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compositionComposition:ENALAPRIL-2.5MG+HYDROCHLOROTHIAZIDE-12.5MG
prescription
Prescription Medicine
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ENACE D 2.5MG TABLET is used to treat hypertension (high blood pressure). It contains Enalapril and Hydrochlorothiazide, which decreases the constriction and narrowing of blood vessels leading to high blood pressure. Thereby, it widens and relaxes blood vessels. Also, it removes excess water and certain salts such as sodium and potassium from the blood. This reduces the fluid volume circulating through blood vessels and lower high blood pressure. In some cases, you may experience dizziness, weakness, blurred vision, nausea, headache, orthostatic hypotension (low blood pressure when standing up from sitting or lying position), high cholesterol or uric acid levels, electrolyte imbalance, diarrhoea, chest pain, fast heartbeat, changes in taste or stomach pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ENALAPRIL-2.5MG+HYDROCHLOROTHIAZIDE-12.5MG

Manufacturer/Marketer :

Nicholas Piramal India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ENACE D 2.5MG TABLET

ENACE D 2.5MG TABLET is a prescription combination tablet used to treat high blood pressure (hypertension). By keeping your blood pressure within a healthy range, this medicine helps decrease the strain on your heart and blood vessels, lowering the risk of future heart problems.

For the best results, you must take ENACE D 2.5MG TABLET consistently every day. It is usually taken once daily, and you can take it either with or without food. To help this medicine work most effectively, doctors recommend combining it with healthy diet and lifestyle changes, such as reducing salt intake and staying physically active.

While taking ENACE D 2.5MG TABLET, some people may experience mild side effects, such as a dry cough, lightheadedness, or feeling tired. If you notice any serious side effects, such as severe dizziness, fainting, or swelling of your face, lips, or throat, you should contact your doctor immediately.

Do not take this if you are pregnant, as this medicine can cause severe harm to an unborn baby. Before starting ENACE D 2.5MG TABLET, make sure to talk to your doctor or pharmacist if you have kidney disease, liver disease, diabetes, or a history of severe allergies.

This medicine can interact with alcohol, making you feel more dizzy or lightheaded when standing up. It can also interact with other prescription drugs, over-the-counter painkillers, and potassium supplements. Pregnant, breastfeeding, or elderly individuals must consult their doctor to ensure this medicine is safe for their specific situation.
 

Uses of ENACE D 2.5MG TABLET

ENACE D 2.5MG TABLET is used to treat high blood pressure (hypertension). The detailed uses of ENACE D 2.5MG TABLET are as follows:

  • High Blood Pressure (Hypertension): ENACE D 2.5MG TABLET is used to lower blood pressure in patients whose hypertension is not adequately controlled with a single medication. Managing blood pressure reduces the risk of serious complications like strokes and heart attacks.

Key Benefits

ENACE D 2.5MG TABLET helps manage high blood pressure by combining two complementary blood pressure-lowering medicines in a single tablet. By providing consistent blood pressure control, it supports long-term cardiovascular health and helps protect vital organs from hypertension-related complications.

  • Long-term cardiovascular protection: By consistently keeping your blood pressure in check, ENACE D 2.5MG TABLET lowers your risk of experiencing a life-threatening stroke, heart attack, or kidney damage.
  • Convenient combination treatment: Because it contains two active blood pressure-lowering components in a single tablet, ENACE D 2.5MG TABLET simplifies your daily routine, reducing the number of pills you need to take each day.
  • Stable 24-hour control: Taking ENACE D 2.5MG TABLET once a day provides stable, round-the-clock blood pressure control, helping you maintain a healthy cardiovascular system throughout the day and night.
Side effects of Enace D 2.5mg Tablet
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Directions for Use

  • Take ENACE D 2.5MG TABLET with or without food or as advised by a doctor.
  • Recommended to take twice a day or as advised by your doctor.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How ENACE D 2.5MG TABLET Works

ENACE D 2.5MG TABLET combines two different mechanisms to lower blood pressure more effectively than either component could alone. The first active component, enalapril, belongs to a class of medicines that relax and widen your blood vessels by blocking a natural substance in your body that causes them to tighten. This makes it easier for your blood to flow and reduces the workload on your heart. The second active component, hydrochlorothiazide, is a mild diuretic, often called a water pill. It helps your kidneys flush excess water and salt out of your body through your urine. By reducing the overall volume of fluid in your bloodstream, it lowers the pressure on your blood vessel walls. Together, these two processes work in harmony to keep your blood pressure stable.
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Alcohol

Unsafe

Avoid alcohol consumption with ENACE D 2.5MG TABLET as it may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

Please consult a doctor if you are pregnant. ENACE D 2.5MG TABLET is not recommended for pregnant women, especially in the second and third trimesters as it may cause birth defects or serious harm to the baby.

