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  3. Duonase 140/50 Nasal Spray 7 gm

Duonase 140/50 Nasal Spray 7 gm, Pack of 1 NASAL SPRAY
Duonase 140/50 Nasal Spray 7 gm, Pack of 1 NASAL SPRAY
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Duonase 140/50 Nasal Spray 7 gm is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose or watery eyes. It contains Fluticasone and Azelastine, which work by acting inside the nasal lining cells and stopping the release of certain chemicals in the body that cause inflammatory reactions, thereby relieving sneezing, runny or blocked nose, and sinus discomfort. Also, it blocks histamine, a substance responsible for causing allergic reactions. Some people may experience side effects such as headaches, taste changes or nose bleeds. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AZELASTINE-140MCG + FLUTICASONE-50MCG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

NASAL

Return Policy :

Not Returnable

Expires on or after :

About Duonase 140/50 Nasal Spray 7 gm

Duonase 140/50 Nasal Spray 7 gm is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose or watery eyes. An allergy is a condition that occurs when the immune system reacts to a foreign substance. These foreign substances are known as 'allergens.' Allergic condition varies from person to person. Some might be allergic to certain foods and seasonal allergies like hay fever, pollen or pet dander. One of the main symptoms of allergy is cough, which acts as a reflex action in the throat when there is any mucus or foreign irritant entering the respiratory system.

Duonase 140/50 Nasal Spray 7 gm is a combination of two drugs: Fluticasone (corticosteroid) and Azelastine (antihistamine/antiallergic). Fluticasone belongs to the class of corticosteroids that works by acting inside the nasal lining cells and stopping the release of certain chemicals in the body that cause inflammatory reactions, thereby relieving sneezing, runny or blocked nose, and sinus discomfort. On the other hand, Azelastine belongs to the class of antihistamines (antiallergic drugs) that works by blocking histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Together, both of them effectively treat allergic symptoms.

Take Duonase 140/50 Nasal Spray 7 gm as advised by your doctor by spraying towards the sides of nostrils. Your doctor will recommend how often you take Duonase 140/50 Nasal Spray 7 gm based on your medical condition. Some people may experience headaches, taste changes or nose bleeds. Most of these side effects of Duonase 140/50 Nasal Spray 7 gm do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Duonase 140/50 Nasal Spray 7 gm or any other medicines, are pregnant or breastfeeding before using Duonase 140/50 Nasal Spray 7 gm. Duonase 140/50 Nasal Spray 7 gm is not recommended for children below six years of age. If you experience vision changes, tiredness, nausea, vomiting, light-headedness, chills, fever, body pains, sores, redness or white patches in the mouth or throat, runny nose, severe nosebleeds, or increased drowsiness, stop taking Duonase 140/50 Nasal Spray 7 gm and consult a doctor immediately. Avoid contact with people who have infections or are sick, as the Duonase 140/50 Nasal Spray 7 gm may weaken the immune system, causing infections easily. If you have chickenpox, measles, tuberculosis, surgery or injury on the nose, glaucoma, cataracts, herpes infection of eyes, ulcers, or sores inside the nose, inform your doctor before taking Duonase 140/50 Nasal Spray 7 gm.

Uses of Duonase 140/50 Nasal Spray 7 gm

Treatment of Allergic symptoms like sneezing, runny nose, congestion, stuffy nose or watery eyes.

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Directions for Use

• Duonase 140/50 Nasal Spray 7 gm is for nasal use only.• It is recommended to spray Duonase 140/50 Nasal Spray 7 gm twice daily into each nostril, or as prescribed by your doctor.• Check the label for directions before using Duonase 140/50 Nasal Spray 7 gm.• Shake the nasal spray bottle gently before each use.• Blow your nose and remove the protective cap. Before the first use, press the pump a few times until an even spray is released. • Insert the tip of the bottle into a nostril while closing the other nostril and spray the medicine into your nose. Keep your head straight and breathe gently. Repeat the same process for the other nostril.• If Duonase 140/50 Nasal Spray 7 gm accidentally gets sprayed into your mouth or eyes, rinse with water thoroughly.

