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ENBREL 50MG INJECTION is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Plaque psoriasis. It contains Etanercept, which works by blocking the effects of TNF-alpha, a pro-inflammatory cytokine that becomes elevated in psoriasis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. Common side effects of this medication include tingling or numbness, dizziness, shortness of breath, bleeding, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETANERCEPT-50MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ENBREL 50MG INJECTION

ENBREL 50MG INJECTION is an injectable prescription medicine used to reduce pain and inflammation caused by certain autoimmune conditions. It is commonly prescribed to treat moderate to severe rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. By controlling chronic swelling, it helps limit progressive joint damage and improves daily physical function.

This medicine is typically injected once or twice a week, and it is crucial to use it consistently to maintain a stable level of the medication in your system. 

Because it is injected under the skin, you can take it with or without food, as meals do not affect how the body absorbs it. Adopting a nutrient-rich, anti-inflammatory diet and engaging in gentle physical activity can further support your joint and skin health during treatment.
 

Some people may experience mild side effects, such as redness, itching, or swelling where the injection was given, as well as minor cold-like symptoms. However, you must contact your doctor immediately if you experience serious side effects, such as a persistent fever, sudden weight loss, severe skin rashes, or unusual bruising or bleeding.

Talk to your doctor before starting this medicine if you have a history of chronic infections, tuberculosis, heart failure, or disorders affecting the nervous system. Do not take this if you currently have a severe, active infection or blood poisoning, as this medicine can weaken your body's ability to fight off illness.

Let your healthcare provider know about all the medicines you use, as certain immune-suppressing therapies can interact with ENBREL 50MG INJECTION and increase your risk of severe infections. It is also important to consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as special monitoring may be required.
 

Uses of ENBREL 50MG INJECTION

ENBREL 50MG INJECTION may be prescribed to treat the following inflammatory and autoimmune conditions:

  • Rheumatoid arthritis: ENBREL 50MG INJECTION helps reduce joint pain, swelling, and stiffness in moderate to severe cases, protecting joints from long-term damage.
  • Plaque psoriasis: It calms down the overproduction of skin cells, significantly reducing red, itchy, and scaly patches.
  • Psoriatic arthritis: It eases joint swelling and pain while simultaneously improving psoriasis-related skin symptoms.
  • Ankylosing spondylitis: It relieves stiffness and back pain caused by chronic inflammation in the spine and pelvis.
  • Polyarticular juvenile idiopathic arthritis: It manages joint swelling, pain, and stiffness in children and teenagers with inflammatory arthritis.
     

Key Benefits

ENBREL 50MG INJECTION is a biologic medicine used to treat certain inflammatory and autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. It works by blocking tumour necrosis factor (TNF), a protein that plays a key role in inflammation.

  • Reduces Joint Inflammation: Helps decrease pain, swelling, and stiffness in inflammatory joint conditions, making everyday movement more comfortable.
  • Improves Physical Function: By controlling inflammation, it may improve mobility and make activities such as walking, climbing stairs, or using the hands easier.
  • Helps Control Psoriasis: Reduces the severity of red, scaly, and itchy plaques in people with moderate to severe plaque psoriasis.
  • Slows Joint Damage: In conditions such as rheumatoid arthritis and psoriatic arthritis, controlling inflammation may help slow the progression of structural joint damage.
  • Supports Long-Term Disease Control: Regular treatment can reduce disease activity and help improve overall quality of life in people with chronic inflammatory conditions.
     
Side effects of Enbrel 50mg Injection
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • ENBREL 50MG INJECTION will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How ENBREL 50MG INJECTION Works

ENBREL 50MG INJECTION contains etanercept. It is a biologic medicine that works by targeting a specific protein in the body called tumour necrosis factor (TNF). In people with autoimmune conditions, the immune system mistakenly produces too much TNF, which triggers healthy tissues to become inflamed, painful, and damaged. By binding directly to excess TNF proteins, ENBREL 50MG INJECTION blocks them from attaching to healthy cells. This action helps calm the overactive immune response, reducing the swelling, joint pain, and skin irritation associated with chronic inflammatory disorders.
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Alcohol

Unsafe

Avoid alcohol consumption as alcohol intake, along with ENBREL 50MG INJECTION, may cause increased dizziness and risk of stomach bleeding/ulcers.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant, or planning pregnancy inform your doctor before receiving ENBREL 50MG INJECTION. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass in to breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving ENBREL 50MG INJECTION. Your doctor may suggest you to stop feeding while on treatment with this medicine

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Driving

Unsafe

ENBREL 50MG INJECTION may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness.

