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  3. EMGRAST M 500MCG INJECTION

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EMGRAST M 500MCG INJECTION, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

EMGRAST M 500MCG INJECTION is used to treat neutropenia, a deficiency of specific white blood cells caused by cancer, bone marrow transplant, chemotherapy, or other diseases. It contains Sargramostim, a growth factor that stimulates the formation of white blood cells and helps reduce the chances of infection in cancer patients receiving chemotherapy.

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Composition :

SARGRAMOSTIM-500MCG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About EMGRAST M 500MCG INJECTION

EMGRAST M 500MCG INJECTION belongs to the class of medications called colony-stimulating factors used to treat neutropenia, a deficiency of specific white blood cells caused by cancer, bone marrow transplant, chemotherapy, or other diseases. EMGRAST M 500MCG INJECTION helps reduce the chance of infection in cancer patients and those receiving chemotherapy medicines. Neutropenia is a condition in which the quantity of neutrophils (white blood cells) in the blood is reduced.

EMGRAST M 500MCG INJECTION contains Sargramostim, a growth factor that stimulates the formation of white blood cells and helps reduce the chances of infection in cancer patients receiving chemotherapy.

A healthcare professional will administer EMGRAST M 500MCG INJECTION. Sometimes, you may experience injection site responses such as pain, redness, or swelling. You may also experience nausea, vomiting, headache, diarrhoea, stomach pain, mouth sores, loss of appetite, hair loss and bone, joint, or muscle pain. Most of these side effects do not necessitate medical treatment and will gradually fade over time. However, if you suffer these side effects regularly, you should consult your doctor.

It is not suggested to use EMGRAST M 500MCG INJECTION in those who have had severe allergic responses, including anaphylaxis, to human granulocyte-macrophage colony-stimulating factor, yeast-derived products, or any component of EMGRAST M 500MCG INJECTION. To rule out any negative effects, keep your doctor informed about your medical condition and all medications you take. Inform your doctor if you are pregnant, intend to become pregnant, or are currently breastfeeding. Contact your doctor if you become pregnant while using EMGRAST M 500MCG INJECTION.

Uses of EMGRAST M 500MCG INJECTION

EMGRAST M 500MCG INJECTION is used in the treatment of Neutropenia. The detailed uses of EMGRAST M 500MCG INJECTION are as follows:

  • Stimulate white blood cell production: EMGRAST M 500MCG INJECTION is a granulocyte-macrophage colony-stimulating factor (GM-CSF) that promotes the growth and activation of neutrophils and macrophages to fight infections.
  • Support bone marrow transplant recovery: EMGRAST M 500MCG INJECTION accelerates immune system restoration after autologous or allogeneic bone marrow transplantation, reducing the risk of infection and graft failure.
  • Aid stem cell mobilization: EMGRAST M 500MCG INJECTION is used before peripheral blood progenitor cell (PBPC) collection to increase circulating stem cells for transplantation.
  • Treat neutropenia after chemotherapy: EMGRAST M 500MCG INJECTION helps shorten the duration of low white blood cell counts in patients undergoing induction chemotherapy for acute myeloid leukemia (AML).
  • Improve survival after radiation exposure: EMGRAST M 500MCG INJECTION is FDA-approved to reduce mortality from bone marrow suppression following acute radiation exposure in adults and children.

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Directions for Use

  • Follow your doctor’s instructions regarding the dosage and duration of treatment.
  • Check the label for directions and use it as advised by the doctor. EMGRAST M 500MCG INJECTION should be injected subcutaneously (under the skin) on your thigh, stomach, or upper arm.
  • Rotate the injection site each time.
  • Do not inject into a tender, bruised, red, or hard spot, or into areas with scars or stretch marks.

Medicinal Benefits

EMGRAST M 500MCG INJECTION contains 'Sargramostim,' which is a growth factor. It belongs to the cytokine family of proteins and is extremely similar to a natural protein (granulocyte-colony stimulating factor) produced by the body. EMGRAST M 500MCG INJECTION acts by encouraging the bone marrow to generate more white blood cells, aiding infection resistance. EMGRAST M 500MCG INJECTION is used to boost white blood cell count following cancer treatment or chemotherapy, bone marrow transplantation, severe persistent neutropenia, neutropenia in HIV patients, and before stem cell donation.