Medicinal Benefits

Duonase 140/50 Nasal Spray 7 gm is primarily used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose or watery eyes. It combines two drugs: Fluticasone (corticosteroid) and Azelastine (antihistamine/antiallergic). Fluticasone belongs to the class of corticosteroids that works by acting inside the nasal lining cells and stopping the release of certain chemicals in the body that cause inflammatory reactions, thereby relieving sneezing, runny or blocked nose and sinus discomfort. On the other hand, Azelastine belongs to the antihistamines class (antiallergic drugs), which works by blocking histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion or stiffness. Together, both of them effectively treat allergic symptoms.

How Duonase 140/50 Nasal Spray 7 gm Works

Duonase 140/50 Nasal Spray 7 gm is a combination of two drugs: Fluticasone (corticosteroid) and Azelastine (antihistamine/antiallergic). Fluticasone belongs to the class of corticosteroids that works by acting inside the nasal lining cells and stopping the release of certain chemicals in the body that cause inflammatory reactions, thereby relieving sneezing, runny or blocked nose, and sinus discomfort. On the other hand, Azelastine belongs to the class of antihistamines (antiallergic drugs) that works by blocking histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Together, both of them effectively treat allergic symptoms.

Storage

Keep Duonase 140/50 Nasal Spray 7 gm out of the sight and reach of children.
Side effects of Duonase 140/50 Nasal Spray 7 gm
  • Focus on eating nutrient-rich foods such as citrus fruits, spinach, ginger, garlic, turmeric, and fermented foods to improve immunity and general health.
  • Drink plenty of water to stay hydrated, and think about taking probiotics, zinc, vitamin C, and vitamin D supplements.
  • Adopt healthful practices such as leading a balanced lifestyle and remaining at home when necessary.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

What if I have taken an overdose of Duonase 140/50 Nasal Spray 7 gm

Do not use Duonase 140/50 Nasal Spray 7 gm in more doses or more often than prescribed. If you have any unusual signs or symptoms, please consult a doctor immediately.

Drug Warnings

Please inform your doctor if you are allergic to Duonase 140/50 Nasal Spray 7 gm or any other medicines. Do not use the Duonase 140/50 Nasal Spray 7 gm if you are pregnant or breastfeeding without consulting the doctor. Duonase 140/50 Nasal Spray 7 gm is not recommended for children below six years of age. If you experience vision changes, tiredness, nausea, vomiting, light-headedness, chills, fever, body pains, sores, redness or white patches in the mouth or throat, runny nose, severe nosebleeds, or increased drowsiness, stop taking Duonase 140/50 Nasal Spray 7 gm and consult a doctor immediately. Avoid contact with people who have infections or are sick as Duonase 140/50 Nasal Spray 7 gm may weaken the immune system, causing infections easily. If you have chickenpox, measles, tuberculosis, surgery or injury on the nose, glaucoma, cataracts, herpes infection of eyes, ulcers, or sores inside the nose, inform your doctor before taking Duonase 140/50 Nasal Spray 7 gm.

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
FluticasoneTelaprevir
Severe

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Duonase 140/50 Nasal Spray 7 gm with Mifepristone may make Duonase 140/50 Nasal Spray 7 gm less effective as a therapy.

How to manage the interaction:
Taking Duonase 140/50 Nasal Spray 7 gm with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
FluticasoneTelaprevir
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Telaprevir may significantly increase the absorption of Duonase 140/50 Nasal Spray 7 gm into the bloodstream.

How to manage the interaction:
Taking Duonase 140/50 Nasal Spray 7 gm with Telaprevir together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - swelling, weight gain, high blood pressure, high blood sugar, weak muscles, feeling down, acne, thinning skin, easy bruising, irregular periods, too much facial or body hair, unusual fat distribution, infection, or a bad asthma attack - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
FluticasoneClarithromycin
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Duonase 140/50 Nasal Spray 7 gm with Clarithromycin may significantly increase the absorption of Duonase 140/50 Nasal Spray 7 gm into the blood stream.

