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  3. Dyronib 50 Tablet 60's

Dyronib 50 Tablet 60's, Pack of 1 TABLET
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dyronib 50 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia and acute lymphoblastic leukaemia. It contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce their further spread to other parts of the body.

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Composition :

DASATINIB-50MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dyronib 50 Tablet

Dyronib 50 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. Dyronib 50 Tablet is used in the treatment of chronic myelogenous leukemia (CML) in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) who are resistant or intolerant to prior therapy, in patients with newly diagnosed chronic Ph+ chronic myelogenous leukemia (CML). This medicine is also used in the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

Dyronib 50 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Dyronib 50 Tablet may cause certain side effects, such as skin rash, fatigue, headache, musculoskeletal pain, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, GI bleeding, muscle inflammation, myalgia, and difficulty breathing. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Dyronib 50 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Dyronib 50 Tablet based on the severity of your condition.

Dyronib 50 Tablet should be avoided if you are allergic to it or any other components present in it. Before taking Dyronib 50 Tablet , caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, cardiac problems, and myelosuppression as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Dyronib 50 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Dyronib 50 Tablet

Dyronib 50 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. The detailed uses of Dyronib 50 Tablet are as follows:<br/>• Chronic Myeloid Leukemia (CML): Dyronib 50 Tablet is used to treat chronic myeloid leukemia especially philadelphia chromosome-positive (Ph+) CML, in both newly diagnosed and resistant/intolerant cases.<br/>• Acute Lymphoblastic Leukemia (ALL): Dyronib 50 Tablet is used to treat acute lymphoblastic leukemia and also Ph+ ALL, who are newly diagnosed or have relapsed.<br/>

Directions for Use

• Dyronib 50 Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.• It is usually taken once a day, or as prescribed by your doctor.• Swallow Dyronib 50 Tablet as a whole with water.• Do not crush, chew or break Dyronib 50 Tablet .

Medicinal Benefits

Dyronib 50 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins (BCR-ABL tyrosine kinase) that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. Dyronib 50 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.

How Dyronib 50 Tablet Works

Dyronib 50 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Dyronib 50 Tablet out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Dyronib 50 Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Managing Medication-Triggered tinnitus (Ringing in the Ears): A Step-by-Step Guide:
  • Inform your doctor immediately if you experience ringing, buzzing, or other unusual sounds in your ears after taking medication.
  • Schedule an appointment to discuss symptoms and determine if the medication is the cause.
  • Your doctor may adjust your treatment plan by changing dosage, switching to a different medication, or stopping the medication.
  • Your doctor may recommend sound therapy or relaxation techniques to manage tinnitus symptoms.
  • Regularly track symptoms and report changes to your healthcare provider to ensure effective management.
  • Focus on heart-healthy foods limiting sodium saturated fat and processed foods.
  • Focus on consuming a balanced diet rich in nutrients, including an abundance of fruits, vegetables, whole grains, and lean protein sources.
  • Limit sodium intake reducing salt consumption to manage fluid retention.
  • Choose low-saturated fat options avoiding fried foods red meat and processed meats.
  • Eat fiber-rich foods like fruits vegetables whole grains for healthy digestion.
  • Opt for lean protein sources like fish chicken breast tofu.
  • Incorporate healthy fats like unsaturated fats from avocados nuts olive oil.
  • Exercise regularly with moderate-intensity exercise as recommended by your doctor.
  • To manage stress, try relaxation methods like deep breathing exercises, meditation, or yoga to help calm your mind and body.
  • Limit alcohol consumption as excessive drinking can worsen heart health.
  • Stay hydrated by drinking plenty of water.
  • Quit smoking as it significantly impacts heart health.
  • Consult your doctor to discuss dietary and lifestyle changes with your healthcare provider.
  • Talk to your doctor about your symptoms and history to find the best treatment.
  • Your doctor may prescribe drugs to treat the problem and adjust the dosage as necessary.
  • Drinking water helps to thin the blood and improve circulation.
  • Eat potassium-rich foods like bananas and leafy greens to help lower blood pressure.
  • Low-sodium diet: Limiting salt consumption can help decrease blood pressure.
  • Avoid smoking to protect your lungs.
  • Maintain a healthy weight to reduce lung pressure.
  • Exercise regularly, like walking or yoga, to improve heart health.
  • If you have serious symptoms such as chest pain or shortness of breath, you should seek medical attention immediately.

