0.44 Injection 2 ml with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between ceritinib and Epbriv 0.44 Injection 2 ml, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
EribulinDisopyramide
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
The combined use of Epbriv 0.44 Injection 2 ml and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Epbriv 0.44 Injection 2 ml and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EribulinAmisulpride
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Using amisulpride together with Epbriv 0.44 Injection 2 ml can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Epbriv 0.44 Injection 2 ml and Amisulpride, you can take these medicines together if prescribed by a doctor. Call a doctor if you notice irregular heart rhythms, dizziness, fainting, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
EribulinChloroquine
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Using chloroquine together with Epbriv 0.44 Injection 2 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Chloroquine with Epbriv 0.44 Injection 2 ml together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EribulinSotalol
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Taking Sotalol and Epbriv 0.44 Injection 2 ml can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Epbriv 0.44 Injection 2 ml, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
EribulinInfliximab
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
Combining Infliximab with Epbriv 0.44 Injection 2 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Infliximab and Epbriv 0.44 Injection 2 ml, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
EribulinHydroxychloroquine
Severe
How does the drug interact with Epbriv 0.44 Injection 2 ml:
The combined use of Epbriv 0.44 Injection 2 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Epbriv 0.44 Injection 2 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Epbriv 0.44 Injection 2 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Epbriv 0.44 Injection 2 ml is administered as an intravenous (IV) injection directly into a vein by a doctor or nurse in a clinic or hospital. The injection usually takes 2 to 5 minutes. Do not self-administer this medicine. Talk to your doctor for more information.
Yes. Hair loss (alopecia) is a common side effect of Epbriv 0.44 Injection 2 ml. It is usually temporary, and hair typically begins to grow back after treatment is completed. However, the amount and timing of regrowth can vary between individuals. Speak with your doctor if you have concerns.
Yes. Epbriv 0.44 Injection 2 ml can lower blood cell counts, especially neutrophils (a type of white blood cell that helps fight infection). It may also reduce red blood cells, leading to anaemia. Your doctor will monitor your blood counts regularly and adjust your treatment if needed.
Some patients feel very tired or dizzy after treatment. It is best to see how the medicine affects you first, or arrange for someone else to drive you home after your appointment. Talk to your doctor.
Seek medical attention immediately. A fever can be a sign of a serious infection, which requires prompt treatment because this medicine can lower your white blood cell count. Talk to your doctor.
Some supplements may interfere with how this medicine works in your body. Always discuss any vitamins, herbal products, or over-the-counter remedies with your healthcare team before using them. Talk to your doctor.
While Epbriv 0.44 Injection 2 ml is not a cure, it is highly effective at slowing down the growth and spread of advanced cancer cells, helping to manage the disease and extend survival. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - EPB0001
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