How to manage the interaction:
Co-administration of Clarithromycin and Duonase 140/50 Nasal Spray 7 gm can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneRitonavir
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Duonase 140/50 Nasal Spray 7 gm and Ritonavir may increase the blood levels of Duonase 140/50 Nasal Spray 7 gm.

How to manage the interaction:
If you are supposed to take Duonase 140/50 Nasal Spray 7 gm and Ritonavir together, your doctor may adjust the dose or monitor you more frequently to use both medications safely. However, if you experience side effects such as palpitations, swelling, high blood sugar, muscle weakness, acne, depression, thinning skin, easy bruising, stretch marks, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, contact a doctor. Do not discontinue the medication without consulting a doctor.
FluticasoneItraconazole
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Coadministration of Itraconazole and Duonase 140/50 Nasal Spray 7 gm may significantly increase the absorption of Duonase 140/50 Nasal Spray 7 gm into the bloodstream.

How to manage the interaction:
Duonase 140/50 Nasal Spray 7 gm and itraconazole may interact, but if a doctor prescribes them, you can still use them. Swelling, high blood pressure, high blood sugar, muscle weakness, depression, acne, stretch marks, easy bruising, bone density loss, cataracts, irregular menstruation, and excessive face or body hair growth are all signs that you need to consult a doctor. Never discontinue taking a medication without consulting a doctor.
FluticasoneCladribine
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Cladribine with Duonase 140/50 Nasal Spray 7 gm can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Duonase 140/50 Nasal Spray 7 gm and Cladribine together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FluticasoneCeritinib
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Taking Ceritinib together with Duonase 140/50 Nasal Spray 7 gm may increase the blood levels of Duonase 140/50 Nasal Spray 7 gm.

How to manage the interaction:
If you are supposed to take Duonase 140/50 Nasal Spray 7 gm and Ceritinib together, your doctor may adjust the dose or monitor you more frequently to use both medications safely. However, if you experience side effects such as high blood pressure, swelling, muscle weakness, acne, depression, thinning skin, easy bruising, stretch marks, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, contact a doctor. Do not discontinue the medication without consulting a doctor.
FluticasoneCobicistat
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
When Duonase 140/50 Nasal Spray 7 gm is taken with Cobicistat, it can cause a decrease in the metabolism of Duonase 140/50 Nasal Spray 7 gm.

How to manage the interaction:
Co-administration of Cobicistat and Duonase 140/50 Nasal Spray 7 gm can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneAtazanavir
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Atazanavir and Duonase 140/50 Nasal Spray 7 gm may significantly increase the absorption of Duonase 140/50 Nasal Spray 7 gm into the bloodstream.

How to manage the interaction:
Co-administration of Atazanavir and Duonase 140/50 Nasal Spray 7 gm can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneTroleandomycin
Severe
How does the drug interact with Duonase 140/50 Nasal Spray 7 gm:
Co-administration of Troleandomycin may significantly increase the absorption of Duonase 140/50 Nasal Spray 7 gm and tend to increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Duonase 140/50 Nasal Spray 7 gm and Troleandomycin, but it can be taken if prescribed by a doctor. If you notice any of these symptoms - swelling, weight gain, high blood pressure, high blood sugar, muscle weakness, feeling down, acne, thinning skin, bruises, changes in your period, too much facial or body hair, unusual fat distribution, infection, injury, or a bad asthma attack - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Add ginger to foods or tea as it contains some anti-inflammatory compounds that can relax membranes in the airways and reduce cough, irritation and swelling in nasal passages.
  • Staying hydrated is vital for those with a cough or cold. Drink liquids at room temperature to relieve a runny nose, cough, and sneezing.
  • Stress affects the immune system and raises the risk of illness. To relieve stress, meditate, deepen breathing, and engage in regular exercise. You can also try progressive muscle relaxation techniques.
  • It is advised to avoid contact with known allergens (allergy-causing agents) such as pollen, dust, etc. Certain food items are known to cause allergies to you.
  • Maintain personal hygiene and keep your surroundings clean.

