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compositionComposition:CLAVULANIC ACID-125MG
prescription
Prescription Medicine
info
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Duo Plus Tablet is an antibiotic medicine used to treat bacterial infections in children. It contains Amoxycillin and Clavulanic acid, which work by killing infection-causing bacteria. This medicine may cause side effects like indigestion, diarrhoea, nausea, and stomach pain. Inform your doctor if your child is taking any other medicines or has pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLAVULANIC ACID-125MG

Manufacturer/Marketer :

Zentiva Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Duo Plus Tablet

Duo Plus Tablet is a prescription medication, available as both a standard tablet and a disintegrating tablet, used to treat a wide variety of bacterial infections in children. It is commonly prescribed for infections of the ears, sinuses, throat, lungs, and skin. By targeting and eliminating the bacteria responsible for these illnesses, it helps your child recover safely and comfortably.

For this medicine to work effectively, it must be given at consistent times every day as directed by your doctor. Giving each dose with a meal or a light snack helps protect your child's stomach and improves how the medicine is absorbed. To support your child's recovery, ensure they get plenty of rest and stay well-hydrated throughout the treatment course.

While taking Duo Plus Tablet, some children may experience mild side effects like loose stools, nausea, or a mild diaper rash. These are typically temporary and resolve on their own once the treatment is finished. However, you should contact your doctor immediately if your child develops severe watery diarrhoea, a high fever, or signs of liver damage such as yellowing of the skin or eyes.

Do not give this medicine if your child has a known allergy to penicillin-type antibiotics or has previously experienced liver issues when taking this medication. Talk to your doctor before starting if your child has a history of kidney disease, liver problems, or glandular fever.

This medication can interact with certain other treatments, such as medicines for gout or live vaccines, which may reduce their effectiveness or increase side effects. If the patient is a teenager who is pregnant or breastfeeding, consult your doctor or pharmacist before use to ensure it is safe.

Uses of Duo Plus Tablet

Duo Plus Tablet is used to treat a wide variety of bacterial infections in children. The detailed uses of Duo Plus Tablet are as follows:

  • Middle ear infections (Otitis Media): Relieves ear pain and swelling by clearing the bacterial infection behind the eardrum.
  • Sinus infections (Sinusitis): Helps drain blocked nasal passages and relieves facial pressure by stopping bacterial growth in the sinuses.
  • Throat and tonsil infections (Tonsillitis/Pharyngitis): Reduces throat soreness and difficulty swallowing by targeting the bacteria causing the infection.
  • Chest and lung infections (Bronchitis/Pneumonia): Eases coughing and breathing difficulties by clearing bacteria from the airways.
  • Skin and soft tissue infections: Reduces redness, warmth, and swelling in skin infections by stopping bacterial spread.

Key Benefits

Duo Plus Tablet helps treat bacterial infections by eliminating the bacteria causing the illness and supporting a faster recovery. Its combination formulation is designed to work effectively against bacteria that may resist some standard antibiotics.

  • Treats the Infection at the Source: By targeting and killing susceptible bacteria, Duo Plus Tablet helps relieve fever, pain, and other symptoms of infection.
  • Provides Effective Treatment Against Resistant Bacteria: The added protective component helps prevent certain bacteria from inactivating the antibiotic, improving treatment effectiveness in many infections.
  • Supports Faster Recovery: As the infection improves, Duo Plus Tablet helps restore energy levels and overall wellbeing, allowing your child to return to normal daily activities more comfortably.

Directions for Use

  • Duo Plus Tablet can be given to your child with or without food. However, giving it with food may help reduce stomach upset.
  • Follow your doctor's instructions regarding the dosage and duration.
  • Dissolve Duo Plus Tablet in the prescribed amount of water and have your child consume it immediately.
  • Do not crush, chew, or let your child swallow the medicine whole.
  • Do not handle Duo Plus Tablet with wet hands.

How Duo Plus Tablet Works

This medicine contains two active parts that work together to defeat bacterial infections. The first active part, amoxycillin, is a penicillin-type antibiotic that directly targets the bacteria causing the illness. It works by preventing the bacteria from building their protective outer walls, which ultimately causes them to break down and die. However, some advanced bacteria produce a special enzyme that can destroy standard antibiotics before they can work. The second active part, clavulanic acid, of this medicine acts as a shield. It binds to and blocks this destructive enzyme, preventing the bacteria from inactivating the antibiotic. Together, these two components ensure the infection is cleared effectively, ensuring the antibiotic part can do its job without interference.
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Alcohol

Not applicable

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Consult your doctor

Please consult your doctor if your child has a liver impairment or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if your child has kidney impairment or if you have any concerns regarding this.

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Children

Safe if prescribed

Duo Plus Tablet is safe for children if prescribed by the doctor. Your paediatrician will decide the dose of the medicine. Do not give your child more than the recommended dose.

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Heart

Caution

Avoid giving Duo Plus Tablet to a child with heart problems without a doctor’s approval. Though generally safe, underlying cardiac conditions may require adjusted dosing or alternative antibiotics.

