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Duranzo Tablet is used to relieve pain. It contains Diclofenac and Codeine which work by reducing the production of chemical substances that cause pain and inflammation and preventing pain signals transmission along the nerves to the brain. This medicine may sometimes cause side effects such as heartburn, indigestion, stomach pain, nausea, vomiting, dizziness, drowsiness and loss of appetite. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Duranzo Tablet

Duranzo Tablet is a prescription medicine used to treat moderate to severe acute pain when simpler pain relievers do not provide adequate relief. It may be prescribed for intense discomfort following surgical or dental procedures or during severe musculoskeletal flare-ups. This medicine combines an anti-inflammatory pain reliever with codeine, an opioid that carries risks of dependence and serious breathing problems and should therefore be used only as directed.

For best results, take this medicine exactly as prescribed and keep your dosing schedule consistent. Take it with or immediately after food to help reduce stomach irritation. Treatment is generally kept as short as clinically appropriate because prolonged codeine use can increase the risk of tolerance, dependence, and withdrawal.

Some people may experience drowsiness, constipation, nausea, or mild stomach upset. Seek immediate medical help if you develop slow or difficult breathing, severe stomach pain, chest pain, sudden weakness on one side of the body, slurred speech, or signs of a severe allergic reaction. Diclofenac may increase the risk of serious cardiovascular events such as heart attack or stroke, particularly with higher doses, prolonged use, or existing cardiovascular risk factors.

Before starting treatment, tell your doctor if you have a history of stomach ulcers, asthma, heart disease, high blood pressure, or kidney or liver problems. Do not take this medicine if you have severe breathing difficulties, active stomach bleeding, a known allergy to its ingredients or similar anti-inflammatory pain relievers, or certain other contraindications identified by your doctor. Codeine should not be used for pain after tonsil or adenoid removal in patients under 18 years of age.

This medicine can interact with alcohol, sedatives, sleeping medicines, and other substances that slow the central nervous system, potentially causing dangerous drowsiness or breathing problems. Codeine is also processed differently from person to person, which can affect safety. Do not use this medicine while breastfeeding because codeine can pass into breast milk and may cause serious opioid effects in the baby. If you are pregnant, an older adult, or taking other medicines, consult your doctor before starting treatment.

Uses of Duranzo Tablet

Duranzo Tablet is used to manage moderate to severe acute pain, particularly when simpler pain relievers do not provide adequate relief. Its uses include:

  • Moderate to severe acute pain: Helps relieve intense pain from sudden injuries, dental procedures, or orthopaedic issues by targeting pain signals in the body.
  • Post-operative pain: Eases discomfort after surgical procedures, helping you rest and recover more comfortably.
  • Severe joint and bone pain: Temporarily reduces intense discomfort during sudden flare-ups of joint and skeletal conditions.

Key Benefits

Duranzo Tablet combines an anti-inflammatory pain reliever with an opioid analgesic to manage moderate to severe pain that may not respond adequately to simpler pain medicines. It helps reduce pain and inflammation, improving comfort and supporting recovery.

  • Provides Effective Pain Relief: Helps relieve moderate to severe pain associated with injuries, surgery, musculoskeletal conditions, and other painful conditions.
  • Reduces Pain and Inflammation: DICLOFENAC helps reduce inflammation and swelling, while CODEINE acts on pain pathways in the central nervous system to reduce pain perception.
  • Improves Mobility: Better pain control can make movement easier and help you perform daily activities with greater comfort.
  • Supports Rest and Recovery: Relief from persistent pain may improve sleep and rest, supporting the overall recovery process.
  • Supports Rehabilitation: Effective pain management may help you participate more comfortably in physiotherapy and prescribed rehabilitation exercises.

