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  3. Duzela M 20 Capsule 10's

Duzela M 20 Capsule 10's, Pack of 10 CAPSULES
Duzela M 20 Capsule 10's, Pack of 10 CAPSULES
Duzela M 20 Capsule 10's, Pack of 10 CAPSULES
Duzela M 20 Capsule 10's, Pack of 10 CAPSULES
Duzela M 20 Capsule 10's, Pack of 10 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Duzela M 20 Capsule is used to treat neuropathic pain. It contains Duloxetine and Methylcobalamin, which work by increasing the levels of neurotransmitters (such as serotonin and noradrenaline) in the brain that are required to regulate pain. Also, it helps rejuvenate and protect damaged nerve cells. It may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, or loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DULOXETINE-20MG + METHYLCOBALAMIN-1.5MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Duzela M 20 Capsule

Duzela M 20 Capsule belongs to the class of medications called ‘anticonvulsants’ used to treat neuropathic pain. Neuropathic pain is a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning. It is mainly seen in patients who have suffered a trauma or nerve injury, diabetes, vitamin deficiencies, cancer, multiple sclerosis (a disease of the brain and spinal cord), shingles (a viral infection), and HIV.

Duzela M 20 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of a chemical messenger (like serotonin and noradrenaline) in the brain required to regulate pain that travels through damaged nerves. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells). 

Take this medicine as prescribed by your doctor. Duzela M 20 Capsule may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and a hot sensation (burning pain). Inform your doctor if any of these side effects persist.

Do not take Duzela M 20 Capsule if you are allergic to Duloxetine, Methylcobalamin, or any of its contents. Before taking Duzela M 20 Capsule , inform your doctor if you have liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. Inform your doctor if you are pregnant or breastfeeding before using Duzela M 20 Capsule .

Uses of Duzela M 20 Capsule

Duzela M 20 Capsule is used in the treatment of nutritional deficiency and neuropathic pain. The detailed uses of Duzela M 20 Capsule are as follows:<br/>• Nerve Health Support: Duzela M 20 Capsule is designed to promote optimal nerve health by supplying essential vitamins that support proper nervous system function.<br/>• Treatment of Neuropathy: Duzela M 20 Capsule is beneficial for individuals with diabetic neuropathy or other neurological conditions, aiding in symptom relief and nerve regeneration.<br/>• Vitamin Deficiency: Duzela M 20 Capsule helps address B vitamin deficiencies, which are vital for energy production and overall metabolic processes.<br/>• Pain Management: Duzela M 20 Capsule may assist in managing nerve-related pain, such as sciatica, by providing relief and improving nerve function.<br/>

Directions for Use

• Take Duzela M 20 Capsule with or without food or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Duzela M 20 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin and noradrenaline levels in the brain, which are required for regulating pain through the damaged nerves. Methylcobalamin is a form of vitamin B12 that helps in rejuvenating and protecting damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells). Together, Duzela M 20 Capsule effectively treats neuropathic pain and improves nerve conduction, promoting proper nerve signal functioning throughout the body.

How Duzela M 20 Capsule Works

Duzela M 20 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of a chemical messenger (like serotonin and noradrenaline) in the brain required to regulate pain that travels through damaged nerves. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells).
Side effects of Duzela M 20 Capsule
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Duzela M 20 Capsule

Do not take more than the prescribed dose of Duzela M 20 Capsule as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Before taking Duzela M 20 Capsule , inform your doctor if you have taken any antidepressants within the last 14 days or any medications used to treat infections. Please consult your doctor before stopping the medicine, as it may cause withdrawal symptoms such as dizziness, tingling sensations, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Therefore, do not abruptly stop taking your medicine, even if your symptoms improve. It may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. Prolonged use of Duzela M 20 Capsule may decrease sodium level, affect blood pressure, and blood sugar level, so regular medical check-ups are required. Duzela M 20 Capsule may increase your bleeding risk, and worsen your glaucoma condition. Hence, if you experience any eye problems or bleeding problems, consult a doctor.

