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compositionComposition:SARGRAMOSTIM-500MCG
prescription
Prescription Medicine
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EMGRAST M 500MCG INJECTION is used to treat neutropenia, a deficiency of specific white blood cells caused by cancer, bone marrow transplant, chemotherapy, or other diseases. It contains Sargramostim, a growth factor that stimulates the formation of white blood cells and helps reduce the chances of infection in cancer patients receiving chemotherapy.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SARGRAMOSTIM-500MCG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About EMGRAST M 500MCG INJECTION

The prescription medicine EMGRAST M 500MCG INJECTION is an injection used to help your body produce more white blood cells after certain medical procedures or treatments. It is primarily used to lower the risk of serious infections in patients undergoing chemotherapy, receiving bone marrow transplants, or experiencing radiation exposure. By boosting these vital defence cells, it helps support your immune system during recovery.

This injection is typically given once a day and must be used consistently exactly as your healthcare provider instructs. Because it is given as an injection, it can be taken with or without food, but practising strict hand hygiene and eating a clean, thoroughly cooked diet is essential to prevent infections. Keeping a consistent daily schedule for your injections helps maintain stable levels of the medicine in your body.

While taking EMGRAST M 500MCG INJECTION, you may experience common side effects like bone pain, muscle aches, or redness at the injection site. However, you must contact your doctor immediately if you experience severe symptoms, such as sudden breathing problems, chest pain, or rapid swelling in your legs or throat.

Before starting this treatment, tell your doctor if you have a history of heart disease, lung conditions, kidney disease, or liver damage. You should not take this medicine if you have a known allergy to yeast-derived products or to any of the ingredients in this injection.

Tell your healthcare team about all other medicines you take, as certain drugs like lithium can increase white blood cell counts too much, and avoid alcohol and smoking to protect your immune system. Pregnant women, breastfeeding mothers, and elderly patients must consult their doctor before using this medicine to evaluate potential risks.

Uses of EMGRAST M 500MCG INJECTION

EMGRAST M 500MCG INJECTION is used to lower the risk of serious infections in patients undergoing chemotherapy, receiving bone marrow transplants, or experiencing radiation exposure. The detailed uses of EMGRAST M 500MCG INJECTION are as follows:

  • Recovery after chemotherapy: Helps speed up the recovery of white blood cells to protect the body against severe infections.
  • Bone marrow transplantation: Helps the newly transplanted cells grow and mature into active white blood cells faster.
  • Radiation exposure recovery: Rebuilds damaged immune cells in patients who have been exposed to high doses of radiation.
  • Fungal infection prevention: Assists the immune system in fighting off life-threatening fungal infections in highly vulnerable transplant patients.

Key Benefits

EMGRAST M 500MCG INJECTION helps increase the number of white blood cells when the immune system is weakened, reducing the risk of serious infections and supporting recovery during intensive medical treatments.

  • Helps Prevent Severe Infections: By stimulating the production of white blood cells, EMGRAST M 500MCG INJECTION strengthens the body's natural defence against bacteria and fungi when immunity is low.
  • Supports Faster Recovery: Improved white blood cell counts can help support recovery after treatments such as chemotherapy or bone marrow transplantation and may contribute to shorter hospital stays in some patients.
  • Helps Keep Treatment on Schedule: By maintaining safer blood counts, EMGRAST M 500MCG INJECTION may reduce the risk of treatment delays caused by low white blood cell levels, helping planned cancer therapy continue as intended.
Side effects of Emgrast M 500mcg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

Directions for Use

  • Follow your doctor’s instructions regarding the dosage and duration of treatment.
  • Check the label for directions and use it as advised by the doctor. EMGRAST M 500MCG INJECTION should be injected subcutaneously (under the skin) on your thigh, stomach, or upper arm.
  • Rotate the injection site each time.
  • Do not inject into a tender, bruised, red, or hard spot, or into areas with scars or stretch marks.