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Liver

Caution

ENBREL 50MG INJECTION should be used with caution if you have liver disease. Dose adjustment may be needed in patients with liver impairment. However, ENBREL 50MG INJECTION is not recommended in patients with active liver diseases.

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Kidney

Caution

ENBREL 50MG INJECTION should be used with caution if you have kidney impairment. Dose adjustment may be needed in patients with liver impairment.

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Children

Caution

ENBREL 50MG INJECTION is not recommended in children below two years of age as the safety and efficacy is not established. In children above two years of age, it will be administered by the paediatrician.

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Heart

Caution

ENBREL 50MG INJECTION may be used in heart patients, but caution is needed, especially with heart failure. Doctors will assess risks carefully and monitor closely during treatment.

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Geriatrics

Caution

Geriatric patients can receive ENBREL 50MG INJECTION, but it may be more susceptible to infections and other side effects. Regular monitoring and medical supervision are important during treatment.

What if I have taken an overdose of ENBREL 50MG INJECTION

If you accidentally inject more than your prescribed dose, seek immediate medical attention or contact a poison control centre right away, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Eat an anti-inflammatory diet: Focus on whole foods rich in antioxidants, such as leafy greens, berries, walnuts, and fatty fish, which can help support overall joint and skin health.
  • Protect your joints: Engage in low-impact exercises like swimming, cycling, or yoga to maintain flexibility and strength without overloading your joints.
  • Practice strict hygiene: Wash your hands frequently and avoid close contact with individuals who have active infections, as ENBREL 50MG INJECTION can temporarily lower your body's defences.
  • Manage your weight: Maintaining a healthy weight reduces mechanical stress on weight-bearing joints like the knees and hips, which helps ease pain.
  • Avoid raw foods: Steer clear of raw meats, runny eggs, and unpasteurised dairy products to minimise the risk of foodborne infections while your immune system is slightly suppressed.
     
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How Soon It Starts Working

The time required for ENBREL 50MG INJECTION to start to work: The onset of time for ENBREL 50MG INJECTION is unknown. The time for which the effects of ENBREL 50MG INJECTION last: The duration of ENBREL 50MG INJECTION’s effect is clinically not established.

What if you forget to take ENBREL 50MG INJECTION

If you miss an injection, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed injection and resume your regular schedule. Do not inject a double dose to make up for a missed one. If you are unsure of what to do, talk to your doctor or pharmacist.

Storage

• Store ENBREL 50MG INJECTION in the refrigerator between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the liquid first: Inspect the solution inside the syringe or pen before injecting; it should be clear and colourless to pale yellow. Do not use it if it is cloudy, discoloured, or contains floating particles.
  • Do not shake: Shaking the syringe or pen can damage the delicate proteins in the medication, making it less effective.
  • Rotate your sites: Consistently changing your injection spot helps prevent the buildup of hard or fatty lumps under the skin.
  • Get screened first: Ensure your doctor tests you for tuberculosis (TB) and hepatitis B before starting treatment, as ENBREL 50MG INJECTION can reactivate dormant infections.
  • Avoid live vaccines: Do not receive live vaccines (such as the nasal spray flu vaccine) while using this medicine, as they could cause a serious infection.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before using ENBREL 50MG INJECTION:

  • Other biologic medicines: Taking this medicine alongside other biologics (like anakinra or abatacept) can significantly increase the risk of severe, life-threatening infections.
  • Immune-weakening treatments: Combining this medicine with strong immunosuppressants (like cyclophosphamide) may raise the risk of developing certain blood disorders.
     
EtanerceptPentostatin
Severe

Drug-Drug Interactions

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EtanerceptPentostatin
Severe
How does the drug interact with Enbrel 50mg Injection:
When Enbrel 50mg Injection is used with Pentostatin, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Enbrel 50mg Injection with Pentostatin can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
When Enbrel 50mg Injection is used with Daratumumab, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Daratumumab with Enbrel 50mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
Co-administration of Enbrel 50mg Injection with Mercaptopurine together can increase the risk of infections.

How to manage the interaction:
Although taking Enbrel 50mg Injection and Mercaptopurine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Enbrel 50mg Injection:
Taking Abemaciclib with Enbrel 50mg Injection can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Abemaciclib with Enbrel 50mg Injection together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Enbrel 50mg Injection:
When Enbrel 50mg Injection is used with Daunorubicin, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Daunorubicin and Enbrel 50mg Injection, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
Taking Temozolomide with Enbrel 50mg Injection can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and Enbrel 50mg Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
How does the drug interact with Enbrel 50mg Injection:
When Enbrel 50mg Injection is used with Primaquine, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Enbrel 50mg Injection and Primaquine, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, breathing difficulty, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
Using Enbrel 50mg Injection together with ruxolitinib may increase the risk of infections.

