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  3. Endoclav Duo Syrup 100 ml

Endoclav Duo Syrup 100 ml, Pack of 1 Syrup
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Endoclav Duo Syrup is used to treat bacterial infections, including ear, sinus, respiratory tract, urinary tract, skin, soft tissue, dental, joint and bone infections. It works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as vomiting, nausea, and diarrhoea. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

AMOXYCILLIN-200MG + CLAVULANIC ACID-28.5MG

Manufacturer/Marketer :

Endocard India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Endoclav Duo Syrup

Endoclav Duo Syrup is used to treat bacterial infections in the body that affect the skin, soft tissues, lungs, ears, urinary tract, and nasal sinuses. It should be mentioned that viral infections like the flu and the common cold are not treated by this medication.

Endoclav Duo Syrup consists of Amoxycillin and Clavulanic acid. This medicine works by destroying the outer protein layer, thereby killing the bacteria (bactericidal action). As a result, it helps treat infection and reduce the further spread of infection. Endoclav Duo Syrup does not work against infections caused by viruses, including colds and flu.

Not everyone who is taking Endoclav Duo Syrup will get these side effects. The common side effects of Endoclav Duo Syrup include vomiting, nausea, and diarrhoea. Everyone may not experience the above side effects. In case of any discomfort, speak with a doctor.

You can take Endoclav Duo Syrup with food to avoid any stomach upset. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your medicine based on your medical condition. It is always important to complete your treatment course for better results.

Before starting Endoclav Duo Syrup , please inform your doctor if you have any allergy (against any antibiotic) or any other components. Do not take Endoclav Duo Syrup on your own as it may lead to antibiotic resistance, in which antibiotics fail to act against specific bacterial infections. Endoclav Duo Syrup is safe for children if prescribed by a doctor; the dose and duration may vary depending on the child’s weight and the severity of the infection. Inform your doctor if you are pregnant or breadfeeding before taking Endoclav Duo Syrup .

Uses of Endoclav Duo Syrup

Endoclav Duo Syrup is used to treat Bacterial Infections. The detailed uses of Endoclav Duo Syrup are as follows:

  • Bacterial Infections: Endoclav Duo Syrup helps treat bacterial illnesses, including pneumonia and bronchitis. The composition of Endoclav Duo Syrup improves efficacy against resistant microorganisms.
  • Sinusitis: Endoclav Duo Syrup treats bacterial sinus infections by lowering inflammation and cleaning them.
  • Urinary Tract Infections (UTIs): Endoclav Duo Syrup treats urinary tract infections caused by susceptible bacteria and provides broad-spectrum protection.
  • Skin and Soft Tissue Infection: Endoclav Duo Syrup is also prescribed for treating skin and soft tissue infections, such as cellulitis and bite wounds, by its antibacterial effects to speed up the healing process.
  • Otitis Media: Endoclav Duo Syrup helps to treat middle ear infections.
  • Pneumonia: Endoclav Duo Syrup is also involved in treating pneumonia by efficiently fighting against the microorganisms that cause the condition.

Directions for Use

  • Endoclav Duo Syrup can be taken with food to avoid stomach upset.
  • It is usually taken every 8-12 hours or as prescribed by your doctor.
  • Swallow Endoclav Duo Syrup as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Endoclav Duo Syrup is a broad-spectrum antibiotic that covers a very wide range of bacterial infections.
  • Endoclav Duo Syrup has Clavulanic acid, which protects amoxycillin from getting destroyed by the bacterial enzyme, thus increasing its efficacy.
  • Endoclav Duo Syrup helps overcome antibiotic resistance in bacteria that is caused by the enzyme beta-lactamase.
  • Endoclav Duo Syrup is an effective medicine used in multiple infections like ear infections (acute otitis media), bronchitis, pneumonia, urinary tract infections, skin infections, etc.

How Endoclav Duo Syrup Works

Endoclav Duo Syrup consists of two medicines: Amoxycillin and Clavulanic acid. Amoxycillin acts by destroying the outer protein layer, thereby killing the bacteria (bactericidal action). Clavulanic acid inhibits the enzyme beta-lactamase, which prevents bacteria from destroying the efficacy of amoxycillin. As a result, the action of Clavulanic acid allows Amoxycillin to work better and kill the bacteria. Endoclav Duo Syrup does not work against infections caused by viruses, including colds and flu.