Directions for Use

  • Duranzo Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Duranzo Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Duranzo Tablet Works

Duranzo Tablet contains diclofenac and codeine, which work in different ways to relieve pain. Diclofenac belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It reduces the production of prostaglandins, chemical messengers that contribute to pain, swelling, and inflammation. Codeine is an opioid pain reliever that acts on the central nervous system to change how the brain and body perceive pain. After it is taken, some codeine is converted into morphine by a liver enzyme called CYP2D6. The activity of this enzyme varies between individuals, so some people convert codeine to morphine much faster than others. These ultra-rapid metabolisers may develop dangerously high morphine levels and serious breathing problems even at standard doses. Together, these actions reduce inflammation and alter pain signalling to provide relief from moderate to severe acute pain.
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Alcohol

Caution

Consumption of alcohol increases the risk of side-effects, such as dizziness, drowsiness, liver damage and bleeding in the stomach.

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Pregnancy

Unsafe

Duranzo Tablet is not recommended during pregnancy as it may cause harmful effects to the unborn baby. The baby may become dependent and show withdrawal symptoms after birth.

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Breast Feeding

Unsafe

Duranzo Tablet may pass into breast milk and cause unwanted effects in the nursing baby. So, it is not prescribed in breastfeeding mothers.

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Driving

Caution

Duranzo Tablet may cause dizziness, drowsiness, confusion or hallucinations, so do not drive or operate heavy machinery if you are not fully alert.

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Liver

Caution

Duranzo Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Duranzo Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Duranzo Tablet is not recommended for children below 12 years of age.

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Heart

Unsafe

Duranzo Tablet is not recommended in cardiac patients due to its adverse effects. However, if prescribed, extreme caution should be exercised.

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Geriatrics

Caution

Duranzo Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Duranzo Tablet

If you take too much of this medication, seek immediate emergency medical help or call a poison control centre. An overdose can cause serious breathing difficulties and severe drowsiness.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water throughout the day to help prevent constipation, a common side effect of this medicine.
  • Eat fibre-rich foods: Include fruits, vegetables, and whole grains in your diet to keep your digestive system moving smoothly.
  • Protect your stomach: Always take this medicine with food or milk to prevent stomach irritation.
  • Avoid strenuous activities: Rest when possible, and avoid sudden movements to prevent dizziness or lightheadedness.
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How Soon It Starts Working

The time required for Duranzo Tablet to start to work: Duranzo Tablet ideally shows its action within 30 to 60 minutes of administration. The time for which the effects of Duranzo Tablet last: Duranzo Tablet effect lasts for 6 to 8 hours.

What if you forget to take Duranzo Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Duranzo Tablet tablets at room temperature, ideally between 15°C and 30°C, in a dry place. •Keep the medication in its original packaging to protect it from direct light and moisture.

Drug Warnings

  • Avoid Alcohol: Do not drink alcohol while taking this medicine, as it can dangerously increase drowsiness and slow your breathing.
  • Check Your Alertness: Do not drive, operate machinery, or perform tasks requiring full concentration until you know how the medicine affects you.
  • Use for the Shortest Prescribed Duration: Codeine can cause tolerance and physical dependence. Do not take more than prescribed or continue treatment longer than advised.
  • Do Not Stop Suddenly After Prolonged Use: Abruptly stopping codeine after regular or extended use may cause withdrawal symptoms such as restlessness, sweating, anxiety, stomach cramps, diarrhoea, or sleep problems. Your doctor may recommend gradual dose reduction.
  • Know the Cardiovascular Warning: Diclofenac may increase the risk of heart attack or stroke, especially with higher doses, longer treatment, or existing cardiovascular risk factors. Seek urgent medical care for chest pain, sudden shortness of breath, one-sided weakness, or slurred speech.
  • Watch for Stomach Bleeding: Contact your doctor urgently if you develop severe abdominal pain, dark or tarry stools, or vomit that contains blood. Do not stop treatment on your own unless emergency medical advice directs you to do so.
  • Inform Your Healthcare Team: Tell your dentist, surgeon, or other healthcare professionals that you are taking this medicine before any procedure.
     