How to manage the interaction:
Co-administration of Enbrel 50mg Injection with Ruxolitinib can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, loose stools, sore throat, muscular pains, shortness of breath, blood in phlegm, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
When Enbrel 50mg Injection is used with Vinblastine, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Enbrel 50mg Injection with Vinblastine can result in an interaction, but it can be taken if your doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Enbrel 50mg Injection:
Co-administration of Enbrel 50mg Injection with fludrocortisone can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Enbrel 50mg Injection with Fludrocortisone can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with ENBREL 50MG INJECTION when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

ENBREL 50MG INJECTION is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis and Plaque psoriasis.
ENBREL 50MG INJECTION consists of Etanercept, which belong to TNF (Tumor necrosis factor) inhibitor class of drug. It works by inhibiting the TNF-α and TNF-β binding to the cell surface and therby makes the TNF cytokine inactive. This helps reduce inflammation and pain caused due to various autoimmune diseases.
ENBREL 50MG INJECTION affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis, hepatitis B, or abnormal liver enzymes. ENBREL 50MG INJECTION can also increase the risk of developing cancers; hence, mentioning your doctor if you have a history of any cancer is essential.
Yes, ENBREL 50MG INJECTION is a disease-modifying anti-rheumatic drug (DMARD) that works by inhibiting tumour necrosis factor (TNF), a key protein involved in the inflammatory response. By blocking TNF, it helps reduce inflammation, manage symptoms of autoimmune diseases like rheumatoid arthritis, and slow disease progression.
ENBREL 50MG INJECTION is neither a steroid nor a monoclonal antibody. It is a biological medicine classified as a TNF inhibitor. It is a fusion protein that binds to tumour necrosis factor (TNF) and prevents it from causing inflammation in autoimmune conditions like rheumatoid arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, and plaque psoriasis.
Yes, ENBREL 50MG INJECTION is safe as it is administered by the doctor or nurse in prescribed dose and duration. Ensure you do not skip scheduled appointments to maintain safety and monitor your progress effectively.
ENBREL 50MG INJECTION may cause weight gain if you use it for a longer duration. If you notice any weight changes, manage stress, exercise regularly, eat a nutritious-rich diet, take a fibre-rich diet, stay hydrated, and cut down on sugary foods and drinks.
ENBREL 50MG INJECTION may cause hair loss in some individuals. If you experience this symptom, manage stress, use gentle hair care practices, and eat nutritious rich food. However, if hair loss persists consult the doctor for further guidance.
ENBREL 50MG INJECTION typically starts to show some effects within one to two weeks. However, it may take 3 to 6 months for noticeable improvement.
The side effects of ENBREL 50MG INJECTION include tingling or numbness, shortness of breath, bleeding, dizziness, pale skin, bruising, vision problems, redness on the skin and arms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.
Yes, but you must keep the medicine cool. Use a travel cooler bag with ice packs to maintain a temperature between 2°C and 8°C, ensuring the syringes or pens do not touch the ice directly to prevent freezing. Talk to your pharmacist for specific travel storage advice.
Contact your doctor immediately if you develop a fever, chills, or a persistent cough. Because this medicine reduces your immune response, even minor infections can quickly become serious and require prompt medical treatment.
You can safely receive non-live vaccines, such as the standard flu shot or updated COVID-19 vaccines. However, you must avoid live vaccines while on this medication, as your immune system may not be able to handle the weakened virus. Talk to your doctor before scheduling any vaccinations.
There is no direct chemical interaction between alcohol and ENBREL 50MG INJECTION. However, it is wise to limit alcohol consumption, as excessive drinking can strain your liver and potentially worsen inflammatory symptoms. Talk to your doctor about what is safe for you.
This medicine should only be used during pregnancy if your doctor determines it is clearly needed. Because it can cross the placenta, especially during the third trimester, you must talk to your doctor to weigh the benefits against potential risks to your baby.
Rotating your injection sites helps prevent skin irritation, tenderness, and the development of hard, fatty lumps under the skin, which can interfere with how the medicine is absorbed. Always inject at least one inch away from your previous site.
Do not inject the medicine if the liquid appears cloudy, thick, discoloured, or contains visible floating particles. The solution should always be clear and colourless to pale yellow. Contact your pharmacist or healthcare provider for a replacement.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

The Capital, 1802 / 1901, Plot No. C-70, G-Block,Bandra Kurla Complex, Bandra (East),Mumbai,Maharashtra,INDIA,400051.
Other Info - ENB0005
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