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Breast Feeding

Unsafe

ENACE D 2.5MG TABLET may be excreted in human milk. Therefore, ENACE D 2.5MG TABLET is not recommended for breastfeeding mothers as it may be unsafe for the baby. However, please consult a doctor.

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Driving

Caution

ENACE D 2.5MG TABLET may cause dizziness or tiredness in some people. Therefore, avoid driving if you feel dizzy or tired after taking ENACE D 2.5MG TABLET.

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Liver

Caution

ENACE D 2.5MG TABLET should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking ENACE D 2.5MG TABLET if you have severe liver problems.

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Kidney

Caution

ENACE D 2.5MG TABLET should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking ENACE D 2.5MG TABLET if you have severe kidney problems.

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Children

Unsafe

It is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

ENACE D 2.5MG TABLET should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using ENACE D 2.5MG TABLET.

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Geriatrics

Caution

ENACE D 2.5MG TABLET should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using ENACE D 2.5MG TABLET.

What if I have taken an overdose of ENACE D 2.5MG TABLET

If you suspect an overdose, seek immediate medical attention right away. Symptoms of an overdose can include extreme dizziness, fainting, or a rapid or unusually slow heartbeat.

Diet & Lifestyle Advise

  • Reduce your salt intake: Avoid adding extra salt to your meals and limit processed foods. Lowering sodium in your diet helps support the action of this medicine.
  • Stay hydrated: Because this medicine contains a diuretic, make sure to drink an adequate amount of water daily. Consult your doctor about the right amount of fluid for you.
  • Avoid potassium-rich salt substitutes: Do not use salt substitutes containing potassium unless your doctor advises you to do so, as they can cause potassium levels in your blood to rise too high.
  • Limit alcohol consumption: Drinking alcohol can increase the blood pressure-lowering effect of ENACE D 2.5MG TABLET, which can make you feel extremely dizzy or faint.
  • Stay active: Engage in regular, moderate exercise such as walking or cycling as approved by your doctor to help improve your heart health.
health query

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How Soon It Starts Working

The time required for ENACE D 2.5MG TABLET to start to work: ENACE D 2.5MG TABLET ideally shows its action within 2 hours after administration. The time for which the effects of ENACE D 2.5MG TABLET last: The effect of ENACE D 2.5MG TABLET lasts for 24 hours.

What if you forget to take ENACE D 2.5MG TABLET

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and resume your regular daily schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store ENACE D 2.5MG TABLET tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original container or packaging to protect it from light and moisture.

Drug Warnings

  • Stand up slowly from a sitting or lying position to reduce the risk of dizziness and prevent falls.
  • Check your blood pressure regularly at home and keep a log to share with your healthcare provider at your next visit.
  • Wear sunscreen and protective clothing when outdoors, as this medication can make your skin more sensitive to sunlight.
  • Let your surgeon or dentist know you are taking ENACE D 2.5MG TABLET before any medical or dental procedures, as it can interact with certain anaesthetics.
  • Avoid taking any potassium supplements or over-the-counter painkillers like ibuprofen without first consulting your doctor.

Drug-Drug Interactions

verifiedApollotooltip
  • Other blood pressure medications: Combining these can lower your blood pressure excessively, causing dizziness or fainting.
  • NSAID pain relievers (like ibuprofen): Can reduce the effectiveness of ENACE D 2.5MG TABLET and significantly increase the risk of kidney damage.
  • Potassium supplements and potassium-sparing diuretics: Can lead to dangerously high potassium levels in your blood.
  • Lithium: ENACE D 2.5MG TABLET can reduce the clearance of lithium from your body, increasing the risk of lithium toxicity.
  • Diabetes medications: May require dose adjustments, as this medicine can alter your blood sugar levels.
Enalapril + HydrochlorothiazideAliskiren
Critical
Enalapril + HydrochlorothiazideDofetilide
Critical

Drug-Drug Interactions

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Enalapril + HydrochlorothiazideAliskiren
Critical
How does the drug interact with Enace D 2.5mg Tablet:
Taking Aliskiren with Enace D 2.5mg Tablet may increase the potassium levels in blood and kidney problems.

