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  3. Domstal NP-250 mg Tablet 10's

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Domstal NP-250 mg Tablet 10's, Pack of 10 TABLETS
Domstal NP-250 mg Tablet 10's, Pack of 10 TABLETS
Domstal NP-250 mg Tablet 10's, Pack of 10 TABLETS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Veda Maddala , M Pharmacy

Domstal NP-250 mg Tablet is used to treat migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It contains Naproxen and Domperidone, which work by reducing certain chemical substances (prostaglandins) that cause pain and swelling. Also, it prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre in the brain. It may cause common side effects such as dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DOMPERIDONE-10MG + NAPROXEN-250MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Domstal NP-250 mg Tablet

Domstal NP-250 mg Tablet belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterised by intense headaches. Pain is a symptom that occurs due to various underlying conditions. It also controls nausea and vomiting associated with migraine.

Domstal NP-250 mg Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclooxygenase (COX) enzyme in the body, which produces certain chemical substances, such as prostaglandins, that cause pain and swelling. Domperidone is an antiemetic agent that prevents nausea and vomiting symptoms by blocking specific receptors, such as dopamine and serotonin, that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.

Take Domstal NP-250 mg Tablet as prescribed by your doctor. You are advised to take Domstal NP-250 mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. Common side effects of Domstal NP-250 mg Tablet are dry mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Consult your doctor if you feel any discomfort.

Before taking the Domstal NP-250 mg Tablet , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor can weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers. Patients above 65 years of age, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Domstal NP-250 mg Tablet only when prescribed by a doctor.

Uses of Domstal NP-250 mg Tablet

Domstal NP-250 mg Tablet is used in the treatment of migraine headache, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). The detailed uses of Domstal NP-250 mg Tablet are as follows:

  • Effective Pain Relief: Domstal NP-250 mg Tablet is commonly prescribed to alleviate moderate to severe pain, including headaches, dental pain, menstrual cramps, and postoperative discomfort. It works by blocking the production of chemicals responsible for inflammation and pain.
  • Powerful Anti-inflammatory Action: With its active ingredient, naproxen, Domstal NP-250 mg Tablet helps reduce inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, providing relief from joint pain and swelling.
  • Fever Management: Domstal NP-250 mg Tablet is also effective in lowering fever across various conditions, offering relief and aiding the body's recovery process.
  • Relief for Muscle Pain: Whether caused by exercise, strains, or injuries, Domstal NP-250 mg Tablet can help alleviate muscle pain, improving comfort and mobility.
  • Nausea and vomiting: It also controls nausea and vomiting associated with migraine headaches.

Have a query?

Directions for Use

  • Domstal NP-250 mg Tablet can be taken with meals, to avoid stomach ulcers and irritation.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the whole tablet with a glass of water.
  • Do not crush, chew or break it.
     

Medicinal Benefits

Domstal NP-250 mg Tablet is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduces inflammation) and analgesic (reduces pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty the stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present in the chemoreceptor trigger zone, which is responsible for regulating nausea and vomiting.

How Domstal NP-250 mg Tablet Works

Domstal NP-250 mg Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Domstal NP-250 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Domstal NP-250 mg Tablet

Do not take more than the prescribed dose of Domstal NP-250 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDS (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDS) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older in age, are an alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.

Drug-Drug Interactions

verifiedApollotooltip
OmeprazoleErlotinib
Critical
OmeprazoleRilpivirine
Critical

Drug-Drug Interactions

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OmeprazoleErlotinib
Critical
How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet can make Erlotinib less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Domstal NP-250 mg Tablet and Erlotinib together is not recommended as it can result in an interaction; it should be taken only if a doctor has advised it. Do not stop using any medications without talking to a doctor.
OmeprazoleRilpivirine
Critical
How does the drug interact with Domstal NP-250 mg Tablet:
Using rilpivirine together with Domstal NP-250 mg Tablet can decrease the absorption and blood levels of rilpivirine.

How to manage the interaction:
Taking Domstal NP-250 mg Tablet with Rilpivirine can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
OmeprazolePazopanib
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet may interfere with pazopanib absorption and reduces its effectiveness.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with pazopanib can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
OmeprazoleIsoniazid
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
When Domstal NP-250 mg Tablet is taken with Isoniazid, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Domstal NP-250 mg Tablet with Isoniazid can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without talking to a doctor.
OmeprazoleItraconazole
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Co-administration of Domstal NP-250 mg Tablet with itraconazole can lessen the amount or effects of itraconazole.