Drug-Drug Interactions

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Inform your doctor if you are taking any of the following medicines, as they may interact with Duranzo Tablet :

  • Sedatives and Other Central Nervous System Depressants: Sleeping medicines, anxiety medicines, muscle relaxants, or other opioid pain relievers may increase the risk of severe drowsiness, respiratory depression, coma, or other serious side effects.
  • Other NSAIDs, Aspirin, or Blood Thinners: These medicines may increase the risk of stomach ulcers, gastrointestinal bleeding, or other bleeding complications.
  • Blood Pressure Medicines and Diuretics: DICLOFENAC may reduce the effectiveness of some blood pressure medicines and increase the risk of kidney problems, particularly when used with diuretics.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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Certain foods and drinks may worsen side effects while taking Duranzo Tablet :

  • Alcohol: Avoid alcohol, as it may increase drowsiness, dizziness, impaired alertness, and the risk of dangerous breathing problems.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANALGESICS]

FAQs

Duranzo Tablet is used to treat short-term pain.
Duranzo Tablet is a combination of two medicines: Diclofenac and Codeine. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing the production of chemical substances that cause pain and inflammation. Codeine is an opioid medication and works by preventing pain signals transmission along the nerves to the brain.
The common side-effects of Duranzo Tablet are heartburn, indigestion, stomach pain, nausea, vomiting, dizziness, drowsiness and loss of appetite. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.
It is recommended not to take other antidepressants, especially monoamine oxidase inhibitors (MAOI) such as phenelzine and isocarboxazid while using Duranzo Tablet . It may lead to unwanted effects. The doctor may advise you to wait for at least 14 days after discontinuing MAOI if you have been prescribed Duranzo Tablet .
Duranzo Tablet is probably safe and well-tolerated in diabetic patients when taken at recommended doses. However, higher doses or prolonged use may affect sugar levels and cause unwanted effects. So, let your doctor know that you have diabetes before taking Duranzo Tablet .
No, consult a doctor before taking Duranzo Tablet for any condition. It is not advised to use Duranzo Tablet without a doctor's recommendation.
No, it's not recommended. Duranzo Tablet contains diclofenac and codeine, which may interact with cold medications like pain relievers, NSAIDs, or decongestants. This could lead to unwanted side effects and complications. Always consult your doctor before combining Duranzo Tablet with cold medications to ensure your safety.
Yes, drowsiness is a common side effect of Duranzo Tablet . You should avoid driving, operating machinery, or doing any activities that require full focus until you know how this medication affects you. Talk to your doctor if the sleepiness becomes severe.
Yes. Duranzo Tablet contains codeine, an opioid, and can cause tolerance, physical dependence, and, in some cases, misuse or addiction. The risk increases with higher doses and longer use. Take this medicine only as prescribed, and do not stop suddenly after prolonged use because withdrawal can occur. Your doctor may gradually reduce the dose when treatment is no longer needed.
You should avoid taking other anti-inflammatory medicines or opioid painkillers while using Duranzo Tablet , as this can increase your risk of serious side effects like stomach bleeding or severe drowsiness. Always talk to your doctor before combining any medications.
No, you should completely avoid alcohol while taking Duranzo Tablet . Alcohol can significantly increase the risk of severe drowsiness, dizziness, and dangerous breathing difficulties. Talk to your doctor if you find it difficult to avoid alcohol.
This medication is generally not recommended during pregnancy, especially in the third trimester, as it can harm the developing baby. If you are pregnant or planning to become pregnant, talk to your doctor to discuss safer alternatives.
If your pain continues or worsens despite taking the medicine as prescribed, do not increase your dose on your own. Contact your healthcare provider, as they may need to reassess your condition or adjust your treatment plan. Talk to your doctor.
No, it is highly recommended to take Duranzo Tablet with or immediately after food. This helps protect your stomach lining and reduces the risk of indigestion or stomach upset. Talk to your doctor if you experience persistent stomach discomfort.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India
Other Info - DUR0130
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