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compositionComposition:DILOXANIDE-250MG+METRONIDAZOLE-200MG
prescription
Prescription Medicine
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DYRADE M TABLET is used to treat infections caused by bacteria and parasites (amoeba). It contains Metronidazole and Diloxanide, which work by killing the infection-causing bacteria and amoeba. This medicine may occasionally cause side effects, such as nausea, vomiting, upset stomach, loss of appetite, dry mouth, and a metallic taste. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DILOXANIDE-250MG+METRONIDAZOLE-200MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About DYRADE M TABLET

DYRADE M TABLET is a prescription medication used to treat intestinal infections caused by amoeba, including amoebic dysentery. This medicine combines two active agents that target the infection at different stages in your digestive system, helping to completely clear the parasites from your body.

To achieve the best results, you must take DYRADE M TABLET regularly and exactly as prescribed, even if your symptoms improve before finishing the course. It is best to take this medicine with food to prevent an upset stomach and improve how well your body absorbs it. Eating cooked, hygienic meals and drinking plenty of clean, filtered water can help support your gut during treatment.

While taking DYRADE M TABLET, you may experience mild side effects like a metallic taste in your mouth, nausea, or a headache. These symptoms are usually temporary, but you should contact your doctor immediately if you experience severe abdominal pain, persistent vomiting, or signs of an allergic reaction such as skin rashes.

Talk to your doctor before starting DYRADE M TABLET if you have a history of liver disease, kidney problems, or nervous system disorders. Do not take this medicine if you have a known allergy to any of its components or have consumed alcohol.

This medicine interacts strongly with alcohol, which can cause severe nausea, rapid heart rate, and vomiting; you must avoid alcohol during treatment and for at least 48 hours after your last dose. Pregnant, breastfeeding, or elderly individuals should consult their doctor before taking DYRADE M TABLET to ensure it is safe for their specific situation.

Uses of DYRADE M TABLET

DYRADE M TABLET is used to treat amoebic infections caused by parasites. The detailed uses of DYRADE M TABLET are as follows:

  • Intestinal Amoebiasis: DYRADE M TABLET helps clear parasitic infections in the gut by killing active amoebae and preventing them from multiplying.
  • Amoebic Dysentery: This medicine treats severe diarrhoea containing blood and mucus by targeting the protozoa responsible for the gut infection and relieving bowel inflammation.
  • Amoebic Liver Abscess: In some cases, DYRADE M TABLET is prescribed to eliminate amoebic parasites that have spread from the intestines to the liver, preventing further tissue damage.
  • Asymptomatic Cyst Passage: It helps eliminate the inactive, cyst stage of the parasite from the intestines of individuals who do not show symptoms but can still spread the infection to others.
     

Key Benefits

DYRADE M TABLET helps treat parasitic infections of the digestive tract, relieving symptoms and supporting complete recovery. The key benefits are as follows:

  • Relief from painful stomach cramps and diarrhoea: By targeting the root cause of the infection, DYRADE M TABLET rapidly reduces abdominal pain, bloating, and frequent bowel movements, helping you return to your normal routine.
  • Complete eradication of the parasite: This medicine works at both the active and dormant stages of the parasite, preventing the infection from returning or spreading to other organs like the liver.
  • Prevents transmission to others: By completely clearing the infectious cysts from your digestive tract, DYRADE M TABLET ensures that you do not accidentally pass the infection to family members or your community.
     
Side effects of Dyrade M Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Inflammation of Vagina needs immediate attention and cannot be ignored.
  • Get a physical examination and prevent wearing clothes that can hold heat and moisture.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Follow your doctor's instructions, and rest well with proper medication.
  • Take a balanced diet and get regular screenings to reduce inflammation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Directions for Use

  • Tablet: Swallow it as a whole with water; do not crush, break, or chew it.
  • Syrup/suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

How DYRADE M TABLET Works

This medicine is a combination of two active ingredients, metronidazole and diloxanide, that work together to fight parasitic infections in different parts of your body. The first active ingredient, metronidazole, acts directly in the tissues of your intestines and other organs. It enters the parasitic cells and damages their DNA, stopping them from growing and effectively destroying the active forms of the parasite. The second active ingredient, diloxanide, works specifically inside the lumen (the hollow space) of your intestines. It targets and kills the dormant cyst forms of the parasite that the first ingredient cannot reach. By combining these two actions, DYRADE M TABLET ensures that both the active, disease-causing parasites and their dormant cysts are thoroughly eliminated from your body, preventing the infection from coming back.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with DYRADE M TABLET to avoid unpleasant side-effects.

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Pregnancy

Unsafe

DYRADE M TABLET should not be used during pregnancy, especially during the first trimester.

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Breast Feeding

Caution

Take DYRADE M TABLET only when prescribed, it is known to pass on in a limited quantity via breast milk to the child.

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Driving

Caution

DYRADE M TABLET may affect driving as it causes dizziness, so it is advised to avoid driving.

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Liver

Caution

DYRADE M TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

DYRADE M TABLET to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Dose to be adjusted and recommended by a child specialist only.