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
DuloxetineSafinamide
Critical

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Duzela M 20 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Duzela M 20 Capsule:
Coadministration of safinamide with Duzela M 20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Duzela M 20 Capsule is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineTranylcypromine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Tranylcypromine with Duzela M 20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Duzela M 20 Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Duzela M 20 Capsule:
Coadministration of eliglustat and Duzela M 20 Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Duzela M 20 Capsule with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Duzela M 20 Capsule with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Duzela M 20 Capsule:
Coadministration of metoclopramide with Duzela M 20 Capsule increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Duzela M 20 Capsule is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetineRasagiline
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Rasagiline with Duzela M 20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Duzela M 20 Capsule is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking Duzela M 20 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Duzela M 20 Capsule and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Duzela M 20 Capsule:
Taking phenelzine with Duzela M 20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Duzela M 20 Capsule with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePimozide
Severe
How does the drug interact with Duzela M 20 Capsule:
Taking pimozide with Duzela M 20 Capsule may significantly increase the blood levels of pimozide. This can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Although taking Duzela M 20 Capsule with Pimozide can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience sleepiness, blurred vision, dry mouth, constipation, and abnormal muscle movements, contact your doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet, as it can help reduce neuropathic pain.
  • Exercising regularly helps improve overall health and combat pain.
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

Alcohol may worsen the condition by increasing the risk of side effects

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Pregnancy

Unsafe

Duzela M 20 Capsule is a category C medicine, so it is not recommended for use in pregnant women.

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Breast Feeding

Caution

Duzela M 20 Capsule should be used with caution in breastfeeding mothers.

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Driving

Unsafe

Duzela M 20 Capsule may cause drowsiness. So, avoid driving or operating heavy machinery while using Duzela M 20 Capsule .

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Liver

Caution

Duzela M 20 Capsule should be used with caution in patients with liver diseases.

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Kidney

Caution

Duzela M 20 Capsule should be used with caution in patients with kidney diseases.

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Children

Unsafe

Duzela M 20 Capsule is not recommended for children and anyone below 18 years. Please consult a medical professional for further information.

Have a query?

FAQs

Duzela M 20 Capsule is used to treat neuropathic pain.

Duzela M 20 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine increases the number of neurotransmitters like serotonin and noradrenaline in the brain that can regulate pain. On the other hand, methylcobalamin (vitamin B12) can protect the nerve cells from further damage. Thus, Duzela M 20 Capsule prevents nerve damage due to various conditions like injury or diabetic neuropathy and ensures smooth conduction of nerve signals throughout the body.

Duzela M 20 Capsule should be taken either in the morning or evening. If you feel drowsy after taking Duzela M 20 Capsule , consider taking it in the evening. Also, it is recommended to take Duzela M 20 Capsule every day at the same time for the best results.

Duzela M 20 Capsule should not be used with antidepressants, especially antidepressants like monoamine oxidase (MAO) inhibitors (moclobemide, linezolid) as they cause serious side-effects. It is advised to wait at least 14 days after stopping MAO inhibitors before taking $namd also wait at least 5 days after stopping Duzela M 20 Capsule before taking any MAO inhibitors.

Seek medical attention immediately if you notice any depressive thoughts while using Duzela M 20 Capsule . Your doctor may change the dose or medicine to treat your condition.

The common side effects of Duzela M 20 Capsule include drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and hot sensation (burning pain). Please inform your doctor if any of these side effects persist or worsen.

No, do not stop taking Duzela M 20 Capsule , even if you start to feel better. Stopping the medication suddenly may cause withdrawal symptoms. If you need to stop the medication, your doctor will guide you on how to gradually reduce the dose safely.

Duzela M 20 Capsule usually takes 2-4 weeks to start working. Keep taking Duzela M 20 Capsule for the prescribed duration to notice the full benefits of the medicine.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - DUZ0006

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:42 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.8650.pdf
  2. https://www.npra.gov.my/images/reg-and-noti/PI/non-poison/Mecobalamin-Template-oral-Website.pdf

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