apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Dufree-M 20/1500 Capsule 10's

Dufree-M 20/1500 Capsule 10's, Pack of 10 CapsuleS
Dufree-M 20/1500 Capsule 10's, Pack of 10 CapsuleS
Dufree-M 20/1500 Capsule 10's, Pack of 10 CapsuleS
Offers on medicine orders
All offers
axis icici
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Dufree-M 20/1500 Capsule is used to treat neuropathic pain. It contains Duloxetine and Methylcobalamin, which work by increasing the levels of neurotransmitters (such as serotonin and noradrenaline) in the brain that are required to regulate pain. Also, it helps rejuvenate and protect damaged nerve cells. It may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, or loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

Read more
rxMedicinePrescription drug

Whats That

tooltip
socialProofing18 people bought
in last 30 days

Also Explore

Momverse
Ask Apollo
insurance

Composition :

DULOXETINE-20MG + METHYLCOBALAMIN-1500MCG

Manufacturer/Marketer :

Maxmo Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dufree-M 20/1500 Capsule

Dufree-M 20/1500 Capsule belongs to the class of medications called ‘anticonvulsants’ used to treat neuropathic pain. Neuropathic pain is a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning. It is mainly seen in patients who have suffered a trauma or nerve injury, diabetes, vitamin deficiencies, cancer, multiple sclerosis (a disease of the brain and spinal cord), shingles (a viral infection), and HIV.

Dufree-M 20/1500 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of a chemical messenger (like serotonin and noradrenaline) in the brain required to regulate pain that travels through damaged nerves. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells). 

Take this medicine as prescribed by your doctor. Dufree-M 20/1500 Capsule may cause side effects such as drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and a hot sensation (burning pain). Inform your doctor if any of these side effects persist.

Do not take Dufree-M 20/1500 Capsule if you are allergic to Duloxetine, Methylcobalamin, or any of its contents. Before taking Dufree-M 20/1500 Capsule , inform your doctor if you have liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. Inform your doctor if you are pregnant or breastfeeding before using Dufree-M 20/1500 Capsule .

Uses of Dufree-M 20/1500 Capsule

Dufree-M 20/1500 Capsule is used in the treatment of nutritional deficiency and neuropathic pain. The detailed uses of Dufree-M 20/1500 Capsule are as follows:<br/>• Nerve Health Support: Dufree-M 20/1500 Capsule is designed to promote optimal nerve health by supplying essential vitamins that support proper nervous system function.<br/>• Treatment of Neuropathy: Dufree-M 20/1500 Capsule is beneficial for individuals with diabetic neuropathy or other neurological conditions, aiding in symptom relief and nerve regeneration.<br/>• Vitamin Deficiency: Dufree-M 20/1500 Capsule helps address B vitamin deficiencies, which are vital for energy production and overall metabolic processes.<br/>• Pain Management: Dufree-M 20/1500 Capsule may assist in managing nerve-related pain, such as sciatica, by providing relief and improving nerve function.<br/>

Directions for Use

• Take Dufree-M 20/1500 Capsule with or without food or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Dufree-M 20/1500 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin and noradrenaline levels in the brain, which are required for regulating pain through the damaged nerves. Methylcobalamin is a form of vitamin B12 that helps in rejuvenating and protecting damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells). Together, Dufree-M 20/1500 Capsule effectively treats neuropathic pain and improves nerve conduction, promoting proper nerve signal functioning throughout the body.

How Dufree-M 20/1500 Capsule Works

Dufree-M 20/1500 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of a chemical messenger (like serotonin and noradrenaline) in the brain required to regulate pain that travels through damaged nerves. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (a protective layer of nerve cells).
Side effects of Dufree-M 20/1500 Capsule
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Dufree-M 20/1500 Capsule

Do not take more than the prescribed dose of Dufree-M 20/1500 Capsule as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Before taking Dufree-M 20/1500 Capsule , inform your doctor if you have taken any antidepressants within the last 14 days or any medications used to treat infections. Please consult your doctor before stopping the medicine, as it may cause withdrawal symptoms such as dizziness, tingling sensations, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Therefore, do not abruptly stop taking your medicine, even if your symptoms improve. It may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. Prolonged use of Dufree-M 20/1500 Capsule may decrease sodium level, affect blood pressure, and blood sugar level, so regular medical check-ups are required. Dufree-M 20/1500 Capsule may increase your bleeding risk, and worsen your glaucoma condition. Hence, if you experience any eye problems or bleeding problems, consult a doctor.