What if I have taken an overdose of Dyronib 50 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Dyronib 50 Tablet are unusual bruising or bleeding, fever, sore throat, chills, and/or other signs of infection, shortness of breath, fast heartbeat, headache, pale skin, confusion and tiredness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Dyronib 50 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, or gastrointestinal disorders, as the use of Dyronib 50 Tablet in these patients may cause serious side effects. Dyronib 50 Tablet may cause myelosuppression, fluid retention, gastrointestinal haemorrhage, QT prolongation, congestive heart failure, Left ventricular dysfunction and Myocardial infarction. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Dyronib 50 Tablet is given in children above one year of age only if prescribed by the doctor. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DasatinibMesoridazine
Critical
DasatinibPimozide
Critical

Drug-Drug Interactions

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DasatinibMesoridazine
Critical
How does the drug interact with Dyronib 50 Tablet:
Using Mesoridazine together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Dyronib 50 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibPimozide
Critical
How does the drug interact with Dyronib 50 Tablet:
Using Pimozide together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibDronedarone
Critical
How does the drug interact with Dyronib 50 Tablet:
Using dronedarone together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibHalofantrine
Critical
How does the drug interact with Dyronib 50 Tablet:
Using Halofantrine together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 50 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
DasatinibHeparin
Severe
How does the drug interact with Dyronib 50 Tablet:
Taking Dyronib 50 Tablet with Heparin can increase the risk and severity of bleeding.

How to manage the interaction:
Although there is a possible interaction between Heparin and Dyronib 50 Tablet, you can take these medicines together if prescribed by a doctor. However, consult a doctor, if you experience bruising, dizziness, red or black, tarry stools, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
DasatinibDexamethasone
Severe
How does the drug interact with Dyronib 50 Tablet:
Taking Dexamethasone may reduce the blood levels of Dyronib 50 Tablet, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Dyronib 50 Tablet if prescribed by the doctor. In case of any unusual side effects, consult a doctor. Do not discontinue the medication without consulting a doctor.
DasatinibVandetanib
Severe
How does the drug interact with Dyronib 50 Tablet:
Using vandetanib together with Dyronib 50 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Dyronib 50 Tablet and Vandetanib, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - irregular heartbeat, heart problems, long qt syndrome, diarrhea, vomiting, dizziness, fainting, shortness of breath, or heart palpitations - please call a doctor right away. Do not discontinue any medications without consulting a doctor.
DasatinibNizatidine
Severe
How does the drug interact with Dyronib 50 Tablet:
Using Dyronib 50 Tablet together with Nizatidine may decrease the blood levels of Dyronib 50 Tablet.

How to manage the interaction:
Co-administration of Nizatidine with Dyronib 50 Tablet can result in an interaction, but it can be taken if a doctor has advised it. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without talking to a doctor.
DasatinibTirofiban
Severe
How does the drug interact with Dyronib 50 Tablet:
Using Dyronib 50 Tablet together with tirofiban may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Tirofiban with Dyronib 50 Tablet can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without a doctor's advice.
DasatinibDeferasirox
Severe
How does the drug interact with Dyronib 50 Tablet:
Coadministration of Deferasirox together with Dyronib 50 Tablet may increase the risk of bleeding.

How to manage the interaction:
Although taking Dyronib 50 Tablet and Deferasirox together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, like stomach pain, feeling dizzy, it's important to call a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Dyronib 50 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Dyronib 50 Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

When given to a pregnant woman, Dyronib 50 Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Dyronib 50 Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.

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Breast Feeding

Unsafe

It is not known if Dyronib 50 Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Dyronib 50 Tablet . Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Dyronib 50 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Dyronib 50 Tablet or until you become alert.

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Liver

Caution

Use Dyronib 50 Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.

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Kidney

Caution

There are presently no clinical investigations with Dyronib 50 Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.

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Children

Consult your doctor

Dyronib 50 Tablet is safe for use in children above one year of age if prescribed by the doctor.

Have a query?

FAQs

Dyronib 50 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

Dyronib 50 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.

Dyronib 50 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Dyronib 50 Tablet as antacids may alter the absorption of this medicine.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - DYR0018

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021986s7s8lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a607063.html
  3. https://go.drugbank.com/drugs/DB01254
  4. https://www.sprycel.com/

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