How to manage the interaction:
Although taking Itraconazole along with Domstal NP-250 mg Tablet can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
OmeprazoleAtazanavir
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
When taken together, Domstal NP-250 mg Tablet, through decreasing stomach acid, can reduce atazanavir absorption and blood levels, making the medication less effective.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with atazanavir can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
OmeprazoleTacrolimus
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Taking tacrolimus with Domstal NP-250 mg Tablet may significantly increase the blood levels of tacrolimus, which may increase the risk of serious side effects (high sugars, infections, kidney problems, hyperkalemia - high blood levels of potassium).

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with tacrolimus can lead to interaction, they can be taken if recommended by a doctor. However, consult the doctor if you experience irregular heart rhythm, palpitations (fast heartbeat), muscle spasm, tremor (shaking of hands & legs), and seizures(fits). Do not stop using any medications without talking to a doctor.
OmeprazoleClopidogrel
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
When taken together Domstal NP-250 mg Tablet can lower the levels of Clopidogrel in the blood, which can result in a decreased effectiveness of clopidogrel.

How to manage the interaction:
Taking Domstal NP-250 mg Tablet and clopidogrel together has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
OmeprazoleCarbamazepine
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Taking Domstal NP-250 mg Tablet and carbamazepine may possibly reduce the effects of Domstal NP-250 mg Tablet, which could reduce its capacity to treat the condition.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet and carbamazepine together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without consulting a doctor.
OmeprazoleAcalabrutinib
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet, through decreasing stomach acidity, may interfere with the absorption of acalabrutinib capsules and reduce their effectiveness.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with acalabrutinib can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of fluids to avoid gastrointestinal problems.
  • Avoid triggers that can increase your migraine headache.
  • Take enough rest.
  • Acupuncture, massage and physical therapy may also be helpful.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Avoid smoking and alcohol consumption.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

Habit Forming

No

Therapeutic Class

ANALGESICS

Domstal NP-250 mg Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

It is advised not to take alcohol as Domstal NP-250 mg Tablet can cause dizziness or drowsiness.

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Pregnancy

Caution

Domstal NP-250 mg Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Domstal NP-250 mg Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Unsafe

It is unsafe to drive after taking Domstal NP-250 mg Tablet as it impacts your ability to drive or operate machinery.

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Liver

Caution

Limited information was available for the use of Domstal NP-250 mg Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-250 mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of Domstal NP-250 mg Tablet in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-250 mg Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

Domstal NP-250 mg Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

FAQs

Domstal NP-250 mg Tablet is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It also controls nausea and vomiting associated with migraines.

Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

Domstal NP-250 mg Tablet cannot permanently cure migraine. It can provide relief from pain and headache.

Domstal NP-250 mg Tablet on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.

Arthritis is a chronic condition of joints with pain and inflammation. Domstal NP-250 mg Tablet does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.

Yes, Domstal NP-250 mg Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Domstal NP-250 mg Tablet .

Dry mouth may be caused by Domperidone in Domstal NP-250 mg Tablet . Chew a sugar-free sweet or sugar-free gum.

Yes, Domstal NP-250 mg Tablet is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Besides this, it can also be used to reduce pain in gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).

Domstal NP-250 mg Tablet usually starts working within 30-60 minutes after oral intake. However, the exact time may vary based on individual response and medical condition. Always consult your doctor for personalized guidance and proper usage.

To ensure safe and effective treatment, it's helpful to know that Domstal NP-250 mg Tablet may have a potential impact on blood pressure, but with proper monitoring, you can minimize risks. By working closely with your healthcare provider, you can enjoy the benefits of Domstal NP-250 mg Tablet while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.

Domstal NP-250 mg Tablet is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an antiemetic and prokinetic agent. This combination helps relieve pain and prevents nausea, improving overall comfort.

The side effects of Domstal NP-250 mg Tablet include dryness of the mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult your doctor if any symptoms persist or worsen.

You should consult your doctor before stopping Domstal NP-250 mg Tablet , even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to treat your medical condition effectively.

Yes, Domstal NP-250 mg Tablet may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.

To ensure a safe and effective treatment experience with Domstal NP-250 mg Tablet , it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimize risks and maximize benefits. Domstal NP-250 mg Tablet is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.

Yes, prolonged or frequent use of Domstal NP-250 mg Tablet may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.

No, you should not take a higher than the recommended dose of Domstal NP-250 mg Tablet , as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.

Domstal NP-250 mg Tablet should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India.
Other Info - DOM0226

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Author Details

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 5, 2025 | 10:56 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a681029.html
  2. https://www.drugs.com/uk/domperidone-10mg-film-coated-tablets-leaflet.html
  3. https://www.nhs.uk/medicines/naproxen/
  4. https://www.nhs.uk/medicines/domperidone/

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