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  3. Dothidep 50 mg Tablet 10's

Dothidep 50 mg Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Dothidep 50 mg Tablet is used to treat depression and anxiety. It contains Dothiepin which works by increasing the levels of chemical messengers responsible for mood. In some cases, this medicine may cause side effects such as restlessness, irritability, tiredness, difficulty concentrating, and sleep disturbances. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

DOTHIEPIN-50MG

Manufacturer/Marketer :

German Remedies Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dothidep 50 mg Tablet

Dothidep 50 mg Tablet belongs to the class of tricyclic antidepressants used to treat depression. It is primarily used to treat depression that is unresponsive to other antidepressants or any other alternative treatment. It is also used to treat disorders related to anxiety. Depression is a mood disorder that affects day to day life of a person. A person may have symptoms such as feeling sad or feeling lost and might have mood swings. Anxiety is defined as an emotion that is characterized by feelings of tension, worried thoughts and symptoms like increased blood pressure. Anxiety disorder also includes panic disorder which is characterized by sudden feelings of terror.

Dothidep 50 mg Tablet contains ‘Dothiepin’ that works by increasing the levels of chemical messengers responsible for stabilizing and elevating the mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. It provides relief from symptoms such as feelings of restlessness, irritability, tiredness, difficulty concentrating, feeling and sleep disturbances. It helps to carry out daily activities easily.

Take this medicine as prescribed by your doctor. In some cases, you may experience side effects such as increased heart rate, blurred vision, dizziness, dryness in the mouth and constipation. Most of these side effects of Dothidep 50 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

It is not recommended to take Dothidep 50 mg Tablet if you are allergic to any contents of it. Do not stop taking this medicine without consulting your doctor, as it may lead to withdrawal symptoms. Do not take this medicine if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder or difficulty in sleeping (sleep apnea), severe liver disease or problem with alcohol or other prescription recreational drugs. Inform your doctor if you are planning to get pregnant, are pregnant or breastfeeding. Dothidep 50 mg Tablet is not recommended for use in children. In elderly people, Dothidep 50 mg Tablet may require dose adjustments. Do not take alcohol while using Dothidep 50 mg Tablet as it increases the risk of side effects. Dothidep 50 mg Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Dothidep 50 mg Tablet

Treatment of Depression, Anxiety.

Directions for Use

• Dothidep 50 mg Tablet can be taken with or without food, as advised by your doctor.• It is usually taken once daily at bedtime. However, your doctor may adjust the dose and duration of Dothidep 50 mg Tablet based on your medical condition• Swallow Dothidep 50 mg Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Dothidep 50 mg Tablet works by increasing the levels of chemical messengers that are responsible for stabilizing and elevating mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. Dothidep 50 mg Tablet relieves symptoms such as restlessness, irritability, tiredness, difficulty concentrating and disturbances in sleep. It helps to carry out daily activities easily and improves the quality of life.

How Dothidep 50 mg Tablet Works

Dothidep 50 mg Tablet contains ‘Dothiepin’ that works by increasing the levels of chemical messengers responsible for stabilizing and elevating the mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. It provides relief from symptoms such as feelings of restlessness, irritability, tiredness, difficulty concentrating, feeling and sleep disturbances. It helps to carry out daily activities easily.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Dothidep 50 mg Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Maintain consistent habits, sleep patterns and food times to help maintain stability and reduce confusion.
  • Mindfulness techniques such as deep breathing or meditation help you stay focused and in the now.
  • Participate in cognitive therapy to enhance your ability to remember, focus and solve problems.
  • As directed by your physician, take your medications to help control underlying disorders like depression, anxiety or cognitive impairment.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

What if I have taken an overdose of Dothidep 50 mg Tablet

Take Dothidep 50 mg Tablet only as prescribed by the doctor. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Dothidep 50 mg Tablet should be given with extreme caution in patients having epilepsy (brain disorder in which brain activity becomes abnormal, causing seizures), impaired liver or kidney function, diabetes, decreased level of sodium in the blood, tendency to develop bleedings or bruises easily, patients receiving electroconvulsive treatment, having coronary heart disease, suffering or have suffered from heart problems or have recently had a heart attack, having a low resting heart-rate, having prolonged severe diarrhoea and vomiting (being sick) or using diuretics (water tablets), experiencing a fast or irregular heartbeat, fainting, collapse or dizziness on standing up, which may indicate abnormal functioning of the heart rate and having or previously had eye problems, such as certain kinds of glaucoma (increased pressure in the eye).

Drug-Drug Interactions

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DosulepinParoxetine
Severe
DosulepinAmitriptyline
Severe

Drug-Drug Interactions

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DosulepinParoxetine
Severe
How does the drug interact with Dothidep 50 mg Tablet:
Coadministration of paroxetine and Dothidep 50 mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking Dothidep 50 mg Tablet and paroxetine together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, increased heart rate, fever, excessive sweating, blurred vision, muscle spasms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DosulepinAmitriptyline
Severe
How does the drug interact with Dothidep 50 mg Tablet:
Coadministration of Amitriptyline and Dothidep 50 mg Tablet may increase the risk of irregular heartbeat. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although combining Amitriptyline with Dothidep 50 mg Tablet may result in an interaction, it can be used when a doctor recommends it. If you experience sudden dizziness or irregular heartbeats during therapy, contact your doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Opt for healthy food, which in turn will help you to elevate your moods.
  • Exercise daily for at least 30 minutes a day. It will help you to reduce stress and improve your mood. It will also improve your quality of sleep.
  • Take deep breaths to calm your mind.
  • Follow a consistent sleep schedule (at least 8 hours a day).
  • Manage your stress levels by doing activities that make you happy such as watching your favourite show, reading a book, listening to music and doing activities of your interest.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Dothidep 50 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Do not consume alcohol while taking Dothidep 50 mg Tablet as it may cause serious side effects.

