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Duovir-N Tablet is used for the treatment of HIV (human immunodeficiency virus) infection. It contains lamivudine, zidovudine, and nevirapine. This medication works by preventing HIV (the virus) from multiplying, thereby reducing the amount of virus in your body and also increasing the CD4 cell count (white blood cells that protect against infection) in your blood. It may cause common side effects such as nausea, vomiting, diarrhoea, headache, heartburn, depression, cough, stuffy nose, joint pain, and insomnia (difficulty falling asleep). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and any pre-existing medical conditions. It can cause birth defects, so use effective contraception while taking this medicine and for 12 weeks after stopping it.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

LAMIVUDINE-150MG+NEVIRAPINE-200MG+ZIDOVUDINE-300MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Duovir-N Tablet

Duovir-N Tablet is a prescription oral tablet used to manage Human Immunodeficiency Virus (HIV-1) infection in adults and children. It is prescribed to help control the virus, protect the immune system, and lower the risk of developing acquired immunodeficiency syndrome (AIDS).

To ensure maximum effectiveness, you must take Duovir-N Tablet consistently at the same times every day, either with or without food. Maintaining a regular schedule helps keep a steady level of the medicine in your blood, preventing the virus from multiplying. Incorporating a nutrient-rich diet and reducing physical stress can further support your immune system during treatment.

While taking Duovir-N Tablet , some people may experience mild side effects like nausea, headaches, or tiredness. However, you must contact your doctor immediately if you experience severe skin rashes, yellowing of your skin or eyes, or dark urine, as these can be signs of serious medical complications.

Before starting Duovir-N Tablet , talk to your doctor if you have a history of liver disease, kidney problems, or low red blood cell counts. Do not take this if you have severe liver damage, extremely low white blood cell levels, or if you have previously had a severe allergic reaction to any of the active ingredients.

Duovir-N Tablet can interact with alcohol, which increases the risk of liver damage, and certain other prescription drugs that can lower its effectiveness. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits before starting treatment.

Uses of Duovir-N Tablet

Duovir-N Tablet is used in the treatment of HIV (human immunodeficiency virus) infection. The detailed uses of Duovir-N Tablet are as follows:

  • HIV-1 Infection: Duovir-N Tablet helps control the replication of the virus in the body, which helps preserve immune function and reduces the frequency of opportunistic infections.

Key Benefits

Duovir-N Tablet helps manage HIV infection by reducing the amount of virus in the body and supporting the immune system. When taken consistently as prescribed, it helps maintain better overall health and supports long-term disease control. Benefits may include:

  • Helps reduce the amount of HIV in the blood (viral load).
  • Supports and protects the immune system by helping preserve important immune cells.
  • Helps the body fight infections more effectively.
  • Supports long-term control of HIV when taken regularly as part of a treatment plan.
  • May help reduce fatigue and improve overall daily functioning.
  • Promotes better long-term health and quality of life for people living with HIV.
     
Side effects of Duovir-N Tablet
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Directions for Use

  • Take Duovir-N Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Duovir-N Tablet Works

Duovir-N Tablet is a combination of three medications: lamivudine, zidovudine, and nevirapine. Lamivudine and zidovudine are nucleosidase reverse transcriptase inhibitors that work together to decrease the amount of virus in your body by inhibiting HIV reverse transcription through viral DNA chain termination. Nevirapine is a non-nucleosidase reverse transcriptase inhibitor that works by lowering the amount of HIV in the blood. Duovir-N Tablet  will not cure HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
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Alcohol

Unsafe

Taking Duovir-N Tablet with alcohol may increase the risk of liver damage. So, avoid alcohol consumption while taking Duovir-N Tablet .

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Pregnancy

Safe

Duovir-N Tablet can be used during pregnancy under the supervision of a doctor. Studies have not shown any defects in the unborn baby, even though Duovir-N Tablet passes through the placenta. Duovir-N Tablet helps reduce the risk of transmitting the virus to the baby during pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding if you are infected with HIV or while taking Duovir-N Tablet .

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Driving

Unsafe

Duovir-N Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.

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Liver

Caution

Inform your doctor before taking Duovir-N Tablet if you have severe liver disease. Your doctor may advise you not to take Duovir-N Tablet . Inform your doctor immediately if you develop symptoms such as abdominal pain, loss of appetite, dizziness, bruising, irregular heartbeats, yellowing of the eyes or skin, or darkened urine.

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Kidney

Caution

Inform your doctor before taking Duovir-N Tablet if you have severe kidney disease. Your doctor may need to adjust the dose of Duovir-N Tablet .

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Children

Unsafe

Duovir-N Tablet should not be used in children weighing less than 35 kg. If their weight is >35, your doctor may prescribe Duovir-N Tablet and adjust the dose.

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Heart

Caution

Duovir-N Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Duovir-N Tablet should be used with extreme caution in elderly patients due to an increased risk of adverse effects. Dose adjustments maybe needed in some patients.

What if I have taken an overdose of Duovir-N Tablet

Do not take more than the prescribed dose of Duovir-N Tablet as it may lead to an overdose. If you suspect you have taken an overdose or notice any unusual symptoms, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Follow a nutrient-rich diet: Eat a balanced diet that includes lean proteins, whole grains, fruits, and vegetables to help support your immune system and maintain healthy muscle mass.
  • Practice safe food handling: Wash fruits and vegetables thoroughly and cook meats completely to help reduce the risk of foodborne infections.
  • Avoid alcohol consumption: Do not drink alcohol while taking Duovir-N Tablet , as alcohol can increase the risk of liver problems and place additional strain on the liver.
  • Stay well hydrated: Drink plenty of water throughout the day to support overall health and help your body process and eliminate medication waste effectively.
health query

Have a query?