Habit Forming

No

Therapeutic Class

ANTIALLERGIC

Duonase 140/50 Nasal Spray 7 gm Substitute

Substitutes safety advice
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Alcohol

Caution

It is unknown whether it is safe to consume alcohol with Duonase 140/50 Nasal Spray 7 gm. However, as a precautionary measure, it is advisable not to take or limit alcohol.

bannner image

Pregnancy

Caution

The safety of Duonase 140/50 Nasal Spray 7 gm in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

It is unknown whether Duonase 140/50 Nasal Spray 7 gm is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

bannner image

Driving

Caution

Duonase 140/50 Nasal Spray 7 gm may cause drowsiness in some people. Therefore, drive only if you are alert after taking Duonase 140/50 Nasal Spray 7 gm.

bannner image

Liver

Safe if prescribed

Inform your doctor before prescribing the Duonase 140/50 Nasal Spray 7 gm if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Safe if prescribed

Inform your doctor before receiving the Duonase 140/50 Nasal Spray 7 gm if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

Duonase 140/50 Nasal Spray 7 gm is not recommended for children below six years as the safety and effectiveness were not established.

FAQs

Duonase 140/50 Nasal Spray 7 gm is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose or watery eyes.

Duonase 140/50 Nasal Spray 7 gm is a combination of two drugs: Fluticasone (corticosteroid) and Azelastine (antihistamine/antiallergic). Fluticasone belongs to the class of corticosteroids that works by acting inside the nasal lining cells and stopping the release of certain chemicals in the body that cause inflammatory reactions, thereby relieving sneezing, runny or blocked nose and sinus discomfort. On the other hand, Azelastine belongs to the class of antihistamines (antiallergic drugs) that works by blocking histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, runny nose, watery eyes, itching, swelling, congestion, or stiffness. Together, both of them effectively treat allergic symptoms.

It is recommended that you avoid taking grapefruit juice with Duonase 140/50 Nasal Spray 7 gm as it may lead to adrenal insufficiency and Cushing’s syndrome (increased cortisol hormone in the body).

Your rhinitis symptoms may improve over several days of regular use. Call your healthcare provider if your symptoms do not improve or worsen.

You are not recommended to take more than the prescribed dose of Duonase 140/50 Nasal Spray 7 gm or for a prolonged time as it may cause adverse effects such as changes in body fat (especially in the back, waist, neck, and face), easy bruising, skin thinning, increased facial hair or acne, loss of interest in sex, impotence or menstrual problems. However, if you experience any of these symptoms while taking Duonase 140/50 Nasal Spray 7 gm, please consult a doctor immediately.

No, you are recommended not to use Duonase 140/50 Nasal Spray 7 gm if you have a recent nose operation or have any nose infections as it may lead to nose bleeding and excessive pain in the nose, leading to further worsening of your condition. Consult your doctor and do as advised for the best results.

No, Duonase 140/50 Nasal Spray 7 gm is not used to treat asthma attacks. It is used to prevent allergic symptoms that can cause asthma. Therefore, it is recommended to always carry a rescue inhaler to treat asthma attacks.

Duonase 140/50 Nasal Spray 7 gm contains Fluticasone which belongs to the class of corticosteroids, and it may result in the development of glaucoma and/or cataracts. Therefore, close monitoring is warranted in patients with a change in vision or a history of increased intraocular pressure, glaucoma, and/or cataracts.

Use Duonase 140/50 Nasal Spray 7 gm as advised by your doctor. Place the tip of the bottle into one nostril while closing the other nostril. Spray towards the side of your nostril, keeping your head upright and breathing in softly.

Store in a cool and dry place at room temperatures. Protect from light. Keep it out of reach of children. Do not refrigerate. Follow the local guidelines for disposal of Duonase 140/50 Nasal Spray 7 gm.

Duonase 140/50 Nasal Spray 7 gm causes side effects as headache, nose bleeds, and taste change. These side effects do not require any medical treatment. They will reduce by time.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - DUO0228

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:39 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/202236s008lbl.pdf
  2. https://www.medicines.org.uk/emc/files/pil.9450.pdf
  3. https://www.drugs.com/cdi/azelastine-and-fluticasone.html

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