Storage

• Store in a cool and dry place away from sunlight.• Keep Endoclav Duo Syrup out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Endoclav Duo Syrup

Take Endoclav Duo Syrup only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms may include nausea, vomiting, diarrhoea, stomach pain, drowsiness, skin rash, hyperactivity, and decreased urination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Endoclav Duo Syrup if you have an allergy to Endoclav Duo Syrup , penicillin or cephalosporin class of antibiotics. Also, if you experience any allergic symptoms, including rash, swelling of the face/lips/throat, difficulty breathing, or chest tightness after taking $ name, immediately contact your doctor. 
  • People with liver diseases or jaundice (yellowing of skin/eyes) should not take Endoclav Duo Syrup , as it can severely affect the liver. Inform your doctor if you have any kidney or heart disease before taking Endoclav Duo Syrup .
  • The dose of Endoclav Duo Syrup can vary depending on your condition and the severity of the infection. 
  • Additionally, it is recommended to complete the course of medicine even if you feel better, as it is an antibiotic, and leaving it incomplete may lead to a severe infection that will, in fact, stop responding to the antibiotic as well (antibiotic resistance).

Drug-Drug Interactions

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AmoxicillinBCG vaccine
Severe
AmoxicillinCholera, live attenuated
Severe

Drug-Drug Interactions

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AmoxicillinBCG vaccine
Severe
How does the drug interact with Endoclav Duo Syrup 100 ml:
Co-administration of BCG vaccine with Endoclav Duo Syrup 100 ml may reduce the effect of BCG vaccine.

How to manage the interaction:
If you are about to receive BCG vaccine, inform the doctor that you are taking Endoclav Duo Syrup 100 ml. Do not discontinue the medication without consulting a doctor.
AmoxicillinCholera, live attenuated
Severe
How does the drug interact with Endoclav Duo Syrup 100 ml:
Co-administration of Endoclav Duo Syrup 100 ml and Cholera, live attenuated may reduce the activity of the vaccine.

How to manage the interaction:
If you are currently being treated with Endoclav Duo Syrup 100 ml or have been treated within the last 14 days, talk to your doctor before receiving cholera vaccine, live. Do not discontinue the medication without consulting a doctor.
AmoxicillinDoxycycline
Severe
How does the drug interact with Endoclav Duo Syrup 100 ml:
Co-administration of Endoclav Duo Syrup 100 ml with doxycycline may reduce the therapeutic effect of Endoclav Duo Syrup 100 ml.

How to manage the interaction:
Although there is a possible interaction between Endoclav Duo Syrup 100 ml and Doxycycline, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
AmoxicillinMethotrexate
Severe
How does the drug interact with Endoclav Duo Syrup 100 ml:
Co-administration of methotrexate with Endoclav Duo Syrup 100 ml can increase the levels and side effects of methotrexate.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Endoclav Duo Syrup 100 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
AmoxicillinZalcitabine
Severe
How does the drug interact with Endoclav Duo Syrup 100 ml:
Co-administration of Endoclav Duo Syrup 100 ml and Zalcitabine can be decreased when combined with Endoclav Duo Syrup 100 ml.

How to manage the interaction:
There may be a possibility of interaction between Zalcitabine and Endoclav Duo Syrup 100 ml, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics.
  • Whole grains like whole-grain bread and brown rice should be included in your diet.
  • Probiotics should be taken after taking a full course of Endoclav Duo Syrup in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea.
  • Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria.
  • Avoid alcoholic beverages with Endoclav Duo Syrup as they can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Endoclav Duo Syrup in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- INFECTIVES

Endoclav Duo Syrup Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid consumption of alcohol during the treatment with Endoclav Duo Syrup as it may worsen the side effects like dizziness.

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Pregnancy

Consult your doctor

If you are pregnant, consult your doctor before taking Endoclav Duo Syrup . Your doctor will prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

This medication passes into breast milk. If you are a nursing mother, consult your doctor before taking Endoclav Duo Syrup . Your doctor will prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Endoclav Duo Syrup may cause dizziness in some people, so it may affect your ability to drive. Avoid driving or operating machines until you are alert after taking Endoclav Duo Syrup .

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Liver

Caution

Endoclav Duo Syrup to be taken with caution if you have a history of liver conditions. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Caution

Endoclav Duo Syrup to be taken with caution, especially if you have a history of kidney conditions. Your doctor may adjust the dose if necessary based on your condition.

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Children

Consult your doctor

Please consult the doctor. Your child's doctor will decide the dosage of this medicine depending on the weight and the severity of the infection.

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Heart

Consult your doctor

Limited information is available. Please consult your doctor.

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Geriatrics

Caution

The use of Endoclav Duo Syrup in elderly patients may increase the risk of serious side effects.

Have a query?

FAQs

Endoclav Duo Syrup is used to prevent middle ear and sinus infections, throat or lung respiratory tract infections, urinary tract infections, skin infections, soft tissue infections, dental infections, and joint and bone infections.

Endoclav Duo Syrup contains Amoxycillin and Clavulanic acid. Amoxycillin works by preventing the formation of bacterial cell covering, which is necessary for the survival of the bacteria. Thus it kills the bacteria. Clavulanic acid works by decreasing bacterial resistance and enhancing the activity of amoxycillin against the bacteria. Together, Endoclav Duo Syrup helps in treating bacterial infections.