How Soon It Starts Working

The time required for Duovir-N Tablet to start to work: The time required for Duovir-N Tablet to show its action is unknown. 

The time for which the effects of Duovir-N Tablet last: The duration of action for Duovir-N Tablet is unknown.

What if you forget to take Duovir-N Tablet

If you miss a dose of Duovir-N Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor for skin reactions: Check your skin regularly, especially during the first 6 to 8 weeks of treatment, when the risk of serious nevirapine-related skin reactions is highest. Seek medical attention immediately if you develop a rash, particularly if it is accompanied by fever, mouth sores, blistering, or facial swelling.
  • Attend regular monitoring appointments: Keep all scheduled follow-up visits. Your doctor may monitor your viral load, CD4 cell count, liver function, kidney function, and blood cell counts to ensure your treatment remains safe and effective.
  • Do not miss doses or stop treatment abruptly: Take your medicine exactly as prescribed. Missing doses or stopping treatment without medical advice can allow HIV to multiply and increase the risk of drug resistance, making future treatment less effective.
  • Follow the prescribed dosing schedule carefully: Some patients may start nevirapine with a lower lead-in dose for the first 14 days to help reduce the risk of skin rash before moving to the regular maintenance dose. Always follow your doctor's instructions regarding dosing.
  • Use with caution in children: In children, the dose is usually based on body weight and individual treatment needs. Parents and caregivers should follow the prescribing doctor's instructions carefully and should never adjust the dose without medical advice.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Tuberculosis medicines (e.g., rifampicin): Taking these medicines alongside Duovir-N Tablet may reduce nevirapine levels in the body and decrease the effectiveness of HIV treatment.
  • Anti-seizure medicines (e.g., phenytoin, carbamazepine): These medicines may lower nevirapine concentrations, increasing the risk of treatment failure.
  • Antifungal medicines (e.g., fluconazole): Combining these with Duovir-N Tablet may increase nevirapine levels and raise the risk of liver-related side effects.
  • Opioid analgesic  (e.g., Methadone): Duovir-N Tablet may reduce methadone levels in the body, which could lead to withdrawal symptoms in some patients.
    Medicines that affect the bone marrow or liver: Taking these alongside Duovir-N Tablet may increase the risk of anemia, low blood cell counts, or liver toxicity.

Drug-Food Interactions

  • Herbal supplements containing St. John's Wort: Avoid using these while taking Duovir-N Tablet , as they may reduce the amount of the medicine in your body and make the treatment less effective.

Drug-Disease Interactions

  • Severe liver disease: Do not take Duovir-N Tablet if you have severe liver problems, as it may worsen liver damage and increase the risk of serious side effects.
  • Kidney disease: Patients with impaired kidney function may require dose adjustments, as the body clears some components of Duovir-N Tablet through the kidneys.
  • Anemia or bone marrow suppression: Duovir-N Tablet should be used with caution in patients with existing blood disorders, as it may further reduce red blood cell counts and worsen anemia.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Duovir-N Tablet belongs to a class of medications called antiretrovirals, primarily used to treat HIV (human immunodeficiency virus) infection. It also helps delay the progression of HIV infection to AIDS and reduces the risk of transmitting the virus to the baby during pregnancy.
If you miss a dose of Duovir-N Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Yes, Duovir-N Tablet causes the weakening of bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Duovir-N Tablet is a combination of three medications: lamivudine, zidovudine, and nevirapine. Lamivudine and zidovudine are nucleosidase reverse transcriptase inhibitors that work together to decrease the amount of virus in your body by inhibiting HIV reverse transcription through viral DNA chain termination. Nevirapine is a non-nucleosidase reverse transcriptase inhibitor that works by lowering the amount of HIV in the blood. Duovir-N Tablet  will not cure HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
The common side effects of Duovir-N Tablet include nausea, vomiting, diarrhoea, headache, heartburn, depression, cough, stuffy nose, joint pain, and insomnia (difficulty falling asleep). Most of the side effects of Duovir-N Tablet do not require medical attention and typically resolve on their own over time. However, if the side effects persist, contact your doctor.
HIV is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). There is currently no effective cure. But with proper medical care, HIV can be controlled. Some people have flu-like symptoms within 2 to 4 weeks after infection (called acute HIV infection). These symptoms may last for a few days or several weeks. Possible symptoms include fever, chills, rash, muscle aches, night sweats, fatigue, sore throat, mouth ulcers, and swollen lymph nodes.
Some medicines in this combination, including lamivudine and zidovudine, have been widely used during pregnancy as part of HIV treatment and prevention of mother-to-child transmission. However, nevirapine requires careful consideration because certain pregnant women, particularly those with higher CD4 cell counts, may have an increased risk of serious liver-related side effects. Your doctor will carefully evaluate your health status, treatment history, and pregnancy needs before recommending the most appropriate antiretroviral regimen. Do not start, stop, or change HIV medicines during pregnancy without medical supervision.
If you develop any rash while taking Duovir-N Tablet , contact your doctor immediately, as some rashes can become severe and life-threatening if ignored.
Yes, you can take Duovir-N Tablet with or without food, but it is important to take it consistently at the same times every day.
No, you must never share Duovir-N Tablet with anyone else, as the dose is personalized and taking it without a prescription can cause severe health risks.
IRIS is a condition that can occur during the first weeks or months after starting effective HIV treatment. As your immune system begins to recover, it may produce a stronger inflammatory response against existing infections that were previously hidden or inactive. This can temporarily make symptoms appear worse even though the HIV treatment is working. Contact your doctor if you develop new fever, swollen lymph nodes, worsening cough, unexplained weight loss, or other new symptoms after starting treatment, so the cause can be properly evaluated.

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DUO0032
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