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Geriatrics

Not applicable

Duo Plus Tablet is specifically for children use and is not meant for geriatric patients.

What if I have taken an overdose of Duo Plus Tablet

If you suspect your child has taken too much of this medicine, seek immediate emergency medical care.

Diet & Lifestyle Advise

  • Offer your child plenty of fluids, such as water or clear broths, to prevent dehydration, especially if they experience mild diarrhoea.
  • Give your child age-appropriate probiotic foods like yoghurt (spaced at least two hours apart from the medicine) to help support healthy gut bacteria.
  • Ensure your child gets plenty of sleep and rest to help their immune system fight off the infection.
  • Always give this medication with a meal or a small snack to protect your child's stomach lining and reduce nausea.
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How Soon It Starts Working

The time required for Duo Plus Tablet to start to work: Duo Plus Tablet ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of Duo Plus Tablet last: The effect of Duo Plus Tablet lasts for 6 to 8 hours.

What if you forget to take Duo Plus Tablet

If you miss giving a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

•Store both standard tablets and disintegrating tablets at room temperature, below 25°C (77°F).•Keep the medication in its original packaging to protect it from light and moisture.

Drug Warnings

  • Check the expiration date on the packaging before giving any dose to your child.
  • Always finish the entire prescribed course of treatment, even if your child feels completely better, to prevent the infection from returning.
  • For disintegrating tablets, ensure your hands are completely dry before handling the tablet, and give it immediately after taking it out of the foil.
  • Stop giving the medication and seek medical help immediately if you notice any sign of a skin rash or hives.
  • Do not share this medicine with other children, even if they have similar symptoms.

verifiedApollotooltip
  • Gout medications (like allopurinol): May increase the risk of developing a skin rash when taken together.
  • Blood thinners (like warfarin): May require closer monitoring, as this antibiotic can alter how your blood clots.
  • Oral typhoid vaccine: This antibiotic may reduce the effectiveness of live bacterial vaccines.

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verifiedApollotooltip
  • While there are no major food restrictions, taking this medication with high-fat meals may slightly alter its absorption. Giving it with a light meal is highly recommended.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Duo Plus Tablet is used to treat bacterial infections in children.
Duo Plus Tablet contains amoxycillin and clavulanic acid. Amoxycillin works by inhibiting the formation of the bacterial cell wall (a protective covering) and causing damage to the bacterial cell wall. This eventually leads to the death of the bacterial cell and thus prevents the growth of bacterial infections. Clavulanic acid inhibits the beta-lactamase enzyme, which prevents bacteria from destroying the efficacy of amoxycillin.
No, Duo Plus Tablet is not used to treat viral infections. It is an antibiotic used only to treat bacterial infections.
No, you must complete the entire course prescribed by your doctor. Stopping early can allow surviving bacteria to multiply, causing the infection to return and potentially become resistant to antibiotics. Talk to your doctor if you have concerns.
You can place the disintegrating tablet directly on your child's tongue, where it will quickly dissolve so they can swallow it. Alternatively, you can dissolve the tablet in a small spoonful of water before giving it. Talk to your doctor or pharmacist if you need help.
If your child vomits within 30 minutes of taking a dose, you may need to give the dose again. If they vomit more than 30 minutes after, wait until the next scheduled dose. Talk to your doctor or pharmacist for specific guidance.
No, do not give Duo Plus Tablet to your child if they have a known allergy to penicillin, as it can cause a severe and potentially dangerous allergic reaction. Talk to your doctor to find a safe alternative treatment.
This medicine can affect the natural bacteria in your child's gut, which often leads to mild diarrhoea. Keep your child well-hydrated. If the diarrhoea becomes severe, watery, or contains blood, stop the medicine and talk to your doctor immediately.
Disintegrating tablets should only be dissolved in a small amount of water. It is best to avoid mixing the medication into a large bottle of milk or juice, as your child may not drink the whole amount and will miss part of their dose. Talk to your pharmacist for advice.
Some antibiotics can temporarily reduce the effectiveness of birth control pills. If your teenager is taking oral contraceptives, it is advised to use an additional barrier method of protection during treatment and for seven days after finishing. Talk to your doctor or pharmacist for personalised advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Amoxicillin/clavulanate potassium. [Accessed on 25 Jan. 2019]Check here
  2. Amoxicillin and clavulanic acid. 2017. [Accessed on 01 Feb. 2019]Check here
  3. Amoxicillin trihydrate and potassium clavulanate [EMC SmPC]. 2025. [Accessed on 02 Jul. 2025]Check here
  4. Augmentin 625 mg Capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 7 July 2025]Check here
  5. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 23665637, Amoxicillin-Potassium Clavulanate Combination. [Accessed on 7 July 2025]Check here
  6. Drugbank.Amoxicillin.Drugbank [Accessed on 7 July 2025]Check here
  7. Akhavan BJ, Khanna NR, Vijhani P. Amoxicillin. [Updated 2023 Nov 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 7 July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Flat No 9&10, First Floor, Kedar Plaza, Coen Road, HUBLI Karnataka-580 020
Other Info - DUO0162
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