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Pregnancy

Unsafe

Dothidep 50 mg Tablet is not recommended for use in pregnancy. If you are pregnant, please inform your doctor before taking this medicine.

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Breast Feeding

Caution

Dothidep 50 mg Tablet passes in very small amounts in breast milk. However, caution is advised while taking it. If you are breastfeeding, inform your doctor before taking this medicine.

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Driving

Unsafe

Do not drive vehicles or operate machines after taking Dothidep 50 mg Tablet as it can make you feel drowsy.

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Liver

Caution

Limited information is available on the use of Dothidep 50 mg Tablet in patients with liver disease. Hence, if you have liver problems, inform your doctor before taking this medicine.

bannner image

Kidney

Caution

Limited information is available on the use of Dothidep 50 mg Tablet in patients with kidney disease. Hence, if you have kidney problems, inform your doctor before taking this medicine.

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Children

Unsafe

Dothidep 50 mg Tablet is not recommended for use in children below 12 years.

Have a query?

FAQs

Dothidep 50 mg Tablet is used to treat depression. It is also used to treat disorders related to anxiety.

No, Dothidep 50 mg Tablet is not a muscle relaxant. It is a tricyclic antidepressant that is used for the treatment of depression and anxiety disorders.

Dothidep 50 mg Tablet starts to show its full effect in 4 to 6 weeks. Please consult your doctor if you feel that you are not feeling better or there is no improvement in the symptoms. In case you feel that you are experiencing any kind of side-effect after taking Dothidep 50 mg Tablet , please contact your doctor immediately.

Dothidep 50 mg Tablet contains ‘Dothiepin’ that works by increasing the levels of chemical messengers responsible for stabilizing and elevating the mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. Dothidep 50 mg Tablet helps improve your symptoms, such as elevating your mood and energy levels and improving sleep.

Based on your condition and symptoms, your doctor will advise the dose and duration of Dothidep 50 mg Tablet . Discuss with your doctor if you have any concerns.

Dothidep 50 mg Tablet is not recommended to treat pain. Rarely, it is advised to treat nerve pain like fibromyalgia or to prevent migraine.

No, Dothidep 50 mg Tablet is not a habit-forming substance. However, it can cause irritability and difficulty sleeping, especially if you stop taking it abruptly.

Dothidep 50 mg Tablet might cause weight gain as taking it makes you feel hungry. However, it varies from person to person, as some people might feel less hungry after taking it.

Always follow the instructions on the label or as directed by the physician for safe and effective use.

Both Dothidep 50 mg Tablet and amitriptyline belong to the tricyclic antidepressant class used to treat symptoms of depression. However, do not replace the Dothidep 50 mg Tablet with amitriptyline unless recommended by the doctor.

Dothidep 50 mg Tablet and doxepin belong to tricyclic antidepressant class medications used to treat symptoms of depression. However, they may have different mechanisms of action. However, do not replace the Dothidep 50 mg Tablet with doxepin unless recommended by the doctor.

You may take several weeks or longer to experience the full effect of Dothidep 50 mg Tablet . Even if you are feeling good, continue to take Dothidep 50 mg Tablet . Do not discontinue taking Dothidep 50 mg Tablet without consulting your doctor. Before quitting, your doctor will most likely recommend that you gradually reduce your dose

Dothidep 50 mg Tablet is associated with high mortality (death rate) in overdose. There is a low margin of safety between the maximum therapeutic dose and potentially fatal doses. So, you should strictly follow the dose and duration of Dothidep 50 mg Tablet as directed by the physician. Do not overdose at any cost. If you feel you or someone overdosed or experience any severe adverse events with Dothidep 50 mg Tablet , consult the doctor or go to the emergency room nearest hospital.

Caution should be exercised. The risk or severity of CNS depression can be increased when Diazepam is combined with Dothidep 50 mg Tablet .

No. Dothidep 50 mg Tablet is not intended to treat trigeminal neuralgia (sudden, severe facial pain. It's commonly described as a sudden shooting pain or as an electric shock to the jaw, teeth, or gums.).

No. $ name is not intended to treat burning mouth syndrome (a painful condition often described as a burning, scalding, or tingling feeling in the mouth that may occur every day for months).

Yes, Dothidep 50 mg Tablet is intended to treat depression. However, it is a prescription medication and should be taken only if the doctor prescribes it to you.

No. Dothidep 50 mg Tablet is not intended to treat IBS (irritable bowel syndrome). Dothidep 50 mg Tablet is a tricyclic antidepressant medication used to treat depression.

It is not intended for insomnia with depression alone. However, your doctor may suggest Dothidep 50 mg Tablet to treat insomnia with depression in some cases. Please consult your doctor for personalized guidance.

Dothidep 50 mg Tablet can change the way your nerves receive pain signals. This can help with some kinds of nerve pain, including fibromyalgia. However, it should only be taken as prescribed by the doctor.

Dothidep 50 mg Tablet is sometimes used to treat some types of nerve pain, such as fibromyalgia, or to prevent migraine. But it's not recommended or officially approved for pain relief.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad ? 380015, Gujarat, India.
Other Info - DOT0030

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

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Reference

  1. https://www.tewv.nhs.uk/content/uploads/2018/09/Dosulepin-guidance.pdf
  2. https://www.nhs.uk/medicines/dosulepin/

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