How EMGRAST M 500MCG INJECTION Works

This medicine works by mimicking a natural protein in your body that controls the production of white blood cells. Once injected, it travels to your bone marrow, which is the spongy tissue inside your bones where all blood cells are made. Inside the bone marrow, the medicine binds to specific cells and stimulates them to divide, grow, and mature. It specifically increases the production of neutrophils and macrophages, which are the primary white blood cells responsible for finding and destroying invading bacteria and fungi. This cellular boost rapidly strengthens your immune defences and helps prevent infection.
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Alcohol

Caution

It is unknown whether consuming alcohol with EMGRAST M 500MCG INJECTION is safe. However, as a precaution, it is best to avoid or limit alcohol consumption.

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Pregnancy

Caution

It is not known if EMGRAST M 500MCG INJECTION will harm your unborn baby. So, inform your doctor if you are pregnant or planning to become pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Your doctor may advise you to discontinue the medicine or breastfeeding based on your medical condition.

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Driving

Caution

The ability to drive or utilize machines is unaffected by EMGRAST M 500MCG INJECTION. However, do not drive or operate machinery if you feel sleepy or dizzy after taking your medicine.

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Liver

Caution

Caution should be exercised while using EMGRAST M 500MCG INJECTION in patients with hepatic dysfunction. Monitoring of patients with hepatic dysfunction is recommended.

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Kidney

Caution

Caution should be exercised while using EMGRAST M 500MCG INJECTION in patients with renal dysfunction. Monitoring of patients with renal dysfunction is recommended.

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Children

Safe if prescribed

Your doctor will prescribe only if the benefits outweigh the risks.

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Heart

Caution

EMGRAST M 500MCG INJECTION can be used in patients with heart problems, but it requires careful monitoring. It may affect heart rhythm or blood pressure, and can cause fluid retention or worsen preexisting cardiac conditions. Your doctor will assess the risks and benefits before prescribing it and may adjust your treatment plan accordingly.

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Geriatrics

Caution

Geriatric patients can receive EMGRAST M 500MCG INJECTION, but with extra caution and monitoring. Older adults may be more sensitive to side effects like fluid retention, changes in blood pressure, or heart rhythm issues, so doctors typically adjust the dosage and watch closely for any complications.

What if I have taken an overdose of EMGRAST M 500MCG INJECTION

In case of an accidental overdose, seek immediate medical attention or contact a poison control center right away. Symptoms of an overdose may include severe bone pain, extreme headache, or difficulty breathing.

Diet & Lifestyle Advise

  • Follow a clean diet: Avoid raw or undercooked meats, raw fish, soft cheeses, and unpasteurised milk to minimise the risk of foodborne bacterial infections.
  • Wash fresh produce: Thoroughly wash all raw fruits and vegetables before eating, or choose cooked vegetables to be safer.
  • Practice strict handwashing: Wash your hands frequently with warm water and soap for at least 20 seconds, especially before eating and after using the restroom.
  • Avoid crowded areas: Stay away from crowded public spaces and avoid close contact with anyone who has a cold, flu, or other contagious illness.
  • Maintain excellent oral hygiene: Use a soft-bristled toothbrush and clean your teeth gently to prevent bleeding gums and oral infections.
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Have a query?

How Soon It Starts Working

The time required for EMGRAST M 500MCG INJECTION to start to work: The time required for EMGRAST M 500MCG INJECTION to show its action is unknown. The time for which the effects of EMGRAST M 500MCG INJECTION last: The duration of action for EMGRAST M 500MCG INJECTION is unknown.

What if you forget to take EMGRAST M 500MCG INJECTION

If you miss a dose of this injection, contact your doctor or pharmacist immediately for guidance. Do not inject a double dose to make up for a missed one, as this can increase your risk of severe side effects.