How EMGRAST M 500MCG INJECTION Works

EMGRAST M 500MCG INJECTION contains Sargramostim, a growth factor that stimulates the formation of white blood cells and helps reduce the chances of infection in cancer patients receiving chemotherapy.

Storage

• Store in a cool and dry place away from sunlight.• Keep EMGRAST M 500MCG INJECTION out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Emgrast M 500mcg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

What if I have taken an overdose of EMGRAST M 500MCG INJECTION

As EMGRAST M 500MCG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Extreme caution and special care should be taken while using EMGRAST M 500MCG INJECTION in patients with heart disorders, liver or renal dysfunction, leukocytosis (elevated white blood cell count), myeloproliferative disorder (blood cancers), pulmonary impairment, asphyxia (a condition of deficient supply of oxygen) and prematurity or underweight in infancy and respiratory symptoms. So, keep your doctor informed about your medical condition and all the medicines you are taking to rule out any side effects.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Consume a well-balanced and healthy food to aid in your recovery.
  • Avoid eating processed food or frozen food. 
  • Consume antioxidant-rich foods such as berries, spinach, kidney beans, dark chocolate, and so on.
  • Flavonoid-rich foods aid in the reduction of inflammation. Soy, berries, broccoli, grapes, and green tea are examples.
  • Limit or quit the consumption of alcohol.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

HEMATOPOIETIC STEM CELL MOBILIZER

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Alcohol

Caution

It is unknown whether consuming alcohol with EMGRAST M 500MCG INJECTION is safe. However, as a precaution, it is best to avoid or limit alcohol consumption.

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Pregnancy

Caution

It is not known if EMGRAST M 500MCG INJECTION will harm your unborn baby. So, inform your doctor if you are pregnant or planning to become pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Your doctor may advise you to discontinue the medicine or breastfeeding based on your medical condition.

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Driving

Caution

The ability to drive or utilize machines is unaffected by EMGRAST M 500MCG INJECTION. However, do not drive or operate machinery if you feel sleepy or dizzy after taking your medicine.

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Liver

Caution

Caution should be exercised while using EMGRAST M 500MCG INJECTION in patients with hepatic dysfunction. Monitoring of patients with hepatic dysfunction is recommended.

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Kidney

Caution

Caution should be exercised while using EMGRAST M 500MCG INJECTION in patients with renal dysfunction. Monitoring of patients with renal dysfunction is recommended.

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Children

Safe if prescribed

Your doctor will prescribe only if the benefits outweigh the risks.

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Heart

EMGRAST M 500MCG INJECTION can be used in patients with heart problems, but it requires careful monitoring. It may affect heart rhythm or blood pressure, and can cause fluid retention or worsen preexisting cardiac conditions. Your doctor will assess the risks and benefits before prescribing it and may adjust your treatment plan accordingly.

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Geriatrics

Caution

Geriatric patients can receive EMGRAST M 500MCG INJECTION, but with extra caution and monitoring. Older adults may be more sensitive to side effects like fluid retention, changes in blood pressure, or heart rhythm issues, so doctors typically adjust the dosage and watch closely for any complications.

FAQs

EMGRAST M 500MCG INJECTION is used to treat Neutropenia.

EMGRAST M 500MCG INJECTION contains 'Sargramostim,' which is a growth factor that stimulates the formation of white blood cells and helps to reduce the chances of infection in cancer patients receiving chemotherapy.

This medication should not be used in individuals who have a known allergy to Sargramostim, filgrastim, or any of the inactive components present in it.

EMGRAST M 500MCG INJECTION may interfere with certain lab tests, such as bone imaging and blood testing, potentially resulting in incorrect test findings. Make sure your doctor and laboratory personnel are aware that you take EMGRAST M 500MCG INJECTION.

EMGRAST M 500MCG INJECTION may sometimes cause capillary leak syndrome, which causes blood leakage from small blood vessels. Inform your doctor immediately if you notice difficulty breathing, swelling, a feeling of fullness, and tiredness.

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - EMG0002

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:50 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/103362s5240lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a693005.html
  3. https://www.drugs.com/drug-interactions/sargramostim-index.html?filter=3

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