Drug-Drug Interactions

verifiedApollotooltip
DuloxetineRasagiline
Critical
DuloxetineSelegiline
Critical

Drug-Drug Interactions

Login/Sign Up

DuloxetineRasagiline
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Rasagiline with Dufree-M 20/1500 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Dufree-M 20/1500 Capsule is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Dufree-M 20/1500 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Dufree-M 20/1500 Capsule and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Dufree-M 20/1500 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Dufree-M 20/1500 Capsule with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Coadministration of eliglustat and Dufree-M 20/1500 Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Dufree-M 20/1500 Capsule with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetineTranylcypromine
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Tranylcypromine with Dufree-M 20/1500 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Dufree-M 20/1500 Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking phenelzine with Dufree-M 20/1500 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Dufree-M 20/1500 Capsule with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineLinezolid
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Dufree-M 20/1500 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Dufree-M 20/1500 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Coadministration of metoclopramide with Dufree-M 20/1500 Capsule increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Dufree-M 20/1500 Capsule is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Dufree-M 20/1500 Capsule:
Coadministration of safinamide with Dufree-M 20/1500 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Dufree-M 20/1500 Capsule is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineCitalopram
Severe
How does the drug interact with Dufree-M 20/1500 Capsule:
Taking Dufree-M 20/1500 Capsule with citalopram can increase the risk of serotonin syndrome( a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although taking Dufree-M 20/1500 Capsule with Citalopram can result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet, as it can help reduce neuropathic pain.
  • Exercising regularly helps improve overall health and combat pain.
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Dufree-M 20/1500 Capsule Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

Alcohol may worsen the condition by increasing the risk of side effects

bannner image

Pregnancy

Unsafe

Dufree-M 20/1500 Capsule is a category C medicine, so it is not recommended for use in pregnant women.

bannner image

Breast Feeding

Caution

Dufree-M 20/1500 Capsule should be used with caution in breastfeeding mothers.

bannner image

Driving

Unsafe

Dufree-M 20/1500 Capsule may cause drowsiness. So, avoid driving or operating heavy machinery while using Dufree-M 20/1500 Capsule .

bannner image

Liver

Caution

Dufree-M 20/1500 Capsule should be used with caution in patients with liver diseases.

bannner image

Kidney

Caution

Dufree-M 20/1500 Capsule should be used with caution in patients with kidney diseases.

bannner image

Children

Unsafe

Dufree-M 20/1500 Capsule is not recommended for children and anyone below 18 years. Please consult a medical professional for further information.

Have a query?

FAQs

Dufree-M 20/1500 Capsule is used to treat neuropathic pain.

Dufree-M 20/1500 Capsule is a combination of two medicines: Duloxetine and Methylcobalamin. Duloxetine increases the number of neurotransmitters like serotonin and noradrenaline in the brain that can regulate pain. On the other hand, methylcobalamin (vitamin B12) can protect the nerve cells from further damage. Thus, Dufree-M 20/1500 Capsule prevents nerve damage due to various conditions like injury or diabetic neuropathy and ensures smooth conduction of nerve signals throughout the body.

Dufree-M 20/1500 Capsule should be taken either in the morning or evening. If you feel drowsy after taking Dufree-M 20/1500 Capsule , consider taking it in the evening. Also, it is recommended to take Dufree-M 20/1500 Capsule every day at the same time for the best results.

Dufree-M 20/1500 Capsule should not be used with antidepressants, especially antidepressants like monoamine oxidase (MAO) inhibitors (moclobemide, linezolid) as they cause serious side-effects. It is advised to wait at least 14 days after stopping MAO inhibitors before taking $namd also wait at least 5 days after stopping Dufree-M 20/1500 Capsule before taking any MAO inhibitors.

Seek medical attention immediately if you notice any depressive thoughts while using Dufree-M 20/1500 Capsule . Your doctor may change the dose or medicine to treat your condition.

The common side effects of Dufree-M 20/1500 Capsule include drowsiness, nausea, constipation, headache, dry mouth, increased sweating, anorexia (loss of appetite), and hot sensation (burning pain). Please inform your doctor if any of these side effects persist or worsen.

No, do not stop taking Dufree-M 20/1500 Capsule , even if you start to feel better. Stopping the medication suddenly may cause withdrawal symptoms. If you need to stop the medication, your doctor will guide you on how to gradually reduce the dose safely.

Dufree-M 20/1500 Capsule usually takes 2-4 weeks to start working. Keep taking Dufree-M 20/1500 Capsule for the prescribed duration to notice the full benefits of the medicine.

Country of origin

India
Other Info - DUF0018

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:42 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.8650.pdf
  2. https://www.npra.gov.my/images/reg-and-noti/PI/non-poison/Mecobalamin-Template-oral-Website.pdf

Buy best C.n.s Drugs products by

whatsapp Floating Button
Buy Now
Add to Cart