How to manage the interaction:
Although taking Aliskiren with Enace D 2.5mg Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, slow or rapid heart rate, or numbness of tingling sensation in hands or legs, consult a doctor. Do not discontinue any medication without consulting a doctor.
Enalapril + HydrochlorothiazideDofetilide
Critical
How does the drug interact with Enace D 2.5mg Tablet:
Co-administration of Dofetilide and Enace D 2.5mg Tablet together can increase the risk of irregular heartrate.

How to manage the interaction:
Although taking Enace D 2.5mg Tablet with Dofetilide can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, slow or rapid heartbeat. Do not stop taking any medication without consulting a doctor.
Enalapril + HydrochlorothiazideCisapride
Critical
How does the drug interact with Enace D 2.5mg Tablet:
Co-administration of Cisapride and Enace D 2.5mg Tablet together can increase the risk of irregular heartrate.

How to manage the interaction:
Although taking Enace D 2.5mg Tablet with Cisapride can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, slow or rapid heartbeat. Do not stop taking any medication without consulting a doctor.
Enalapril + HydrochlorothiazideTriamterene
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Taking Triamterene with Enace D 2.5mg Tablet may increase the potassium levels in blood.

How to manage the interaction:
Although taking Triamterene with Enace D 2.5mg Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as weakness, confusion, numbness of tingling sensation in hands or legs, slow or rapid heartbeat, consult a doctor. Do not discontinue any medication without consulting a doctor.
Enalapril + HydrochlorothiazidePimozide
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Co-administration of Pimozide and Enace D 2.5mg Tablet together can increase the risk of irregular heartrate and other side effects.

How to manage the interaction:
Although taking Enace D 2.5mg Tablet with Pimozide can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, slow or rapid heartbeat, weakness, tiredness, muscle pains or confusion. Do not stop taking any medication without consulting a doctor.
Enalapril + HydrochlorothiazideTizanidine
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Co-administration of Enace D 2.5mg Tablet and Tizanidine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Enace D 2.5mg Tablet and Tizanidine can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any symptoms like headache, dizziness, rapid heart rate, or chest pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
Enalapril + HydrochlorothiazideMipomersen
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Co-administration of Mipomersen and Enace D 2.5mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking Enace D 2.5mg Tablet with Mipomersen may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms like fever, chills, unusual bleeding, dark-colored urine, light-colored stools, yellowish discoloration of skin and eyes, and abdominal pain. Do not discontinue any medications without consulting a doctor.
Enalapril + HydrochlorothiazideSpironolactone
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Taking Spironolactone with Enace D 2.5mg Tablet may increase the potassium levels in blood.

How to manage the interaction:
Although taking Spironolactone with Enace D 2.5mg Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as weakness, confusion, numbness of tingling sensation in hands or legs, slow or rapid heartbeat, consult a doctor. Do not discontinue any medication without consulting a doctor.
Enalapril + HydrochlorothiazideLosartan
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Taking Losartan with Enace D 2.5mg Tablet may increase the potassium levels in blood and kidney problems.

How to manage the interaction:
Although taking Losartan with Enace D 2.5mg Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, slow or rapid heart rate, or numbness of tingling sensation in hands or legs, consult a doctor. Do not discontinue any medication without consulting a doctor.
Enalapril + HydrochlorothiazidePotassium citrate
Severe
How does the drug interact with Enace D 2.5mg Tablet:
Taking Potassium citrate with Enace D 2.5mg Tablet may increase the potassium levels in blood and kidney problems.

How to manage the interaction:
Although taking Potassium citrate with Enace D 2.5mg Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, slow or rapid heart rate, or numbness of tingling sensation in hands or legs, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Potassium-based salt substitutes: Can cause unsafe potassium buildup in your bloodstream.
  • Alcohol: Can worsen dizziness, lightheadedness, and the risk of fainting.
     
ENALAPRIL-2.5MG+HYDROCHLOROTHIAZIDE-12.5MGPotassium rich foods
Moderate

Drug-Food Interactions

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ENALAPRIL-2.5MG+HYDROCHLOROTHIAZIDE-12.5MGPotassium rich foods
Moderate
Common Foods to Avoid:
Apricots, Avocado, Bananas, Beans, Beetroot, Broccoli, Coconut Water, Lentils, Orange Juice, Oranges, Potatoes, Raisins, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Yogurt

How to manage the interaction:
Consumption of potassium rich food while on the treatment with Enace D 2.5mg Tablet can lead to weakness, confusion, numbness of tingling sensation in hands or legs, or slow or rapid heartbeat. Avoid or limit consumption of potassium rich food while on the treatment with Enace D 2.5mg Tablet.