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Heart

Unsafe

DYRADE M TABLET is contraindicated in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

DYRADE M TABLET can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of DYRADE M TABLET

If you suspect an overdose or experience severe symptoms such as extreme dizziness, persistent vomiting, or loss of balance, seek immediate medical attention.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Stay hydrated with clean, filtered water, oral rehydration solutions, or clear broths to replace fluids lost from diarrhoea.
  • Eat bland, easily digestible foods: Stick to a simple diet including bananas, rice, applesauce, and toast until your digestion settles.
  • Avoid dairy and fatty foods: Steer clear of milk, cheese, fried foods, and highly spiced meals while your gut is recovering, as these can worsen diarrhoea.
  • Practice strict hygiene: Wash your hands thoroughly with soap and water after using the bathroom and before preparing or eating food to prevent reinfection.
  • Avoid alcohol completely: Do not drink alcohol or use products containing alcohol (like certain cough syrups) during treatment and for at least 48 hours after finishing to prevent severe reactions.
     
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How Soon It Starts Working

  • The time required for DYRADE M TABLET to start to work: DYRADE M TABLET starts to show its action within 1 to 2 hour of administration.
  • The time for which the effects of DYRADE M TABLET last: DYRADE M TABLET effect lasts for 6 to 8 hours.

What if you forget to take DYRADE M TABLET

If you miss a dose of DYRADE M TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store DYRADE M TABLET at room temperature, ideally below 30°C, in a cool, dry place away from direct heat, moisture, and sunlight. •Keep the medicine in its original packaging until you need to take it, to protect it from moisture.

Drug Warnings

  • Inspect the packaging: Always check the blister pack or bottle before use to ensure the tablets are intact and have not been exposed to moisture.
  • Complete the full course: Never stop taking this medicine early, even if you feel completely better, to ensure the parasite is fully eradicated.
  • Avoid alcohol without exception: Be aware that even small amounts of alcohol can cause a severe reaction with symptoms like hot flashes, throbbing headache, and vomiting.
  • Monitor for nerve issues: Inform your doctor immediately if you feel any unusual tingling, burning, or weakness in your hands or feet.
  • Use caution when driving: This medicine can sometimes cause dizziness or drowsiness; do not drive or operate machinery until you know how it affects you.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): DYRADE M TABLET may increase the effect of blood thinners, raising the risk of bleeding. Your doctor may need to adjust your dose.
  • Lithium: Taking this medicine with lithium can increase lithium levels in your blood, potentially leading to side effects.
  • Seizure medications (like phenobarbital or phenytoin): These medicines can speed up how your body processes DYRADE M TABLET, making it less effective, or DYRADE M TABLET may affect their levels in your body.
  • Disulfiram: Taking this medicine within two weeks of disulfiram can cause confusion or mental changes.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Interacts severely with this medication, causing a disulfiram-like reaction (severe nausea, vomiting, headache, and rapid heartbeat). Avoid alcohol completely during treatment and for 48 hours afterward.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

DYRADE M TABLET is used to treat infections caused by bacteria and parasites (amoeba). It is prescribed for the treatment of diarrhoea caused by Clostridium difficile, Entamoeba histolytica and Giardia lamblia. Additionally, it also treats vaginal infections.
DYRADE M TABLET is an antibiotic medication so it is advised to complete the full course even if you start to feel better to prevent the return of the infection.
Yes, it could be due to jaundice as in rare cases DYRADE M TABLET can lead to it. Please consult your doctor immediately if the yellowing of the skin persists and does not subside.
DYRADE M TABLET is an antibacterial medicine that acts only against bacterial infections and not viral infections like common cold and flu. You should not take DYRADE M TABLET without prior consulting your doctor. Self-medication is dangerous and can lower the efficacy of DYRADE M TABLET, leading to antibiotic resistance.
If you miss a dose of DYRADE M TABLET, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
The side effects of DYRADE M TABLET include stomach upset, nausea, vomiting, loss of appetite, dry mouth and metallic taste. Consult the doctor if any of these side effects persist or worsen.
No, you must not drink alcohol while taking DYRADE M TABLET. Combining this medicine with alcohol can cause a severe reaction, including throbbing headaches, rapid heart rate, severe nausea, vomiting, and flushing. You should also avoid alcohol for at least 48 hours after your last dose. Talk to your doctor if you have questions about this.
You should avoid taking DYRADE M TABLET during the first trimester of pregnancy unless your doctor decides it is absolutely necessary. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to weigh the benefits and risks.
A metallic taste is a very common and harmless side effect of one of the active ingredients in DYRADE M TABLET. This taste is temporary and will go away once you finish your course of medicine. Drinking water or chewing sugar-free gum can help manage this. If it becomes severe, talk to your doctor.
If you vomit shortly after taking DYRADE M TABLET, do not immediately take another dose without guidance. Contact your pharmacist or doctor to find out if you need to take a replacement dose or adjust your schedule.
Yes, DYRADE M TABLET can cause your urine to turn a dark or reddish-brown color. This is a harmless side effect of the medicine being processed by your body and will disappear after you stop taking it. If you experience pain when urinating, talk to your doctor.
It is highly recommended to take DYRADE M TABLET with or immediately after food. Taking this medicine on an empty stomach can cause significant stomach upset, nausea, and cramping. Talk to your doctor or pharmacist if you struggle to take this medicine with meals.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.11318 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Metronidazole 400Mgs Bp Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Metronidazole - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.9238 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Metronidazole Metronidazole. 2013. [Accessed on 08 Apr. 2019]Check here
  6. ScienceDirect ScienceDirect. [Accessed on 08 Apr. 2019]Check here
  7. Diloxanide. Diloxanide tablets and side effects at Patient. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DYR0003
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