Storage

•Store EMGRAST M 500MCG INJECTION in the refrigerator between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the timing: Do not inject EMGRAST M 500MCG INJECTION within 24 hours before you start chemotherapy or within 24 hours after your chemotherapy session ends.
  • Inspect the solution: Always check the liquid before injecting. It must be clear and colourless; do not inject it if you see cloudiness, colour changes, or floating particles.
  • Change injection spots: Always rotate your injection site with each dose (such as your abdomen, thigh, or outer arm) to reduce pain and skin irritation.
  • Avoid shaking: Never shake the vial of medication. If you need to mix it, roll it gently between your palms.
  • Dispose of needles safely: Never reuse needles or syringes. Always discard them immediately in an approved sharps container.
  • Watch for fluid buildup: Contact your doctor immediately if you notice rapid weight gain or sudden swelling in your feet, ankles, or hands.

Drug-Drug Interactions

verifiedApollotooltip
  • Chemotherapy and Radiation: Using EMGRAST M 500MCG INJECTION within 24 hours before or after chemotherapy or radiation therapy can decrease its effectiveness and interfere with blood cell recovery.
  • Lithium: Taking lithium alongside this injection may cause your body to release excessively high amounts of white blood cells, which requires close monitoring by your doctor.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

  • No clinically significant food interactions are known with EMGRAST M 500MCG INJECTION when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HEMATOPOIETIC STEM CELL MOBILIZER]

FAQs

EMGRAST M 500MCG INJECTION is used to treat Neutropenia.
EMGRAST M 500MCG INJECTION contains 'Sargramostim,' which is a growth factor that stimulates the formation of white blood cells and helps to reduce the chances of infection in cancer patients receiving chemotherapy.
This medication should not be used in individuals who have a known allergy to Sargramostim, filgrastim, or any of the inactive components present in it.
EMGRAST M 500MCG INJECTION may interfere with certain lab tests, such as bone imaging and blood testing, potentially resulting in incorrect test findings. Make sure your doctor and laboratory personnel are aware that you take EMGRAST M 500MCG INJECTION.
EMGRAST M 500MCG INJECTION may sometimes cause capillary leak syndrome, which causes blood leakage from small blood vessels. Inform your doctor immediately if you notice difficulty breathing, swelling, a feeling of fullness, and tiredness.
It is given as an injection under the skin (subcutaneously) or through an intravenous (IV) line into a vein. Your healthcare team will train you on how to prepare and perform the injection safely at home if you are using the subcutaneous method. Talk to your doctor or pharmacist if you have questions about the injection process.
Yes, many patients can safely inject this medicine under the skin at home after receiving proper training from a nurse or doctor. Never attempt to inject this medicine until you feel completely comfortable with the process. Talk to your doctor or pharmacist to see if home injection is right for you.
Bone pain is a common sign that the medication is actively working in your bone marrow to produce new white blood cells. This pain is usually temporary and can often be managed with mild pain relievers. Talk to your doctor before taking any over-the-counter pain medications.
A fever can be a side effect of the medicine, but it can also be a sign of an underlying infection, which is dangerous when blood counts are low. You must contact your healthcare provider immediately if you develop a fever. Talk to your doctor to get precise instructions on when to seek urgent care.
This medicine should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks. There is limited data on how it affects unborn babies or if it passes into breast milk. Talk to your doctor to discuss the risks and benefits for your situation.
Used needles and syringes must be placed in a puncture-resistant sharps disposal container immediately after use. Do not throw them into the household trash, and never recycle them. Talk to your pharmacist or local health department about safe disposal options in your community.
No, you should never use the injection if the solution is cloudy, discoloured, or contains any visible floating particles. It should always be completely clear and colourless. Talk to your pharmacist immediately to get a replacement vial if your medication looks unusual.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 103362S5240Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A693005 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Sargramostim Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Emgrast M 500Mcg Injection
  5. Masters SB Agents Used in Anemias; Hematopoetic Growth Factors. In: Katzung BG, Masters SB, Trevor AJ, eds. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 581-82

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - EMG0002
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