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

ENACE D 2.5MG TABLET is used to treat hypertension (high blood pressure).
ENACE D 2.5MG TABLET contains Enalapril and Hydrochlorothiazide. Enalapril belongs to the class angiotensin-converting enzyme (ACE) inhibitors that work by blocking an angiotensin-converting enzyme which decreases the production of angiotensin II in the body that causes constriction and narrowing of blood vessels leading to high blood pressure. Thereby, it widens and relaxes blood vessels. Hydrochlorothiazide is a diuretic (water tablet) that increases the removal of excess water and certain salts such as sodium and potassium from the blood. This removal of water from blood reduces the fluid volume circulating through blood vessels. Thus, together they lower high blood pressure.
You are not recommended to take furosemide with ENACE D 2.5MG TABLET as co-administration of these two medicines may increase the risk of low blood pressure. However, if you experience dizziness, reduced heart rate, headache or fainting, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted to use safely.
It is advised to inform your doctor if you have had skin cancer or develop an unexpected skin lesion as hydrochlorothiazide in ENACE D 2.5MG TABLET may increase the risk of certain types of skin and lip cancer especially when taken in high doses for a long period. Therefore, it is recommended to protect the skin from UV rays and sun exposure while taking ENACE D 2.5MG TABLET.
No, you are not recommended to take potassium supplements with ENACE D 2.5MG TABLET as it may increase the levels of potassium in the blood (hyperkalaemia). However, please consult a doctor before taking other medicines with ENACE D 2.5MG TABLET.
If you have any kidney problems, it is advised to inform your doctor before taking ENACE D 2.5MG TABLET as ENACE D 2.5MG TABLET may worsen kidney functioning if there is any existing kidney problem. However, if you experience unexplained weight gain, swelling in feet, ankles or hands, please consult your doctor immediately.
You are not recommended to take more than the prescribed dose of ENACE D 2.5MG TABLET as it may cause ENACE D 2.5MG TABLET overdose resulting in symptoms such as low blood pressure, cough, nausea, dizziness, cramps, drowsiness, fast or slow heartbeat, anxiety, increased urination or difficulty in urination. However, if you experience any of these symptoms while taking ENACE D 2.5MG TABLET, please consult a doctor immediately.ENACE D 2.5MG TABLET belongs to a class of medication called 'anti-hypertensive' primarily used to treat hypertension (high blood pressure). Hypertension is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease.
No, do not take ENACE D 2.5MG TABLET if you are pregnant or planning to become pregnant. This medicine can cause severe injury or death to an unborn baby. If you suspect you are pregnant, stop taking this medicine immediately and contact your doctor for a safer alternative.
One of the active ingredients in this medicine is a diuretic, which helps your body get rid of excess fluid and sodium. This naturally results in more frequent urination, especially when you first start the medication. Taking your daily dose in the morning can help prevent this from disrupting your sleep.
You should avoid salt substitutes containing potassium, as they can cause unsafe potassium levels in your blood. It is also wise to limit alcohol and high-sodium foods. Talk to your doctor or pharmacist for specific dietary advice.
A dry, tickling cough is a known side effect of one of the active components in this medicine. It is usually harmless but can be bothersome. Do not take over-the-counter cough remedies without asking your doctor first, as they are rarely effective for this specific type of cough. Talk to your doctor if the cough is severe.
This medicine can make you feel dizzy or tired, particularly when you first start taking it or after a dose increase. Avoid driving, operating machinery, or performing tasks that require full mental alertness until you know how this medication affects you. Talk to your doctor if the dizziness persists.
No, you must not stop taking ENACE D 2.5MG TABLET without consulting your doctor. High blood pressure is a chronic condition that typically requires long-term management. Stopping the medication abruptly can cause your blood pressure to rise quickly, increasing your risk of a heart attack or stroke.
Hot weather can cause you to sweat more, leading to a loss of fluids and a potential drop in blood pressure. This can make you feel unusually dizzy or lightheaded. Drink plenty of water, avoid prolonged exposure to direct sunlight, and talk to your doctor if you experience persistent

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Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - ENA0012
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