Endoclav Duo Syrup is known to cause stomach upset, indigestion, nausea, and diarrhea. To avoid these side effects, please take Endoclav Duo Syrup with a meal. Also, Endoclav Duo Syrup should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.

Generally, the penicillin group of antibiotics is not advised to be taken with methotrexate, which is used for conditions like psoriasis, rheumatoid arthritis, etc. They may cause unpleasant side effects when taken together. However, Endoclav Duo Syrup is relatively safer to take with methotrexate, but only if prescribed by the doctor. It is best to discuss with your doctor about using the two medicines together, who may weigh the pros and cons and decide what is best for you.

Usually, Endoclav Duo Syrup does not cause jaundice. But sometimes, it can cause jaundice in elderly people who have been taking the medication for a prolonged time. Please consult your doctor immediately if you notice any yellowing of the skin/eyes.

Endoclav Duo Syrup does not treat a viral infection like the flu or a common cold. It is best to consult the doctor to know if you need Endoclav Duo Syrup for your condition.

Yes, after taking Endoclav Duo Syrup , you may have diarrhea. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration). Do not take anti-diarrhea medicine on your own; consult your doctor if the condition worsens.

Endoclav Duo Syrup is not known to reduce the efficacy of birth control pills and emergency contraceptive pills. However, if you develop diarrhea or vomiting due to Endoclav Duo Syrup , you are recommended to use other contraceptive methods such as condoms along with contraceptives to avoid unwanted pregnancies. Discuss with your doctor if you have any concerns regarding using Endoclav Duo Syrup and your birth control pills.

Endoclav Duo Syrup may show its effect 1.5 hours after taking the medicine. However, clinical improvement may be noticed after 48 hours.

Endoclav Duo Syrup should be taken for the duration prescribed by the doctor based on your condition. Usually, it is taken every 8-12 hours.

Endoclav Duo Syrup contains amoxicillin and clavulanic acid used to treat bacterial infections of the ear, sinus, respiratory tract, urinary tract, skin, soft tissue, dental, joints and bones.

Yes, Endoclav Duo Syrup is safe to use if prescribed by the doctor.

Endoclav Duo Syrup should not be used if you are allergic to any of its components or if you had jaundice or liver problems when taking an antibiotic.

Do not exceed the recommended dose of Endoclav Duo Syrup as it might cause stomach upset or convulsions. Take Endoclav Duo Syrup only as advised by the doctor.

Store Endoclav Duo Syrup at room temperature (below 25°C). Keep it out of sight and reach of children. To help protect the environment, avoid throwing away any medicines via wastewater or household waste. Ask your pharmacist regarding the disposal of medicines.

To treat your infection effectively, continue taking Endoclav Duo Syrup for the prescribed duration even if your symptoms are relieved.

Endoclav Duo Syrup may cause an allergic reaction like skin rash, vasculitis (inflammation of blood vessels), angioedema (swelling), and difficulty breathing. Consult the doctor if you experience these symptoms.

No, Endoclav Duo Syrup does not cause drowsiness. Sometimes, it might cause dizziness as an uncommon side effect. Drive or operate machinery only if you are alert.

Endoclav Duo Syrup should be swallowed as a whole with water. Take the medicine with a meal.

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking Endoclav Duo Syrup .

The common side effects of Endoclav Duo Syrup include vomiting, nausea, and diarrhoea. In case of any discomfort, speak with a doctor.

Endoclav Duo Syrup should be taken only if prescribed by the doctor. It should not be taken by people who are allergic to amoxicillin, clavulanic acid, penicillin or any of the other ingredients of this medicine, ever had a severe allergic reaction (skin rash or swelling of the face or throat) to any other antibiotic or liver problems/jaundice (yellowing of the skin) when taking an antibiotic.

Let the doctor know if you are taking gout medicine (allopurinol, probenecid), blood thinners (warfarin), anticancer, or anti-arthritis drugs (methotrexate), and drugs to prevent organ transplant (mycophenolate mofetil).

Seek immediate medical attention if you have overdosed on Endoclav Duo Syrup . Taking too much of Endoclav Duo Syrup may cause upset stomach (nausea, vomiting or diarrhoea) or convulsions.

Country of origin

India

Manufacturer/Marketer address

205 Blue Star PlazaSarja Market, 2nd Floor Sector-7 Rohini East New Delhi-110065
Other Info - END0274

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 8:48 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.9127.pdf
  2. https://gskpro.com/en-mt/products/augmentin/indication/
  3. https://www.nhs.uk/medicines/co-amoxiclav/
  4. https://www.drugs.com/augmentin.html

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